KEGG   ORTHOLOGY: K01371
Entry
K01371                      KO                                     

Name
CTSK
Definition
cathepsin K [EC:3.4.22.38]
Pathway
ko04142  Lysosome
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko05323  Rheumatoid arthritis
Disease
H00273  Pycnodysostosis
H00425  Lysosomal cysteine protease deficiencies
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01371  CTSK; cathepsin K
  09143 Cell growth and death
   04210 Apoptosis
    K01371  CTSK; cathepsin K
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K01371  CTSK; cathepsin K
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K01371  CTSK; cathepsin K
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K01371  CTSK; cathepsin K
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01371  CTSK; cathepsin K
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01371  CTSK; cathepsin K
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.38  cathepsin K
     K01371  CTSK; cathepsin K
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C1: papain family
   K01371  CTSK; cathepsin K
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Papain family
   K01371  CTSK; cathepsin K
Genes
HSA: 1513(CTSK)
PTR: 457278(CTSK)
PPS: 100974656(CTSK)
GGO: 101145486(CTSK)
PON: 100432447(CTSK)
NLE: 100580351(CTSK)
MCC: 574112(CTSK)
MCF: 102120416(CTSK)
CSAB: 103247207(CTSK)
RRO: 104681068(CTSK)
RBB: 108533261(CTSK)
CJC: 100410169(CTSK)
SBQ: 101045222(CTSK)
MMU: 13038(Ctsk)
MCAL: 110291053(Ctsk)
MPAH: 110320301(Ctsk)
RNO: 29175(Ctsk)
MUN: 110541001(Ctsk)
CGE: 100765407(Ctsk) 113833185
NGI: 103729102(Ctsk)
HGL: 101716993(Ctsk)
CCAN: 109681204(Ctsk)
OCU: 100009334(CTSK)
TUP: 102469152(CTSK)
CFA: 608843(CTSK)
VVP: 112907784(CTSK)
AML: 100483004(CTSK)
UMR: 103667534(CTSK)
UAH: 113246211(CTSK)
ORO: 101371209(CTSK)
ELK: 111161944
FCA: 101093379(CTSK)
PTG: 102968588(CTSK)
PPAD: 109257023(CTSK)
AJU: 106979872(CTSK)
BTA: 513038(CTSK)
BOM: 102287709(CTSK)
BIU: 109555331(CTSK)
BBUB: 102407535(CTSK)
CHX: 102183473(CTSK)
OAS: 101108972(CTSK)
SSC: 397569(CTSK)
CFR: 102511322(CTSK)
CDK: 105103193(CTSK)
BACU: 103008252(CTSK)
LVE: 103075087(CTSK)
OOR: 101270188(CTSK)
DLE: 111169765(CTSK)
PCAD: 102980378(CTSK)
ECB: 100054991(CTSK)
EPZ: 103547638(CTSK)
EAI: 106846533(CTSK)
MYB: 102259503(CTSK)
MYD: 102771486(CTSK)
MNA: 107539127(CTSK)
HAI: 109372279(CTSK)
DRO: 112313792(CTSK)
PALE: 102885198(CTSK)
RAY: 107498992(CTSK)
MJV: 108408263(CTSK)
LAV: 100673950(CTSK)
TMU: 101349596
MDO: 100017449(CTSK)
SHR: 100917440(CTSK)
PCW: 110220566(CTSK)
OAA: 100088286(CTSK)
GGA: 395818(CTSK)
MGP: 104914440(CTSK)
APLA: 101794155(CTSK)
ACYG: 106049270(CTSK)
TGU: 101233119(CTSK)
LSR: 110476861(CTSK)
SCAN: 103824024(CTSK)
GFR: 102031691(CTSK)
PHI: 102102166(CTSK)
PMAJ: 107214633(CTSK)
CCAE: 111939475(CTSK)
FPG: 101919682(CTSK)
FCH: 102049655(CTSK)
CLV: 102096035(CTSK)
NNI: 104014432(CTSK)
AAM: 106495413(CTSK)
ASN: 112547876(CTSK)
AMJ: 109281035(CTSK)
PSS: 102447447 102459334
CMY: 102937600 102948156
CPIC: 101953906 101954188
