KEGG   ORTHOLOGY: K00022Help
Entry
K00022                      KO                                     

Name
HADH
Definition
3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
Pathway
ko00062  Fatty acid elongation
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko00281  Geraniol degradation
ko00310  Lysine degradation
ko00380  Tryptophan metabolism
ko00650  Butanoate metabolism
ko00930  Caprolactam degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01212  Fatty acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Disease
H00525  Disorders of mitochondrial fatty-acid oxidation
H01267  Familial hyperinsulinemic hypoglycemia
H01364  3-Hydroxyacyl-CoA dehydrogenase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00650 Butanoate metabolism
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00071 Fatty acid degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00310 Lysine degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
   00380 Tryptophan metabolism
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09109 Metabolism of terpenoids and polyketides
   00281 Geraniol degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K00022  HADH; 3-hydroxyacyl-CoA dehydrogenase
BRITE hierarchy
Other DBs
RN: R01778 R01975 R04203 R04737 R04739 R04741 R04743 R04745 R04748 R05066 R06941 R08094
GO: 0003857
Genes
HSA: 3033(HADH)
PTR: 461424(HADH)
PPS: 100995262(HADH)
GGO: 101139662(HADH)
PON: 100447416(HADH)
NLE: 100592501(HADH)
MCC: 696181(HADH)
MCF: 101865482(HADH)
CSAB: 103236085(HADH)
RRO: 104670046(HADH)
RBB: 108515890(HADH)
CJC: 100400121(HADH)
SBQ: 101048002(HADH)
MMU: 15107(Hadh)
MCAL: 110290812(Hadh)
MPAH: 110320141(Hadh)
RNO: 113965(Hadh)
MUN: 110553441(Hadh)
CGE: 100761491(Hadh)
NGI: 103742549(Hadh)
HGL: 101712136(Hadh)
CCAN: 109684298 109684305(Hadh)
OCU: 100352945(HADH)
TUP: 102474187(HADH)
CFA: 478506(HADH)
VVP: 112934205(HADH)
AML: 100466232(HADH)
UMR: 103661727(HADH)
UAH: 113255543(HADH)
ORO: 101371823(HADH)
ELK: 111154677
FCA: 101088327(HADH)
PTG: 102972274(HADH)
PPAD: 109247833(HADH)
AJU: 106983658(HADH)
BTA: 532785(HADH)
BOM: 102267786(HADH)
BIU: 109560267(HADH)
BBUB: 102410510(HADH)
CHX: 102171856(HADH)
OAS: 101122862(HADH)
SSC: 397604(HADH)
CFR: 102510383(HADH)
CDK: 105105288(HADH)
BACU: 103020566(HADH)
LVE: 103069724(HADH)
OOR: 101288394(HADH)
DLE: 111171489(HADH)
PCAD: 102996325(HADH)
ECB: 100072956(HADH)
EPZ: 103557034(HADH)
EAI: 106829815(HADH)
MYB: 102256814(HADH)
MYD: 102768229(HADH)
MNA: 107538297(HADH)
HAI: 109379463(HADH)
DRO: 112296341(HADH)
PALE: 102886680(HADH)
RAY: 107511528(HADH)
MJV: 108405594(HADH)
LAV: 100658675(HADH)
TMU: 101344876
MDO: 100010946(HADH)
SHR: 100933168(HADH)
PCW: 110218606(HADH)
OAA: 100080904(HADH)
GGA: 420290(HADH)
MGP: 100542994(HADH)
CJO: 107313259(HADH)
NMEL: 110398347(HADH)
