KEGG ORTHOLOGY: K00320

ORTHOLOGY: K00320

Entry

K00320                      KO

Symbol

mer

Name

5,10-methylenetetrahydromethanopterin reductase [EC:1.5.98.2]

Pathway

map00680

Methane metabolism

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01200

Carbon metabolism

Module

M00567

Methanogenesis, CO2 => methane

Reaction

R04464

5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00320  mer; 5,10-methylenetetrahydromethanopterin reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.98  With other, known, physiological acceptors
    1.5.98.2  5,10-methylenetetrahydromethanopterin reductase
     K00320  mer; 5,10-methylenetetrahydromethanopterin reductase

Other DBs

COG:

COG2141

GO:

0018537

Genes

ZAL:	AZF00_03740

HALC:

EY643_08545

KIM:	G3T16_19900

PSPW:

BJG93_33595

DOE:	DENOEST_1262

BIC:	LMTR13_24555 LMTR13_24680

BRAZ:

LRP30_33355 LRP30_33475

RPB:	RPB_4412 RPB_4431

NRE:	BES08_26800

SWI:

Swit_0724

SPHD:

HY78_07885 HY78_23075

RDI:	CMV14_12235

SPKC:

KC8_06245

SBIN:

SBA_ch2_0970

SCH:	Sphch_1884

SYB:	TZ53_18460

SBD:	ATN00_17390 ATN00_17485

SPMI:

K663_17326 K663_17801

SPHT:

K426_23754 K426_23849

SHYD:

CJD35_15390 CJD35_15495

SUFL:

FIL70_06830 FIL70_06930 FIL70_11560

CMAN:

A9D14_14795

KHA:	IFJ82_10875

ERZ:	ER308_02385 ER308_09985 ER308_12970 ER308_13090

MPA:

MAO:

MAVI:

MAVU:

MAV:	MAV_1930 MAV_5061

MIT:	OCO_13230 OCO_25030 OCO_39800

MIA:	OCU_07100 OCU_13700 OCU_24900 OCU_39700

MID:	MIP_00259 MIP_03465 MIP_05993

MYO:

OEM_23460

MCHI:

AN480_04710 AN480_12585 AN480_20895

MIR:	OCQ_23580 OCQ_28210 OCQ_29400 OCQ_40880

MMAL:

CKJ54_11345

MSA:	Mycsm_03546 Mycsm_04592 Mycsm_06787 Mycsm_06803

MMC:

Mmcs_3824

MKM:

Mkms_3898

MJL:	Mjls_3810 Mjls_4047

MMM:	W7S_08445 W7S_12080 W7S_19830

MYV:	G155_01495 G155_03345 G155_28015

MYE:	AB431_15950

MDX:	BTO20_10285 BTO20_23080 BTO20_34590

MFJ:	MFLOJ_08070 MFLOJ_18720 MFLOJ_23560 MFLOJ_42820 MFLOJ_56420

MSTO:

MSTO_09290 MSTO_20260 MSTO_27520 MSTO_46930

MSIM:

MSIM_14700

MXE:	MYXE_08020(hmd)

MPAG:

MGOR:

MCOO:

MSEO:

MHEK:

JMUB5695_00830(fgd)

MBRD:

MBRA_11340

MMAM:

K3U93_09515

MPAA:

MKK62_12720

MWU:	PT015_06220

MSM:	MSMEG_2103 MSMEG_2456 MSMEG_3445

MSG:	MSMEI_2056 MSMEI_2395 MSMEI_3365

MSB:	LJ00_10475 LJ00_12225 LJ00_17140

MSN:	LI99_10475 LI99_12225 LI99_17145

MSH:	LI98_10475 LI98_12230 LI98_17150

MVA:	Mvan_0261 Mvan_4259

MGI:

Mflv_0410

MSP:	Mspyr1_03440

MCB:	Mycch_0231

MNE:	D174_03035

MYN:	MyAD_02965

MFT:	XA26_03220 XA26_06010 XA26_56620

MPHL:

MPHLCCUG_03824

MVQ:	MYVA_0266 MYVA_2357 MYVA_4061

MLL:	B1R94_12750 B1R94_16695

MRH:	MycrhN_3896

MTHN:

4412656_00262 4412656_03260(fgd1_4)

MHAS:

MHAS_00010(fgd1_1)

MDU:	MDUV_19340 MDUV_30540 MDUV_40590

MCHT:

MCHIJ_11280(hmd_2)

MAUU:

NCTC10437_00266 NCTC10437_02307(fgd1_5) NCTC10437_04003 NCTC10437_05699

MMAG:

MMAD_05430 MMAD_16820 MMAD_39820

MMOR:

