KEGG   ORTHOLOGY: K00497
Entry
K00497                      KO                                     
Symbol
CYP11B1
Name
steroid 11beta-monooxygenase [EC:1.14.15.4]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H00216  Congenital adrenal hyperplasia
H00602  Glucocorticoid-remediable aldosteronism (GRA)
H01603  Primary aldosteronism
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00497  CYP11B1; steroid 11beta-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    K00497  CYP11B1; steroid 11beta-monooxygenase
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00497  CYP11B1; steroid 11beta-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00497  CYP11B1; steroid 11beta-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K00497  CYP11B1; steroid 11beta-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP11 family
   K00497  CYP11B1; steroid 11beta-monooxygenase
Other DBs
RN: R02218 R02725 R02843 R03329 R03851 R04850 R08949
GO: 0004507
Genes
HSA: 1584(CYP11B1)
PTR: 464437(CYP11B1)
PPS: 100971586(CYP11B1)
GGO: 115930159
PON: 100459910
NLE: 100605657
MCC: 695793(CYP11B1)
MCF: 102136659(CYP11B1)
CSAB: 103237546(CYP11B1)
CATY: 105581188
RRO: 104679773
RBB: 108536535
PTEH: 111535654
CJC: 100415667(CYP11B1)
SBQ: 101048076
CSYR: 103276447
MMU: 110115(Cyp11b1) 13072(Cyp11b2)
RNO: 24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)
HGL: 101701311
CPOC: 111755182
OCU: 100328543(CYP11B2) 100342863
OPI: 101518686
CFA: 482071(CYP11B2)
VVP: 112911200
VLG: 121499022
AML: 100478197
UMR: 103680551
ELK: 111146729
ORO: 101364874
MLX: 118015252
FCA: 101097790
PTG: 102972244
PPAD: 109258417
AJU: 106989683
HHV: 120227687
BTA: 112449566 282422(CYP11B1) 787628
OAS: 101102377 767576(CYP11B1)
ODA: 120859420
CCAD: 122451091
SSC: 110260194
CFR: 102517728
CBAI: 105077899
CDK: 105106427
VPC: 102532708
BACU: 103009357
LVE: 103089121
OOR: 101286768
DLE: 111165107
PCAD: 102988484
PSIU: 116742421
EPZ: 103543718
MYD: 102752229
MMYO: 118670722
MNA: 107542744
PKL: 118718613
HAI: 109390820
DRO: 112315587
SHON: 118988945
AJM: 119064760
PDIC: 114514446
PHAS: 123833011
MMF: 118643316
RFQ: 117033759
PALE: 102881458
PGIG: 120588772
RAY: 107507877
MJV: 108400067
TOD: 119232024
SARA: 101544036
LAV: 100654178
TMU: 101354125
DNM: 101424711
MDO: 100032885
GAS: 123255806
SHR: 100930767
PCW: 110214194
OAA: 100082065
TGU: 116807520
LSR: 110479458
PHI: 102113159
FPG: 101918505
FCH: 102046275
AROW: 112976664
ASN: 102375758
AMJ: 102575737(CYP11B1)
CPOO: 109310774
CMY: 102933677
CPIC: 101950678
TST: 117873891
CABI: 116833743
MRV: 120396417
ACS: 100560890
PVT: 110084842
SUND: 121929727
PBI: 103058342
PMUR: 107300041
TSR: 106545562
PGUT: 117666942
VKO: 123035256
PMUA: 114600140
ZVI: 118089700
GJA: 107116366
STOW: 125425154
XLA: 108718624
XTR: 101731070
RTEM: 120921857
BBUF: 121001585
BGAR: 122938238
DRE: 791124(cyp11c1)
SRX: 107745157
SANH: 107698185
SGH: 107570796
CCAR: 109110857
CAUA: 113059430
PPRM: 120491104
MAMB: 125243223
IPU: 108263488
PHYP: 113525473
SMEO: 124384380
TFD: 113647799
AMEX: 103026652
EEE: 113574779
TRU: 101075863
LCO: 104920541
NCC: 104944920
CGOB: 115021232
ELY: 117265363
PLEP: 121945728
SLUC: 116049596
ECRA: 117946724
PFLV: 114556971
GAT: 120810783
PPUG: 119198098
MSAM: 119897544
CUD: 121514148
MZE: 101463871
ONL: 100533461(cyp11b)
OAU: 116320943
OLA: 100125822(cyp11b)
OML: 112143274
XMA: 102236274
XCO: 114139300
XHE: 116715552
PRET: 103478110
PFOR: 103136813
PLAI: 106957061
PMEI: 106922010
GAF: 122830567
CVG: 107088793
CTUL: 119783082
GMU: 124865602
NFU: 107379700
KMR: 108235361
ALIM: 106515094
NWH: 119410002
CSEM: 103388284
POV: 109633048
SSEN: 122774868
HHIP: 117777191
LCF: 108885901
SDU: 111230014
SLAL: 111652162
XGL: 120784322
HCQ: 109522775
BPEC: 110163163
MALB: 109970182
SASA: 100136945
OTW: 121840636
OMY: 100135891(cyp11b) 110534298
ONE: 115122985
SALP: 112074060
SNH: 120047273
ELS: 105018961
SFM: 108925533
PKI: 111853322
AANG: 118210794
LOC: 102683152
PSPA: 121306922
LCM: 102345423
 » show all
Reference
PMID:2592361
  Authors
Mornet E, Dupont J, Vitek A, White PC
  Title
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
  Journal
J Biol Chem 264:20961-7 (1989)
  Sequence
[hsa:1584]
Reference
PMID:3485096
  Authors
Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P
  Title
The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.
  Journal
J Biol Chem 261:3556-62 (1986)

DBGET integrated database retrieval system