KEGG   PATHWAY: ko01058
Entry
ko01058                     Pathway                                

Name
Acridone alkaloid biosynthesis
Description
Acridone alkaloids are anthranillic acid-derived plant alkaloids found in Rutaceae (rue family). Compounds in this class have been tested for antitumor and antimicrobial activities.
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ko01058  Acridone alkaloid biosynthesis
ko01058

Orthology
K12643  anthranilate N-methyltransferase [EC:2.1.1.111]
K12644  acridone synthase [EC:2.3.1.159]
Compound
C00108  Anthranilate
C03005  N-Methylanthranilate
C10632  Acronycine
C10722  Melicopicine
C10738  Rutacridone
C12092  N-Methylanthraniloyl-CoA
C12093  1,3-Dihydroxy-N-methylacridone
Reference
  Authors
Funayama S.
  Title
[Arukaroido -Doku to Kusuri no Houko-] (In Japanese)
  Journal
Kyouritu shuppan kabusikikaisya:183-187 (1998)
Reference
  Authors
Dewick PM.
  Title
Medicinal Natural Products: A Biosynthetic Approach, Second Edition
  Journal
John Wiley and Sons (2001)
Reference
  Authors
Harborne JB, Baxter H, Moss GP.
  Title
Phytochemical Dictionary: A Handbook of Bioactive Compounds from Plants, Second Edition
  Journal
Taylor and Francis (1999)
Reference
  Authors
Lukacin R, Springob K, Urbanke C, Ernwein C, Schroder G, Schroder J, Matern U.
  Title
Native acridone synthases I and II from Ruta graveolens L. form homodimers
  Journal
FEBS Lett 448:135-40 (1999)
DOI:10.1016/S0014-5793(99)00355-5
Related
pathway
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis

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