KEGG   PATHWAY: ko00562Help
Entry
ko00562                     Pathway                                

Name
Inositol phosphate metabolism
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
ko00562  Inositol phosphate metabolism
ko00562

Ortholog table
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 [PATH:ko00562]
M00131  Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol [PATH:ko00562]
M00132  Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate [PATH:ko00562]
Disease
H00530  Joubert syndrome
H00692  Lowe syndrome
H00694  Dent disease
H00700  Centronuclear myopathy
H00957  Fleck corneal dystrophy (FCD)
H01195  VACTERL/VATER association
H01387  Activated PI3K-delta syndrome (APDS)
Other DBs
BSID: 362
GO: 0006020
Orthology
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
K01108  myotubularin [EC:3.1.3.95 3.1.3.64]
K18081  myotubularin-related protein 1/2 [EC:3.1.3.95 3.1.3.64]
K18082  myotubularin-related protein 3/4 [EC:3.1.3.95 3.1.3.64 3.1.3.48]
K18083  myotubularin-related protein 6/7/8 [EC:3.1.3.95 3.1.3.64]
K18086  myotubularin-related protein 14 [EC:3.1.3.95 3.1.3.64]
K21302  phosphatidylinositol-3-phosphatase [EC:3.1.3.64]
K00888  phosphatidylinositol 4-kinase A [EC:2.7.1.67]
K19801  phosphatidylinositol 4-kinase B [EC:2.7.1.67]
K13711  phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
K21797  phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
K21798  phosphatidylinositol 4-phosphatase [EC:3.1.3.-]
K00889  1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
K13712  phosphatidylinositol-4-phosphate 5-kinase-like protein 1 [EC:2.7.1.68]
K01099  inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
K20278  inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]
K20279  synaptojanin [EC:3.1.3.36]
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K21289  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
K01110  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.67 3.1.3.48 3.1.3.16]
K03084  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [EC:3.1.3.86]
K15909  phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [EC:3.1.3.86]
K00923  phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K01109  inositol polyphosphate-4-phosphatase [EC:3.1.3.66]
K00921  1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
K00920  1-phosphatidylinositol-5-phosphate 4-kinase [EC:2.7.1.149]
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05857  phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K05861  phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]
K19006  phosphatidylinositol phospholipase C, eta [EC:3.1.4.11]
K01114  phospholipase C [EC:3.1.4.3]
K16619  phospholipase C / alpha-toxin [EC:3.1.4.3]
K01771  1-phosphatidylinositol phosphodiesterase [EC:4.6.1.13]
K01092  myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
K10047  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.93 3.1.3.25]
K18649  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.15 3.1.3.93 3.1.3.25]
K15759  inositol monophosphatase 3 [EC:3.1.3.7 3.1.3.25]
K00999  CDP-diacylglycerol--inositol 3-phosphatidyltransferase [EC:2.7.8.11]
K01858  myo-inositol-1-phosphate synthase [EC:5.5.1.4]
K01107  inositol polyphosphate 1-phosphatase [EC:3.1.3.57]
K15422  3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase [EC:3.1.3.57 3.1.3.7]
K19517  1D-myo-inositol 3-kinase [EC:2.7.1.64]
K01106  inositol-1,4,5-trisphosphate 5-phosphatase [EC:3.1.3.56]
K03103  multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase [EC:3.1.3.80 3.1.3.62]
K00911  1D-myo-inositol-triphosphate 3-kinase [EC:2.7.1.127]
K00913  inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.134 2.7.1.159]
K01765  inositol-1,3,4-trisphosphate 5/6-kinase [EC:2.7.1.159]
K00915  inositol-polyphosphate multikinase [EC:2.7.1.151 2.7.1.140]
K10572  inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]
K19786  inositol-pentakisphosphate 2-kinase [EC:2.7.1.158]
K01083  3-phytase [EC:3.1.3.8]
K01093  4-phytase / acid phosphatase [EC:3.1.3.2 3.1.3.26]
K07281  1L-myo-inositol 1-phosphate cytidylyltransferase [EC:2.7.7.74]
K07291  CDP-L-myo-inositol myo-inositolphosphotransferase [EC:2.7.8.34]
K00469  inositol oxygenase [EC:1.13.99.1]
K00010  myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase [EC:1.1.1.369 1.1.1.18]
K06606  2-keto-myo-inositol isomerase [EC:5.3.99.11]
K16043  scyllo-inositol 2-dehydrogenase (NAD+) [EC:1.1.1.370]
K16044  scyllo-inositol 2-dehydrogenase (NADP+) [EC:1.1.1.371]
K22230  scyllo-inositol 2-dehydrogenase (NADP+) [EC:1.1.1.-]
K22231  scyllo-inosose 3-dehydrogenase [EC:1.1.1.-]
K22232  3-dehydro-scyllo-inosose hydrolase [EC:3.7.1.-]
K22233  5-keto-L-gluconate epimerase [EC:5.1.-.-]
K03335  inosose dehydratase [EC:4.2.1.44]
K03336  3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing) [EC:3.7.1.22]
K03337  5-deoxy-glucuronate isomerase [EC:5.3.1.30]
K03338  5-dehydro-2-deoxygluconokinase [EC:2.7.1.92]
K03339  6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase [EC:4.1.2.29]
K00140  malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.27 1.2.1.18]
K01803  triosephosphate isomerase (TIM) [EC:5.3.1.1]
Compound
C00024  Acetyl-CoA
C00092  D-Glucose 6-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00137  myo-Inositol
C00191  D-Glucuronate
C00222  3-Oxopropanoate
C00558  D-Tagaturonate
C00641  1,2-Diacyl-sn-glycerol
C00691  2,4,6/3,5-Pentahydroxycyclohexanone
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C03659  D-Bornesitol
C03660  L-Bornesitol
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04287  3D-3,5/4-Trihydroxycyclohexane-1,2-dione
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04520  1D-myo-Inositol 3,4,5,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04563  D-myo-Inositol 1,2,4,5,6-pentakisphosphate
C04579  Inositol 1,2,3,5,6-pentakisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06153  scyllo-Inositol
C06892  2-Deoxy-5-keto-D-gluconic acid
C06893  2-Deoxy-5-keto-D-gluconic acid 6-phosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C16737  5-Deoxy-D-glucuronate
C19794  CDP-1L-myo-inositol
C19799  Bis(1L-myo-inositol)-3,1'-phosphate 1-phosphate
C19891  1D-chiro-Inositol
C20251  1-Keto-D-chiro-inositol
C21643  3-Dehydro-scyllo-inosose
C21644  5-Dehydro-L-gluconate
Reference
  Authors
Yoshida K, Yamaguchi M, Ikeda H, Omae K, Tsurusaki K, Fujita Y
  Title
The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase.
  Journal
Microbiology 150:571-80 (2004)
DOI:10.1099/mic.0.26768-0
Reference
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y.
  Title
myo-Inositol catabolism in Bacillus subtilis.
  Journal
J Biol Chem 283:10415-24 (2008)
DOI:10.1074/jbc.M708043200

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