KEGG   PATHWAY: ko03013
ko03013                     Pathway                                

RNA transport
RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.
Genetic Information Processing; Translation
Pathway map
ko03013  RNA transport

H00455  Spinal muscular atrophy
H00465  Fragile X syndrome
H00869  Leukoencephalopathy with vanishing white matter
H01177  Infantile bilateral striatal necrosis
H01731  Fragile X tremor/ataxia syndrome
H02195  MEHMO syndrome
H02253  Beaulieu-Boycott-Innes syndrome
Other DBs
GO: 0050658
K01164  ribonuclease P/MRP protein subunit POP1 [EC:]
K14522  ribonuclease P/MRP protein subunit POP3 [EC:]
K14523  ribonucleases P/MRP protein subunit RPP38 [EC:]
K03538  ribonuclease P protein subunit POP4 [EC:]
K03537  ribonuclease P/MRP protein subunit POP5 [EC:]
K14524  ribonuclease P/MRP protein subunit POP6 [EC:]
K14525  ribonucleases P/MRP protein subunit RPP25 [EC:]
K14526  ribonuclease P/MRP protein subunit POP7 [EC:]
K14527  ribonuclease P/MRP protein subunit RPP20 [EC:]
K14528  ribonuclease P/MRP protein subunit POP8 [EC:]
K14529  ribonuclease P protein subunit RPP14 [EC:]
K03539  ribonuclease P/MRP protein subunit RPP1 [EC:]
K03540  ribonuclease P protein subunit RPR2 [EC:]
K14530  ribonucleases P/MRP protein subunit RPP40 [EC:]
K18213  proteinaceous RNase P [EC:]
K14533  ribonuclease P protein component, mitochondrial [EC:]
K00784  ribonuclease Z [EC:]
K00974  tRNA nucleotidyltransferase (CCA-adding enzyme) [EC: 3.1.3.- 3.1.4.-]
K07936  GTP-binding nuclear protein Ran
K14288  exportin-T
K14289  exportin-5
K03231  elongation factor 1-alpha
K14290  exportin-1
K14291  phosphorylated adapter RNA export protein
K12882  nuclear cap-binding protein subunit 1
K12883  nuclear cap-binding protein subunit 2
K05019  chloride channel, nucleotide-sensitive, 1A
K02516  type II protein arginine methyltransferase [EC:]
K14292  trimethylguanosine synthase [EC:2.1.1.-]
K14293  importin subunit beta-1
K13151  snurportin-1
K07562  nonsense-mediated mRNA decay protein 3
K14294  partner of Y14 and mago
K09291  nucleoprotein TPR
K14295  nuclear pore complex protein Nup50
K14296  nuclear pore complex protein Nup153
K03345  sentrin-specific protease 2 (axin associating molecule) [EC:]
K14297  nuclear pore complex protein Nup98-Nup96
K14298  mRNA export factor
K14004  protein transport protein SEC13
K14299  nucleoporin SEH1
K14300  nuclear pore complex protein Nup133
K14301  nuclear pore complex protein Nup107
K14302  nuclear pore complex protein Nup37
K14303  nuclear pore complex protein Nup160
K14304  nuclear pore complex protein Nup85
K14305  nuclear pore complex protein Nup43
K14306  nuclear pore complex protein Nup62
K14307  nucleoporin p58/p45
K14308  nuclear pore complex protein Nup54
K14309  nuclear pore complex protein Nup93
K14310  nuclear pore complex protein Nup205
K14311  nuclear pore complex protein Nup188
K14312  nuclear pore complex protein Nup155
K14313  nuclear pore complex protein Nup53
K14314  nuclear pore complex protein Nup210
K14315  nucleoporin NDC1
K14316  nuclear pore complex protein Nup121
K14317  nuclear pore complex protein Nup214
K14318  nuclear pore complex protein Nup88
K12172  E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
K14319  Ran GTPase-activating protein 1
K10577  ubiquitin-conjugating enzyme E2 I
K12160  small ubiquitin-related modifier
K14320  aladin
K14321  nucleoporin-like protein 2
K13129  survival motor neuron protein
K13130  gem associated protein 2
K13131  ATP-dependent RNA helicase DDX20 [EC:]
K13132  gem associated protein 4
K13133  gem associated protein 5
K13134  gem associated protein 6
K13135  gem associated protein 7
K13136  gem associated protein 8
K13137  serine-threonine kinase receptor-associated protein
K03245  translation initiation factor 3 subunit J
K03246  translation initiation factor 3 subunit I
K03247  translation initiation factor 3 subunit H
