KEGG   ORTHOLOGY: K00026Help
Entry
K00026                      KO                                     

Name
MDH2
Definition
malate dehydrogenase [EC:1.1.1.37]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00270  Cysteine and methionine metabolism
ko00620  Pyruvate metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko00710  Carbon fixation in photosynthetic organisms
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00012  Glyoxylate cycle
M00168  CAM (Crassulacean acid metabolism), dark
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00026  MDH2; malate dehydrogenase
   00620 Pyruvate metabolism
    K00026  MDH2; malate dehydrogenase
   00630 Glyoxylate and dicarboxylate metabolism
    K00026  MDH2; malate dehydrogenase
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00026  MDH2; malate dehydrogenase
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K00026  MDH2; malate dehydrogenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate metabolism
   Central carbohydrate metabolism
    M00009  Citrate cycle (TCA cycle, Krebs cycle)
     K00026  MDH2; malate dehydrogenase
    M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
     K00026  MDH2; malate dehydrogenase
   Other carbohydrate metabolism
    M00012  Glyoxylate cycle
     K00026  MDH2; malate dehydrogenase
  Energy metabolism
   Carbon fixation
    M00168  CAM (Crassulacean acid metabolism), dark
     K00026  MDH2; malate dehydrogenase
    M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
     K00026  MDH2; malate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     K00026  MDH2; malate dehydrogenase
BRITE hierarchy
Other DBs
RN: R00342 R07136
GO: 0030060
Genes
HSA: 4191(MDH2)
PTR: 463484(MDH2)
PPS: 100991112(MDH2)
GGO: 101137732(MDH2)
PON: 100174759(MDH2)
NLE: 100602020(MDH2)
MCC: 719983(MDH2)
MCF: 101867276(MDH2)
CSAB: 103246656(MDH2)
RRO: 104663627 104671997 104681214(MDH2)
RBB: 108518918(MDH2)
CJC: 100407619(MDH2)
SBQ: 101035915(MDH2)
MMU: 17448(Mdh2)
RNO: 81829(Mdh2)
CGE: 100763194(Mdh2)
NGI: 103733471(Mdh2)
HGL: 101713764(Mdh2)
CCAN: 109700987(Mdh2)
OCU: 100354776(MDH2)
TUP: 102499069(MDH2)
CFA: 482945(MDH2)
AML: 100464508(MDH2)
UMR: 103670144(MDH2)
FCA: 101084845(MDH2)
PTG: 102972029(MDH2)
AJU: 106980706(MDH2)
BTA: 281306(MDH2)
BOM: 102282724(MDH2)
BIU: 109578485(MDH2)
PHD: 102332403(MDH2)
CHX: 102174799(MDH2)
OAS: 443091(MDH2)
SSC: 397039(MDH2)
CFR: 102509576(MDH2)
CDK: 105089651(MDH2)
BACU: 103008368(MDH2)
LVE: 103084096(MDH2)
OOR: 101287547(MDH2)
ECB: 100061046(MDH2)
EPZ: 103560973(MDH2)
EAI: 106839275(MDH2)
MYB: 102253136(MDH2)
MYD: 102765341(MDH2)
HAI: 109385021(MDH2)
PALE: 102894928(MDH2)
LAV: 100654242(MDH2)
TMU: 101345659
MDO: 100018146(MDH2)
SHR: 100927693(MDH2)
OAA: 100082520(MDH2)
GGA: 417517(MDH2)
MGP: 100544516(MDH2)
CJO: 107322573(MDH2)
APLA: 101804610(MDH2)
ACYG: 106041498(MDH2)
TGU: 100190484(MDH2)
SCAN: 103820076(MDH2)
GFR: 102031464(MDH2)
FAB: 101806190(MDH2)
PHI: 102108401(MDH2)
PMAJ: 107212730(MDH2)
CCAE: 111937933(MDH2)
CCW: 104691227(MDH2)
FPG: 101923367(MDH2)
FCH: 102051253(MDH2)
CLV: 102096727(MDH2)
EGZ: 104131800(MDH2)
NNI: 104016135(MDH2)
ACUN: 113487190(MDH2)
AAM: 106497338(MDH2)
ASN: 102383144(MDH2)
AMJ: 102569347(MDH2)
CMY: 102930226(MDH2)
CPIC: 101934562(MDH2)
ACS: 100563761(mdh2)
PVT: 110085149(MDH2)
PBI: 103048702(MDH2)
PMUR: 107290031(MDH2)
GJA: 107107697(MDH2)
XLA: 443751(mdh2.S) 446263(mdh2.L)
XTR: 496892(mdh2)
NPR: 108791073(MDH2)
DRE: 406405(mdh2)
IPU: 100528931(mdh2)
PHYP: 113523716(mdh2)
AMEX: 103036822(mdh2)
TRU: 101064979(mdh2)
LCO: 104926207(mdh2)
NCC: 104955197(mdh2)
MZE: 101483745(mdh2)
OLA: 101166000(mdh2)
XMA: 102231838(mdh2)
PRET: 103478336(mdh2)
