KEGG   ORTHOLOGY: K00699Help
Entry
K00699                      KO                                     

Name
UGT
Definition
glucuronosyltransferase [EC:2.4.1.17]
Pathway
ko00040  Pentose and glucuronate interconversions
ko00053  Ascorbate and aldarate metabolism
ko00140  Steroid hormone biosynthesis
ko00830  Retinol metabolism
ko00860  Porphyrin and chlorophyll metabolism
ko00980  Metabolism of xenobiotics by cytochrome P450
ko00982  Drug metabolism - cytochrome P450
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko05204  Chemical carcinogenesis
Module
M00014  Glucuronate pathway (uronate pathway)
M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate
Disease
H00208  Hyperbilirubinemia
H01593  Osteoporosis
H02054  Crigler-Najjar syndrome
H02055  Gilbert syndrome
H02152  Transient familial neonatal hyperbilirubinemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    K00699  UGT; glucuronosyltransferase
   00053 Ascorbate and aldarate metabolism
    K00699  UGT; glucuronosyltransferase
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00699  UGT; glucuronosyltransferase
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K00699  UGT; glucuronosyltransferase
   00860 Porphyrin and chlorophyll metabolism
    K00699  UGT; glucuronosyltransferase
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00699  UGT; glucuronosyltransferase
   00982 Drug metabolism - cytochrome P450
    K00699  UGT; glucuronosyltransferase
   00983 Drug metabolism - other enzymes
    K00699  UGT; glucuronosyltransferase
 09160 Human Diseases
  09161 Cancers
   05204 Chemical carcinogenesis
    K00699  UGT; glucuronosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00699  UGT; glucuronosyltransferase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Other carbohydrate metabolism
    M00014  Glucuronate pathway (uronate pathway)
     K00699  UGT; glucuronosyltransferase
  Nucleotide and amino acid metabolism
   Cofactor and vitamin biosynthesis
    M00129  Ascorbate biosynthesis, animals, glucose-1P => ascorbate
     K00699  UGT; glucuronosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.17  glucuronosyltransferase
     K00699  UGT; glucuronosyltransferase
Glycosyltransferases [BR:ko01003]
 Others
  Hydrophobic molecule
   K00699  UGT; glucuronosyltransferase
BRITE hierarchy
Other DBs
RN: R01383 R02358 R02389 R02478 R02502 R02902 R03091 R04352 R04353 R04354 R04683 R07106 R08259 R08261 R08262 R08263 R08615 R09426 R09427 R09428
GO: 0015020
CAZy: GT1
Genes
HSA: 10720(UGT2B11) 10941(UGT2A1) 54490(UGT2B28) 54575(UGT1A10) 54576(UGT1A8) 54577(UGT1A7) 54578(UGT1A6) 54579(UGT1A5) 54600(UGT1A9) 54657(UGT1A4) 54658(UGT1A1) 54659(UGT1A3) 574537(UGT2A2) 7363(UGT2B4) 7364(UGT2B7) 7365(UGT2B10) 7366(UGT2B15) 7367(UGT2B17) 79799(UGT2A3)
