KEGG   ORTHOLOGY: K00212
Entry
K00212                      KO                                     

Name
AKR1C1
Definition
20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
Pathway
ko00140  Steroid hormone biosynthesis
ko00980  Metabolism of xenobiotics by cytochrome P450
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.149  20alpha-hydroxysteroid dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.20  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
Other DBs
RN: R02207 R02209 R03325 R07015 R08958 R08959 R09420
GO: 0047006 0047115
Genes
HSA: 1645(AKR1C1)
PTR: 100607996
PPS: 100986729(AKR1C1)
GGO: 101146324 115936027
PON: 100171658(AKR1C1) 100189776
NLE: 100605934
MCC: 711198(AKR1C1)
MCF: 101865536(AKR1C1)
CSAB: 103237807
RRO: 104678924 104678925
CJC: 100404656(AKR1C1)
SBQ: 101042532
MCAL: 110308710
MPAH: 110315750
RNO: 307092(Akr1c1)
CGE: 100770100
NGI: 103725895
HGL: 101716553
CCAN: 109680485
OCU: 100348607(PGER1) 100352716
ECB: 100070570
EPZ: 103540778
EAI: 106827244
 » show all
Reference
PMID:8172617
  Authors
Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A
  Title
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.
  Journal
Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545
  Sequence
[hsa:1645]
Reference
  Authors
Higaki Y, Usami N, Shintani S, Ishikura S, El-Kabbani O, Hara A
  Title
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
  Journal
Chem Biol Interact 143-144:503-13 (2003)
DOI:10.1016/S0009-2797(02)00206-5

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