KEGG   ORTHOLOGY: K00910
Entry
K00910                      KO                                     
Symbol
ADRBK, GRK
Name
beta-adrenergic-receptor kinase [EC:2.7.11.15]
Pathway
map04062  Chemokine signaling pathway
map04144  Endocytosis
map04340  Hedgehog signaling pathway
map04724  Glutamatergic synapse
map04740  Olfactory transduction
map04745  Phototransduction - fly
map05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
  09156 Nervous system
   04724 Glutamatergic synapse
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
  09157 Sensory system
   04745 Phototransduction - fly
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
   04740 Olfactory transduction
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.15  beta-adrenergic-receptor kinase
     K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K00910  ADRBK, GRK; beta-adrenergic-receptor kinase
Other DBs
GO: 0047696
Genes
HSA: 156(GRK2) 157(GRK3)
PTR: 100614029(GRK3) 451363(GRK2)
PPS: 100984800(GRK3) 100991802(GRK2)
GGO: 101140574(GRK2) 101148325(GRK3)
PON: 100454669(GRK3) 100461893(GRK2)
NLE: 100582671(GRK3) 100604826(GRK2)
MCC: 714510(GRK3) 721754(GRK2)
MCF: 102141861(GRK2) 102141926(GRK3)
CSAB: 103219132(GRK2) 103223079(GRK3)
CATY: 105575649(ADRBK2) 105577363(ADRBK1)
PANU: 101003424(GRK3) 101017434(GRK2)
TGE: 112606411(GRK2) 112633452(GRK3)
RRO: 104664749(GRK2) 104671949(GRK3)
RBB: 108515962(GRK3) 108518610(GRK2)
TFN: 117080248(GRK2) 117096104(GRK3)
PTEH: 111522233(GRK2) 111525328(GRK3)
CJC: 100396838(GRK3)
SBQ: 101027803(ADRBK2) 101049133(ADRBK1)
CSYR: 103258733(GRK2) 103265957(GRK3)
MMUR: 105866915(GRK3) 105867521(GRK2)
OGA: 100943694(GRK2) 100966357(GRK3)
MMU: 110355(Grk2) 320129(Grk3)
MCAL: 110285277(Grk2) 110295078(Grk3)
MPAH: 110312827(Grk2) 110312920(Grk3)
RNO: 25238(Grk2) 25372(Grk3)
MCOC: 116068187(Grk3) 116103332(Grk2)
MUN: 110554001(Grk3) 110560356(Grk2)
CGE: 100761290 100762552(Grk2)
PLEU: 114684308(Grk3) 114685988(Grk2)
NGI: 103725575(Grk2) 103746714(Grk3)
HGL: 101708742(Grk3) 101708906(Grk2)
CPOC: 100730505(Grk3) 100732560(Grk2)
CCAN: 109684472 109690706(Grk2) 109701375(Grk3)
DORD: 105984177(Adrbk2) 105989215(Adrbk1)
DSP: 122097920(Grk3) 122104916(Grk2)
OCU: 100349708(GRK3) 103345045(GRK2)
OPI: 101524133(GRK2) 101526829(GRK3)
TUP: 102482004(GRK2) 102499442(GRK3)
CFA: 483701(GRK2) 486327(GRK3)
VVP: 112923199(GRK3) 112924194(GRK2)
VLG: 121471974(GRK2) 121475364(GRK3)
AML: 100469854(GRK2) 100475417(GRK3)
UMR: 103659256(GRK3) 103679607(GRK2)
UAH: 113244040(GRK2) 113244983(GRK3)
UAR: 123778398(GRK2) 123788122(GRK3)
MPUF: 101676854(ADRBK2) 101690956(ADRBK1)
ORO: 101384757(ADRBK1) 101385645(ADRBK2)
EJU: 114220504(GRK2) 114225191
ZCA: 113912434(GRK3) 113914853(GRK2)
MLX: 118016116(GRK2) 118018603(GRK3)
FCA: 101090393(GRK3) 101101082(GRK2)