MMOR_05480 MMOR_22830 MMOR_28450(hmd) MMOR_42210

MAIC:

MAIC_27490

MALV:

MALV_21310 MALV_28120 MALV_30900 MALV_32630

MTY:	MTOK_12730 MTOK_26490 MTOK_30960

MPSC:

MPSYJ_06270

MARZ:

MARA_16780 MARA_35350 MARA_40190

MGAD:

MGAD_45740 MGAD_56050

MHEV:

MHEL_32200 MHEL_51230

MANY:

MANY_24330(hmd) MANY_41960

MAUB:

MAUB_13640 MAUB_36340 MAUB_37910

MPOF:

MPOR_08040 MPOR_27800

MPHU:

MPHO_32370 MPHO_33950

MMUC:

C1S78_001170 C1S78_001810 C1S78_018685

MMAT:

MMAGJ_54430

MBOK:

MBOE_17960 MBOE_50810

MFG:	K6L26_28525

MSEI:

MSEDJ_16290

MGO:	AFA91_08815 AFA91_27215 AFA91_32745

MSEN:

K3U95_03240

MPAE:

K0O64_15015

MRF:	MJO55_01245

MDF:	K0O62_17150

MCRO:

MI149_16010

MGRO:

FZ046_08030 FZ046_16835

MKR:	MKOR_28420

MTER:

4434518_02913 4434518_02982

MMIN:

MMIN_35190

MHIB:

MHIB_00990(hmd)

MHER:

K3U94_10745

MVM:	MJO54_10775

NBR:	O3I_022250

NNO:	NONO_c47850 NONO_c58860

NSL:	BOX37_14070

NOZ:	DMB37_02885

NWL:	NWFMUON74_53980 NWFMUON74_57790

NTC:	KHQ06_23305

NYA:	LTV02_02545

NYU:	D7D52_02180

ROA:	Pd630_LPD12069

RRT:	4535765_00819

RKO:	JWS14_25785 JWS14_43070 JWS14_45920

ROZ:	CBI38_22735

RPSK:

JWS13_43360

GBR:

Gbro_3836

GPO:	GPOL_c36980

GOR:

KTR9_3774

GOQ:	ACH46_18365

GTA:	BCM27_19765

GOC:	CXX93_05420

GRU:	GCWB2_11310(fgd4) GCWB2_12090(ssuD) GCWB2_19375

GOM:	D7316_01986 D7316_02156(fgd2_4)

GAV:	C5O27_08760

GOD:	GKZ92_18305 GKZ92_19915

GAM:	GII34_07275

GJI:	H1R19_18105

GHN:	MVF96_18700

GAMI:

IHQ52_22285

DIZ:	CT688_02325

DPC:	A6048_02280

SGB:

WQO_00840

SFI:

SFUL_290

SCB:	SCAB_88981

SSX:	SACTE_5139

SVL:	Strvi_3235

SRC:	M271_09195

SMAL:

SMALA_8438

SCW:	TU94_30975

SXI:	SXIM_17420

STRC:

AA958_24575

SPRI:

SPRI_3761 SPRI_6783

SLE:	sle_06190(sle_06190) sle_10720(sle_10720)

SCLF:

BB341_28080

SLS:	SLINC_0648 SLINC_2815

SNR:	SNOUR_24160

SALU:

DC74_6554

SALL:

SAZ_34125

SVU:	B1H20_00460

SGE:	DWG14_02663(fgd2_1)

SQZ:	FQU76_28675

SAST:

CD934_00975

SFY:	GFH48_04670

SBY:	H7H31_03885

SPHV:

STSU:

SCOE:

SBAT:

SHAR:

SFEU:

SVD:	CP969_02205

SCAL:

I6J39_00585

SLF:	JEQ17_44815

SDEC:

L3078_04100

SLON:

LGI35_42285

SANT:

QR300_07695

SOV:	QZH56_33460

SCOA:

QU709_44345

STRZ:

OYE22_03725

STRI:

C7M71_029915

YIA:	LO772_01055

MIO:	AOA12_21255

MCW:	A8L33_00440

MLV:	CVS47_00302 CVS47_02477 CVS47_02481

MINV:

T9R20_04950

RTN:	A6122_0692

RRY:	C1O28_02305

RIA:	C7V51_08830

RFS:	C1I64_01265

RTE:	GSU10_11605

AGY:	ATC03_03845

AGM:	DCE93_00245

CART:

PA27867_2020

CRY:	B7495_09995

MYL:	C3E77_14575

SALA:

