KEGG   ORTHOLOGY: K00149
Entry
K00149                      KO                                     
Symbol
ALDH9A1
Name
aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00053  Ascorbate and aldarate metabolism
map00071  Fatty acid degradation
map00280  Valine, leucine and isoleucine degradation
map00310  Lysine degradation
map00330  Arginine and proline metabolism
map00340  Histidine metabolism
map00380  Tryptophan metabolism
map00410  beta-Alanine metabolism
map00561  Glycerolipid metabolism
map00620  Pyruvate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map04936  Alcoholic liver disease
Module
M00135  GABA biosynthesis, eukaryotes, putrescine => GABA
Reaction
R00631  aldehyde:NAD+ oxidoreductase
R00710  acetaldehyde:NAD+ oxidoreductase
R00904  3-aminopropanal:NAD+ oxidoreductase
R01752  D-glyceraldehyde:NAD+ oxidoreductase
R01986  4-aminobutyraldehyde:NAD+ oxidoreductase
R02549  4-aminobutanal:NAD+ 1-oxidoreductase
R02678  indole-3-acetaldehyde:NAD+ oxidoreductase
R02940  2-propyn-1-al:NAD+ oxidoreductase
R02957  D-glucuronolactone:NAD+ oxidoreductase
R03283  4-trimethylammoniobutanal:NAD+ 1-oxidoreductase
R03869  (S)-methylmalonate semialdehyde:NAD+ oxidoreductase
R04065  imidazole acetaldehyde:NAD+ oxidoreductase
R04506  3alpha,7alpha-dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase
R04903  5-hydroxyindoleacetaldehyde:NAD+ oxidoreductase
R05050  N4-acetylaminobutanal:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
   00053 Ascorbate and aldarate metabolism
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
   00620 Pyruvate metabolism
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
   00561 Glycerolipid metabolism
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
   00310 Lysine degradation
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
   00330 Arginine and proline metabolism
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
   00340 Histidine metabolism
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
   00380 Tryptophan metabolism
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.3  aldehyde dehydrogenase (NAD+)
     K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
    1.2.1.47  4-trimethylammoniobutyraldehyde dehydrogenase
     K00149  ALDH9A1; aldehyde dehydrogenase family 9 member A1
Other DBs
GO: 0047105 0004029
Genes
HSA: 223(ALDH9A1)
PTR: 457478(ALDH9A1)
PPS: 100993750(ALDH9A1)
GGO: 101154127(ALDH9A1)
PON: 100173126(ALDH9A1)
PPYG: 129033470(ALDH9A1)
NLE: 100594899(ALDH9A1)
HMH: 116473299(ALDH9A1)
SSYN: 134733979(ALDH9A1)
MCC: 695383(ALDH9A1)
MCF: 102139794(ALDH9A1)
MTHB: 126941794
MNI: 105492964(ALDH9A1)
CSAB: 103230676(ALDH9A1)
CATY: 105598281(ALDH9A1)
PANU: 101016128 116268495(ALDH9A1)
TGE: 112608179(ALDH9A1)
MLEU: 105539613(ALDH9A1)
RRO: 104670179(ALDH9A1)
RBB: 108538368(ALDH9A1)
TFN: 117074300(ALDH9A1)
