KEGG   PATHWAY: ko00740Help
Entry
ko00740                     Pathway                                

Name
Riboflavin metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
ko00740  Riboflavin metabolism
ko00740

Ortholog table
Module
M00125  Riboflavin biosynthesis, GTP => riboflavin/FMN/FAD [PATH:ko00740]
Disease
H01002  Generalized arterial calcification of infancy
H01113  Acid phosphatase deficiency
H01394  Cole disease
Other DBs
BSID: 398
GO: 0006771
Orthology
K01497  GTP cyclohydrolase II [EC:3.5.4.25]
K14652  3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:3.5.4.25 4.1.99.12]
K08096  GTP cyclohydrolase IIa [EC:3.5.4.29]
K14653  2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase [EC:3.5.1.102]
K01498  diaminohydroxyphosphoribosylaminopyrimidine deaminase [EC:3.5.4.26]
K00082  5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193]
K11752  diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:1.1.1.193 3.5.4.26]
K14654  2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [EC:1.1.1.302]
K14655  tRNA pseudouridine32 synthase / 2,5-diamino-6-(5-phospho-D-ribitylamino)-pyrimidin-4(3H)-one deaminase [EC:5.4.99.28]
K20860  FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104 3.1.3.102]
K20861  FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104 3.1.3.102]
K20862  FMN hydrolase / 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104 3.1.3.102]
K21063  5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
K21064  5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
K02858  3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12]
K00794  6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
K00793  riboflavin synthase [EC:2.5.1.9]
K00861  riboflavin kinase [EC:2.7.1.26]
K20884  riboflavin kinase / FMN hydrolase [EC:3.1.3.102 2.7.1.26]
K11753  riboflavin kinase / FMN adenylyltransferase [EC:2.7.7.2 2.7.1.26]
K07732  riboflavin kinase, archaea type [EC:2.7.1.161]
K01078  acid phosphatase [EC:3.1.3.2]
K01093  4-phytase / acid phosphatase [EC:3.1.3.2 3.1.3.26]
K03788  acid phosphatase (class B) [EC:3.1.3.2]
K09474  acid phosphatase (class A) [EC:3.1.3.2]
K14379  tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]
K14394  low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.48 3.1.3.2]
K14410  lysosomal acid phosphatase [EC:3.1.3.2]
K00953  FAD synthetase [EC:2.7.7.2]
K14656  FAD synthetase [EC:2.7.7.2]
K01513  ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.6.1.9 3.1.4.1]
K18453  ADP-ribose/FAD diphosphatase [EC:3.6.1.18 3.6.1.13]
K00484  flavin reductase (NADH) [EC:1.5.1.36]
K22393  flavin reductase (NADH) subunit 1 [EC:1.5.1.36]
K22394  flavin reductase (NADH) subunit 2 [EC:1.5.1.36]
K00299  FMN reductase [EC:1.5.1.38]
K19285  FMN reductase (NADPH) [EC:1.5.1.38]
K19286  FMN reductase [NAD(P)H] [EC:1.5.1.39]
K20146  nitrilotriacetate monooxygenase reductase component [EC:1.5.1.42]
K15245  chlorophenol-4-monooxygenase component 1 [EC:1.5.1.37]
K16902  FAD reductase [NAD(P)H] [EC:1.5.1.45]
K05901  biliverdin reductase / flavin reductase [EC:1.5.1.30 1.3.1.24]
K05368  aquacobalamin reductase / NAD(P)H-flavin reductase [EC:1.5.1.41 1.16.1.3]
K04719  5,6-dimethylbenzimidazole synthase [EC:1.13.11.79]
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
Reference
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780

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