KEGG   ORTHOLOGY: K00889Help
Entry
K00889                      KO                                     

Name
PIP5K
Definition
1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04011  MAPK signaling pathway - yeast
ko04070  Phosphatidylinositol signaling system
ko04072  Phospholipase D signaling pathway
ko04139  Mitophagy - yeast
ko04144  Endocytosis
ko04666  Fc gamma R-mediated phagocytosis
ko04810  Regulation of actin cytoskeleton
ko05135  Yersinia infection
ko05231  Choline metabolism in cancer
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H00865  Lethal congenital contractural syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
 09130 Environmental Information Processing
  09132 Signal transduction
   04011 MAPK signaling pathway - yeast
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
   04070 Phosphatidylinositol signaling system
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
   04072 Phospholipase D signaling pathway
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
   04139 Mitophagy - yeast
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.68  1-phosphatidylinositol-4-phosphate 5-kinase
     K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
 Endocytosis
  Clathrin-mediated endocytosis
   LDLR adaptor proteins
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
 Endosome - Golgi transport
  Others
   Others
    K00889  PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase
BRITE hierarchy
Other DBs
RN: R03469
COG: COG5253
GO: 0016308
Genes
HSA: 23396(PIP5K1C) 8394(PIP5K1A) 8395(PIP5K1B)
PTR: 455590(PIP5K1C) 457288(PIP5K1A) 464513(PIP5K1B)
PPS: 100975341(PIP5K1C) 100976973 100982914(PIP5K1B) 100990998 100994510(PIP5K1A)
GGO: 101132245(PIP5K1A) 101132548(PIP5K1C) 101149662 101150370(PIP5K1B) 101153493
PON: 100432274(PIP5K1B) 100435603(PIP5K1C) 100443776 100456775(PIP5K1A)
NLE: 100582763(PIP5K1B) 100586076 100588455(PIP5K1C) 100589134(PIP5K1A) 100599403
MCC: 700538(PIP5K1B) 710007(PIP5K1A) 721744(PIP5K1C)
MCF: 101865406(PIP5K1B) 101925607(PIP5K1A) 102133242(PIP5K1C)
CSAB: 103219545(PIP5K1B) 103224044(PIP5K1A) 103233690(PIP5K1C)
RRO: 104662064(PIP5K1B) 104665440(PIP5K1C) 104681048(PIP5K1A)
RBB: 108512122 108512667(PIP5K1C) 108530266(PIP5K1B) 108533237(PIP5K1A)
CJC: 100397115(PIP5K1C) 100398080(PIP5K1A) 100398292(PIP5K1B)
SBQ: 101035105(PIP5K1C) 101044308(PIP5K1B) 104649929(PIP5K1A)
MMU: 18717(Pip5k1c) 18719(Pip5k1b) 18720(Pip5k1a)
MCAL: 110285491(Pip5k1b) 110291192(Pip5k1a) 110302948(Pip5k1c)
MPAH: 110316115(Pip5k1b) 110320843(Pip5k1a) 110326224(Pip5k1c)
RNO: 309419(Pip5k1b) 314641(Pip5k1c) 365865(Pip5k1a)
MUN: 110548510(Pip5k1c) 110560780(Pip5k1a) 110561260(Pip5k1b)