ESZ53_01560

AGG:	C1N71_12800

AGX:	AGREI_0926

BCV:	Bcav_0157 Bcav_1677

BEI:	GCM100_01690

IDO:	I598_2061(fgd1_2)

CET:	B8281_01045 B8281_02715

CCEU:

CBR64_09100 CBR64_10955

SKE:	Sked_00690

CFL:

Cfla_3359

CFI:

Celf_0191

CEZ:	CBP52_12925

CELZ:

E5225_00855 E5225_03090

CEJ:	GC089_00780

CELH:

GXP71_17345

CIRA:

LFM56_01045

CDON:

KKR89_14295

OEK:	FFI11_002680

PSEI:

GCE65_14670

SERW:

FY030_06825

ORZ:	FNH13_06330

HALT:

RHAL:

RSUA:

MICG:

NCA:	Noca_0856 Noca_1630

NDK:

I601_3217

NOY:	EXE57_05580

NANO:

G5V58_00785 G5V58_03785

NARO:

CFH99_04900

PSIM:

KR76_02295 KR76_07600

AEF:	GEV26_09440

KFL:

Kfla_5429

KQI:	F1D05_08235

TCU:	Tcur_0507 Tcur_2584

ACTW:

F7P10_01995 F7P10_02275 F7P10_05375 F7P10_37955

AMAZ:

LUW76_20480 LUW76_21410 LUW76_45520 LUW76_46175

ACIR:

OG979_00835

SPIQ:

OHA34_15675

ACTQ:

OG417_09765 OG417_33540 OG417_52320

SRO:

Sros_4162

NOA:	BKM31_20960

NFS:	OIE67_14085

FRE:	Franean1_4778

FAL:	FRAAL3106 FRAAL4875

FRI:	FraEuI1c_2529 FraEuI1c_3450 FraEuI1c_3839

NAKA:

H7F38_07035 H7F38_07050

MMAR:

MODMU_5441

KRA:

Krad_3725

AOI:	AORI_1327(hmd)

AJA:	AJAP_32920(hmd)

AMQ:	AMETH_1112(hmd)

AMYC:

CU254_15235 CU254_17055

AAB:	A4R43_03750 A4R43_05955 A4R43_15265

AMYY:

YIM_15240 YIM_19200(fgd7) YIM_38415

AORI:

SD37_34555

AACD:

LWP59_32320

ARHD:

VSH64_05340 VSH64_17390 VSH64_21535

PDX:	Psed_0903 Psed_6467

PSEE:

PSEH:

PSEQ:

PECQ:

PHH:	AFB00_19275

PAUT:

Pdca_12860 Pdca_25040 Pdca_29260 Pdca_36040

PBRO:

HOP40_21815 HOP40_22515 HOP40_24350 HOP40_29430 HOP40_33255

PPEL:

APRE:

AMI:

SESP:

SSYI:

KUT:	JJ691_65440

KBU:	Q4V64_26565

AHM:	TL08_05110

ACTI:

UA75_05060

ACAD:

UA74_04945

AHG:	AHOG_04820

ACTA:

C1701_04395

PMAD:

BAY61_05085 BAY61_09825 BAY61_22070 BAY61_24880

ACTY:

OG774_02155

MAU:	Micau_1979

MIL:

ML5_2085

MICB:

MicB006_4996

MTUA:

CSH63_15015

VMA:	VAB18032_19125

MCRA:

ID554_06825 ID554_07060 ID554_30065 ID554_30185

VER:	HUT12_06135 HUT12_12195 HUT12_14575 HUT12_14800

MCHL:

MPRN:

AFS:

PLAB:

PLAT:

PFLA:

Pflav_022530 Pflav_030270 Pflav_045200

PSUU:

Psuf_080170 Psuf_082450 Psuf_093780

ATL:	Athai_11400

PRY:	Prubr_38560(hmd_1) Prubr_57330 Prubr_59130

DFU:	Dfulv_27640 Dfulv_32255

NHY:	JQS43_06565

EKE:	EK0264_07735

ABAI:

IMCC26256_111288 IMCC26256_111527

RMAR:

GBA65_18010

BSOL:

FSW04_00070 FSW04_23130

CWO:

Cwoe_5617

AYM:	YM304_13900

DHI:	LH044_19275

ATM:

ANT_14450

ABAT:

CFX1CAM_1029

PSUB:

Pelsub_P1656 Pelsub_P1764

CAP:	CLDAP_07980 CLDAP_15430

PBF:	CFX0092_A2812

KBB:	ccbrp13_67000

THUG:

KNN16_08060

PMET:

G4Y79_17220 G4Y79_17225

STI:	Sthe_2316 Sthe_2879

MICA:

P0L94_12400

MJA:

MJ_1534

MFE:	Mefer_1535

MVU:	Metvu_0160

MFS:	MFS40622_0752

MIF:	Metin_0159

MJH:	JH146_0139

MESG:

MLAUSG7_0920(mer)

MESA:

MLASG1_0449(mer)

MIG:	Metig_1293

MMP:	MMP0058(mer)

MMQ:	MmarC5_1619

MMX:	MmarC6_0892

MMZ:	MmarC7_1055

MMD:

GYY_00295

MMAK:

MMKA1_00600(mer)

MMAO:

MMOS7_00840(mer)

MMAD:

MMJJ_10380

MAE:

Maeo_0749

MVN:	Mevan_1073

MVO:

Mvol_1374

MOK:	Metok_0200

METF:

CFE53_02485(mer)

MTH:

MTH_1752

MMG:	MTBMA_c03270(mer)

MWO:	MWSIV6_0292(mer)

MTEE:

METC:

METE:

METZ:

METK:

FVF72_02910(mer)

MTHM:

FZP57_01345(mer)

METJ:

FZP68_06355(mer)

MST:	Msp_1128(mer)

METB:

AW729_10140

MEIS:

PXD04_02020

MRU:	mru_0569(mer)

MSI:

Msm_0542

MEB:	Abm4_1417(mer)

MMIL:

sm9_0419(mer)

MEYE:

TL18_02180

MOL:

YLM1_0233

MARO:

MarbSA_08410

METV:

K4897_03275(mer)

MEL:	Metbo_0510

MEW:	MSWAN_1889

METH:

MBMB1_1520(mer)

MFC:	BRM9_0745(mer)

MFI:	DSM1535_0704(mer)

MCUB:

MCBB_1769(mer)

MSUB:

BK009_06580

METN:

BK008_02175

METT:

CIT01_07510(mer)

METO:

CIT02_10410(mer)

MEME:

HYG87_08125(mer)

MFEG:

GCM10025860_00380

MFV:

Mfer_0274

MKA:	MK0524(mer)

AFU:

AF_1066

AFG:	AFULGI_00011650

APO:	Arcpr_1585

AVE:	Arcve_0808 Arcve_1055

AST:	Asulf_00466 Asulf_02156

FPL:

Ferp_0743

GAC:

GACE_0389

GAH:

GAH_01105

MBA:	Mbar_A0254

MBY:	MSBRM_2698

MBW:	MSBRW_0741

MBAR:

MSBR2_2654

MBAK:

MSBR3_0245 MSBR3_2771

MAC:	MA_3733(mer)

MMA:

MM_0628

MMJ:	MSMAS_0681

MMAC:

MSMAC_0682

MVC:	MSVAZ_0679

MEK:	MSKOL_0657

MLS:	MSLAZ_2235

METM:

MSMTP_0746

MEF:	MSWH1_0878

MEQ:	MSWHS_0937

MSJ:	MSSAC_3543

MSZ:	MSSIH_3084

MSW:	MSSIT_3142

MTHR:

MSTHT_2388

MTHE:

MSTHC_0892

MHOR:

MSHOH_0799

MFZ:	AOB57_003480(mer)

MBU:	Mbur_2372(mer)

MMET:

MCMEM_0517

MELO:

J7W08_00610(mer)

MMH:

Mmah_1513

MHAZ:

BHR79_06165

MPOT:

BKM01_02375

MEV:	Metev_2139

MZH:	Mzhil_0168

MPY:

Mpsy_2035

MZI:	HWN40_11975(mer)

MMAV:

RE476_11455(mer)

MSEB:

RE474_08075(mer)

MHZ:	Metho_2247

MEHF:

MmiHf6_02030(fgd1)

MEES:

MmiEs2_08170(fgd1)

MTP:

Mthe_0205

MCJ:	MCON_2394(mer)

MHI:

MHU:

MRTJ:

MLA:

MEM:	Memar_0557

MBG:	BN140_1674(mer)

MEMA:

MMAB1_2155(mer)

MCHK:

MchiMG62_06860

MSUM:

OH143_09515

MRC:	R6Y96_00050

MPI:

MEND:

MEFW:

MAQE:

MFK:	E2N92_06510

MOU:	OU421_03230

MESB:

L1S32_06815

MANQ:

L1994_02945

MBN:

Mboo_0528

MFO:	Metfor_2659

MPL:

Mpal_0327

MPD:	MCP_2681(mer)

MEZ:	Mtc_0135(mer)

RCI:	RCIX564(mer)

HDL:	HALDL1_03000

HHB:	Hhub_1106(mer)