PTEH: 111539280(ALDH9A1)
CANG: 105505518(ALDH9A1)
CJC: 100385191(ALDH9A1)
SBQ: 101041228(ALDH9A1)
CIMI: 108308298(ALDH9A1)
ANAN: 105728501(ALDH9A1)
CSYR: 103273649(ALDH9A1)
MMUR: 105860496(ALDH9A1)
LCAT: 123634927(ALDH9A1)
PCOQ: 105806446(ALDH9A1)
OGA: 100940587(ALDH9A1)
MMU: 56752(Aldh9a1)
MCAL: 110291593(Aldh9a1)
MPAH: 110321543(Aldh9a1)
RNO: 64040(Aldh9a1)
MCOC: 116103062(Aldh9a1)
ANU: 117716148(Aldh9a1)
MUN: 110551797(Aldh9a1)
CGE: 100758951(Aldh9a1)
MAUA: 101838319(Aldh9a1)
PROB: 127223537(Aldh9a1)
PLEU: 114689914(Aldh9a1) 114694603 114695271
MORG: 121455143(Aldh9a1)
MFOT: 126511267
AAMP: 119827527(Aldh9a1)
NGI: 103746122(Aldh9a1)
HGL: 101717741(Aldh9a1)
CPOC: 100732288(Aldh9a1)
CCAN: 109693621(Aldh9a1)
DORD: 105989613(Aldh9a1)
DSP: 122106062(Aldh9a1)
PLOP: 125360268(Aldh9a1)
NCAR: 124962313
MMMA: 107147436(Aldh9a1)
OCU: 100354540
OPI: 101524250(ALDH9A1)
TUP: 102490252(ALDH9A1)
GVR: 103595312(ALDH9A1)
CFA: 478991(ALDH9A1)
CLUD: 112643080(ALDH9A1)
VVP: 112914316(ALDH9A1)
VLG: 121471727(ALDH9A1)
NPO: 129515354(ALDH9A1)
AML: 100478544(ALDH9A1)
UMR: 103658223(ALDH9A1)
UAH: 113268692(ALDH9A1)
UAR: 123800139(ALDH9A1)
ELK: 111151106
LLV: 125086052
MPUF: 101670514(ALDH9A1)
MNP: 132025732(ALDH9A1)
MLK: 131815098(ALDH9A1)
NVS: 122918401(ALDH9A1)
ORO: 101369155(ALDH9A1)
EJU: 114210485(ALDH9A1)
ZCA: 113933528(ALDH9A1)
MLX: 118014052(ALDH9A1)
NSU: 110588170(ALDH9A1)
LWW: 102729065(ALDH9A1)
FCA: 101080506(ALDH9A1)
PYU: 121020938(ALDH9A1)
PCOO: 112864770(ALDH9A1)
PBG: 122476213(ALDH9A1)
PVIV: 125155854(ALDH9A1)
LRUF: 124509924
PTG: 102951347(ALDH9A1)
PPAD: 109276686 109276687(ALDH9A1)
PUC: 125925933
AJU: 106965587
HHV: 120223223(ALDH9A1)
BTA: 537539(ALDH9A1)
BOM: 102268762(ALDH9A1)
BIU: 109577815(ALDH9A1)
BBUB: 102402462(ALDH9A1)
BBIS: 104997306(ALDH9A1)
CHX: 102174989(ALDH9A1)
OAS: 101109411(ALDH9A1)
BTAX: 128044457(ALDH9A1) 128045524
ODA: 120855495(ALDH9A1)
CCAD: 122429812(ALDH9A1)
MBEZ: 129541305(ALDH9A1)
SSC: 100153809(ALDH9A1)
CFR: 102516577(ALDH9A1)
CBAI: 105068048(ALDH9A1)
CDK: 105092715(ALDH9A1)
VPC: 102541141(ALDH9A1)
BACU: 103018805(ALDH9A1)
BMUS: 118899147(ALDH9A1)
LVE: 103080404(ALDH9A1)
OOR: 101290165(ALDH9A1)
DLE: 111169235(ALDH9A1)
PCAD: 102978670(ALDH9A1)
PSIU: 116754267(ALDH9A1)
NASI: 112397715(ALDH9A1)
ECB: 100060577(ALDH9A1)
EPZ: 103547344(ALDH9A1)
EAI: 106831128(ALDH9A1)
MYB: 102242624(ALDH9A1)
MYD: 102768395(ALDH9A1)
MMYO: 118672934(ALDH9A1)
MLF: 102428549(ALDH9A1)
PKL: 118721740(ALDH9A1)
EFUS: 103296559(ALDH9A1)
MNA: 107537941(ALDH9A1)
DRO: 112298789(ALDH9A1)
SHON: 118979265(ALDH9A1)
AJM: 119065427(ALDH9A1)
PDIC: 114512161(ALDH9A1)
PHAS: 123818508(ALDH9A1)
MMF: 118637299(ALDH9A1)
PPAM: 129082069(ALDH9A1)
HAI: 109385009(ALDH9A1)
RFQ: 117014975(ALDH9A1)
PALE: 102890956(ALDH9A1)
PGIG: 120617722(ALDH9A1)
PVP: 105301520(ALDH9A1)
RAY: 107512731(ALDH9A1)
MJV: 108402717(ALDH9A1)