APLA: 101795779(HADH)
ACYG: 106038615(HADH)
TGU: 100231239(HADH)
LSR: 110468006(HADH)
SCAN: 103826257(HADH)
GFR: 102035108(HADH)
FAB: 101807376(HADH)
PHI: 102109282(HADH)
PMAJ: 107203268(HADH)
CCAE: 111928333(HADH)
CCW: 104697292(HADH)
ETL: 114057905(HADH)
FPG: 101918111(HADH)
FCH: 102050479(HADH)
CLV: 102084813(HADH)
EGZ: 104135502(HADH)
NNI: 104021316(HADH)
ACUN: 113479674(HADH)
PADL: 103919565(HADH)
AAM: 106491832(HADH)
ASN: 102386854(HADH)
AMJ: 102561189(HADH)
PSS: 102443484(HADH)
CMY: 102929959(HADH)
CPIC: 101953292(HADH)
ACS: 100556994(hadh)
PVT: 110080465(HADH)
PBI: 103064897(HADH)
PMUR: 107282826(HADH)
TSR: 106543017(HADH)
PMUA: 114604109(HADH)
GJA: 107123147(HADH)
XLA: 380594(hadh.L)
XTR: 496484(hadh)
NPR: 108785417(HADH)
DRE: 445121(hadh)
SRX: 107729339 107756993(hadh)
SANH: 107675781(hadh) 107684325
SGH: 107583243(hadh) 107594428
IPU: 100528694(hadh)
PHYP: 113546051(hadh)
AMEX: 103033308(hadh)
EEE: 113591283(hadh)
TRU: 101064489(hadh)
LCO: 104927263(hadh)
NCC: 104953566(hadh)
MZE: 101465947(hadh)
ONL: 100704813(hadh)
OLA: 101166688(hadh)
XMA: 102226893(hadh)
XCO: 114145464(hadh)
PRET: 103472731(hadh)
CVG: 107094619(hadh)
NFU: 107375321(hadh)
KMR: 108235435(hadh)
ALIM: 106517065(hadh)
POV: 109638243(hadh)
LCF: 108888245(hadh)
SDU: 111236647(hadh)
SLAL: 111671175(hadh)
HCQ: 109511078(hadh)
BPEC: 110165377(hadh)
MALB: 109955489(hadh)
SASA: 106610339(hadh)
SALP: 112071963(hadh)
ELS: 105020990(hadh)
PKI: 111837334(hadh)
LCM: 102353593(HADH)
CMK: 103182114(hadh)
RTP: 109931148(hadh)
CIN: 100187496
SPU: 582126
APLC: 110986845
AAG: 5576217
TCA: 661810
DPA: 109544547
NVL: 108563366
BMOR: 100862760(3HCD) 732951
API: 100169569(Hadh)
DNX: 107169133
AGS: 114130161
RMD: 113553196
BTAB: 109035749
ZNE: 110831040
PVM: 113810046
CBR: CBG03387(Cbr-ech-8) CBG03388(Cbr-ech-9) CBG06566(Cbr-hacd-1) CBG10094 CBG16139
TSP: Tsp_06158
PCAN: 112569773
CRG: 105348652
MYI: 110451237
OBI: 106868457
EGL: EGR_03347
EPA: 110240159
ADF: 107338199
AMIL: 114963753
PDAM: 113677957
SPIS: 111346544
HMG: 100198712
AQU: 100637276
QSU: 112036853
MAJ: MAA_08842
ANI: AN7238.2
ANG: ANI_1_1658104(An12g03260) ANI_1_70184(An19g00140)
MGL: MGL_2947
MRT: MRET_3548
PTI: PHATRDRAFT_39681(HAD2)
FCY: FRACYDRAFT_270026(HADH1)
SPAR: SPRG_01616
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8687463
  Authors
Vredendaal PJ, van den Berg IE, Malingre HE, Stroobants AK, Olde Weghuis DE, Berger R
  Title
Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.
  Journal
Biochem Biophys Res Commun 223:718-23 (1996)
DOI:10.1006/bbrc.1996.0961
  Sequence
[hsa:3033]
Reference
  Authors
Yang SY, He XY, Schulz H
  Title
3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease.
  Journal
FEBS J 272:4874-83 (2005)
DOI:10.1111/j.1742-4658.2005.04911.x

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