KEGG   ORTHOLOGY: K01115Help
Entry
K01115                      KO                                     

Name
PLD1_2
Definition
phospholipase D1/2 [EC:3.1.4.4]
Pathway
ko00564  Glycerophospholipid metabolism
ko00565  Ether lipid metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04014  Ras signaling pathway
ko04024  cAMP signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04144  Endocytosis
ko04666  Fc gamma R-mediated phagocytosis
ko04724  Glutamatergic synapse
ko04912  GnRH signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko05200  Pathways in cancer
ko05212  Pancreatic cancer
ko05231  Choline metabolism in cancer
Disease
H02375  Cardiac valvular defect, developmental
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K01115  PLD1_2; phospholipase D1/2
   00565 Ether lipid metabolism
    K01115  PLD1_2; phospholipase D1/2
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04072 Phospholipase D signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04071 Sphingolipid signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04024 cAMP signaling pathway
    K01115  PLD1_2; phospholipase D1/2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K01115  PLD1_2; phospholipase D1/2
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K01115  PLD1_2; phospholipase D1/2
  09152 Endocrine system
   04912 GnRH signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04928 Parathyroid hormone synthesis, secretion and action
    K01115  PLD1_2; phospholipase D1/2
  09156 Nervous system
   04724 Glutamatergic synapse
    K01115  PLD1_2; phospholipase D1/2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01115  PLD1_2; phospholipase D1/2
   05231 Choline metabolism in cancer
    K01115  PLD1_2; phospholipase D1/2
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K01115  PLD1_2; phospholipase D1/2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01115  PLD1_2; phospholipase D1/2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.4  phospholipase D
     K01115  PLD1_2; phospholipase D1/2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K01115  PLD1_2; phospholipase D1/2
 Endosome - Golgi transport
  Others
   Others
    K01115  PLD1_2; phospholipase D1/2
BRITE hierarchy
Other DBs
RN: R01310 R02051 R07385
GO: 0004630
Genes
HSA: 5337(PLD1) 5338(PLD2)
PTR: 454454(PLD2) 470996(PLD1)
PPS: 100984892(PLD1) 100985373(PLD2)
GGO: 101135150(PLD1) 101135996(PLD2)
PON: 100439813(PLD1) 100457163(PLD2)
NLE: 100601695(PLD2) 100605600(PLD1)
MCC: 694963(PLD1) 721573(PLD2)
MCF: 102130012(PLD2) 102132109(PLD1)
CSAB: 103221251(PLD1) 103242204(PLD2)
RRO: 104663087(PLD2) 104666985(PLD1)
RBB: 108524801(PLD2) 108540404(PLD1)
CJC: 100391217(PLD2) 100397093(PLD1)
SBQ: 101028583(PLD1) 101035480(PLD2)