CGE: 100750926 100753298(Pip5k1a) 100772168(Pip5k1c)
NGI: 103730072(Pip5k1a) 103737261(Pip5k1c) 103749401(Pip5k1b)
HGL: 101700633(Pip5k1c) 101703623(Pip5k1a) 101726083(Pip5k1b)
CCAN: 109681221(Pip5k1a) 109682981 109696413 109697571(Pip5k1c)
OCU: 100356255(PIP5K1B) 103350059(PIP5K1A)
TUP: 102470898(PIP5K1C) 102488955(PIP5K1B) 102497135(PIP5K1A)
CFA: 475846(PIP5K1A) 476331(PIP5K1B) 485054(PIP5K1C)
VVP: 112907758(PIP5K1A) 112922124(PIP5K1B) 112935606(PIP5K1C)
AML: 100472550(PIP5K1B) 100476738(PIP5K1C) 100478325(PIP5K1A)
UMR: 103663244(PIP5K1B) 103667518(PIP5K1A) 103681825(PIP5K1C)
UAH: 113242809(PIP5K1C) 113246140(PIP5K1A) 113270193(PIP5K1B)
ORO: 101371074(PIP5K1B) 101378646(PIP5K1A) 101379866(PIP5K1C)
FCA: 101081420(PIP5K1B) 101097791(PIP5K1C) 101098154(PIP5K1A)
PTG: 102952372(PIP5K1A) 102958782(PIP5K1C) 102966331(PIP5K1B)
PPAD: 109255916(PIP5K1C) 109256994(PIP5K1A) 109275437(PIP5K1B)
AJU: 106968162(PIP5K1B) 106979654(PIP5K1A) 106982132(PIP5K1C)
BTA: 100125224(PIP5K1A) 508819(PIP5K1C) 537654(PIP5K1B)
BOM: 102268615(PIP5K1C) 102270008(PIP5K1A) 102280222(PIP5K1B)
BIU: 109555129(PIP5K1A) 109561764(PIP5K1C) 109562486(PIP5K1B)
BBUB: 102391879(PIP5K1A) 102398426(PIP5K1C) 102398762(PIP5K1B)
CHX: 102174079(PIP5K1A) 102174559(PIP5K1C) 102186592(PIP5K1B)
OAS: 101107667(PIP5K1B) 101114069(PIP5K1A) 101115537(PIP5K1C)
SSC: 100521362(PIP5K1C) 100624272(PIP5K1A) 102167387(PIP5K1B)
CFR: 102505269(PIP5K1B) 102516377(PIP5K1A) 102517441(PIP5K1C)
CDK: 105102665(PIP5K1C) 105103212(PIP5K1A) 105105952(PIP5K1B)
BACU: 103001934(PIP5K1B) 103007755(PIP5K1C) 103016244(PIP5K1A)
LVE: 103080867(PIP5K1C) 103081872(PIP5K1A) 103084474(PIP5K1B)
OOR: 101275063(PIP5K1C) 101276737(PIP5K1A) 101279069(PIP5K1B)
DLE: 111165911(PIP5K1C) 111169717(PIP5K1A) 111174620(PIP5K1B)
PCAD: 102973790(PIP5K1B) 102988075(PIP5K1A) 102990690(PIP5K1C)
ECB: 100050520(PIP5K1B) 100059655(PIP5K1A) 111774175(PIP5K1C)
EPZ: 103543283 103546289(PIP5K1B) 103547657(PIP5K1A)
EAI: 106832317(PIP5K1C) 106834849(PIP5K1B) 106846511(PIP5K1A)
MYB: 102250383(PIP5K1B) 102256140(PIP5K1C) 102261636(PIP5K1A)
MYD: 102757567(PIP5K1C) 102768014(PIP5K1A) 102773253(PIP5K1B)
MNA: 107525631(PIP5K1C) 107538124(PIP5K1B) 107539122(PIP5K1A)
HAI: 109372273(PIP5K1A) 109388601(PIP5K1C) 109392539(PIP5K1B)
DRO: 112299933(PIP5K1B) 112312597(PIP5K1C) 112314084(PIP5K1A)
PALE: 102887359(PIP5K1B) 102889348(PIP5K1A) 102890845(PIP5K1C)
RAY: 107498996(PIP5K1A) 107505403(PIP5K1B) 107520114(PIP5K1C)
MJV: 108393051(PIP5K1B) 108393271(PIP5K1C) 108403623(PIP5K1A)
LAV: 100655311 100674713(PIP5K1A) 100675521(PIP5K1B) 104847104
MDO: 100010549(PIP5K1C) 100017950(PIP5K1A) 100021835(PIP5K1B)