PYU: 121022621(GRK3) 121023660(GRK2)
PBG: 122470448(GRK3) 122484042(GRK2)
PTG: 102957039(GRK3) 102970752(GRK2)
PPAD: 109246837(GRK2) 109253514(GRK3)
AJU: 106971185(GRK2) 106982294(GRK3)
HHV: 120227230(GRK3) 120233906(GRK2)
BTA: 282136(GRK3) 282682(GRK2)
BOM: 102286310(GRK2) 102288247(GRK3)
BIU: 109554452(GRK2) 109571286(GRK3)
BBUB: 102408612(GRK2) 102414435(GRK3)
CHX: 102180735(GRK2) 102185296(GRK3)
OAS: 101108265(GRK2) 101117366(GRK3)
ODA: 120871211(GRK3) 120874764(GRK2)
CCAD: 122421867(GRK3) 122430520(GRK2)
SSC: 100156449(GRK3) 100513842(GRK2)
CFR: 102505202(GRK3) 102523137(GRK2)
CBAI: 105066103(ADRBK2) 105070324(ADRBK1)
CDK: 105099520(GRK3) 105104436(GRK2)
VPC: 102536025(GRK3) 102543317(GRK2)
BACU: 103005732(GRK3) 103019615(GRK2)
LVE: 103073421(GRK3) 103076247(GRK2)
OOR: 101270842(ADRBK2) 101283682(ADRBK1)
DLE: 111162697(GRK3) 111183685(GRK2)
PCAD: 102978788(GRK3) 102996848(GRK2) 114485015
PSIU: 116738732(GRK3) 116757833(GRK2)
ECB: 100059001(GRK2) 100065495(GRK3) 111767400(GRK3)
EPZ: 103550032(GRK3) 103559830(GRK2)
EAI: 106833505(GRK2) 106841709(GRK3)
MYB: 102243341(GRK2) 102248143(GRK3)
MYD: 102761774(GRK3) 102764962(GRK2)
MMYO: 118665230(GRK2) 118678342(GRK3)
MNA: 107533587(ADRBK1) 107533866(ADRBK2)
PKL: 118706968(GRK2) 118725511(GRK3)
HAI: 109384296(GRK2) 109394134(GRK3)
DRO: 112310529(GRK3) 112317213(GRK2)
SHON: 118991232(GRK3) 118991804(GRK2)
AJM: 119041860(GRK2) 119057439(GRK3)
PDIC: 114499827(GRK2) 114509548(GRK3)
PHAS: 123820806(GRK3) 123829489(GRK2)
MMF: 118627698(GRK2) 118639875(GRK3)
RFQ: 117017286(GRK3) 117030570(GRK2)
PALE: 102881239(GRK3) 102893733(GRK2)
PGIG: 120584771(GRK2) 120601990(GRK3)
PVP: 105301826(GRK3) 105309917(GRK2)
RAY: 107499745(ADRBK2) 107503771(ADRBK1)
MJV: 108387037(GRK3) 108393151(GRK2)
TOD: 119244788(GRK3) 119249919(GRK2)
SARA: 101548616(ADRBK1) 101549489(ADRBK2)
LAV: 100666578(GRK3) 100671884(GRK2)
DNM: 101428937(GRK2) 101433169(GRK3)
MDO: 100009844(GRK3)
GAS: 123245282(GRK3) 123254338
SHR: 100913578(GRK3) 116420004(GRK2)
PCW: 110195409(GRK2) 110215258(GRK3)
OAA: 100078284(GRK3) 100090102(GRK2)
GGA: 416904(GRK3) 426000(GRK2)
PCOC: 116228526(GRK3) 116243006(GRK2)
MGP: 100541374(GRK3) 100545380(GRK2)
CJO: 107314190(GRK2) 107321443(GRK3)
NMEL: 110400830(GRK2) 110406207(GRK3)
APLA: 101801089(GRK2)
ACYG: 106029321(ADRBK1) 106031075(ADRBK2)
AFUL: 116489819(GRK2) 116495958(GRK3)
TGU: 100217970(GRK3) 100227701(GRK2)
LSR: 110478203(GRK3) 110484938(GRK2)
SCAN: 103818288(GRK3) 103822132(GRK2)
PMOA: 120499554(GRK2) 120509589(GRK3)
OTC: 121338834(GRK3) 121339908(GRK2)
PRUF: 121355192(GRK2) 121364845(GRK3)
GFR: 102032477(GRK2) 102036360(GRK3)
FAB: 101810197(GRK3) 101811193(GRK2)
PHI: 102108753(GRK3) 102114443(GRK2)
PMAJ: 107205270(GRK2) 107211779(GRK3)
CCAE: 111936727(GRK3) 111945589
