KEGG   PATHWAY: ko04360
Entry
ko04360                     Pathway                                
Name
Axon guidance
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
ko04360  Axon guidance
ko04360

Other DBs
GO: 0007411
Orthology
K07522  netrin-G1
K16359  netrin-G2
K07523  netrin-G1 ligand
K16351  netrin-G2 ligand
K06843  netrin 1
K06844  netrin 3
K06845  netrin 4
K06765  deleted in colorectal carcinoma
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K04964  transient receptor potential cation channel subfamily C member 1
K04966  transient receptor potential cation channel subfamily C member 3
K04967  transient receptor potential cation channel subfamily C member 4
K04968  transient receptor potential cation channel subfamily C member 5
K04969  transient receptor potential cation channel subfamily C member 6
K04348  serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K06268  serine/threonine-protein phosphatase 2B regulatory subunit
K17332  nuclear factor of activated T-cells, cytoplasmic 2
K17333  nuclear factor of activated T-cells, cytoplasmic 3
K17334  nuclear factor of activated T-cells, cytoplasmic 4
K05725  focal adhesion kinase 1 [EC:2.7.10.2]
K05703  tyrosine-protein kinase Fyn [EC:2.7.10.2]
K05704  tyrosine-protein kinase Src [EC:2.7.10.2]
K04392  Ras-related C3 botulinum toxin substrate 1
K07860  Ras-related C3 botulinum toxin substrate 2
K07861  Ras-related C3 botulinum toxin substrate 3
K04393  cell division control protein 42
K07520  actin-binding LIM protein
K07365  NCK adaptor protein 1
K04409  p21-activated kinase 1 [EC:2.7.11.1]
K04410  p21-activated kinase 2 [EC:2.7.11.1]
K05733  p21-activated kinase 3 [EC:2.7.11.1]
K05734  p21-activated kinase 4 [EC:2.7.11.1]
K05736  p21-activated kinase 5 [EC:2.7.11.1]
K05735  p21-activated kinase 6 [EC:2.7.11.1]
K04513  Ras homolog gene family, member A
K04514  Rho-associated protein kinase 1 [EC:2.7.11.1]
K17388  Rho-associated protein kinase 2 [EC:2.7.11.1]
K07521  netrin receptor unc-5
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K23096  repulsive guidance molecule A
K06766  neogenin
K12753  myosin regulatory light chain 5
K12755  myosin regulatory light chain 9
K12757  myosin regulatory light chain 12
K07532  Rho guanine nucleotide exchange factor 12
K24609  leucine-rich repeats and immunoglobulin-like domains protein 2
K05462  ephrin-A
K05463  ephrin-B
K05102  Eph receptor A1 [EC:2.7.10.1]
K05103  Eph receptor A2 [EC:2.7.10.1]
K05104  Eph receptor A3 [EC:2.7.10.1]
K05105  Eph receptor A4 [EC:2.7.10.1]
K05106  Eph receptor A5 [EC:2.7.10.1]
K05107  Eph receptor A6 [EC:2.7.10.1]
K05108  EphA7 [EC:2.7.10.1]
K05109  Eph receptor A8 [EC:2.7.10.1]
K05110  Eph receptor B1 [EC:2.7.10.1]
K05111  Eph receptor B2 [EC:2.7.10.1]
K05112  Eph receptor B3 [EC:2.7.10.1]
K05113  Eph receptor B4 [EC:2.7.10.1]
K05114  Eph receptor B6 [EC:2.7.10.1]
K06619  abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
K05746  enabled
K04352  Ras GTPase-activating protein 1
K07525  neuronal guanine nucleotide exchange factor
K02833  GTPase HRas
K07827  GTPase KRas
K07828  GTPase NRas
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K19862  NCK adaptor protein 2
K07524  regulator of G-protein signalling 3
K10031  C-X-C motif chemokine 12
K04189  C-X-C chemokine receptor type 4
K04630  guanine nucleotide-binding protein G(i) subunit alpha
K06838  slit 1
K06839  slit 2
K06850  slit 3
K06753  roundabout, axon guidance receptor 1
K06754  roundabout, axon guidance receptor 2
K06755  roundabout, axon guidance receptor 3
K07526  SLIT-ROBO Rho GTPase activating protein
K06840  semaphorin 3
K06820  plexin A
K06724  neuropilin 1
K06550  L1 cell adhesion molecule
K05743  LIM domain kinase 1 [EC:2.7.11.1]
K05744  LIM domain kinase 2 [EC:2.7.11.1]
K05765  cofilin
K07530  Ras homolog gene family, member D
K07531  Rho family GTPase 1
K07527  tyrosine-protein kinase Fes/Fps [EC:2.7.10.2]
K07529  dihydropyrimidinase-like 5
K07528  dihydropyrimidinase-like 2
K02090  cyclin-dependent kinase 5 [EC:2.7.11.22]
K03083  glycogen synthase kinase 3 beta [EC:2.7.11.26]
K06521  semaphorin 4
K06841  semaphorin 5
K06842  semaphorin 6
K06821  plexin B
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K07829  Ras-related protein R-Ras
K06529  semaphorin 7
K06572  plexin C
K05719  integrin beta 1
K11988  sonic hedgehog
K06225  patched 1
K06226  smoothened
K02677  classical protein kinase C alpha type [EC:2.7.11.13]
K06272  integrin-linked kinase [EC:2.7.11.1]
K20020  brother of CDO
K00444  wingless-type MMTV integration site family, member 5
K02329  frizzled 3
K05128  RYK receptor-like tyrosine kinase [EC:2.7.10.1]
K04515  calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K00408  wingless-type MMTV integration site family, member 4
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276  3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04237  partitioning defective protein 3
K18952  atypical protein kinase C zeta type [EC:2.7.11.13]
K06093  partitioning defective protein 6
K05766  protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]
K16621  bone morphogenetic protein 7
K20013  growth differentiation factor 7
K04671  bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K13578  bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04310  Wnt signaling pathway
ko04810  Regulation of actin cytoskeleton

  All links  
Gene (128)   
   KEGG ORTHOLOGY (128)   
All databases (128)   

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