KEGG   ORTHOLOGY: K00408Help
Entry
K00408                      KO                                     

Name
WNT4
Definition
wingless-type MMTV integration site family, member 4
Pathway
ko04150  mTOR signaling pathway
ko04310  Wnt signaling pathway
ko04360  Axon guidance
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04916  Melanogenesis
ko04919  Thyroid hormone signaling pathway
ko04934  Cushing's syndrome
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05217  Basal cell carcinoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00677  Wnt signaling
Disease
H00598  46,XX disorders of sex development (Disorders of gonadal development)
H00600  46,XX disorders of sex development (Other)
H00607  46,XY disorders of sex development (Disorders of gonadal development)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   04390 Hippo signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   04150 mTOR signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
 Cellular Processes
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K00408  WNT4; wingless-type MMTV integration site family, member 4
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   04916 Melanogenesis
    K00408  WNT4; wingless-type MMTV integration site family, member 4
  Development
   04360 Axon guidance
    K00408  WNT4; wingless-type MMTV integration site family, member 4
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05205 Proteoglycans in cancer
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05225 Hepatocellular carcinoma
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05226 Gastric cancer
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05217 Basal cell carcinoma
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05224 Breast cancer
    K00408  WNT4; wingless-type MMTV integration site family, member 4
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K00408  WNT4; wingless-type MMTV integration site family, member 4
  Infectious diseases
   05166 HTLV-I infection
    K00408  WNT4; wingless-type MMTV integration site family, member 4
   05165 Human papillomavirus infection
    K00408  WNT4; wingless-type MMTV integration site family, member 4
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00677  Wnt signaling
     K00408  WNT4; wingless-type MMTV integration site family, member 4
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Morphogens
   K00408  WNT4; wingless-type MMTV integration site family, member 4
BRITE hierarchy
Genes
HSA: 54361(WNT4)
PTR: 469212(WNT4)
PPS: 100992168(WNT4)
GGO: 101139722(WNT4)
PON: 100436330(WNT4)
NLE: 100604353(WNT4)
MCC: 707864(WNT4)
MCF: 102143058(WNT4)
CSAB: 103225420(WNT4)
RRO: 104663222(WNT4)
RBB: 108538467(WNT4)
CJC: 100387135(WNT4)
SBQ: 101050255(WNT4)
MMU: 22417(Wnt4)
RNO: 84426(Wnt4)
CGE: 100769003(Wnt4)
NGI: 103746395(Wnt4)
HGL: 101701972(Wnt4)
CCAN: 109694918(Wnt4)
OCU: 100303773(WNT4)
TUP: 102493340(WNT4)
CFA: 612367(WNT4)
AML: 100468584(WNT4)
UMR: 103666795(WNT4)
ORO: 101365138(WNT4)
FCA: 101095185(WNT4)
BTA: 789600(WNT4)
BOM: 102269858(WNT4)
BIU: 109576138(WNT4)
PHD: 102334111(WNT4)
CHX: 102187819(WNT4)
OAS: 101122423(WNT4)
SSC: 100327037(WNT4)
CFR: 102522577(WNT4)
CDK: 105088869(WNT4)
BACU: 103009300(WNT4)
LVE: 103087836(WNT4)
OOR: 101270876(WNT4)
ECB: 100071678(WNT4)
EPZ: 103558485(WNT4)
EAI: 106840003(WNT4)
MYB: 102240589(WNT4)
MYD: 102756007(WNT4)
HAI: 109396735(WNT4)
RSS: 109435066(WNT4)
PALE: 102888866(WNT4)
LAV: 100664388(WNT4)
TMU: 101361433
MDO: 100026048(WNT4)
SHR: 100925510(WNT4)
OAA: 100075238(WNT4)
GGA: 395561(WNT4)
MGP: 100547391(WNT4)
CJO: 107323388(WNT4)
APLA: 101791711(WNT4) 101793827
ACYG: 106047829 106049157(WNT4)
TGU: 100230804(WNT4)
GFR: 102040060(WNT4) 106631805
FAB: 101806519(WNT4)
PHI: 102106062(WNT4) 102113442
PMAJ: 107212798 107213785(WNT4)
CCW: 104687219 104697541(WNT4)
FPG: 101918156 101922779(WNT4)
FCH: 102048943(WNT4) 102056989
CLV: 102083488 102098373(WNT4)
EGZ: 104126592 104131863(WNT4)
AAM: 106497177 106498597(WNT4)
ASN: 102367890 102376031(WNT4)
AMJ: 102561676(WNT4) 102573669
PSS: 102450128(WNT4) 102455801
CMY: 102931707 102945642(WNT4)
CPIC: 101941332(WNT4) 101944542
ACS: 100567689(wnt4)
PVT: 110086828(WNT4)
PBI: 103054356(WNT4)
XLA: 108697659 397706(wnt4.S)
XTR: 100491282(wnt4)
NPR: 108797396(WNT4)
DRE: 30123(wnt4a)
IPU: 108255178(wnt4) 108263562
AMEX: 103021666 103046581(wnt4)
TRU: 101067916 101068089(wnt4)
LCO: 104923622(wnt4) 104932544
MZE: 101473265(wnt4) 101479331
OLA: 100301590(wnt4) 100301591(wnt4b)
XMA: 102232798(wnt4) 102236316
PRET: 103465422(wnt4) 103477994
NFU: 107374130(wnt4) 107379462
CSEM: 103386287(wnt4) 103388020
LCF: 108877528(wnt4) 108880750
HCQ: 109515380 109521622(wnt4)
BPEC: 110163101 110165764(wnt4)
ELS: 105025459(wnt4) 105029960
LCM: 102358331(WNT4) 102366334
CMK: 103181434(wnt4)
SPU: 100892060
APLC: 110984610
SKO: 100329013(Wnt4)
BMOR: 101735411
DNX: 107168857
TUT: 107361270
CEL: CELE_F38E1.7(mom-2) CELE_K10B4.6(cwn-1)
CBR: CBG11282(Cbr-mom-2)
CRG: 105343129
MYI: 110451002
OBI: 106874406
SHX: MS3_03642
AQU: 100641115(Wnt)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bernardi H, Gay S, Fedon Y, Vernus B, Bonnieu A, Bacou F
  Title
Wnt4 activates the canonical beta-catenin pathway and regulates negatively myostatin: functional implication in myogenesis.
  Journal
Am J Physiol Cell Physiol 300:C1122-38 (2011)
DOI:10.1152/ajpcell.00214.2010
Reference
  Authors
Saulnier DM, Ghanbari H, Brandli AW
  Title
Essential function of Wnt-4 for tubulogenesis in the Xenopus pronephric kidney.
  Journal
Dev Biol 248:13-28 (2002)
DOI:10.1006/dbio.2002.0712
  Sequence
[xla:397706]
Reference
  Authors
Jordan BK, Mohammed M, Ching ST, Delot E, Chen XN, Dewing P, Swain A, Rao PN, Elejalde BR, Vilain E
  Title
Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.
  Journal
Am J Hum Genet 68:1102-9 (2001)
DOI:10.1086/320125
  Sequence
[hsa:54361]

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