MMU: 18805(Pld1) 18806(Pld2)
MCAL: 110290757(Pld1) 110304819(Pld2)
MPAH: 110320262(Pld1) 110331978(Pld2)
RNO: 25096(Pld1) 25097(Pld2)
MUN: 110553679(Pld1) 110557322(Pld2)
CGE: 100689404(Pld1) 100752582(Pld2)
NGI: 103731722(Pld1) 103752195(Pld2)
HGL: 101700438(Pld1) 101713528(Pld2)
CCAN: 109684749(Pld2) 109694743(Pld1)
OCU: 100339661(PLD1) 103351480
TUP: 102495205(PLD1) 102499889(PLD2)
CFA: 479473(PLD2) 488167(PLD1)
VVP: 112924795(PLD2) 112926674(PLD1)
AML: 100477588(PLD2) 100484111(PLD1)
UMR: 103660447(PLD2) 103676145(PLD1)
UAH: 113255060(PLD1) 113271085(PLD2)
ORO: 101369263(PLD1) 101383564(PLD2)
FCA: 101084052(PLD1) 101092214(PLD2)
PTG: 102962016(PLD1) 102971823(PLD2)
PPAD: 109246097(PLD2) 109275130(PLD1)
AJU: 106972398(PLD2) 106990052(PLD1)
BTA: 514554(PLD1) 522159(PLD2)
BOM: 102279771(PLD1) 102288325(PLD2)
BIU: 109558091(PLD1) 109574235(PLD2)
BBUB: 102392536(PLD2) 102414958(PLD1)
CHX: 102174434(PLD1) 102176556(PLD2)
OAS: 101110687(PLD2) 101114661(PLD1)
SSC: 100519446(PLD1) 414900(PLD2)
CFR: 102505040(PLD1) 102520901(PLD2)
CDK: 105085948(PLD1) 105101475(PLD2)
BACU: 102999715(PLD1) 103008865(PLD2)
LVE: 103069742(PLD2) 103084538(PLD1)
OOR: 101278706(PLD2) 101284082(PLD1)
DLE: 111174011(PLD1) 111185941(PLD2)
PCAD: 102978946(PLD2) 102986218(PLD1)
ECB: 100057774(PLD1) 100072863(PLD2)
EPZ: 103546360(PLD1) 103560664(PLD2)
EAI: 106844149(PLD2) 106847524(PLD1)
MYB: 102239050(PLD1) 102264100(PLD2)
MYD: 102756028(PLD1) 102760085(PLD2)
MNA: 107528068(PLD2) 107529520(PLD1) 107533526
HAI: 109371666(PLD1) 109394696(PLD2)
DRO: 112307458(PLD1) 112308502(PLD2)
PALE: 102884736(PLD1) 102894598(PLD2)
RAY: 107509491(PLD2) 107515926(PLD1)
MJV: 108403340(PLD2) 108404196(PLD1)
LAV: 100658318(PLD2) 100660595(PLD1)
MDO: 100009769(PLD1) 100618309(PLD2)
SHR: 100914579(PLD2) 100926651(PLD1)
PCW: 110194332(PLD2) 110204050(PLD1)
OAA: 100083157(PLD1) 103169305(PLD2)
GGA: 424986(PLD1)
MGP: 100547741(PLD1)
CJO: 107318313(PLD1)
NMEL: 110397970(PLD1)
APLA: 101802558(PLD1)
ACYG: 106031996(PLD1)
TGU: 100224050(PLD1)
LSR: 110480373(PLD1)
SCAN: 103815294(PLD1)
GFR: 102038107(PLD1)
FAB: 101820022(PLD1)
PHI: 102101034(PLD1)
PMAJ: 107208899(PLD1)
CCAE: 111933332(PLD1)
CCW: 104688039(PLD1)
ETL: 114061178(PLD1)
FPG: 101923489(PLD1)
FCH: 102052716(PLD1)
CLV: 102090500(PLD1)
EGZ: 104132470(PLD1)
NNI: 104022057(PLD1)
ACUN: 113483342(PLD1)
PADL: 103924963(PLD1)
AAM: 106486569
ASN: 102371892(PLD1)
AMJ: 102573958(PLD1)
PSS: 102453139(PLD1) 102453375(PLD2)
CMY: 102945664(PLD1)
CPIC: 101931414(PLD1)
ACS: 100566734(pld1)
PVT: 110079069(PLD1) 110082332(PLD2)
PBI: 103048104(PLD2) 103062756(PLD1)
PMUR: 107285044(PLD2) 107286542(PLD1)
PMUA: 114582880(PLD2) 114597981(PLD1)
GJA: 107113860(PLD1) 107124417(PLD2)
XLA: 100191021(pld1.L) 108711785(pld2.L) 108718097
