Entry
Name
Epstein-Barr virus infection
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
ko05169 Epstein-Barr virus infection
Ortholog table
Disease
H00367 Infectious mononucleosis
Orthology
K19450 Lymphocryptovirus envelope glycoprotein GP350
K04012 complement receptor type 2
K06465 B-lymphocyte antigen CD19
K19451 Lymphocryptovirus envelope glycoprotein H
K19452 Lymphocryptovirus envelope glycoprotein L
K19453 Lymphocryptovirus virion egress protein UL7
K04729 myeloid differentiation primary response protein MyD88
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NF-kappa-B inhibitor alpha
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K03156 tumor necrosis factor superfamily, member 2
K12648 mitochondrial antiviral-signaling protein
K03174 TNF receptor-associated factor 3
K07211 inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K09447 interferon regulatory factor 7
K19455 Lymphocryptovirus serine/threonine-protein kinase BGLF4 [EC:2.7.11.1 ]
K05411 interferon regulatory factor 3
K19460 Lymphocryptovirus latent membrane protein 2A
K23074 Lymphocryptovirus latent membrane protein 2B
K19459 Lymphocryptovirus latent membrane protein 1
K11220 signal transducer and activator of transcription 1
K11221 signal transducer and activator of transcription 2
K04693 interferon regulatory factor 9
K16195 eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1 ]
K12671 C-X-C motif chemokine 10
K12159 ubiquitin cross-reactive protein
K04390 tumor necrosis factor receptor superfamily member 6
K02373 FAS-associated death domain protein
K04726 BH3 interacting domain death agonist
K19458 Lymphocryptovirus nuclear antigen 6
K22973 Lymphocryptovirus secreted protein BARF1
K02161 apoptosis regulator Bcl-2
K19463 Lymphocryptovirus apoptosis regulator BHRF1
K02159 apoptosis regulator BAX
K14021 Bcl-2 homologous antagonist/killer
K02084 apoptotic protease-activating factor
K10784 T cell receptor alpha chain V region
K10785 T-cell receptor beta chain V region
K06451 T-cell surface glycoprotein CD3 epsilon chain
K06452 T-cell surface glycoprotein CD3 gamma chain
K06450 T-cell surface glycoprotein CD3 delta chain
K06453 CD3Z antigen, zeta polypeptide
K03061 26S proteasome regulatory subunit T1
K03062 26S proteasome regulatory subunit T2
K03063 26S proteasome regulatory subunit T3
K03064 26S proteasome regulatory subunit T4
K03065 26S proteasome regulatory subunit T5
K03066 26S proteasome regulatory subunit T6
K03028 26S proteasome regulatory subunit N1
K03032 26S proteasome regulatory subunit N2
K03033 26S proteasome regulatory subunit N3
K03035 26S proteasome regulatory subunit N5
K03036 26S proteasome regulatory subunit N6
K03037 26S proteasome regulatory subunit N7
K03038 26S proteasome regulatory subunit N8
K03039 26S proteasome regulatory subunit N9
K03029 26S proteasome regulatory subunit N10
K03030 26S proteasome regulatory subunit N11
K03031 26S proteasome regulatory subunit N12
K06691 26S proteasome regulatory subunit N13
K10881 26 proteasome complex subunit DSS1
K19461 Lymphocryptovirus nuclear antigen 1
K22974 Lymphocryptovirus protein BNLF2a
K05653 ATP-binding cassette, subfamily B (MDR/TAP), member 2 [EC:7.4.2.14 ]
K05654 ATP-binding cassette, subfamily B (MDR/TAP), member 3 [EC:7.4.2.14 ]
K08058 TAP binding protein (tapasin)
K22975 Lymphocryptovirus G-protein coupled receptor BILF1
K19456 Lymphocryptovirus nuclear antigen leader protein
K19457 Lymphocryptovirus nuclear antigen 2
K06063 SNW domain-containing protein 1
K11644 paired amphipathic helix protein Sin3a
K06065 nuclear receptor co-repressor 2
K19202 histone deacetylase complex subunit SAP30
K06066 CBF1 interacting corepressor
K21855 Lymphocryptovirus nuclear antigen 3
K21856 Lymphocryptovirus nuclear antigen 4
K06053 recombining binding protein suppressor of hairless
K06054 hairy and enhancer of split 1
K06468 low affinity immunoglobulin epsilon Fc receptor
K09279 runt-related transcription factor 3
K04377 Myc proto-oncogene protein
K19462 Lymphocryptovirus trans-activator protein BZLF1
K06625 cyclin-dependent kinase inhibitor 1A
K04402 growth arrest and DNA-damage-inducible protein
K10140 DNA damage-binding protein 2
K09849 TNF receptor-associated factor 5
K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K09253 transcription factor RelB
