KEGG   ORTHOLOGY: K00037
Entry
K00037                      KO                                     

Name
AKR1C4
Definition
3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]
Pathway
ko00120  Primary bile acid biosynthesis
ko00140  Steroid hormone biosynthesis
ko01100  Metabolic pathways
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
   00140 Steroid hormone biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.225  chlordecone reductase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Other DBs
RN: R02476 R02477 R04309 R04310 R04818 R04819 R04824 R04825 R04829 R04830 R04832 R04833 R04835 R04836 R04837 R04838 R04842 R04843 R04845 R04846 R08963
GO: 0047042 0047743
Genes
HSA: 1109(AKR1C4)
PTR: 450274(AKR1C4)
PPS: 100987989
GGO: 101148343
PON: 100434557(AKR1C4)
NLE: 100605385
MCC: 711440 722490(AKR1C4)
MCF: 102117205(AKR1C4) 102142023(HSD17B5)
CSAB: 103237814
RRO: 104674748
RBB: 108521035
CJC: 100405255 100405615(AKR1C4)
SBQ: 101041915
ECB: 100057251
EPZ: 103540777
EAI: 106827243
LAV: 100660861
XLA: 108712557(akr1c4.S)
XTR: 496490(akr1c4)
NPR: 108799292
 » show all
Reference
PMID:3479982
  Authors
Penning TM, Sharp RB
  Title
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem Biophys Res Commun 148:646-52 (1987)
DOI:10.1016/0006-291X(87)90925-9
Reference
PMID:8172617
  Authors
Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A
  Title
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.
  Journal
Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545
  Sequence
[hsa:1109]
Reference
PMID:2187532
  Authors
Winters CJ, Molowa DT, Guzelian PS
  Title
Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase.
  Journal
Biochemistry 29:1080-7 (1990)
DOI:10.1021/bi00456a034
  Sequence
[hsa:1109]

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