SHR: 100918263(PIP5K1C) 100925674(PIP5K1B) 100930714(PIP5K1A)
PCW: 110196103(PIP5K1C) 110216678 110218825(PIP5K1B)
OAA: 100074263(PIP5K1B) 100080469(PIP5K1C) 103168955(PIP5K1A)
GGA: 420072(PIP5K1C) 427243(PIP5K1B) 429983(PIP5K1A)
MGP: 100540819(PIP5K1B) 100542814(PIP5K1A) 100543434(PIP5K1C)
CJO: 107306182(PIP5K1B) 107324564(PIP5K1A) 107325498(PIP5K1C)
NMEL: 110388035(PIP5K1A) 110388874(PIP5K1C) 110389787(PIP5K1B)
APLA: 101790731(PIP5K1C) 101796455(PIP5K1A) 101798239(PIP5K1B)
ACYG: 106044156(PIP5K1B) 106045672(PIP5K1C) 106049273(PIP5K1A)
TGU: 100221379(PIP5K1C) 100232143(PIP5K1B)
LSR: 110469460(PIP5K1C) 110470676(PIP5K1B) 110476879(PIP5K1A)
SCAN: 103819439(PIP5K1B) 103821892(PIP5K1C) 103824990(PIP5K1A)
GFR: 102038093 102040285(PIP5K1C) 102041792(PIP5K1B)
FAB: 101807917(PIP5K1B) 101808443(PIP5K1C)
PHI: 102103398(PIP5K1C) 102104210(PIP5K1B) 102110678(PIP5K1A)
PMAJ: 107215403(PIP5K1C) 107216369(PIP5K1B)
CCAE: 111940280(PIP5K1C) 111940733(PIP5K1B) 111945579
CCW: 104685216(PIP5K1B) 104696960(PIP5K1C)
ETL: 114056552(PIP5K1B) 114070570(PIP5K1C) 114072474
FPG: 101914066(PIP5K1C) 101914129(PIP5K1B) 101921427(PIP5K1A)
FCH: 102047752(PIP5K1A) 102049277(PIP5K1C) 102057654(PIP5K1B)
CLV: 102093468(PIP5K1B) 102094562(PIP5K1C) 102098142(PIP5K1A)
EGZ: 104123826(PIP5K1B) 104125051(PIP5K1C) 104130566(PIP5K1A)
NNI: 104008676(PIP5K1B) 104014454(PIP5K1A) 104019631(PIP5K1C)
ACUN: 113489462(PIP5K1C) 113490107(PIP5K1B) 113490878
PADL: 103916065(PIP5K1C) 103920365(PIP5K1B) 103924092(PIP5K1A)
AAM: 106484414(PIP5K1B) 106484829(PIP5K1A) 106484848(PIP5K1C)
ASN: 102371844(PIP5K1A) 102381237(PIP5K1C) 102388681(PIP5K1B)
AMJ: 102563754(PIP5K1C) 102571601(PIP5K1B) 106737171(PIP5K1A)
PSS: 102450458(PIP5K1A) 102455751(PIP5K1C) 102459615(PIP5K1B)
CMY: 102940695(PIP5K1A) 102947027(PIP5K1B) 102947100(PIP5K1C)
CPIC: 101933832(PIP5K1C) 101941302(PIP5K1B) 101941479(PIP5K1A)
ACS: 100553211(pip5k1a) 100564566(pip5k1b) 103282473
PVT: 110072667(PIP5K1C) 110081456(PIP5K1A) 110085457(PIP5K1B)
PMUR: 107282850(PIP5K1C) 107294420(PIP5K1B) 107295575
TSR: 106537995(PIP5K1B) 106548377(PIP5K1A) 106553414(PIP5K1C)
PMUA: 114586075(PIP5K1A) 114588245(PIP5K1C) 114606114(PIP5K1B)
GJA: 107105814(PIP5K1B) 107118282(PIP5K1C) 107121582(PIP5K1A)
XLA: 100653493 108699471 108712206 398687(pip5k1c.S) 399203(pip5k1a.L) 444238(pip5k1b.L)
XTR: 100145583(pip5k1c) 100380056(pip5k1b) 448746(pip5k1a)
NPR: 108786375(PIP5K1B) 108794327(PIP5K1C) 108795209(PIP5K1A)
DRE: 447840(pip5k1bb) 449831(pip5k1ba) 492549(pip5k1ab) 553629(pip5k1aa) 798876(pip5k1ca)
IPU: 108265367 108268485 108271405(pip5k1c) 108272671(pip5k1a) 108276882(pip5k1b) 108280566
SFM: 108919914(pip5k1c) 108921682 108923776 108939001(pip5k1b)