K04469 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein
K02581 NF-kappa-B inhibitor beta
K05872 NF-kappa-B inhibitor epsilon
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K02861 receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1 ]
K04448 transcription factor AP-1
K03160 tumor necrosis factor receptor superfamily member 5
K06490 intercellular adhesion molecule 1
K04692 signal transducer and activator of transcription 3
K04392 Ras-related C3 botulinum toxin substrate 1
K06856 immunoglobulin heavy chain
K03875 F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)
K06624 cyclin-dependent kinase inhibitor 1B
K04503 G1/S-specific cyclin-D1
K10151 G1/S-specific cyclin-D2
K10152 G1/S-specific cyclin-D3
K06626 G1/S-specific cyclin-E1
K06618 retinoblastoma-associated protein
K17454 transcription factor E2F1
K09389 transcription factor E2F2
K06620 transcription factor E2F3
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Young LS, Rickinson AB.
Title
Epstein-Barr virus: 40 years on.
Journal
Reference
Authors
Saha A, Robertson ES
Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
Journal
Reference
Authors
Ning S
Title
Innate immune modulation in EBV infection.
Journal
Reference
Authors
Stanfield BA, Luftig MA
Title
Recent advances in understanding Epstein-Barr virus.
Journal
Reference
Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Journal
Reference
Authors
Rajsbaum R, Garcia-Sastre A
Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
Journal
Reference
Authors
Hoffmann HH, Schneider WM, Rice CM
Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
Journal
Reference
Authors
Spender LC, Inman GJ
Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
Journal
Reference
Authors
Fu Q, He C, Mao ZR
Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
Journal
Reference
Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Journal
Reference
Authors
Melchjorsen J
Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Journal
Reference
Authors
Hansen TH, Bouvier M
Title
MHC class I antigen presentation: learning from viral evasion strategies.
Journal
Reference
Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Ghosh Roy S, Robertson ES, Saha A
Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
Journal
Reference
Authors
Dawson CW, Port RJ, Young LS
Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
Journal
Reference
Authors
Cai Q, Chen K, Young KH
Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Journal
Reference
Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
Authors
Ersing I, Bernhardt K, Gewurz BE
Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Journal
Reference
Authors
Wang LW, Jiang S, Gewurz BE
Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Journal
Reference
Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Journal
Reference
Authors
Edwards RH, Marquitz AR, Raab-Traub N
Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
Journal
Reference
Authors
Thorley-Lawson DA
Title
Epstein-Barr virus: exploiting the immune system.
Journal
Reference
Authors
Eliopoulos AG, Young LS
Title
LMP1 structure and signal transduction.
Journal
Reference
Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
Journal
Reference
Authors
Kang H, Kiess A, Chung CH
Title
Emerging biomarkers in head and neck cancer in the era of genomics.
Journal
Reference
Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Journal
Reference
Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
Journal
Reference
Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Journal
Reference
Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
Journal
Reference
Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
Journal
Reference
Authors
Longnecker R
Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Journal
Reference
Authors
El-Sharkawy A, Al Zaidan L, Malki A
Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
Journal
Reference
Authors
Dolcetti R, Masucci MG
Title
Epstein-Barr virus: induction and control of cell transformation.
Journal
Reference
Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Journal
Related pathway
ko04064 NF-kappa B signaling pathway
ko04612 Antigen processing and presentation
ko04620 Toll-like receptor signaling pathway
ko04622 RIG-I-like receptor signaling pathway
ko04662 B cell receptor signaling pathway