K03248  translation initiation factor 3 subunit G
K03249  translation initiation factor 3 subunit F
K03250  translation initiation factor 3 subunit E
K03251  translation initiation factor 3 subunit D
K03252  translation initiation factor 3 subunit C
K03253  translation initiation factor 3 subunit B
K03254  translation initiation factor 3 subunit A
K03236  translation initiation factor 1A
K03113  translation initiation factor 1
K03262  translation initiation factor 5
K03237  translation initiation factor 2 subunit 1
K03238  translation initiation factor 2 subunit 2
K03242  translation initiation factor 2 subunit 3
K03239  translation initiation factor eIF-2B subunit alpha
K03754  translation initiation factor eIF-2B subunit beta
K03680  translation initiation factor eIF-2B subunit delta
K03241  translation initiation factor eIF-2B subunit gamma
K03240  translation initiation factor eIF-2B subunit epsilon
K03243  translation initiation factor 5B
K03260  translation initiation factor 4G
K03259  translation initiation factor 4E
K03257  translation initiation factor 4A
K03258  translation initiation factor 4B
K13126  polyadenylate-binding protein
K14322  polyadenylate-binding protein-interacting protein 1
K07205  eukaryotic translation initiation factor 4E binding protein 1
K18644  eukaryotic translation initiation factor 4E binding protein 2
K18645  eukaryotic translation initiation factor 4E binding protein 3
K14283  transforming acidic coiled-coil-containing protein 3
K05749  cytoplasmic FMR1 interacting protein
K15516  fragile X mental retardation protein
K12876  RNA-binding protein 8A
K12877  protein mago nashi
K14323  protein CASC3
K13025  ATP-dependent RNA helicase [EC:]
K14324  histone deacetylase complex subunit SAP18
K13114  pinin
K12875  apoptotic chromatin condensation inducer in the nucleus
K14325  RNA-binding protein with serine-rich domain 1
K12881  THO complex subunit 4
K12812  ATP-dependent RNA helicase UAP56/SUB2 [EC:]
K12878  THO complex subunit 1
K12879  THO complex subunit 2
K13174  THO complex subunit 5
K13175  THO complex subunit 6
K13176  THO complex subunit 7
K12880  THO complex subunit 3
K13171  serine/arginine repetitive matrix protein 1
K14284  nuclear RNA export factor
K14285  NTF2-related export protein 1/2
K14543  mRNA transport regulator MTR2
K14326  regulator of nonsense transcripts 1 [EC:3.6.4.-]
K14327  regulator of nonsense transcripts 2
K14328  regulator of nonsense transcripts 3
K14276  U1 spliceosomal RNA
K14277  U2 spliceosomal RNA
K14278  U4 spliceosomal RNA
K14279  U5 spliceosomal RNA
K14280  U6 spliceosomal RNA
K14483  U3 small nucleolar RNA
C00035  GDP
C00044  GTP
C01647  tRNA(Met)
Rodriguez MS, Dargemont C, Stutz F
Nuclear export of RNA.
Biol Cell 96:639-55 (2004)
Suzuki T, Izumi H, Ohno M
Cajal body surveillance of U snRNA export complex assembly.
J Cell Biol 190:603-12 (2010)
Palancade B, Doye V
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
Trends Cell Biol 18:174-83 (2008)
Pellizzoni L
Chaperoning ribonucleoprotein biogenesis in health and disease.
EMBO Rep 8:340-5 (2007)
Gingras AC, Raught B, Sonenberg N
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
Annu Rev Biochem 68:913-63 (1999)
Asano K, Clayton J, Shalev A, Hinnebusch AG
A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.
Genes Dev 14:2534-46 (2000)
Craig AW, Haghighat A, Yu AT, Sonenberg N
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
Nature 392:520-3 (1998)
Reed R, Cheng H
TREX, SR proteins and export of mRNA.
Curr Opin Cell Biol 17:269-73 (2005)
Tange TO, Shibuya T, Jurica MS, Moore MJ
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
RNA 11:1869-83 (2005)
ko03008  Ribosome biogenesis in eukaryotes
ko03010  Ribosome
ko03015  mRNA surveillance pathway
ko03020  RNA polymerase
ko03040  Spliceosome

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