LCM: 102351676(PIP5K1C) 102353988(PIP5K1B) 102355241(PIP5K1A)
CMK: 103173224(pip5k1a) 103178107(pip5k1b) 103188137(pip5k1c)
RTP: 109920622(pip5k1c) 109922898(pip5k1a) 109926660(pip5k1b)
CIN: 100187365
SPU: 579944
APLC: 110978095
SKO: 100372234
DME: Dmel_CG17471(PIP4K) Dmel_CG3682(PIP5K59B) Dmel_CG9985(sktl)
DSI: Dsimw501_GD11719(Dsim_GD11719) Dsimw501_GD25249(Dsim_GD25249)
AAG: 5566784
AALB: 109416244
AME: 724991
BIM: 100748690
BTER: 100650026
CCAL: 108631400
OBB: 114878788
SOC: 105199894
MPHA: 105830792
AEC: 105147238
ACEP: 105623690
PBAR: 105423919
VEM: 105565932
HST: 105182918
DQU: 106741044
CFO: 105247862
LHU: 105675097
PGC: 109856092
OBO: 105286595
PCF: 106783643
NVI: 100123047
CSOL: 105361599
MDL: 103579907
TCA: 663424
DPA: 109532741
ATD: 109608271
NVL: 108562810
BMOR: 101747094
PMAC: 106715282
PRAP: 110992642
HAW: 110384607
TNL: 113504269
AGS: 114122765
RMD: 113555471
BTAB: 109041670
CLEC: 106674100
ZNE: 110837965
FCD: 110858362
CSCU: 111622167
PTEP: 107444683
CEL: CELE_F55A12.3(ppk-1) CELE_VF11C1L.1(ppk-3)
CBR: CBG12324(Cbr-ppk-1) CBG16921(Cbr-ppk-3)
TSP: Tsp_09431
PCAN: 112556925
MYI: 110448791
OBI: 106882892
LAK: 106152776
SHX: MS3_07602
EGL: EGR_00885
EPA: 110237860
ADF: 107347233
PDAM: 113685063
SPIS: 111334331
DGT: 114525494
ATH: AT1G01460(PIPK11) AT1G10900 AT1G21980(PIP5K1) AT1G60890 AT1G77740(PIP5K2) AT2G26420(PIP5K3) AT2G41210(PIP5K5) AT3G07960(PIP5K6) AT3G09920(PIP5K9) AT3G56960(PIP5K4) AT4G01190(PIPK10)
LJA: Lj0g3v0050169.1(Lj0g3v0050169.1) Lj0g3v0072529.1(Lj0g3v0072529.1) Lj0g3v0072529.2(Lj0g3v0072529.2) Lj0g3v0258569.1(Lj0g3v0258569.1) Lj0g3v0263929.1(Lj0g3v0263929.1) Lj0g3v0306249.1(Lj0g3v0306249.1) Lj1g3v1380870.1(Lj1g3v1380870.1) Lj1g3v1380870.2(Lj1g3v1380870.2) Lj1g3v4144860.1(Lj1g3v4144860.1) Lj1g3v4668120.1(Lj1g3v4668120.1) Lj3g3v0766130.1(Lj3g3v0766130.1) Lj3g3v0766130.2(Lj3g3v0766130.2) Lj4g3v2704630.1(Lj4g3v2704630.1) Lj4g3v2704630.2(Lj4g3v2704630.2) Lj4g3v2704630.3(Lj4g3v2704630.3) Lj4g3v2704630.4(Lj4g3v2704630.4) Lj4g3v2846360.1(Lj4g3v2846360.1) Lj5g3v0670630.1(Lj5g3v0670630.1) Lj6g3v2273260.1(Lj6g3v2273260.1)
DOSA: Os02t0822500-01(Os02g0822500) Os03t0262000-01(Os03g0262000) Os03t0356582-01(Os03g0356582) Os03t0356596-01(Os03g0356596) Os03t0701800-01(Os03g0701800) Os03t0705300-01(Os03g0705300) Os07t0658700-01(Os07g0658700) Os11t0145000-01(Os11g0145000) Os11t0146100-01(Os11g0146100) Os12t0141100-01(Os12g0141100)
ATS: 109736820(LOC109736820) 109749224(LOC109749224) 109753061(LOC109753061) 109753131(LOC109753131) 109753230(LOC109753230) 109756902(LOC109756902) 109757525(LOC109757525) 109762696(LOC109762696) 109765709(LOC109765709) 109775873(LOC109775873) 109779947(LOC109779947) 109781708(LOC109781708) 109782958(LOC109782958)
