KEGG   ORTHOLOGY: K00501Help
Entry
K00501                      KO                                     

Name
TH
Definition
tyrosine 3-monooxygenase [EC:1.14.16.2]
Pathway
ko00350  Tyrosine metabolism
ko00790  Folate biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04728  Dopaminergic synapse
ko04917  Prolactin signaling pathway
ko05012  Parkinson's disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Disease
H00831  Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00350 Tyrosine metabolism
    K00501  TH; tyrosine 3-monooxygenase
  Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
  Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00501  TH; tyrosine 3-monooxygenase
 Organismal Systems
  Endocrine system
   04917 Prolactin signaling pathway
    K00501  TH; tyrosine 3-monooxygenase
  Nervous system
   04728 Dopaminergic synapse
    K00501  TH; tyrosine 3-monooxygenase
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    K00501  TH; tyrosine 3-monooxygenase
  Substance dependence
   05030 Cocaine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05031 Amphetamine addiction
    K00501  TH; tyrosine 3-monooxygenase
   05034 Alcoholism
    K00501  TH; tyrosine 3-monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide and amino acid metabolism
   Aromatic amino acid metabolism
    M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
     K00501  TH; tyrosine 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.2  tyrosine 3-monooxygenase
     K00501  TH; tyrosine 3-monooxygenase
BRITE hierarchy
Other DBs
RN: R01815 R07212
GO: 0004511
Genes
HSA: 7054(TH)
PTR: 450955(TH)
PPS: 100967895(TH)
GGO: 101135345(TH)
PON: 100454349(TH)
NLE: 100591963(TH)
MCC: 721137(TH)
MCF: 102134074(TH)
CSAB: 103238895(TH)
RRO: 104677105(TH)
RBB: 108539190(TH)
CJC: 100393454(TH)
SBQ: 101037795(TH)
MMU: 21823(Th)
RNO: 25085(Th)
CGE: 100760127(Th)
NGI: 103738985(Th)
HGL: 101721615(Th)
CCAN: 109689795(Th)
TUP: 102482570(TH)
CFA: 403444(TH)
AML: 100483681(TH)
UMR: 103671121(TH)
ORO: 101384343(TH)
FCA: 101090720(TH)
PTG: 102954972(TH)
AJU: 106971078(TH)
BTA: 280707(TH)
BOM: 102274970(TH)
BIU: 109554672(TH)
PHD: 102343816(TH)
CHX: 102179849(TH)
OAS: 101120619(TH)
SSC: 110259705(TH)
CFR: 102508286(TH)
CDK: 105106406(TH)
BACU: 103020745(TH)
LVE: 103086024(TH)
OOR: 101278256(TH)
ECB: 100146648(TH)
EPZ: 103545553
EAI: 106824091(TH)
MYB: 102254096(TH)
MYD: 102756871(TH)
HAI: 109395916(TH)
RSS: 109435669(TH)
LAV: 100665276(TH)
TMU: 101347132
MDO: 100021373
OAA: 100075982
GGA: 395592(TH) 771761(THL)
MGP: 100546438 723977(TH)
APLA: 101794316 101794610(TH)
ACYG: 106035805 106042638(TH)
PMAJ: 107204189 107205413(TH)
CPIC: 101937054(TH) 101942670
XLA: 100037248(th.S) 108710245 108713461(th.L)
DRE: 30384(th)
AMEX: 103023599(th) 103026162
TRU: 101078018(th) 446095(2nd_copy)
OLA: 101168664(th2) 101171548(th)
PRET: 103459397 103466160(th)
BPEC: 110161487 110165894(th)
CIN: 493867(th)
SPU: 581094
SKO: 100329060(TH)
DME: Dmel_CG10118(ple)
DSI: Dsimw501_GD13115(Dsim_GD13115)
MDE: 101896218
AAG: 23687518
AME: 408930(TyHyd)
BIM: 100750025
BTER: 100646624
SOC: 105194448
AEC: 105145056
ACEP: 105619344
PBAR: 105423652
HST: 105182098
CFO: 105248912
LHU: 105678075
PGC: 109861504
NVI: 100116056
TCA: 654918(Th)
DPA: 109541904
NVL: 108569991
BMOR: 100270767(Th)
PMAC: 106717258
PRAP: 110997603
PXY: 105380496(Th)
API: 100167369
DNX: 107161975
ZNE: 110829545
FCD: 110862051
TUT: 107359687
CEL: CELE_B0432.5(cat-2)
CBR: CBG07026(Cbr-cat-2)
BMY: Bm1_46865
TSP: Tsp_12013
CRG: 105337798
MYI: 110459086
OBI: 106871451
SHX: MS3_00810
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Daubner SC, Le T, Wang S
  Title
Tyrosine hydroxylase and regulation of dopamine synthesis.
  Journal
Arch Biochem Biophys 508:1-12 (2011)
DOI:10.1016/j.abb.2010.12.017

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