KEGG   ORTHOLOGY: K00288Help
Entry
K00288                      KO                                     

Name
MTHFD
Definition
methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Pathway
ko00670  One carbon pool by folate
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Module
M00141  C1-unit interconversion, eukaryotes
Disease
H00262  Spina bifida
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
BRITE hierarchy
Other DBs
RN: R00943 R01220 R01655
GO: 0004488 0004477 0004329
Genes
HSA: 4522(MTHFD1)
PTR: 452965(MTHFD1)
PPS: 100986093(MTHFD1)
GGO: 101145772(MTHFD1)
PON: 100173036(MTHFD1)
NLE: 100592446(MTHFD1)
MCC: 707059(MTHFD1)
MCF: 102146226(MTHFD1)
CSAB: 103229163(MTHFD1)
RRO: 104678419(MTHFD1)
RBB: 108542410(MTHFD1)
CJC: 100385373(MTHFD1)
SBQ: 101050716(MTHFD1)
MMU: 108156(Mthfd1)
MCAL: 110306712(Mthfd1)
MPAH: 110324943(Mthfd1)
RNO: 64300(Mthfd1)
MUN: 110547762(Mthfd1)
CGE: 100763862(Mthfd1)
NGI: 103730291 103749265(Mthfd1)
HGL: 101707403(Mthfd1)
CCAN: 109691124(Mthfd1)
OCU: 100347271(MTHFD1)
TUP: 102473748(MTHFD1)
CFA: 480352(MTHFD1)
VVP: 112922441 112927162(MTHFD1)
AML: 100467466(MTHFD1)
UMR: 103672303(MTHFD1)
ORO: 101381197(MTHFD1)
ELK: 111139993
FCA: 101086816(MTHFD1)
PTG: 102971656(MTHFD1)
PPAD: 109268333(MTHFD1)
AJU: 106971326(MTHFD1)
BTA: 534382(MTHFD1)
BOM: 102275233(MTHFD1)
BIU: 109565242(MTHFD1)
BBUB: 102414409(MTHFD1)
CHX: 102186214(MTHFD1)
OAS: 101109020(MTHFD1)
SSC: 414382(MTHFD1)
CFR: 102504065(MTHFD1)
CDK: 105086194(MTHFD1)
BACU: 103017005(MTHFD1)
LVE: 103090767(MTHFD1)
OOR: 101275041(MTHFD1)
DLE: 111173070(MTHFD1)
PCAD: 102996417(MTHFD1)
ECB: 100062154(MTHFD1)
EPZ: 103559580(MTHFD1)
EAI: 106840123
MYB: 102241254(MTHFD1)
MYD: 102757978(MTHFD1)
MNA: 107545676(MTHFD1)
HAI: 109382053(MTHFD1)
DRO: 112311419(MTHFD1)
PALE: 102878910(MTHFD1)
RAY: 107509318(MTHFD1)
MJV: 108396567
LAV: 100661814(MTHFD1)
TMU: 101351465
MDO: 100027684(MTHFD1)
SHR: 100917465(MTHFD1)
PCW: 110220613(MTHFD1)
OAA: 100079541(MTHFD1)
GGA: 423508(MTHFD1)
MGP: 100542376(MTHFD1)
CJO: 107315290(MTHFD1)
NMEL: 110401467(MTHFD1)
APLA: 101798457(MTHFD1)
ACYG: 106037251(MTHFD1)
TGU: 100218066(MTHFD1)
LSR: 110484120(MTHFD1)
SCAN: 103826371(MTHFD1)
GFR: 102040140(MTHFD1)
FAB: 101820743(MTHFD1)
PHI: 102101641(MTHFD1)
PMAJ: 107206040(MTHFD1)
CCW: 104687153(MTHFD1)
ETL: 114063210(MTHFD1)
FPG: 101913340(MTHFD1)
FCH: 102059574(MTHFD1)
CLV: 102091689(MTHFD1)
EGZ: 104131673(MTHFD1)
NNI: 104010143(MTHFD1)
ACUN: 113480420(MTHFD1)
PADL: 103924255(MTHFD1)
AAM: 106483010(MTHFD1)
ASN: 102377792(MTHFD1)
AMJ: 102576903(MTHFD1)
PSS: 102452269(MTHFD1)
CMY: 102943369(MTHFD1)
CPIC: 101941983(MTHFD1)
ACS: 100553949(mthfd1)
PVT: 110082847(MTHFD1)
PBI: 103058437(MTHFD1)
PMUR: 107285163(MTHFD1)
TSR: 106542509(MTHFD1)
PMUA: 114603772(MTHFD1)
GJA: 107119326(MTHFD1)
XLA: 380266(mthfd1.L)
XTR: 493369(mthfd1)
NPR: 108787125(MTHFD1)
DRE: 260441(mthfd1b)
CCAR: 109107607
IPU: 108257577(mthfd1) 108269612(Mthfd1)
PHYP: 113538830(mthfd1) 113547678
AMEX: 103042181(mthfd1) 103044195
TRU: 101079275(mthfd1)
LCO: 104924805(mthfd1)
NCC: 104947195(mthfd1)
MZE: 101477222(mthfd1)
ONL: 100709978(mthfd1)
OLA: 101174548
XMA: 102224500(mthfd1)
XCO: 114133834
PRET: 103458564(mthfd1)
CVG: 107094373(mthfd1)