CCW: 104688799(GRK3) 120410071(GRK2)
ETL: 114066071(GRK3) 114067868(GRK2)
ZAB: 102062501 102065350(GRK3)
FPG: 101911656(GRK2) 101916842(GRK3)
FCH: 102048951(GRK3) 102058946(GRK2)
CLV: 102092240(GRK2) 102096658(GRK3)
EGZ: 104128318(ADRBK2) 104129654
NNI: 104009467(ADRBK1) 104020459(ADRBK2)
ACUN: 113485979(GRK3)
TALA: 104367315(GRK3) 116965084(GRK2)
PADL: 103925680(ADRBK2)
ACHC: 115345756(GRK3) 115351926(GRK2)
AAM: 106492546(GRK3) 106493396
AROW: 112963364(GRK3) 112967069(GRK2)
NPD: 112945167(GRK3) 112954249(GRK2)
DNE: 112988615(GRK2) 112991748(GRK3)
ASN: 102367979(GRK2) 102378654(GRK3)
AMJ: 102563874(GRK2) 106737118(GRK3)
CPOO: 109312973(GRK3) 109324606(GRK2)
GGN: 109290257(GRK3)
PSS: 102443539(GRK2) 102454375
CMY: 102946005(GRK3) 102947181(GRK2)
CPIC: 101944586(GRK2) 101953922(GRK3)
TST: 117876033(GRK2) 117888032(GRK3)
CABI: 116818695(GRK3) 116833414(GRK2)
MRV: 120386194(GRK3) 120393445(GRK2)
ACS: 100555775(grk2) 103282961
PVT: 110083438(GRK3) 110085629(GRK2)
SUND: 121923548(GRK2)
PBI: 103064129(GRK2) 103066055(GRK3)
PMUR: 107287274(GRK3) 107296663(GRK2)
TSR: 106547124(ADRBK1) 106556848(ADRBK2)
PGUT: 117667175(GRK2) 117672298(GRK3)
VKO: 123027372(GRK2) 123028537(GRK3)
PMUA: 114582570 114601867(GRK2)
ZVI: 118090157(GRK2) 118094381(GRK3)
GJA: 107116822(GRK2) 107123215(GRK3)
XTR: 100379889(grk3)
NPR: 108790542
RTEM: 120937831(GRK3)
BBUF: 120988837(GRK3)
BGAR: 122924360(GRK3)
DRE: 569403(grk3)
PPRM: 120482724(grk3)
IPU: 108276813(grk3)
PHYP: 113544847(grk3)
SMEO: 124393295(grk3)
TFD: 113638351(grk3)
AMEX: 103046030
TRU: 101073064(grk3)
LCO: 104934568(grk3)
ELY: 117269522(grk3)
SLUC: 116041782(grk3)
PFLV: 114570869(grk3)
PPUG: 119226472(grk3)
MSAM: 119914686(grk3)
CUD: 121524869(grk3)
MZE: 101476711(grk3)
ONL: 100707869(grk3)
OAU: 116329300(grk3)
OLA: 111948284(grk3)
OML: 112163042(grk3)
XMA: 102224709(grk3)
XCO: 114150251(grk3)
XHE: 116724737(grk3)
PRET: 103473184
PFOR: 103151765(adrbk2) 103156162
PLAI: 106955254(adrbk2) 106958266
PMEI: 106911922 106923393(adrbk2)
GAF: 122846969(grk3)
CVG: 107101402
CTUL: 119795954(grk3)
GMU: 124872423(grk3)
NFU: 107396329
KMR: 108245400(grk3)
ALIM: 106526089
NWH: 119424810(grk3)
AOCE: 111566117
CSEM: 103389928(grk3)
POV: 109626032(grk3)
SSEN: 122758514(grk3)
HHIP: 117771896(grk3)
LCF: 108895613(grk3)
SDU: 111224273(grk3)
SLAL: 111664712(grk3)
XGL: 120806051(grk3)
HCQ: 109527953(grk3)
BPEC: 110166677(grk3)
MALB: 109974750(grk3)
OTW: 112230856 112237178(grk3)
OMY: 110512753 110523401(grk3)
SALP: 112070845
ELS: 105015221(grk3)
SFM: 108930044
PKI: 111851486(grk3)
AANG: 118212322(grk3)
LOC: 102695299
LCM: 102362780(GRK2) 102365333(ADRBK2)
CMK: 103184070(grk3)
RTP: 109914938(grk3)
BFO: 118425552
BBEL: 109467794
CIN: 100184862
SCLV: 120343533
SPU: 100888242
APLC: 110987558
SKO: 100366720
