KEGG   ORTHOLOGY: K00502Help
Entry
K00502                      KO                                     

Name
TPH1_2
Definition
tryptophan 5-monooxygenase [EC:1.14.16.4]
Pathway
ko00380  Tryptophan metabolism
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
ko04361  Axon regeneration
ko04726  Serotonergic synapse
Module
M00037  Melatonin biosynthesis, tryptophan => serotonin => melatonin
Disease
H01646  Major depressive disorder
H01895  Attention deficit hyperactivity disorder (ADHD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K00502  TPH1_2; tryptophan 5-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K00502  TPH1_2; tryptophan 5-monooxygenase
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K00502  TPH1_2; tryptophan 5-monooxygenase
  09158 Development and regeneration
   04361 Axon regeneration
    K00502  TPH1_2; tryptophan 5-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     K00502  TPH1_2; tryptophan 5-monooxygenase
BRITE hierarchy
Other DBs
RN: R01814 R07213
GO: 0004510
Genes
HSA: 121278(TPH2) 7166(TPH1)
PTR: 466453(TPH1) 467070(TPH2)
PPS: 100977344(TPH2) 103782654(TPH1)
GGO: 101132108(TPH1) 101146582(TPH2)
PON: 100459809(TPH2) 103891844(TPH1)
NLE: 100588345(TPH2) 100601780(TPH1)
MCC: 664730(TPH2) 695363(TPH1)
MCF: 102124167(TPH2) 102145077(TPH1)
CSAB: 103238730(TPH2) 103239320(TPH1)
RRO: 104667637(TPH1) 104668095(TPH2)
RBB: 108526665(TPH2) 108528377(TPH1)
CJC: 100403096(TPH2) 100415029(TPH1)
SBQ: 101051709(TPH2) 104652952(TPH1)
MMU: 216343(Tph2) 21990(Tph1)
MCAL: 110298535(Tph1) 110303601(Tph2)
MPAH: 110326744(Tph2) 110330199(Tph1)
RNO: 24848(Tph1) 317675(Tph2)
MUN: 110550489(Tph1) 110555372(Tph2)
CGE: 100763947(Tph2) 100767923(Tph1)
NGI: 103734460(Tph1) 103735331(Tph2)
HGL: 101710219(Tph1) 101714361(Tph2)
CCAN: 109675533 109679995(Tph1)
OCU: 100009100(TPH1) 100101558(TPH1) 100344397(TPH2)
TUP: 102481223(TPH2) 102487889(TPH1)
CFA: 481165(TPH2) 611956(TPH1)
VVP: 112922180(TPH2) 112927027(TPH1)
AML: 100467699(TPH1) 100472165(TPH2)
UMR: 103656892(TPH2) 103679407(TPH1)
UAH: 113246602(TPH1) 113256261(TPH2)
ORO: 101364741(TPH1) 101369839(TPH2)
FCA: 101082165(TPH2) 101098575(TPH1)
PTG: 102948910(TPH2) 102969936(TPH1)
PPAD: 109270520(TPH2) 109271211(TPH1)
AJU: 106967384(TPH2) 106977480(TPH1)
BTA: 100336620(TPH2) 781941(TPH1)
BOM: 102269915(TPH1) 102275621(TPH2)
BIU: 109558652(TPH2) 109569943(TPH1)
BBUB: 102396992(TPH2) 102411029(TPH1)
CHX: 102174722(TPH2) 102184739(TPH1)
OAS: 101113620(TPH1) 101120314(TPH2)
SSC: 100511002(TPH1) 100627725(TPH2)
CFR: 102512650(TPH2) 102522464(TPH1)
CDK: 105086665(TPH1) 105095994(TPH2)
BACU: 102997866(TPH1) 103006656(TPH2)
LVE: 103083324(TPH1) 103087968(TPH2)
OOR: 101271217(TPH2) 101273510(TPH1)
DLE: 111165253(TPH1) 111173732(TPH2)
PCAD: 102985446(TPH2) 102994832(TPH1)
ECB: 100009684(TPH2) 100056614(TPH1)
EPZ: 103559190(TPH1) 103561950(TPH2)
EAI: 106826108(TPH2) 106835485(TPH1)
MYB: 102241626(TPH2) 102244804(TPH1)
MYD: 102753485(TPH2) 102767513(TPH1)
MNA: 107526733(TPH2) 107546725(TPH1)
HAI: 109387680(TPH2) 109388096(TPH1)
DRO: 112303363(TPH1) 112319064(TPH2)
PALE: 102882683(TPH1) 102891331(TPH2)
RAY: 107508027(TPH1) 107512624(TPH2)
MJV: 108400665(TPH2) 108404860(TPH1)
LAV: 100658860(TPH1) 100669911(TPH2) 104847369
MDO: 100011937(TPH2) 100020009(TPH1)
SHR: 100915442(TPH1) 100923184(TPH2) 111721271
PCW: 110195961(TPH2) 110221097(TPH1)
OAA: 100079349(TPH2) 100090381(TPH1)
GGA: 395799(TPH1) 408026(TPH2)
MGP: 100303678(TPH2) 100549515(TPH1)
CJO: 107310284(TPH2) 107314681(TPH1)
NMEL: 110392823(TPH2) 110401279(TPH1)
APLA: 101793780(TPH2) 101797806(TPH1)
TGU: 100228542(TPH2) 100229598(TPH1)
LSR: 110468084(TPH1) 110469834(TPH2)
SCAN: 103813668(TPH2) 103826774(TPH1)