TOD: 119241361(ALDH9A1)
SARA: 101548414(ALDH9A1)
SETR: 126013406(ALDH9A1)
LAV: 100654610(ALDH9A1)
TMU: 101357831
ETF: 101660372(ALDH9A1)
DNM: 101425023(ALDH9A1)
MDO: 100016819(ALDH9A1)
GAS: 123245877(ALDH9A1)
SHR: 100932529(ALDH9A1)
AFZ: 127562963
PCW: 110202730(ALDH9A1)
TVP: 118846363(ALDH9A1)
OAA: 100076925(ALDH9A1)
GGA: 424405(ALDH9A1)
PCOC: 116230466(ALDH9A1)
MGP: 100546048(ALDH9A1)
CJO: 107317241(ALDH9A1)
TPAI: 128072499(ALDH9A1)
LMUT: 125693339(ALDH9A1)
NMEL: 110402617(ALDH9A1)
APLA: 101799816(ALDH9A1)
ACYG: 106047784(ALDH9A1)
CATA: 118243559(ALDH9A1)
AFUL: 116492081(ALDH9A1)
TGU: 100225645(ALDH9A1)
LSR: 110478928(ALDH9A1)
SCAN: 103823370(ALDH9A1)
PMOA: 120512203(ALDH9A1)
OTC: 121344258(ALDH9A1)
PRUF: 121359756(ALDH9A1)
GFR: 102035153(ALDH9A1)
FAB: 101805672(ALDH9A1)
OMA: 130256170(ALDH9A1)
PHI: 102099646(ALDH9A1)
PMAJ: 107208324(ALDH9A1)
CCAE: 111932630(ALDH9A1)
CCW: 104695470(ALDH9A1)
CBRC: 103612514(ALDH9A1)
ETL: 114063532(ALDH9A1)
ZAB: 102074492(ALDH9A1)
ZLE: 135450781(ALDH9A1)
ACHL: 103806597(ALDH9A1)
SVG: 106852270(ALDH9A1)
MMEA: 130583591(ALDH9A1)
HRT: 120756289(ALDH9A1)
FPG: 101920083(ALDH9A1)
FCH: 102058365(ALDH9A1)
CLV: 102087254(ALDH9A1)
EGZ: 104132054(ALDH9A1)
NNI: 104010385(ALDH9A1)
PCRI: 104033069(ALDH9A1)
PLET: 104627477(ALDH9A1)
EHS: 104504155(ALDH9A1)
PCAO: 104051486(ALDH9A1)
ACUN: 113482682(ALDH9A1)
TALA: 104368445(ALDH9A1)
PADL: 103914112(ALDH9A1)
AFOR: 103893982(ALDH9A1)
ACHC: 115348812(ALDH9A1)
HALD: 104316564(ALDH9A1)
HLE: 104840644(ALDH9A1)
AGEN: 126042168
GCL: 127018915
CCRI: 104163762(ALDH9A1)
CSTI: 104560212(ALDH9A1)
CMAC: 104474432(ALDH9A1)
MUI: 104543235(ALDH9A1)
BREG: 104630005(ALDH9A1)
FGA: 104078039(ALDH9A1)
GSTE: 104259204(ALDH9A1)
LDI: 104341112(ALDH9A1)
MNB: 103778612(ALDH9A1)
OHA: 104333710(ALDH9A1)
NNT: 104402409(ALDH9A1)
SHAB: 115611874(ALDH9A1)
DPUB: 104301538(ALDH9A1)
PGUU: 104470352(ALDH9A1)
ACAR: 104528703(ALDH9A1)
CPEA: 104392904(ALDH9A1)
AVIT: 104270405(ALDH9A1)
CVF: 104293413(ALDH9A1)
RTD: 128913600(ALDH9A1)
CUCA: 104058350(ALDH9A1)
TEO: 104375266(ALDH9A1)
BRHI: 104496263(ALDH9A1)
AAM: 106494013(ALDH9A1)
AROW: 112975020(ALDH9A1)
NPD: 112950395(ALDH9A1)
TGT: 104578432(ALDH9A1)
DNE: 112983696(ALDH9A1)
SCAM: 104142675(ALDH9A1)
ASN: 102375346(ALDH9A1)
AMJ: 102576324(ALDH9A1)
CPOO: 109307135(ALDH9A1)
GGN: 109305349(ALDH9A1)
PSS: 102457679(ALDH9A1)
CMY: 102933952(ALDH9A1)
CCAY: 125641070(ALDH9A1)
DCC: 119859999(ALDH9A1)
CPIC: 101934924(ALDH9A1)
TST: 117881335(ALDH9A1)
CABI: 116839902(ALDH9A1)
MRV: 120370350(ALDH9A1)
ACS: 100555336(aldh9a1)
ASAO: 132774302(ALDH9A1)
PVT: 110089732(ALDH9A1)
SUND: 121929230
PBI: 103056986(ALDH9A1)
PMUR: 107301157(ALDH9A1)
CTIG: 120300230(ALDH9A1)
TSR: 106553466(ALDH9A1)
PGUT: 117661250(ALDH9A1)
APRI: 131194855
PTEX: 113448144(ALDH9A1)
VKO: 123028003(ALDH9A1)
PMUA: 114598470(ALDH9A1)
PRAF: 128415159(ALDH9A1)