XTR: 100216200(pld2) 100379682(pld1)
NPR: 108784828(PLD1) 108800202
DRE: 556641(pld1a) 565743(pld2) 572492(pld1b) 799278(si:ch211-168k14.2)
LCM: 102353212(PLD2) 102359218(PLD1)
CMK: 103189334(pld1) 103190576(pld2)
RTP: 109920481 109936146(pld1)
CIN: 100182057
APLC: 110987506
SKO: 100366642(PLD1)
DME: Dmel_CG12110(Pld)
DER: 6540960
DSE: 116800372
DSI: Dsimw501_GD10404(Dsim_GD10404)
DAN: 6493918
DSR: 110189471
DPE: 113565068
DWI: 6639777
DAZ: 108615652
DNV: 108654014
DHE: 111604343
DVI: 6625246
MDE: 101896559
LCQ: 111687296
AME: 725119
BIM: 100742072
BTER: 100652186
CCAL: 108628900
OBB: 114882078
SOC: 105201964
MPHA: 105830415
AEC: 105149246
ACEP: 105627094
PBAR: 105427752
VEM: 105561603
HST: 105192308
DQU: 106747092
CFO: 105254432
LHU: 105672039
PGC: 109854134
OBO: 105281694
PCF: 106787677
NVI: 100123116
CSOL: 105363898
MDL: 103580130
TCA: 658196
DPA: 109544965
ATD: 109608890
NVL: 108565175
BMOR: 101746390
PMAC: 106715649
HAW: 110370970
TNL: 113507031
BTAB: 109032109
CLEC: 106669710
ZNE: 110835596
FCD: 110858053
TUT: 107371515
DPTE: 113789380
CEL: CELE_C04G6.3(pld-1)
CBR: CBG02320(Cbr-pld-1)
BMY: Bm1_08640
TSP: Tsp_10708
PCAN: 112566038
CRG: 105332889
MYI: 110454166
OBI: 106868096
SHX: MS3_08230
NVE: 5515662
EPA: 110241295
ADF: 107352864
PDAM: 113681466
SPIS: 111322011
HMG: 100213342
ATH: AT1G52570(PLDALPHA2) AT1G55180(PLDEPSILON) AT2G42010(PLDBETA1) AT3G05630(PLDP2) AT3G15730(PLDALPHA1) AT3G16785(PLDP1) AT4G00240(PLDBETA2) AT4G11830(PLDGAMMA2) AT4G11840(PLDGAMMA3) AT4G11850(PLDGAMMA1) AT4G35790(PLDDELTA) AT5G25370(PLDALPHA3)
LJA: Lj0g3v0004479.1(Lj0g3v0004479.1) Lj0g3v0057229.1(Lj0g3v0057229.1) Lj0g3v0060819.1(Lj0g3v0060819.1) Lj0g3v0101819.1(Lj0g3v0101819.1) Lj0g3v0116389.1(Lj0g3v0116389.1) Lj0g3v0255459.1(Lj0g3v0255459.1) Lj0g3v0335969.1(Lj0g3v0335969.1) Lj1g3v1911660.1(Lj1g3v1911660.1) Lj1g3v1911690.1(Lj1g3v1911690.1) Lj2g3v1647880.1(Lj2g3v1647880.1) Lj2g3v1659550.1(Lj2g3v1659550.1) Lj2g3v2003100.1(Lj2g3v2003100.1) Lj3g3v0305820.1(Lj3g3v0305820.1) Lj5g3v1500430.1(Lj5g3v1500430.1) Lj6g3v1491480.1(Lj6g3v1491480.1)
VVI: 100232987(PLD) 100241982(PLDdelta2) 100250490(PLDbeta2) 100252422(PLDdelta) 100252995(PLDbeta1) 100256679(PLDepsilon) 100257647(PLDalpha3) 100259366(PLDalpha4) 100261019(PLDdelta1) 100261040(PLDalpha1) 100261987(PLDp)
DOSA: Os01t0172400-01(Os01g0172400) Os02t0120200-01(Os02g0120200) Os03t0119100-01(Os03g0119100) Os03t0391400-01(Os03g0391400) Os05t0171000-01(Os05g0171000) Os06t0604200-02(Os06g0604200) Os06t0604300-01(Os06g0604300) Os06t0604400-01(Os06g0604400) Os07t0260400-01(Os07g0260400) Os08t0401800-00(Os08g0401800) Os09t0421300-01(Os09g0421300) Os10t0524400-01(Os10g0524400)