NFU: 107378788(mdh2)
KMR: 108232189(mdh2)
CSEM: 103388600(mdh2)
LCF: 108888566(mdh2)
SDU: 111227633(mdh2)
HCQ: 109531051(mdh2)
BPEC: 110171587(mdh2)
MALB: 109958229(mdh2)
SASA: 100194641(MDHM) 100196673(MDHM)
ELS: 105011098(mdh2)
SFM: 108928129(mdh2)
LCM: 102351122(MDH2)
CMK: 103186901(mdh2)
CIN: 100178529
SPU: 587163
APLC: 110980666
SKO: 100374306
DME: Dmel_CG10748(CG10748) Dmel_CG10749(CG10749) Dmel_CG7998(Mdh2)
DSI: Dsimw501_GD12684(Dsim_GD12684) Dsimw501_GD14416(Dsim_GD14416) Dsimw501_GD19217(Dsim_GD19217)
AAG: 5570233
MPHA: 105837450
ACEP: 105623235
NVI: 100114033
MDL: 103571949
API: 100145825
DNX: 107161319
ZNE: 110840229
DPX: DAPPUDRAFT_301215(MDHM)
DPTE: 113791514
CEL: CELE_F20H11.3(mdh-2)
CBR: CBG15213(Cbr-mdh-1)
BMY: Bm1_46465
MYI: 110446880
OBI: 106872209
LAK: 106159255
SHX: MS3_02136
EGL: EGR_07010
EPA: 110236455
PDAM: 113686005
SPIS: 111336554
AQU: 100641593
ATH: AT1G53240(mMDH1) AT2G22780(PMDH1) AT3G15020(mMDH2) AT3G47520(MDH) AT5G09660(PMDH2)
LJA: Lj0g3v0169339.1(Lj0g3v0169339.1) Lj0g3v0292959.1(Lj0g3v0292959.1) Lj2g3v1984320.1(Lj2g3v1984320.1) Lj3g3v0428550.1(Lj3g3v0428550.1) Lj3g3v0428550.2(Lj3g3v0428550.2) Lj3g3v0428550.3(Lj3g3v0428550.3) Lj4g3v1635340.1(Lj4g3v1635340.1)
DOSA: Os01t0649100-01(Os01g0649100) Os01t0829800-01(Os01g0829800) Os03t0773800-01(Os03g0773800) Os05t0574400-01(Os05g0574400) Os07t0630800-01(Os07g0630800) Os08t0434300-01(Os08g0434300) Os12t0632700-01(Os12g0632700)
ATS: 109749008(LOC109749008) 109751657(LOC109751657) 109759790(LOC109759790) 109772367(LOC109772367) 109782175(LOC109782175) 109784558(LOC109784558)
SCE: YDL078C(MDH3) YKL085W(MDH1) YOL126C(MDH2)
KMX: KLMA_40055(MDH3) KLMA_40391(MDH2) KLMA_60167(MDH1)
NCS: NCAS_0A04020(NCAS0A04020) NCAS_0C04560(NCAS0C04560) NCAS_0H03320(NCAS0H03320)
NDI: NDAI_0C00340(NDAI0C00340) NDAI_0E01670(NDAI0E01670) NDAI_0G03940(NDAI0G03940)
TPF: TPHA_0A00460(TPHA0A00460) TPHA_0G02100(TPHA0G02100) TPHA_0L01990(TPHA0L01990) TPHA_0P01350(TPHA0P01350)
TBL: TBLA_0A07800(TBLA0A07800) TBLA_0B08630(TBLA0B08630) TBLA_0B09220(TBLA0B09220) TBLA_0C00860(TBLA0C00860)
TDL: TDEL_0B07350(TDEL0B07350) TDEL_0E00560(TDEL0E00560) TDEL_0G03230(TDEL0G03230)
KAF: KAFR_0C01710(KAFR0C01710) KAFR_0C03960(KAFR0C03960) KAFR_0F02690(KAFR0F02690)
PIC: PICST_40132(MDHM) PICST_66451(MDH1) PICST_78343(MDH2)
SLB: AWJ20_2901(MDH1) AWJ20_411(MDH1)
NCR: NCU04899(tca-15) NCU06211(tca-16)
NTE: NEUTE1DRAFT116885(NEUTE1DRAFT_116885) NEUTE1DRAFT59383(NEUTE1DRAFT_59383)
BFU: BCIN_12g05210(Bcmdh1)
ANG: ANI_1_12134(An15g00070) ANI_1_268064(An07g02160)
ABP: AGABI1DRAFT115666(AGABI1DRAFT_115666) AGABI1DRAFT119105(AGABI1DRAFT_119105)
ABV: AGABI2DRAFT187815(AGABI2DRAFT_187815) AGABI2DRAFT192140(AGABI2DRAFT_192140)
EHI: EHI_067860(8.t00059)
SMIN: v1.2.016412.t1(symbB.v1.2.016412.t1) v1.2.017877.t2(symbB.v1.2.017877.t2) v1.2.017877.t3(symbB.v1.2.017877.t3) v1.2.023331.t1(symbB.v1.2.023331.t1) v1.2.023511.t1(symbB.v1.2.023511.t1) v1.2.023511.t3(symbB.v1.2.023511.t3) v1.2.028119.t1(symbB.v1.2.028119.t1)
PTI: PHATRDRAFT_51297(MDH)
TPS: THAPSDRAFT_20726(MDH1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Minarik P, Tomaskova N, Kollarova M, Antalik M
  Title
Malate dehydrogenases--structure and function.
  Journal
Gen Physiol Biophys 21:257-65 (2002)
Reference
PMID:7849603
  Authors
Goward CR, Nicholls DJ
  Title
Malate dehydrogenase: a model for structure, evolution, and catalysis.
  Journal
Protein Sci 3:1883-8 (1994)
DOI:10.1002/pro.5560031027
Reference
  Authors
Madern D
  Title
Molecular evolution within the L-malate and L-lactate dehydrogenase super-family.
  Journal
J Mol Evol 54:825-40 (2002)
DOI:10.1007/s00239-001-0088-8

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