ZVI: 118078513(ALDH9A1)
HCG: 128323775(ALDH9A1)
GJA: 107106980 107118664(ALDH9A1)
STOW: 125433300(ALDH9A1)
XLA: 379229(aldh9a1.S)
XTR: 448752(aldh9a1)
NPR: 108798628(ALDH9A1)
RTEM: 120945531(ALDH9A1)
BBUF: 120990494(ALDH9A1)
BGAR: 122938711(ALDH9A1)
MUO: 115471969(ALDH9A1)
GSH: 117367636(ALDH9A1)
DRE: 100005587(aldh9a1a.1) 100006238(aldh9a1a.2) 399481(aldh9a1b)
PTET: 122350862 122360208(aldh9a1b)
LROH: 127169692(aldh9a1a.1) 127180362(aldh9a1b)
OMC: 131526279(aldh9a1b) 131545954(aldh9a1a.1)
PPRM: 120471402(aldh9a1b) 120482966 120483018(aldh9a1a.1)
RKG: 130086192(aldh9a1a.1) 130096956(aldh9a1b)
MAMB: 125250605(aldh9a1b) 125279352(aldh9a1a.1)
TROS: 130554689(aldh9a1b) 130568025
TDW: 130417688(aldh9a1b) 130439923(aldh9a1a.1)
MANU: 129414195 129414196 129442685(aldh9a1b)
IPU: 100304680(aldh9a1a.1) 108267615(aldh9a1b)
IFU: 128607960(aldh9a1a.1) 128609742(aldh9a1b)
PHYP: 113534319(aldh9a1) 113540404
SMEO: 124387435(aldh9a1b) 124400405(aldh9a1a.1)
TFD: 113649154(aldh9a1b) 113655774(aldh9a1a.1)
TVC: 132848237(aldh9a1b) 132853470(aldh9a1a.1)
TRN: 134312139(aldh9a1b) 134318191(aldh9a1a.1)
AMEX: 103023076(aldh9a1b) 125806057(aldh9a1a.1)
CMAO: 118813734(aldh9a1a.1) 118826290(aldh9a1b)
CHAR: 105891333(aldh9a1b) 105900887 105900888
TFS: 130528117 130538401(aldh9a1b)
NCC: 104949684 104957497(aldh9a1)
TBEN: 117488682(aldh9a1b) 117491002(aldh9a1a.1)
CGOB: 115006566(aldh9a1) 115022391
PGEO: 117445033 117462240(aldh9a1b)
GACU: 117545470(aldh9a1b) 117559030(aldh9a1a.1)
EMAC: 134866593(aldh9a1b) 134869107(aldh9a1a.1)
ELY: 117254436 117254503 117272275(aldh9a1b)
EFO: 125895315 125895316 125902067(aldh9a1b)
PLEP: 121941337 121951599(aldh9a1b)
SLUC: 116039685 116045793(aldh9a1b)
ECRA: 117953527 117953994(aldh9a1b)
GAT: 120815650(aldh9a1b) 120823514 120823517
PPUG: 119209085(aldh9a1b) 119216616(aldh9a1a.1)
AFB: 129094263(aldh9a1a.1) 129112635(aldh9a1b)
CLUM: 117730125(aldh9a1a.1) 117746252(aldh9a1b)
PSWI: 130194001(aldh9a1a.1) 130198570(aldh9a1b)
MSAM: 119901224 119902372(aldh9a1b) 119915248
SCHU: 122877642 122887538(aldh9a1b)
CUD: 121512793(aldh9a1a.1) 121520033(aldh9a1b)
ALAT: 119011614(aldh9a1b) 119029163(aldh9a1a.1)
OAU: 116331995(aldh9a1b) 116334433(aldh9a1a.1) 116334435 116334439
OLA: 100049493(aldh9a1) 101155544
OML: 112147259(aldh9a1b) 112150670(aldh9a1a.1)
CSAI: 133453074(aldh9a1b) 133457960
PRET: 103463999(aldh9a1) 103479006
PFOR: 103139831(aldh9a1) 103140077
PLAI: 106936229(aldh9a1) 106954306
PMEI: 106928206(aldh9a1) 106930841
GAF: 122838345(aldh9a1a.1) 122841585(aldh9a1b)
PPRL: 129362015(aldh9a1b) 129379695(aldh9a1a.1)
CVG: 107083604 107091527(aldh9a1)
CTUL: 119776054(aldh9a1b) 119787723(aldh9a1a.1)
GMU: 124869680(aldh9a1b) 124873311(aldh9a1a.1)
KMR: 108238305(aldh9a1b) 108246250(aldh9a1a.1)
ALIM: 106527178 106529303(aldh9a1)
NWH: 119415014(aldh9a1b) 119430681
AOCE: 111576143(aldh9a1) 111587224
