KEGG   ORTHOLOGY: K01279Help
Entry
K01279                      KO                                     

Name
TPP1, CLN2
Definition
tripeptidyl-peptidase I [EC:3.4.14.9]
Pathway
ko04142  Lysosome
Disease
H00149  Neuronal ceroid lipofuscinosis (NCL)
H00810  Progressive myoclonic epilepsy (PME/ EPM)
H01891  Autosomal recessive spinocerebellar ataxias
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01279  TPP1, CLN2; tripeptidyl-peptidase I
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases
    K01279  TPP1, CLN2; tripeptidyl-peptidase I
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01279  TPP1, CLN2; tripeptidyl-peptidase I
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01279  TPP1, CLN2; tripeptidyl-peptidase I
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.14  Dipeptidyl-peptidases and tripeptidyl-peptidases
    3.4.14.9  tripeptidyl-peptidase I
     K01279  TPP1, CLN2; tripeptidyl-peptidase I
Peptidases [BR:ko01002]
 Serine Peptidases
  Family S53
   K01279  TPP1, CLN2; tripeptidyl-peptidase I
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Subtilisin family
   K01279  TPP1, CLN2; tripeptidyl-peptidase I
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01279  TPP1, CLN2; tripeptidyl-peptidase I
BRITE hierarchy
Genes
HSA: 1200(TPP1)
PTR: 450999(TPP1)
PPS: 100969179(TPP1)
GGO: 101149790(TPP1)
PON: 100440001(TPP1)
NLE: 100586648(TPP1)
MCC: 709838(TPP1)
MCF: 101867272(TPP1)
CSAB: 103241292(TPP1)
RRO: 104678305(TPP1)
RBB: 108543236(TPP1)
CJC: 100895900(TPP1)
SBQ: 101030033(TPP1)
MMU: 12751(Tpp1)
RNO: 83534(Tpp1)
CGE: 100759190(Tpp1)
NGI: 103737566(Tpp1)
HGL: 101707185(Tpp1)
CCAN: 109696314(Tpp1)
OCU: 100356773(TPP1)
TUP: 102474485(TPP1)
CFA: 485337(TPP1)
AML: 100473391(TPP1)
UMR: 103681402(TPP1)
ORO: 101364552(TPP1)
FCA: 101093296(TPP1) 111559084
PTG: 102968271(TPP1)
AJU: 106981175(TPP1)
BTA: 515575(TPP1)
BOM: 102279785(TPP1)
BIU: 109569865(TPP1)
PHD: 102332223(TPP1)
CHX: 102176981(TPP1)
OAS: 101116858(TPP1)
SSC: 100623352(TPP1)
CFR: 102512212(TPP1)
CDK: 105097984(TPP1)
BACU: 103017792(TPP1)
LVE: 103084335(TPP1)
OOR: 101288758(TPP1)
ECB: 100070095(TPP1)
EPZ: 103553536(TPP1)
EAI: 106838179(TPP1)
MYB: 102249131(TPP1)
MYD: 102763994(TPP1)
HAI: 109376530(TPP1)
RSS: 109460450(TPP1)
PALE: 102887010(TPP1)
LAV: 100666542(TPP1)
TMU: 101346186
MDO: 100030970(TPP1)
SHR: 100918462(TPP1)
OAA: 100682200
GGA: 425576(TPP1)
MGP: 104916731(TPP1)
CJO: 107308570(TPP1)
APLA: 101792345(TPP1)
ACYG: 106049774(TPP1)
TGU: 100232321(TPP1)
GFR: 102035657(TPP1)
FAB: 101810332(TPP1)
PHI: 102114063(TPP1)
PMAJ: 107198426(TPP1)
CCW: 104698105(TPP1)
FPG: 101920803(TPP1)
FCH: 102051334(TPP1)
CLV: 102094093
EGZ: 104130616(TPP1)
ASN: 102377067(TPP1)
AMJ: 102560569(TPP1)