HNO:	LT974_14745

HLU:	LT972_12970

HSU:	HLASF_0416(mer)

HSF:	HLASA_0415(mer)

HAHS:

HSRCO_0593

SALR:

FQU85_03600 FQU85_08510

HALR:

EFA46_004740

HJE:	HacjB3_04915 HacjB3_13295

HDO:	MUK72_11295

HALX:

HAXZ:

HAYC:

HAXY:

SALI:

SAIM:

HARA:

HMA:	rrnAC2437(mer1)

HHI:	HAH_2870(mer3)

HHN:	HISP_14590

HAB:	SG26_06730

HTA:	BVU17_13960

HALJ:

G9465_05265

HSIN:

KDQ40_15110

NPH:	NP_1056A(mer)

NMO:	Nmlp_1133(mer)

NHO:	HWV23_08180

NSAL:

HUT:

HTI:

HALA:

HASV:

SVXHr_0236(mer)

HABN:

HBNXHr_0227(mer)

HMU:

Hmuk_0341

HALZ:

E5139_04990

HALL:

LC1Hm_2870(mer)

HAZP:

GBQ70_04985

HALI:

BV210_10785

HSN:	DV733_10440

HDS:	HSR122_0385

HRR:	HZS55_02155

HPEL:

HZS54_01595

HLT:	I7X12_11140

HARC:

HARCEL1_05640

SSAI:

N0B31_17585

HAAD:

MW046_10005

HWA:	HQ_3154A(mer)

HWC:	Hqrw_3697(mer)

HVO:	HVO_1937(mer)

HME:	HFX_2030(mer)

HGI:	ABY42_09440

HALE:

G3A49_12675

HLS:	KU306_02840

HLN:	SVXHx_2682(mer)

HBO:	Hbor_05330

HAQ:	DU484_03660 DU484_04770

HAJ:	DU500_04145 DU500_05210

HAER:

DU502_01690

HRA:	EI982_10810 EI982_11685

HLM:	DV707_14720

HALM:

HLA:

HALP:

HALB:

HEZZ:

HALQ:

HSS:	J7656_06825

HSAI:

HPS36_12235

HAZZ:

KI388_07775

SRUB:

C2R22_17165

HAE:	halTADL_0321 halTADL_1346

HALN:

B4589_005885

HALG:

HUG10_11070

HALU:

HUG12_00730 HUG12_05610

HMP:	K6T50_07940

HRE:	K6T36_07775

HRM:	K6T25_08045

HACB:

Hbl1158_14415

HAH:	Halar_1772

HTU:

Htur_3573

HSAL:

JMJ58_10490

HAKZ:

J0X25_05575 J0X25_19080 J0X25_19090

NMG:	Nmag_1582(mer)

HXA:	Halxa_3407

NAT:

NJ7G_2905

NPE:	Natpe_0251

NVR:	FEJ81_01420

NPL:	FGF80_09575

NAY:	HYG81_09345

HALY:

HYG82_12020

HJT:	DVR14_10650

HLO:	J0X27_12155

NGE:	Natgr_2297

HRU:	Halru_2719

SAWL:

NGM29_00760

HALV:

NGM15_10290

NOU:	Natoc_2482

HLR:	HALLA_18435

HLC:	CHINAEXTREME06980

NAJ:	B1756_04330

NAG:	AArcMg_0283

NAN:	AArc1_0293

NARA:

QQ977_13020

NBG:	DV706_06150

NAS:	GCU68_07730

HDA:	BB347_11940

MELU:

MTLP_01530

MEAM:

MU439_00980

MEAE:

QEN48_01625

NIR:	NSED_04635

NKR:	NKOR_04660

NID:	NPIRD3C_1360

NIW:	Nisw_00540

NCL:	C5F47_04655

NOX:	C5F49_04565

NUE:	C5F50_06300

NVN:	NVIE_004930(mer)

NEV:

NTE_01814

NCV:

NCAV_1415

CSU:	CSUB_C0377 CSUB_C0386 CSUB_C0571 CSUB_C0806 CSUB_C1220 CSUB_C1712

TAH:	SU86_001930

CCAI:

NAS2_0789

BARC:

AOA65_0782(mer_2)

» show all

Reference

PMID:2298726

Authors

te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C, Vogels GD

Title

Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.

Journal

J Biol Chem 265:1852-7 (1990)

Sequence

[mth:MTH_1752]

Reference

PMID:2379499

Authors

Ma K, Thauer RK

Title

Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg).

Journal

Eur J Biochem 191:187-93 (1990)
DOI:10.1111/j.1432-1033.1990.tb19109.x

Sequence

[mmg:MTBMA_c03270]

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