PTR: 100611992 107973969 461285(UGT2B4) 461287 461289 471217 471218(UGT2B7) 471219 471220(UGT2A3) 742890(UGT2A2) 743607
PPS: 100973813(UGT2A1) 100974381(UGT2B17) 100974387(UGT2B4) 100974709 100975382 100975751(UGT1A1) 100976704(UGT2B7) 100977043 100977378 100978938 100980327 100980995 100984166(UGT2B15) 100985173 103784396
GGO: 101133016 101133387 101135156(UGT2B7) 101135980 101139531 101140249(UGT2A3) 101140616 101141374(UGT2B4) 101141727 101146584(UGT1A1) 109025837
PON: 100171521(UGT2B7) 100172533(UGT1A3) 100174202(UGT2A3) 100441531 100444573 100445423 100446313 100446928(UGT2B4) 100447782(UGT2A1) 100460599(UGT2B17) 100461334
NLE: 100591991(UGT2B15) 100592283(UGT1A7) 100595401(UGT2B17) 100595736(UGT2B10) 100596311(UGT2A3) 100596642(UGT2B7) 100597206(UGT2B28) 100598804(UGT2B4) 100599361 100599929(UGT2A1) 105738256
MCC: 100427327 574147(UGT2B33) 574210(UGT1A1) 613249(UGT2B9*2) 709132(UGT2B4) 709234(UGT2B4) 709420(UGT2A3) 710412(UGT2B15) 720405(UGT2A1)
MCF: 102118731 102121904(UGT2A1) 102122035(UGT1A1) 102123935(UGT2B19) 102124844(UGT2A3) 102125239(UGT2B23) 102126139(mfUGT2B33) 102127013(UGT2B18) 102127692(UGT2B30) 102127901(UGT2B9) 102128580(UGT2B20)
CSAB: 103218110 103218113 103235585 103235588 103235590 103235708 103235720 103235724 103247815
RRO: 104663543 104664126 104664128 104664129 104666351 104666426 104667779 104667780 104667781 104668690(UGT2A1)
CJC: 100388812(UGT2A3) 100391186 100405984(UGT1A1) 100409222(UGT2A2) 100412562(UGT2B7) 100413404 100414245(UGT2B4) 103792017
MMU: 100559(Ugt2b38) 100727(Ugt2b34) 112417(Ugt2b37) 22236(Ugt1a2) 22238(Ugt2b5) 231396(Ugt2b36) 243085(Ugt2b35) 394430(Ugt1a10) 394432(Ugt1a7c) 394433(Ugt1a5) 394434(Ugt1a9) 394435(Ugt1a6b) 394436(Ugt1a1) 552899(Ugt2a2) 71773(Ugt2b1) 72094(Ugt2a3) 94215(Ugt2a1) 94284(Ugt1a6a)
RNO: 113992(Ugt1a6) 154516(Ugt1a7c) 24861(Ugt1a1) 24862(Ugt2b) 266685(Ugt2b17) 286954(Ugt2b1) 286989(Ugt2b7) 289533(Ugt2a3) 29623(Ugt2b37) 301595(Ugt1a8) 305264(Ugt2b10) 396527(Ugt1a2) 396551(Ugt1a3) 396552(Ugt1a9) 501907(RGD1559459) 574523(Ugt1a5) 63867(Ugt2a1) 83808(Ugt2b35)
FCA: 101087059 101087662 493955(UGT1A1)
PTG: 102959578(UGT1A1) 102967993 102968284(UGT2A1)
BACU: 103008324(UGT2B4) 103008900 103009971(UGT2A3) 103011957(UGT1A3)
LVE: 103071327 103078119(UGT1A1) 103078627 103081112(UGT2B4)
MDO: 100010818(UGT2A1) 100025642
OAA: 100079726 100081856(UGT2A1)
GGA: 422660(UGT2A1) 424028(UGT1A1)
APLA: 101796668(UGT2A1) 101802378
TGU: 100226418(UGT2B17) 100229734(UGT1A1)
FPG: 101913401 101923845(UGT1A1) 101924619(UGT2A1)
FCH: 102049059 102058629(UGT2A1)
AMJ: 102558477(UGT1A1) 102568629(UGT2A3)
PSS: 102443979(UGT1A1) 102458862 102459100 102460451(UGT2B17)
PBI: 103057215(UGT2A2) 103068173
XLA: 100037183(ugt1a6.S) 108701409(ugt1a1.L) 108711396
