KEGG   PATHWAY: ko00071Help
Entry
ko00071                     Pathway                                

Name
Fatty acid degradation
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
ko00071  Fatty acid degradation
ko00071

Ortholog table
Module
M00086  beta-Oxidation, acyl-CoA synthesis [PATH:ko00071]
M00087  beta-Oxidation [PATH:ko00071]
Disease
H00162  Sjogren-Larsson syndrome
H00178  Glutaric acidemia
H00375  SBCAD deficiency
H00392  VLCAD deficiency
H00488  MCAD deficiency
H00525  Disorders of mitochondrial fatty-acid oxidation
H01267  Familial hyperinsulinemic hypoglycemia
H01352  Mitochondrial trifunctional protein deficiency
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
H01400  Secondary hyperammonemia
H01980  SCAD deficiency
H01981  Carnitine palmitoyltransferase I deficiency
H01982  Carnitine palmitoyltransferase II deficiency
H02096  Peroxisomal acyl-CoA oxidase deficiency
Orthology
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K00632  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07513  acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
K07508  acetyl-CoA acyltransferase 2 [EC:2.3.1.16]
K07509  acetyl-CoA acyltransferase [EC:2.3.1.16]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07511  enoyl-CoA hydratase [EC:4.2.1.17]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
K00232  acyl-CoA oxidase [EC:1.3.3.6]
K00248  butyryl-CoA dehydrogenase [EC:1.3.8.1]
K00249  acyl-CoA dehydrogenase [EC:1.3.8.7]
K00255  long-chain-acyl-CoA dehydrogenase [EC:1.3.8.8]
K06445  acyl-CoA dehydrogenase [EC:1.3.99.-]
K09478  short/branched chain acyl-CoA dehydrogenase [EC:1.3.99.12]
K09479  very long chain acyl-CoA dehydrogenase [EC:1.3.8.9]
K00252  glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01897  long-chain acyl-CoA synthetase [EC:6.2.1.3]
K15013  long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]
K08765  carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
K19523  carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21]
K19524  carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
K08766  carnitine O-palmitoyltransferase 2 [EC:2.3.1.21]
K01909  long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:6.2.1.20]
K05939  acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20]
K13238  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K13239  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K07517  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K18880  Delta3-Delta2-enoyl-CoA isomerase [EC:5.3.3.8]
K00496  alkane 1-monooxygenase [EC:1.14.15.3]
K07425  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K15401  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K20495  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K22887  long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K05297  rubredoxin---NAD+ reductase [EC:1.18.1.1]
K21738  rubredoxin---NAD+ reductase [EC:1.18.1.1]
K22567  rubredoxin---NAD+ reductase [EC:1.18.1.1]
K13951  alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980  alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K13952  alcohol dehydrogenase 6 [EC:1.1.1.1]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
K13953  alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954  alcohol dehydrogenase [EC:1.1.1.1]
K18857  alcohol dehydrogenase class-P [EC:1.1.1.1]
K00001  alcohol dehydrogenase [EC:1.1.1.1]
K00128  aldehyde dehydrogenase (NAD+) [EC:1.2.1.3]
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
K00149  aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
K00493  unspecific monooxygenase [EC:1.14.14.1]
K14338  cytochrome P450 / NADPH-cytochrome P450 reductase [EC:1.14.14.1 1.6.2.4]
Compound
C00010  CoA
C00024  Acetyl-CoA
C00071  Aldehyde
C00136  Butanoyl-CoA
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00226  Primary alcohol
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00332  Acetoacetyl-CoA
C00340  Reduced rubredoxin
C00435  Oxidized rubredoxin
C00489  Glutarate
C00517  Hexadecanal
C00527  Glutaryl-CoA
C00638  Long-chain fatty acid
C00823  1-Hexadecanol
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01371  Alkane
C01832  Lauroyl-CoA
C01944  Octanoyl-CoA
C02593  Tetradecanoyl-CoA
C02990  L-Palmitoylcarnitine
C03221  2-trans-Dodecenoyl-CoA
C03547  omega-Hydroxy fatty acid
C03561  (R)-3-Hydroxybutanoyl-CoA
C05102  alpha-Hydroxy fatty acid
C05258  (S)-3-Hydroxyhexadecanoyl-CoA
C05259  3-Oxopalmitoyl-CoA
C05260  (S)-3-Hydroxytetradecanoyl-CoA
C05261  3-Oxotetradecanoyl-CoA
C05262  (S)-3-Hydroxydodecanoyl-CoA
C05263  3-Oxododecanoyl-CoA
C05264  (S)-Hydroxydecanoyl-CoA
C05265  3-Oxodecanoyl-CoA
C05266  (S)-3-Hydroxyoctanoyl-CoA
C05267  3-Oxooctanoyl-CoA
C05268  (S)-Hydroxyhexanoyl-CoA
C05269  3-Oxohexanoyl-CoA
C05270  Hexanoyl-CoA
C05271  trans-Hex-2-enoyl-CoA
C05272  trans-Hexadec-2-enoyl-CoA
C05273  trans-Tetradec-2-enoyl-CoA
C05274  Decanoyl-CoA
C05275  trans-Dec-2-enoyl-CoA
C05276  trans-Oct-2-enoyl-CoA
C05279  trans,cis-Lauro-2,6-dienoyl-CoA
C05280  cis,cis-3,6-Dodecadienoyl-CoA
C20683  Long-chain acyl-[acyl-carrier protein]
Reference
PMID:869535
  Authors
Parekh VR, Traxler RW, Sobek JM
  Title
N-Alkane oxidation enzymes of a pseudomonad.
  Journal
Appl Environ Microbiol 33:881-4 (1977)

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