DME: Dmel_CG40129(Gprk1)
DER: 6541861
DSE: 6620153
DSI: Dsimw501_GD17695(Dsim_GD17695)
DAN: 6497632
DSR: 110185369
DPE: 6602044
DMN: 117188156
DWI: 6640045
DGR: 6559369
DAZ: 108616079
DNV: 115564429
DHE: 111600089
DVI: 6635312
CCAT: 101454248
BOD: 118683218
MDE: 101896222
SCAC: 106083442
LCQ: 111677046
ACOZ: 120954673
AARA: 120902452
AALB: 109426380
CPII: 120415167
AME: 413197
ALAB: 122716961
BIM: 100748232
BBIF: 117207879
BVK: 117238306
BVAN: 117158816
BTER: 100651375
BPYO: 122570540
CCAL: 108621983
OBB: 114883156
MGEN: 117220029
NMEA: 116431916
CGIG: 122396225
SOC: 105194556
MPHA: 105832639
AEC: 105153411
ACEP: 105619512
PBAR: 105422796
VEM: 105564800
HST: 105181552
DQU: 106746819
CFO: 105258109
FEX: 115238912
LHU: 105678424
PGC: 109856349
OBO: 105276693
PCF: 106783861
PFUC: 122525965
VPS: 122632866
NVI: 100121113
CSOL: 105363982
TPRE: 106648977
MDL: 103575167
CGLO: 123265859
FAS: 105269996
DAM: 107040937
AGIF: 122848918
CCIN: 107271505
TCA: 654946
DPA: 109537817
SOY: 115887220
CSET: 123316262
AGB: 108903923
LDC: 111505067
NVL: 108568789
APLN: 108732559
PPYR: 116179800
OTU: 111417188
BMOR: 101741546
BMAN: 114249881
MSEX: 115447635
BANY: 112051822
PMAC: 106717955
PPOT: 106108436
PXU: 106115946
PRAP: 110992337
ZCE: 119830779
HAW: 110372807
TNL: 113499032
SLIU: 111364977
OFU: 114364577
API: 100166085
DNX: 107162156
AGS: 114126939
RMD: 113560481
BTAB: 109037372
DCI: 103519341
HHAL: 106685857
NLU: 111046871
FOC: 113204646
ZNE: 110841237
CSEC: 111871818
FCD: 110856660
DPX: DAPPUDRAFT_194156(Grk2)
DMK: 116917985
PVM: 113809193
PJA: 122251215
HAME: 121855948
PCLA: 123766420
PTRU: 123503990
HAZT: 108664662
EAF: 111703766
DSV: 119446021
RSAN: 119390439
RMP: 119171976
VDE: 111252280
VJA: 111266831
TUT: 107361145
DPTE: 113793852
DFR: 124500542
CSCU: 111628135
PTEP: 107446386
SDM: 118181383
CEL: CELE_W02B3.2(grk-2)
CBR: CBG_15249(Cbr-grk-2)
BMY: BM_BM7964(Bma-grk-2)
TSP: Tsp_00495
PCAN: 112562704
BGT: 106069803
GAE: 121369275
HRF: 124134938
HRJ: 124266637
CRG: 105319304
MYI: 110461337
PMAX: 117332490
MMER: 123533318
OBI: 106871981
OSN: 115224846
LAK: 106181894
NVE: 5506466
EPA: 110243336
ATEN: 116303328
ADF: 107338012
AMIL: 114960143
PDAM: 113665499
SPIS: 111345132
DGT: 114538288
XEN: 124434319
HMG: 100214170
AQU: 100638292
 » show all
Reference
PMID:9122168
  Authors
Daaka Y, Pitcher JA, Richardson M, Stoffel RH, Robishaw JD, Lefkowitz RJ
  Title
Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
  Journal
Proc Natl Acad Sci U S A 94:2180-5 (1997)
DOI:10.1073/pnas.94.6.2180
Reference
  Authors
Pao CS, Benovic JL
  Title
Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2.
  Journal
J Biol Chem 280:11052-8 (2005)
DOI:10.1074/jbc.M412996200
  Sequence
[hsa:156]

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