XTR: 100135191(ugt1a6) 100489505(ugt1a1) 101731695 447975(ugt2a1)
DRE: 100006320(ugt2a1) 406731(ugt1ab) 553952(ugt2a2) 570913(ugt5g1) 641488(ugt1a1) 792506(zgc:172315)
DSI: Dsimw501_GD12034(Dsim_GD12034) Dsimw501_GD12307(Dsim_GD12307) Dsimw501_GD16447(Dsim_GD16447) Dsimw501_GD18734(Dsim_GD18734) Dsimw501_GD18859(Dsim_GD18859) Dsimw501_GD19978(Dsim_GD19978) Dsimw501_GD20543(Dsim_GD20543) Dsimw501_GD20680(Dsim_GD20680) Dsimw501_GD20681(Dsim_GD20681) Dsimw501_GD20682(Dsim_GD20682) Dsimw501_GD20683(Dsim_GD20683) Dsimw501_GD20684(Dsim_GD20684) Dsimw501_GD20686(Dsim_GD20686) Dsimw501_GD21706(Dsim_GD21706) Dsimw501_GD23245(Dsim_GD23245) Dsimw501_GD23396(Dsim_GD23396) Dsimw501_GD23454(Dsim_GD23454) Dsimw501_GD24083(Dsim_GD24083) Dsimw501_GD24084(Dsim_GD24084) Dsimw501_GD24158(Dsim_GD24158) Dsimw501_GD24159(Dsim_GD24159) Dsimw501_GD24160(Dsim_GD24160) Dsimw501_GD25117(Dsim_GD25117) Dsimw501_GD25217(Dsim_GD25217) Dsimw501_GD25218(Dsim_GD25218) Dsimw501_GD25513(Dsim_GD25513) Dsimw501_GD27744(Dsim_GD27744) Dsimw501_GD29191(Dsim_GD29191)
AME: 107965199 408788(GB16747) 409203(GB10367) 411021 413043(GB17015) 727593(GB15163)
BMOR: 100174975(Ugt2) 100216349(Ugt) 100500754(UGT10286) 100500755(UGT10287A) 100500757(UGT10289B) 100500758(UGT10100) 100500763(UGT10288) 100862802(UGT33D2) 100862803(UGT33D3) 100862804(UGT33D6) 100862805(UGT33K1) 100862806(UGT33N1) 100862807(UGT33Q1) 100862808(UGT33R1) 100862809(UGT340C1) 100862810(UGT340C2) 100862811(UGT39C1) 100862812(UGT40B1) 100862815(UGT41A2) 100862816(UGT41A3) 100862817(UGT42A1) 100862818(UGT42A2) 100862819(UGT43B1) 100862820(UGT44A1) 100862821(UGT46A2) 100862822(UGT46C2) 100862823(UGT47A1) 100862828(UGT013830) 100862830(UGT39B1) 100862832(UGT46A1) 100862841(UGT33D7) 100862842(UGT33R2) 100862843(UGT41A1) 100862845(UGT33D5) 101739741(UGT42B1) 692593(UGT40A1) 732962(UGT33D4)
CEL: CELE_B0310.5(ugt-46) CELE_C17G1.3(ugt-23) CELE_C18C4.3(ugt-48) CELE_C44H9.1(ugt-15) CELE_F35H8.6(ugt-58) CELE_F39G3.1(ugt-61) CELE_M88.1(ugt-62) CELE_T04H1.7(ugt-55) CELE_T04H1.8(ugt-56) CELE_T07C5.1(ugt-50) CELE_ZC443.5(ugt-18) CELE_ZC455.4(ugt-6)
CBR: CBG00090(Cbr-ugt-50) CBG00954(Cbr-ugt-58) CBG01959(Cbr-ugt-23) CBG09373(Cbr-ugt-48) CBG17190(Cbr-ugt-46) CBG17629(Cbr-ugt-54) CBG18047(Cbr-ugt-62) CBG23424(Cbr-ugt-56) CBG24724
BMY: Bm1_13480
GMX: 100798391
VRA: 106778516
DCR: 108226135
SMIN: v1.2.019176.t1(symbB.v1.2.019176.t1) v1.2.022688.t1(symbB.v1.2.022688.t1) v1.2.023601.t1(symbB.v1.2.023601.t1)
TCR: 510761.76
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3931633
  Authors
Green MD, Falany CN, Kirkpatrick RB, Tephly TR
  Title
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.
  Journal
Biochem J 230:403-9 (1985)
DOI:10.1042/bj2300403

DBGET integrated database retrieval system