ACS: 100561728(ctsk)
PVT: 110081453(CTSK)
PBI: 103053602(CTSK)
PMUR: 107292918(CTSK)
TSR: 106554193
PMUA: 114586294(CTSK)
GJA: 107120548(CTSK)
XLA: 100127265(ctsk.L) 108699348 108699349 108700337
XTR: 100490139 100492634 448216(ctsk) 779889(ctsk)
NPR: 108789812 108789813
DRE: 550475(ctsk)
SRX: 107717769 107741754
SANH: 107663458 107689854
SGH: 107576564 107587836
CCAR: 109056407 109084523
IPU: 100528180(catk) 108274827(ctssa)
PHYP: 113525378 113533989
AMEX: 103044235
EEE: 113575274 113585755
TRU: 101066261
TNG: GSTEN00011686G001
LCO: 104923938
NCC: 104944927 104955931
MZE: 101486434 106675288
ONL: 102080361(ctsk) 109204084
OLA: 101160005 101164922
XMA: 102230067
XCO: 114142267
PRET: 103477640
CVG: 107086845 107088362
NFU: 107379225
KMR: 108243181
ALIM: 106524066
AOCE: 111569218 111571631
CSEM: 103388696
POV: 109633525
LCF: 108883173(ctsk) 108884675
SDU: 111222414 111234098
SLAL: 111644723 111668412 111668430 111669222
HCQ: 109512208
BPEC: 110170731
MALB: 109968905 109968961
SASA: 100195370(catk) 106580864
OTW: 112222948 112229285
SALP: 111959001
ELS: 105009269(ctsk)
SFM: 108930421 108941878
PKI: 111838383 111853517 111853532 111860671
LCM: 102352136(CTSK)
RTP: 109919200
DME: Dmel_CG4847(CG4847)
DYA: Dyak_GE11675
BIM: 100748409
CCAL: 108624475
AEC: 105146908
ACEP: 105627376
DQU: 106741339
CFO: 105252674
OBO: 105284231
PCF: 106790486
TCA: 658343 660669
DPL: KGM_213646
BTAB: 109030340 109031191 109039210 109039211
FCD: 110852181
DPX: DAPPUDRAFT_306050 DAPPUDRAFT_312319 DAPPUDRAFT_315184 DAPPUDRAFT_320635 DAPPUDRAFT_47691 DAPPUDRAFT_8167
TUT: 107367640 107371849 112538500
DPTE: 113792611
PTEP: 107450796
BMY: Bm1_13265 Bm1_19965 Bm1_53615
LOA: LOAG_18685
LGI: LOTGIDRAFT_116870 LOTGIDRAFT_161642 LOTGIDRAFT_172091
LAK: 106167228
EGL: EGR_02195
NAU: 109220629
DFA: DFA_03112
EIV: EIN_325530
TPV: TP02_0140
PTM: GSPATT00008837001 GSPATT00009853001
CFUS: CYFUS_004023
PSER: ABRG53_3160
HHY: Halhy_1431
SLI: Slin_5291
RUN: DR864_07255
ZPR: ZPR_4593
WIN: WPG_0559
FBE: FF125_17725
 » show all
Reference
  Authors
Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
  Title
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
  Journal
Science 319:624-7 (2008)
DOI:10.1126/science.1150110
Reference
PMID:8703060
  Authors
Gelb BD, Shi GP, Chapman HA, Desnick RJ
  Title
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
  Journal
Science 273:1236-8 (1996)
DOI:10.1126/science.273.5279.1236
Reference
  Authors
Tepel C, Bromme D, Herzog V, Brix K
  Title
Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.
  Journal
J Cell Sci 113 Pt 24:4487-98 (2000)
  Sequence
[mmu:13038]

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Pathway (10)   
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Disease (2)   
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Gene (1353)   
   KEGG GENES (225)   
   KEGG MGENES (53)   
   RefGene (1066)   
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Protein sequence (94)   
   UniProt (85)   
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