MCEP: 125009774(aldh9a1a.1) 125010532(aldh9a1b)
POV: 109625726(aldh9a1) 109643918
SSEN: 122774348(aldh9a1b) 122780333(aldh9a1a.1)
HHIP: 117759770(aldh9a1a.1) 117778156(aldh9a1b)
HSP: 118117824(aldh9a1b) 118121327(aldh9a1a.1)
PPLT: 128448458(aldh9a1a.1) 128454089(aldh9a1b)
SMAU: 118310541(aldh9a1b) 118317948(aldh9a1a.1)
LCF: 108878969(aldh9a1a.1) 108883809(aldh9a1b)
SLAL: 111662617(aldh9a1) 111670534
XGL: 120790502(aldh9a1a.1) 120799386(aldh9a1b)
SBIA: 133503009(aldh9a1a.1) 133510408(aldh9a1b)
PEE: 133406426(aldh9a1a.1) 133412149(aldh9a1b)
PTAO: 133480294(aldh9a1a.1) 133488619(aldh9a1b)
BPEC: 110154734(aldh9a1) 110173534
BSPL: 114844019(aldh9a1b) 114853357(aldh9a1a.1)
SJO: 128361753(aldh9a1a.1) 128369091(aldh9a1b)
SASA: 100195073(aldh9a1)
STRU: 115157269 115158685(aldh9a1)
OTW: 112251350(aldh9a1a.1) 112260713(aldh9a1b)
OMY: 110524695(aldh9a1a.1)
OGO: 123996681(aldh9a1a.1) 124009501(aldh9a1b)
ONE: 115108629(aldh9a1) 115114631
OKE: 118393555(aldh9a1a.1) 118401913(aldh9a1b)
SNH: 120054983(aldh9a1a.1) 120056049(aldh9a1b)
CCLU: 121533848 121535589(aldh9a1b)
ELS: 105021913 105030670(aldh9a1)
PKI: 111834917(aldh9a1)
AANG: 118225547(aldh9a1a.1)
LOC: 102690012(aldh9a1)
PSPA: 121326944
ARUT: 117414144
PSEX: 120515228(aldh9a1a.1)
LCM: 102350441(ALDH9A1)
CMK: 103180031(aldh9a1a.1)
RTP: 109934140(aldh9a1a.1)
CPLA: 122554585
HOC: 132818970(aldh9a1a.1)
LERI: 129701198(aldh9a1a.1)
PMRN: 116944976(ALDH9A1)
LRJ: 133341845(ALDH9A1)
BFO: 118422089
BBEL: 109466188
CIN: 100175707
SCLV: 120327504
APLC: 110988120
ARUN: 117302874
AJC: 117106271
SKO: 100373270
SGRE: 126364944
IEL: 124158770
DMK: 116918997
DPZ: 124344155
PJA: 122249287
PCHN: 125024670
PMOO: 119579016
HAME: 121858672
PCLA: 123767126
PTRU: 123515200
ESN: 126985858
MNZ: 135226539
HAZT: 108664939
LSM: 121116498
TCF: 131890186
DSV: 119442151
CSCU: 111642601
PTEP: 107456012
ABRU: 129981061
UDV: 129222163
SDM: 118198540
LPOL: 106468030
CEL: CELE_F42G9.5(alh-11) CELE_Y69F12A.2(alh-12)
CBR: CBG_09190(Cbr-alh-12) CBG_15207(Cbr-alh-11)
BMY: BM_BM4035(Bma-alh-11)
PVUL: 126832027
PCAN: 112564937
BGT: 106072008
GAE: 121381337
HRF: 124146729
HRJ: 124264878
CRG: 105326193
CANU: 128162343
OED: 130050972
MYI: 110463364
PMAX: 117344030
MCAF: 127731074
RPHI: 132752550
DPOL: 127877684
MAEA: 128228880
OBI: 106875644
OSN: 115225913
LJP: 135477483
LAK: 106174689
SHX: MS3_00009869(ALDH9A1_3)
LLON: 135500272
EPA: 110231719
ATEN: 116300320
ADF: 107327307
AMIL: 114969260
PDAM: 113684365
SPIS: 111332314
DGT: 114518896
XEN: 124439653
HMG: 100205388
HSY: 130612661
RES: 135693315
 » show all
Reference
  Authors
Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ
  Title
Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.
  Journal
J Biol Chem 275:7390-4 (2000)
DOI:10.1074/jbc.275.10.7390
  Sequence
[rno:64040]

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