KEGG   ORTHOLOGY: K00025Help
Entry
K00025                      KO                                     

Name
MDH1
Definition
malate dehydrogenase [EC:1.1.1.37]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00270  Cysteine and methionine metabolism
ko00620  Pyruvate metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko00710  Carbon fixation in photosynthetic organisms
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko04964  Proximal tubule bicarbonate reclamation
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00012  Glyoxylate cycle
M00168  CAM (Crassulacean acid metabolism), dark
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00025  MDH1; malate dehydrogenase
   00620 Pyruvate metabolism
    K00025  MDH1; malate dehydrogenase
   00630 Glyoxylate and dicarboxylate metabolism
    K00025  MDH1; malate dehydrogenase
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00025  MDH1; malate dehydrogenase
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K00025  MDH1; malate dehydrogenase
 09150 Organismal Systems
  09155 Excretory system
   04964 Proximal tubule bicarbonate reclamation
    K00025  MDH1; malate dehydrogenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate metabolism
   Central carbohydrate metabolism
    M00009  Citrate cycle (TCA cycle, Krebs cycle)
     K00025  MDH1; malate dehydrogenase
    M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
     K00025  MDH1; malate dehydrogenase
   Other carbohydrate metabolism
    M00012  Glyoxylate cycle
     K00025  MDH1; malate dehydrogenase
  Energy metabolism
   Carbon fixation
    M00168  CAM (Crassulacean acid metabolism), dark
     K00025  MDH1; malate dehydrogenase
    M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
     K00025  MDH1; malate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     K00025  MDH1; malate dehydrogenase
BRITE hierarchy
Other DBs
RN: R00342 R07136
GO: 0030060
Genes
HSA: 4190(MDH1)
PTR: 459271(MDH1)
PPS: 100977785(MDH1)
GGO: 101134761(MDH1)
PON: 100454132(MDH1)
NLE: 100581689(MDH1)
MCC: 694703(MDH1)
MCF: 101865736(MDH1)
CSAB: 103220175(MDH1)
RRO: 104669214(MDH1)
RBB: 108517135(MDH1)
CJC: 100402890(MDH1)
SBQ: 101040730(MDH1)
MMU: 17449(Mdh1)
RNO: 24551(Mdh1)
CGE: 100764352(Mdh1)
NGI: 103748091(Mdh1)
HGL: 101719728(Mdh1)
CCAN: 109685017(Mdh1) 109701612
OCU: 100341412(MDH1)
TUP: 102501679(MDH1)
CFA: 474614(MDH1)
AML: 100482261(MDH1)
UMR: 103671312(MDH1)
ORO: 101376601(MDH1)
FCA: 493924(MDH1)
PTG: 102951622(MDH1)
AJU: 106973479(MDH1)
BTA: 535182(MDH1)
BOM: 102270407(MDH1)
BIU: 109566205(MDH1)
CHX: 102176699(MDH1)
OAS: 101116035(MDH1)
SSC: 396894(MDH1)
CFR: 102516914(MDH1)
CDK: 105101816(MDH1)
BACU: 103016557(MDH1)
LVE: 103076659(MDH1)
OOR: 101288343(MDH1)
ECB: 100051612(MDH1)
EPZ: 103561022(MDH1)
EAI: 106828371(MDH1)
MYB: 102253671(MDH1)
MYD: 102758532(MDH1)
HAI: 109378994(MDH1)
RSS: 109438190(MDH1) 109441787
PALE: 102878302(MDH1)
LAV: 100665411(MDH1)
TMU: 101349161
MDO: 100031872(MDH1)
SHR: 100925139(MDH1)
OAA: 100082315(MDH1)
GGA: 421281(MDH1)
MGP: 100539955(MDH1)
CJO: 107310702(MDH1)
APLA: 101794999(MDH1)
ACYG: 106045616(MDH1)
TGU: 100190381
SCAN: 103821392(MDH1)
GFR: 102043811(MDH1)
FAB: 101814527(MDH1)