OLU: OSTLU_850
APRO: F751_1541
SCE: YDR208W(MSS4)
ERC: Ecym_4149
KMX: KLMA_50129(MSS4)
NCS: NCAS_0B02920(NCAS0B02920) NCAS_0C02720(NCAS0C02720)
NDI: NDAI_0C04800(NDAI0C04800) NDAI_0E03450(NDAI0E03450)
TPF: TPHA_0L01040(TPHA0L01040)
TBL: TBLA_0H03310(TBLA0H03310)
TDL: TDEL_0F05420(TDEL0F05420)
KAF: KAFR_0B06280(KAFR0B06280) KAFR_0H01810(KAFR0H01810)
PIC: PICST_64487(MSS4)
SPAA: SPAPADRAFT_61964(MSS4)
CAL: CAALFM_C301160WA(MSS4)
SLB: AWJ20_1965(MSS4) AWJ20_3906(MSS4) AWJ20_4025(MSS4) AWJ20_4033(MSS4) AWJ20_4034(MSS4) AWJ20_4041(MSS4) AWJ20_4048(MSS4) AWJ20_4054(MSS4) AWJ20_4086(MSS4) AWJ20_4734 AWJ20_4855(MSS4) AWJ20_4968(MSS4) AWJ20_4991(MSS4) AWJ20_5041(MSS4) AWJ20_595 AWJ20_632 AWJ20_69(MSS4) AWJ20_693(MSS4) AWJ20_759 AWJ20_779(MSS4) AWJ20_807(MSS4) AWJ20_817(MSS4) AWJ20_818(MSS4) AWJ20_868(MSS4) AWJ20_869(MSS4) AWJ20_874(MSS4) AWJ20_883(MSS4) AWJ20_899(MSS4) AWJ20_931(MSS4)
NCR: NCU02295(mss4)
NTE: NEUTE1DRAFT67503(NEUTE1DRAFT_67503)
SMP: SMAC_08733(putative mss4)
MGR: MGG_06572
SSCK: SPSK_03886
MAW: MAC_01491
MAJ: MAA_04911
CMT: CCM_01361
BFU: BCIN_02g04880(Bcmss4)
MBE: MBM_02972
ANI: AN2766.2
ANG: ANI_1_1356094(An11g10410)
ABE: ARB_07224
TVE: TRV_07668
PTE: PTT_12883
SPO: SPAC19G12.14(its3)
CNE: CNA03760
CNB: CNBA3560
ABP: AGABI1DRAFT20563(AGABI1DRAFT_20563)
ABV: AGABI2DRAFT120298(AGABI2DRAFT_120298)
MGL: MGL_0138
MRT: MRET_1181
EHI: EHI_153770(13.t00009)
PYO: PY17X_0204500(PY02398)
PCB: PCHAS_020150(PC000509.02.0)
TAN: TA11845
TPV: TP02_0200
BBO: BBOV_II007470(18.m06619)
CPV: cgd8_3280
SMIN: v1.2.012339.t1(symbB.v1.2.012339.t1) v1.2.016860.t1(symbB.v1.2.016860.t1) v1.2.016860.t2(symbB.v1.2.016860.t2) v1.2.023214.t1(symbB.v1.2.023214.t1) v1.2.023487.t1(symbB.v1.2.023487.t1) v1.2.025054.t1(symbB.v1.2.025054.t1) v1.2.025054.t2(symbB.v1.2.025054.t2) v1.2.025054.t3(symbB.v1.2.025054.t3) v1.2.025639.t1(symbB.v1.2.025639.t1) v1.2.031198.t1(symbB.v1.2.031198.t1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
D'Souza-Schorey C, Chavrier P
  Title
ARF proteins: roles in membrane traffic and beyond.
  Journal
Nat Rev Mol Cell Biol 7:347-58 (2006)
DOI:10.1038/nrm1910
Reference
  Authors
Xie Z, Chang SM, Pennypacker SD, Liao EY, Bikle DD
  Title
Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.
  Journal
Mol Biol Cell 20:1695-704 (2009)
DOI:10.1091/mbc.E08-07-0756
  Sequence
[hsa:8394]
Reference
  Authors
Wang K, Yang Z, Liu X, Mao K, Nair U, Klionsky DJ
  Title
Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking.
  Journal
J Biol Chem 287:37964-72 (2012)
DOI:10.1074/jbc.M112.371591
  Sequence
[sce:YDR208W]

DBGET integrated database retrieval system