KEGG   ORTHOLOGY: K00049Help
Entry
K00049                      KO                                     

Name
GRHPR
Definition
glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
Pathway
ko00260  Glycine, serine and threonine metabolism
ko00620  Pyruvate metabolism
ko00630  Glyoxylate and dicarboxylate metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Disease
H00117  Primary hyperoxaluria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
   00630 Glyoxylate and dicarboxylate metabolism
    K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.79  glyoxylate reductase (NADP+)
     K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
    1.1.1.81  hydroxypyruvate reductase
     K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
BRITE hierarchy
Other DBs
RN: R00465 R01388 R01392 R02527
GO: 0030267 0016618
Genes
HSA: 9380(GRHPR)
PTR: 465099(GRHPR)
PPS: 100986688(GRHPR)
GGO: 101130665(GRHPR)
PON: 100171680(GRHPR)
NLE: 100583603(GRHPR)
MCC: 694185(GRHPR)
MCF: 102144581(GRHPR)
CSAB: 103219183(GRHPR)
RRO: 104667514(GRHPR)
RBB: 108516211(GRHPR)
CJC: 100391044(GRHPR)
SBQ: 101048292(GRHPR)
MMU: 76238(Grhpr)
RNO: 680021(Grhpr)
CGE: 100752744(Grhpr)
NGI: 103745721(Grhpr)
HGL: 101701531(Grhpr)
CCAN: 109682753(Grhpr)
OCU: 100347792(GRHPR)
TUP: 102477381(GRHPR)
CFA: 612041(GRHPR)
AML: 100475145(GRHPR)
UMR: 103678479(GRHPR)
ORO: 101369961(GRHPR)
FCA: 100302391(GRHPR)
PTG: 102967428(GRHPR)
AJU: 106981283(GRHPR)
BTA: 504764(GRHPR)
BOM: 102267118(GRHPR)
BIU: 109563042(GRHPR)
PHD: 102334761(GRHPR)
CHX: 102183324(GRHPR)
OAS: 101108191(GRHPR)
SSC: 100154014(GRHPR)
CFR: 102524449(GRHPR)
CDK: 105102265(GRHPR)
BACU: 103010948(GRHPR)
LVE: 103071384(GRHPR)
OOR: 101280139(GRHPR)
ECB: 100066566(GRHPR)
EPZ: 103560692(GRHPR)
EAI: 106843901(GRHPR)
MYB: 102254963(GRHPR)
MYD: 102768028(GRHPR)
HAI: 109386378(GRHPR)
RSS: 109446139(GRHPR)
PALE: 102888080(GRHPR)
LAV: 100653729(GRHPR)
TMU: 101344280
MDO: 100018478(GRHPR)
SHR: 100928696(GRHPR)
OAA: 100078890(GRHPR)
GGA: 426806(GRHPR)
MGP: 100549242(GRHPR)
CJO: 107306744(GRHPR)
APLA: 101789544(GRHPR)
ACYG: 106048866
TGU: 100229871(GRHPR)
FAB: 101813929(GRHPR)
PHI: 102114621(GRHPR)
PMAJ: 107215710(GRHPR)
CCAE: 111942935
CCW: 104695842(GRHPR)
FPG: 101912104(GRHPR)
FCH: 102048912(GRHPR)
CLV: 102096371(GRHPR)
EGZ: 104129511(GRHPR)
NNI: 104012536(GRHPR)
ACUN: 113490425(GRHPR)
AMJ: 102561417 102562816(GRHPR)
CPIC: 101939051(GRHPR) 101940973
ACS: 100558748(grhpr)
PVT: 110077846(GRHPR)
PBI: 103059051(GRHPR)
PMUR: 107291253(GRHPR)
GJA: 107107231(GRHPR)
XLA: 398508(grhpr.2.L) 398631 414606(grhpr.1.L)
XTR: 493279(grhpr.2) 594879 780243(grhpr.1)
DRE: 402985(grhprb) 497183(grhpra)
CCAR: 109086669(grhpr)
IPU: 100528185(grhpr) 108260755
PHYP: 113544290 113547165(grhpr)
AMEX: 103027682 103046658(grhpr)
EEE: 113582659(grhpr) 113586468
LCO: 104924345 104933258(grhpr)
NCC: 104945892 104947241(grhpr)
PRET: 103466594 103471304(grhpr)
CSEM: 103383717(grhpr) 103390973
HCQ: 109518759 109519752(grhpr)
ELS: 105009649(grhpr) 105026161
PKI: 111833437(grhpr) 111844225
CMK: 103182154(grhpr)
CIN: 100178763
SPU: 588349
APLC: 110984951
SKO: 100375265
DME: Dmel_CG1236(CG1236)
DSI: Dsimw501_GD19816(Dsim_GD19816) Dsimw501_GD24284(Dsim_GD24284) Dsimw501_GD24286(Dsim_GD24286)
PBAR: 105431892
LHU: 105671920
PGC: 109854288
OBO: 105281358
NVI: 100116505
TCA: 662063
DPA: 109536909
CLEC: 106660939
ZNE: 110831039
FCD: 110862584
DPTE: 113789079
EGL: EGR_05219
PDAM: 113665004
SPIS: 111329423
PTE: PTT_17661
CNE: CNC02760
CNB: CNBC4460
ABV: AGABI2DRAFT120752(AGABI2DRAFT_120752)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Booth MP, Conners R, Rumsby G, Brady RL
  Title
Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase.
  Journal
J Mol Biol 360:178-89 (2006)
DOI:10.1016/j.jmb.2006.05.018
  Sequence
[hsa:9380]

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