GFR: 102036017(TPH2) 102041307(TPH1)
FAB: 101817911(TPH2) 101820220(TPH1)
PHI: 102103962(TPH2) 102106431(TPH1)
PMAJ: 107204683(TPH2) 107205260(TPH1)
CCAE: 111930805(TPH1) 111937577(TPH2)
CCW: 104685325(TPH1) 104698473(TPH2)
ETL: 114059440(TPH1) 114059989(TPH2)
FPG: 101914983(TPH1) 101918183(TPH2)
FCH: 102052919(TPH2) 102057315(TPH1)
CLV: 102092014(TPH2) 102095810(TPH1)
EGZ: 104123206(TPH1) 104132957(TPH2)
NNI: 104010591(TPH1) 104011038(TPH2)
ACUN: 113481125(TPH1) 113489370(TPH2)
PADL: 103920030(TPH2) 103920766(TPH1)
AAM: 106488161(TPH2) 106497047(TPH1)
ASN: 102376121(TPH2) 102380987(TPH1)
AMJ: 102560538(TPH1) 102572294(TPH2)
PSS: 102445658(TPH2) 102460535(TPH1)
CMY: 102930035(TPH2) 102934830
CPIC: 101933912(TPH2) 101948172(TPH1)
ACS: 100562860(tph1) 100564918(tph2)
PVT: 110084890(TPH2) 110088804(TPH1)
PMUR: 107283841(TPH2) 107296796(TPH1)
TSR: 106541682(TPH2) 106552357
PMUA: 114598774(TPH1) 114605959(TPH2)
GJA: 107115340(TPH2) 107115550(TPH1)
XLA: 108710258 108713144(tph2) 387560(tph1.L)
XTR: 100486097(tph2) 100497239(tph1)
NPR: 108785999(TPH1) 108788312(TPH2)
DRE: 352943(tph1a) 407712(tph2) 415103(tph1b)
IPU: 108259139(tph) 108263971 108274454(tph1)
TRU: 446047(tph1) 446048(tph2)
MZE: 101480764(tph2) 101484460 101486409(tph1)
OLA: 101166957(tph2) 101170994 101175562(tph1)
XMA: 102216868(tph1) 102234879 102236889(tph2)
XCO: 114142506 114150104(tph2) 114151044(tph1)
PRET: 103462259 103466377(tph2) 103466482(tph1)
CVG: 107099807(tph2) 107101475 107103791(tph1)
NFU: 107381938 107388661(tph1) 107389098(tph2)
KMR: 108229864(tph1) 108237877 108251439(tph2)
ALIM: 106516735 106521168(tph1) 106531022(tph2)
AOCE: 111578292 111584097(tph1)
CSEM: 103379608(tph2) 103380212(tph1)
POV: 109624178(tph1) 109644721
LCF: 108876698(tph1) 108891738(tph2)
SDU: 111229584(tph1) 111233710(tph2)
HCQ: 109507516(tph1) 109518199(tph2) 109529786
BPEC: 110162577 110168313(tph2) 110169358(tph1)
MALB: 109951036(tph1) 109969076(tph2)
ELS: 105018201(tph1) 105018238(tph2)
LCM: 102362567(TPH1) 102363250(TPH2)
CMK: 103174831(tph1) 103185330(tph2)
CIN: 100049066
SPU: 578903
APLC: 110981081
SKO: 100329006(tph-1)
DME: Dmel_CG9122(Trh)
DER: 6543860
DSI: Dsimw501_GD13494(Dsim_GD13494)
DSR: 110178615
DPE: 6603951
DMN: 108153552
DWI: 6639428
DAZ: 108614428
DNV: 108651306
DHE: 111600458
MDE: 101893101
LCQ: 111676820
AAG: 23687540
AALB: 109413958
AME: 411200
BIM: 100742465
BTER: 100647460
CCAL: 108624633
OBB: 114876888
SOC: 105194454
MPHA: 105839937
AEC: 105145053
ACEP: 105619346
PBAR: 105430282
VEM: 105567116
HST: 105182103
DQU: 106750935
CFO: 105251016
LHU: 105678051
PGC: 109861523
OBO: 105279028
PCF: 106791737
NVI: 100123183
CSOL: 105363200
MDL: 103579283
TCA: 655758
DPA: 109539121
ATD: 109598736
NVL: 108562706
BMOR: 101740691
BMAN: 114244523
PMAC: 106717008
PRAP: 110999042
HAW: 110378221
TNL: 113499708
PXY: 105389797
API: 100158737
DNX: 107164769
RMD: 113549417
BTAB: 109030678
CLEC: 106661596
ZNE: 110836317
FCD: 110856969
PVM: 113812558
TUT: 107363777
DPTE: 113789434
PTEP: 107448718
CEL: CELE_ZK1290.2(tph-1)
CBR: CBG12991(Cbr-tph-1)
TSP: Tsp_05203
PCAN: 112566861
CRG: 105336312
MYI: 110454322
OBI: 106875341
LAK: 106175748
SHX: MS3_06981
EGL: EGR_07589
APRO: F751_2362
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M
  Title
Tryptophan hydroxylase as novel target for the treatment of depressive disorders.
  Journal
Pharmacology 85:95-109 (2010)
DOI:10.1159/000279322
Reference
PMID:2377472
  Authors
Boularand S, Darmon MC, Ganem Y, Launay JM, Mallet J
  Title
Complete coding sequence of human tryptophan hydroxylase.
  Journal
Nucleic Acids Res 18:4257 (1990)
DOI:10.1093/nar/18.14.4257
  Sequence
[hsa:7166]

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