NFU: 107392490(mthfd1)
KMR: 108232073
ALIM: 106519747
AOCE: 111577893(mthfd1)
CSEM: 103390162(mthfd1)
LCF: 108892567
SDU: 111225814
SLAL: 111652470(mthfd1)
HCQ: 109526130(mthfd1)
BPEC: 110155272
MALB: 109968362
SASA: 106581504(mthfd1) 106607641
OTW: 112217304 112261855(mthfd1)
SALP: 111968792(mthfd1) 111973247
ELS: 105015635(mthfd1) 105021712
SFM: 108919610(mthfd1)
PKI: 111838814(mthfd1)
LCM: 102347033(MTHFD1)
CMK: 103189752(mthfd1)
RTP: 109912330
CIN: 100185664
SPU: 589933
APLC: 110975175
SKO: 100366866
DME: Dmel_CG4067(pug)
DER: 6551976
DSI: Dsimw501_GD18702(Dsim_GD18702)
DSR: 110189968
DPE: 6594045
DMN: 108156189
DWI: 6648231
DAZ: 108608669
DNV: 115563676
DHE: 111597189
MDE: 101891351
LCQ: 111683240
AAG: 5567414
AALB: 109411581
AME: 550749
BIM: 100741383
BTER: 100644014
CCAL: 108624805
OBB: 114882865
SOC: 105195662
MPHA: 105831994
AEC: 105144492
ACEP: 105622571
PBAR: 105431753
VEM: 105567713
HST: 105192491
DQU: 106744693
CFO: 105252037
LHU: 105668747
PGC: 109852088
OBO: 105274937
PCF: 106792378
NVI: 100118909
CSOL: 105362769
MDL: 103575930
NVL: 108563026
BMOR: 101743494
BMAN: 114247836
PMAC: 106721613
PRAP: 110993574
HAW: 110379090
TNL: 113498638
PXY: 105382326
API: 100167020
DNX: 107167392
AGS: 114123150
RMD: 113549729
BTAB: 109035160
CLEC: 106671085
ZNE: 110829788
FCD: 110845338
TUT: 107361733
DPTE: 113795631
CSCU: 111620117
PTEP: 107442163
CEL: CELE_K07E3.4(K07E3.4)
TSP: Tsp_00651
PCAN: 112570838
CRG: 105345937
MYI: 110450445
OBI: 106869903
LAK: 106174568
EPA: 110244187
ADF: 107335679
AMIL: 114955603
PDAM: 113676803
SPIS: 111342997
DGT: 114531584
AQU: 100634307
SCE: YBR084W(MIS1) YGR204W(ADE3)
KMX: KLMA_60087(ADE3) KLMA_70359(MIS1)
NCS: NCAS_0A07290(NCAS0A07290) NCAS_0I01350(NCAS0I01350)
NDI: NDAI_0A07650(NDAI0A07650) NDAI_0D02270(NDAI0D02270)
TPF: TPHA_0A03820(TPHA0A03820) TPHA_0A04840(TPHA0A04840)
TBL: TBLA_0B07610(TBLA0B07610) TBLA_0I02160(TBLA0I02160)
TDL: TDEL_0E04950(TDEL0E04950) TDEL_0F02070(TDEL0F02070)
KAF: KAFR_0B04020(KAFR0B04020) KAFR_0C00240(KAFR0C00240)
PIC: PICST_80013(MIS1) PICST_88119(ADE3)
SLB: AWJ20_1713(MIS1) AWJ20_943(MIS1)
NCR: NCU03877
NTE: NEUTE1DRAFT88125(NEUTE1DRAFT_88125)
MGR: MGG_01014
SSCK: SPSK_10843
MAW: MAC_07740
MAJ: MAA_00020
ANI: AN2998.2
ANG: ANI_1_3132024(An02g12420)
ABE: ARB_04625
TVE: TRV_06219
PNO: SNOG_01593(SNOG_01592)
PTE: PTT_13570
CNE: CNG00590
CNB: CNBG4190
ABP: AGABI1DRAFT118122(AGABI1DRAFT_118122)
ABV: AGABI2DRAFT183212(AGABI2DRAFT_183212)
MGL: MGL_2903
MRT: MRET_3502
SMIN: v1.2.012576.t1(symbB.v1.2.012576.t1)
TCR: 511741.50
LMA: LMJF_30_2600(FTHS)
LIF: LINJ_30_2590(FTHS)
LBZ: LBRM_30_2550(FTHS)
ATM: ANT_16290(fhs)
ABAT: CFX1CAM_0631(fhs)
CAP: CLDAP_24240(fhs)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3053686
  Authors
Hum DW, Bell AW, Rozen R, MacKenzie RE
  Title
Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
  Journal
J Biol Chem 263:15946-50 (1988)
  Sequence
[hsa:4522]
Reference
  Authors
Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, Molloy AM, O'Leary VB, Parle-McDermott A, Scott JM, Swanson DA
  Title
A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.
  Journal
Am J Hum Genet 71:1207-15 (2002)
DOI:10.1086/344213

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