PSS: 102443613(TPP1) 102459935
CMY: 102933063(TPP1)
CPIC: 101951787(TPP1)
ACS: 100556940(tpp1)
PVT: 110078112(TPP1)
PBI: 103059366(TPP1)
GJA: 107116951(TPP1)
XLA: 414505(tpp1.L)
XTR: 100124868(tpp1)
NPR: 108799885(TPP1)
DRE: 798347(tpp1)
SGH: 107594810
IPU: 108270113(tpp1)
AMEX: 103045803(tpp1)
TRU: 101071259(tpp1)
LCO: 104921573(tpp1) 109142670
NCC: 104960361(tpp1)
MZE: 101481977(tpp1)
OLA: 101174237(tpp1)
XMA: 102217421(tpp1)
PRET: 103458893(tpp1)
NFU: 107392300(tpp1)
CSEM: 103376880(tpp1)
HCQ: 109526111(tpp1)
BPEC: 110155486(tpp1)
SASA: 100195058(tpp1)
ELS: 105015977(tpp1)
SFM: 108941423(tpp1)
LCM: 102367029(TPP1)
CMK: 103185353(tpp1)
EPA: 110249513
ADF: 107356232
HMG: 100213935
NCR: NCU08418
NTE: NEUTE1DRAFT108290(NEUTE1DRAFT_108290) NEUTE1DRAFT64480(NEUTE1DRAFT_64480)
ANG: ANI_1_10054(An06g00190) ANI_1_1008034(An03g01010) ANI_1_1554144(An16g02250) ANI_1_1628094(An11g01110) ANI_1_218014(An01g01750) ANI_1_368124(An14g02470) ANI_1_676074(An08g04640)
ABP: AGABI1DRAFT72616(AGABI1DRAFT_72616) AGABI1DRAFT83390(AGABI1DRAFT_83390)
ABV: AGABI2DRAFT193429(AGABI2DRAFT_193429) AGABI2DRAFT195772(AGABI2DRAFT_195772)
DDI: DDB_G0269914(tpp1)
SMIN: v1.2.016800.t1(symbB.v1.2.016800.t1) v1.2.026734.t1(symbB.v1.2.026734.t1)
NGD: NGA_0706700(TPP1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Golabek AA, Kida E, Walus M, Wujek P, Mehta P, Wisniewski KE
  Title
Biosynthesis, glycosylation, and enzymatic processing in vivo of human tripeptidyl-peptidase I.
  Journal
J Biol Chem 278:7135-45 (2003)
DOI:10.1074/jbc.M211872200
  Sequence
[hsa:1200]
Reference
  Authors
Van Beersel G, Tihon E, Demine S, Hamer I, Jadot M, Arnould T
  Title
Different molecular mechanisms involved in spontaneous and oxidative stress-induced mitochondrial fragmentation in tripeptidyl peptidase-1 (TPP-1)-deficient fibroblasts.
  Journal
Biosci Rep 33:e00023 (2013)
DOI:10.1042/BSR20120104
  Sequence
[hsa:1200]
Reference
  Authors
Ezaki J, Takeda-Ezaki M, Oda K, Kominami E
  Title
Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis.
  Journal
Biochem Biophys Res Commun 268:904-8 (2000)
DOI:10.1006/bbrc.2000.2207
  Sequence
[rno:83534]
Reference
  Authors
Junaid MA, Wu G, Pullarkat RK
  Title
Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis.
  Journal
J Neurochem 74:287-94 (2000)
DOI:10.1046/j.1471-4159.2000.0740287.x
  Sequence
[bta:515575]
Reference
  Authors
Reichard U, Lechenne B, Asif AR, Streit F, Grouzmann E, Jousson O, Monod M
  Title
Sedolisins, a new class of secreted proteases from Aspergillus fumigatus with endoprotease or tripeptidyl-peptidase activity at acidic pHs.
  Journal
Appl Environ Microbiol 72:1739-48 (2006)
DOI:10.1128/AEM.72.3.1739-1748.2006
  Sequence

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