PHI: 102108399(MDH1)
PMAJ: 107202297(MDH1)
CCAE: 111926540(MDH1)
CCW: 104696612(MDH1)
FPG: 101913475(MDH1)
FCH: 102046600(MDH1)
CLV: 102084654(MDH1)
EGZ: 104129206(MDH1)
NNI: 104014929(MDH1)
ACUN: 113477723(MDH1)
AAM: 106499922(MDH1)
ASN: 102372118(MDH1)
AMJ: 102566997(MDH1)
PSS: 102463290(MDH1)
CMY: 102938108(MDH1)
CPIC: 101947638(MDH1)
ACS: 100553622(mdh1)
PVT: 110084218(MDH1)
PBI: 103058397(MDH1)
PMUR: 107284309(MDH1)
GJA: 107120025(MDH1)
XLA: 108716589(mdh1.L) 398872(mdh1.S)
XTR: 448318(mdh1)
NPR: 108786327(MDH1)
DRE: 335715(mdh1ab) 399662(mdh1aa)
PHYP: 113537366(mdh1) 113544999
TRU: 101072315 101073761(mdh1)
LCO: 104918526(mdh1) 104931836
OLA: 100049475(mdhb) 100302445(mdh1)
XMA: 102234083(mdh1) 102234452
KMR: 108242660 108247105(mdh1)
SDU: 111227419 111232961(mdh1)
MALB: 109952294(mdh1) 109961149
SASA: 106564857(MDHC) 106577387 106577388(mdh1b) 106585868(MDHC) 106593044(MDHC) 106596468
OTW: 112230370
ELS: 105008309 105021528(mdh1)
LCM: 102357680(MDH1)
CMK: 103172058 103177941(mdh1)
CIN: 100187217
SPU: 591635
APLC: 110976738
SKO: 100375508
DME: Dmel_CG5362(Mdh1)
DER: 6542444
DPE: 6588726
DSI: Dsimw501_GD22263(Dsim_GD22263)
DWI: 6653335
MDE: 101889109
AAG: 5569520
AME: 411014
BIM: 100741753
SOC: 105204759
MPHA: 105838367
AEC: 105146275
ACEP: 105620456
PBAR: 105424381
HST: 105188233
DQU: 106742320
CFO: 105258207
LHU: 105671860
PGC: 109853049
OBO: 105287655
PCF: 106788153
NVI: 100119291
MDL: 103578641
TCA: 664447
DPA: 109544302
NVL: 108556428
BMOR: 692952(MDH)
PMAC: 106719505
HAW: 110378161
PXY: 105383268
DNX: 107170335
CLEC: 106667067
ZNE: 110834552
FCD: 110845081
DPX: DAPPUDRAFT_308915(MDHC)
TUT: 107364466
DPTE: 113790507
CEL: CELE_F46E10.10(mdh-1)
CBR: CBG18957
BMY: Bm1_04060
TSP: Tsp_08379
CRG: 105343888
MYI: 110456733
OBI: 106879647
LAK: 106154959
SHX: MS3_07730
ADF: 107337641
PDAM: 113667217
HMG: 100208718
AQU: 100639823
ATH: AT1G04410(c-NAD-MDH1) AT5G43330(c-NAD-MDH2) AT5G56720(c-NAD-MDH3)
CPAP: 110815859
LJA: Lj3g3v3752070.2(Lj3g3v3752070.2) Lj5g3v1201280.1(Lj5g3v1201280.1) Lj6g3v0028890.1(Lj6g3v0028890.1)
SLY: 101253131 778330(cMDH)
BVG: 104887939(nr1) 104905328
DOSA: Os04t0551200-01(Os04g0551200) Os10t0478200-01(Os10g0478200)
ATS: 109742567(LOC109742567)
PEQ: 110031066
PPP: 112273839
CRE: CHLREDRAFT_158129(MDH3)
APRO: F751_0245
DDI: DDB_G0280255(mdhC) DDB_G0290207(mdhA)
DFA: DFA_04718(mdhC) DFA_10949(mdhA)
EHI: EHI_030810(195.t00006) EHI_152670(24.t00003)
SMIN: v1.2.015731.t1(symbB.v1.2.015731.t1)
SPAR: SPRG_09101
LMA: LMJF_28_2860(cMDH)
LIF: LINJ_28_3090(cMDH)
LBZ: LBRM_28_3070(cMDH)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Minarik P, Tomaskova N, Kollarova M, Antalik M
  Title
Malate dehydrogenases--structure and function.
  Journal
Gen Physiol Biophys 21:257-65 (2002)
Reference
PMID:7849603
  Authors
Goward CR, Nicholls DJ
  Title
Malate dehydrogenase: a model for structure, evolution, and catalysis.
  Journal
Protein Sci 3:1883-8 (1994)
DOI:10.1002/pro.5560031027
Reference
  Authors
Madern D
  Title
Molecular evolution within the L-malate and L-lactate dehydrogenase super-family.
  Journal
J Mol Evol 54:825-40 (2002)
DOI:10.1007/s00239-001-0088-8

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