KEGG   PATHWAY: ko03015Help
Entry
ko03015                     Pathway                                

Name
mRNA surveillance pathway
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
ko03015  mRNA surveillance pathway
ko03015

Ortholog table
Module
M00399  Cap binding complex [PATH:ko03015]
M00430  Exon junction complex (EJC) [PATH:ko03015]
Disease
H00704  Oculopharyngeal muscular dystrophy (OPMD)
H00897  Pontocerebellar hypoplasia
Other DBs
BSID: 193184
GO: 0071028
Orthology
K12882  nuclear cap-binding protein subunit 1
K12883  nuclear cap-binding protein subunit 2
K14328  regulator of nonsense transcripts 3
K12876  RNA-binding protein 8A
K12877  protein mago nashi
K14323  protein CASC3
K13025  ATP-dependent RNA helicase [EC:3.6.4.13]
K14324  histone deacetylase complex subunit SAP18
K13114  pinin
K12875  apoptotic chromatin condensation inducer in the nucleus
K14325  RNA-binding protein with serine-rich domain 1
K12881  THO complex subunit 4
K14284  nuclear RNA export factor
K14285  NTF2-related export protein 1/2
K14543  mRNA transport regulator MTR2
K12812  ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13]
K14294  partner of Y14 and mago
K13171  serine/arginine repetitive matrix protein 1
K13917  mRNA-capping enzyme [EC:3.6.1.- 2.7.7.50]
K00565  mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
K14396  polyadenylate-binding protein 2
K14397  cleavage and polyadenylation specificity factor subunit 5
K14398  cleavage and polyadenylation specificity factor subunit 6/7
K14376  poly(A) polymerase [EC:2.7.7.19]
K14399  polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
K14400  pre-mRNA cleavage complex 2 protein Pcf11
K14401  cleavage and polyadenylation specificity factor subunit 1
K14402  cleavage and polyadenylation specificity factor subunit 2
K14403  cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
K14404  cleavage and polyadenylation specificity factor subunit 4
K14405  pre-mRNA 3'-end-processing factor FIP1
K15541  protein MPE1
K15542  polyadenylation factor subunit 2
K14962  COMPASS component SWD2
K15543  RNA end formation protein 2
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
K15544  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
K14406  cleavage stimulation factor subunit 1
K14407  cleavage stimulation factor subunit 2
K14408  cleavage stimulation factor subunit 3
K06100  symplekin
K12595  superkiller protein 7
K14411  RNA-binding protein Musashi
K13126  polyadenylate-binding protein
K03265  peptide chain release factor subunit 1
K03267  peptide chain release factor subunit 3
K14326  regulator of nonsense transcripts 1 [EC:3.6.4.-]
K14327  regulator of nonsense transcripts 2
K08873  serine/threonine-protein kinase SMG1 [EC:2.7.11.1]
K14409  protein SMG7
K11125  protein SMG5
K11124  protein SMG6 [EC:3.1.-.-]
K04382  serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
K03456  serine/threonine-protein phosphatase 2A regulatory subunit A
K04354  serine/threonine-protein phosphatase 2A regulatory subunit B
K11583  serine/threonine-protein phosphatase 2A regulatory subunit B''
K11584  serine/threonine-protein phosphatase 2A regulatory subunit B'
K14416  elongation factor 1 alpha-like protein
K06965  protein pelota
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299

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