ATS: 109735067(LOC109735067) 109735812(LOC109735812) 109738906(LOC109738906) 109745354(LOC109745354) 109752875(LOC109752875) 109757341(LOC109757341) 109761343(LOC109761343) 109761352(LOC109761352) 109761476(LOC109761476) 109763387(LOC109763387) 109763403(LOC109763403) 109765171(LOC109765171) 109768018(LOC109768018) 109771434(LOC109771434) 109773406(LOC109773406) 109777211(LOC109777211) 109780953(LOC109780953)
MNG: MNEG_3611
SCE: YKR031C(SPO14)
ERC: Ecym_6364
KMX: KLMA_40231(SPO14)
NCS: NCAS_0B07800(NCAS0B07800)
NDI: NDAI_0B05150(NDAI0B05150)
TPF: TPHA_0I00790(TPHA0I00790)
TBL: TBLA_0H02990(TBLA0H02990)
TDL: TDEL_0D01270(TDEL0D01270)
KAF: KAFR_0A03420(KAFR0A03420)
PIC: PICST_81277(SPO14)
CAL: CAALFM_C111590WA(PLD1)
SLB: AWJ20_2932(SPO14)
NTE: NEUTE1DRAFT132041(NEUTE1DRAFT_132041) NEUTE1DRAFT145274(NEUTE1DRAFT_145274) NEUTE1DRAFT78227(NEUTE1DRAFT_78227)
ANG: ANI_1_1734134(An15g07040) ANI_1_2596094(An11g11010) ANI_1_282064(An07g02240)
SPO: SPAC2F7.16c(pld1)
ABP: AGABI1DRAFT132820(AGABI1DRAFT_132820) AGABI1DRAFT58967(AGABI1DRAFT_58967)
ABV: AGABI2DRAFT186563(AGABI2DRAFT_186563) AGABI2DRAFT188389(AGABI2DRAFT_188389)
MGL: MGL_0321
MRT: MRET_0982
DDI: DDB_G0277949(pldC) DDB_G0279483(pldB) DDB_G0281031(pldA)
DFA: DFA_08300(pldA) DFA_08480(pldB) DFA_10706(pldC)
EHI: EHI_082560(145.t00004) EHI_146550(350.t00005)
SMIN: v1.2.008765.t1(symbB.v1.2.008765.t1) v1.2.012415.t1(symbB.v1.2.012415.t1)
CTU: CTU_19640
AMAL: I607_15880
AMAE: I876_16175
AMAO: I634_16120
AMAI: I635_16820
AMAG: I533_15700
AAUS: EP12_16430
ASP: AOR13_146
ALG: AQULUS_09790(clsA_2)
MMAI: sS8_2624
MEJ: Q7A_425
MEC: Q7C_2072
NOC: Noc_1912
NHL: Nhal_1635
NWA: Nwat_1713
TEE: Tel_01060
SVA: SVA_2285
RSL: RPSI07_mp0694(pld)
REH: H16_B0932(h16_B0932)
CGD: CR3_4461
BPH: Bphy_5412
PPUL: RO07_21795
PSPU: NA29_15260
HSE: Hsero_2476(cls)
CARE: LT85_0735
TBD: Tbd_1474
MFA: Mfla_1421
MEP: MPQ_1409(cls)
EBA: ebA6946
AZO: azo1783
AZA: AZKH_2641
AOA: dqs_1932
GEO: Geob_0958
DEU: DBW_1976
PPRF: DPRO_1097
DOL: Dole_2521
CCX: COCOR_07344(cls4)
HOH: Hoch_3786
PLA: Plav_1139
RLE: pRL120739
RLG: Rleg_5129
BRAD: BF49_6978
VGO: GJW-30_1_04197(ydjZ)
SNO: Snov_3983
MEX: Mext_0106
MCH: Mchl_0043
MCG: GL4_0147
HDI: HDIA_2150(cls)
RSP: RSP_0113
RRU: Rru_A0202
RRF: F11_01010
AZL: AZL_d02250(pld)
NJA: NSJP_1157
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8530346
  Authors
Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, Morris AJ, Frohman MA
  Title
Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.
  Journal
J Biol Chem 270:29640-3 (1995)
DOI:10.1074/jbc.270.50.29640
  Sequence
[hsa:5337]
Reference
  Authors
Speranza F, Mahankali M, Henkels KM, Gomez-Cambronero J
  Title
The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.
  Journal
J Biol Chem 289:28885-97 (2014)
DOI:10.1074/jbc.M114.597146
  Sequence
[mmu:18805 18806]

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