KEGG   ORTHOLOGY: K01371
Entry
K01371                      KO                                     

Name
CTSK
Definition
cathepsin K [EC:3.4.22.38]
Pathway
ko04142  Lysosome
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko05323  Rheumatoid arthritis
Disease
H00273  Pycnodysostosis
H00425  Lysosomal cysteine protease deficiencies
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01371  CTSK; cathepsin K
  09143 Cell growth and death
   04210 Apoptosis
    K01371  CTSK; cathepsin K
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K01371  CTSK; cathepsin K
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K01371  CTSK; cathepsin K
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    K01371  CTSK; cathepsin K
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01371  CTSK; cathepsin K
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K01371  CTSK; cathepsin K
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.38  cathepsin K
     K01371  CTSK; cathepsin K
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C1: papain family
   K01371  CTSK; cathepsin K
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Papain family
   K01371  CTSK; cathepsin K
Genes
HSA: 1513(CTSK)
PTR: 457278(CTSK)
PPS: 100974656(CTSK)
GGO: 101145486(CTSK)
PON: 100432447(CTSK)
NLE: 100580351(CTSK)
MCC: 574112(CTSK)
MCF: 102120416(CTSK)
CSAB: 103247207(CTSK)
RRO: 104681068(CTSK)
RBB: 108533261(CTSK)
CJC: 100410169(CTSK)
SBQ: 101045222(CTSK)
MMU: 13038(Ctsk)
MCAL: 110291053(Ctsk)
MPAH: 110320301(Ctsk)
RNO: 29175(Ctsk)
MUN: 110541001(Ctsk)
CGE: 100765407(Ctsk) 113833185
NGI: 103729102(Ctsk)
HGL: 101716993(Ctsk)
CCAN: 109681204(Ctsk)
OCU: 100009334(CTSK)
TUP: 102469152(CTSK)
CFA: 608843(CTSK)
VVP: 112907784(CTSK)
AML: 100483004(CTSK)
UMR: 103667534(CTSK)
UAH: 113246211(CTSK)
ORO: 101371209(CTSK)
ELK: 111161944
FCA: 101093379(CTSK)
PTG: 102968588(CTSK)
PPAD: 109257023(CTSK)
AJU: 106979872(CTSK)
BTA: 513038(CTSK)
BOM: 102287709(CTSK)
BIU: 109555331(CTSK)
BBUB: 102407535(CTSK)
CHX: 102183473(CTSK)
OAS: 101108972(CTSK)
SSC: 397569(CTSK)
CFR: 102511322(CTSK)
CDK: 105103193(CTSK)
BACU: 103008252(CTSK)
LVE: 103075087(CTSK)
OOR: 101270188(CTSK)
DLE: 111169765(CTSK)
PCAD: 102980378(CTSK)
ECB: 100054991(CTSK)
EPZ: 103547638(CTSK)
EAI: 106846533(CTSK)
MYB: 102259503(CTSK)
MYD: 102771486(CTSK)
MNA: 107539127(CTSK)
HAI: 109372279(CTSK)
DRO: 112313792(CTSK)
PALE: 102885198(CTSK)
RAY: 107498992(CTSK)
MJV: 108408263(CTSK)
LAV: 100673950(CTSK)
TMU: 101349596
MDO: 100017449(CTSK)
SHR: 100917440(CTSK)
PCW: 110220566(CTSK)
OAA: 100088286(CTSK)
GGA: 395818(CTSK)
MGP: 104914440(CTSK)
APLA: 101794155(CTSK)
ACYG: 106049270(CTSK)
TGU: 101233119(CTSK)
LSR: 110476861(CTSK)
SCAN: 103824024(CTSK)
GFR: 102031691(CTSK)
PHI: 102102166(CTSK)
PMAJ: 107214633(CTSK)
CCAE: 111939475(CTSK)
FPG: 101919682(CTSK)
FCH: 102049655(CTSK)
CLV: 102096035(CTSK)
NNI: 104014432(CTSK)
AAM: 106495413(CTSK)
ASN: 112547876(CTSK)
AMJ: 109281035(CTSK)
ACS: 100561728(ctsk)
PVT: 110081453(CTSK)
PBI: 103053602(CTSK)
PMUR: 107292918(CTSK)
TSR: 106554193
PMUA: 114586294(CTSK)
GJA: 107120548(CTSK)
XTR: 100490139 100492634 448216(ctsk) 779889(ctsk)
DRE: 550475(ctsk)
IPU: 100528180(catk) 108274827(ctssa)
AMEX: 103044235
TRU: 101066261
LCO: 104923938
ONL: 102080361(ctsk) 109204084
XMA: 102230067
XCO: 114142267
PRET: 103477640
NFU: 107379225
KMR: 108243181
ALIM: 106524066
CSEM: 103388696
POV: 109633525
LCF: 108883173(ctsk) 108884675
HCQ: 109512208
BPEC: 110170731
SASA: 100195370(catk) 106580864
SALP: 111959001
ELS: 105009269(ctsk)
LCM: 102352136(CTSK)
RTP: 109919200
DME: Dmel_CG4847(CG4847)
BIM: 100748409
CCAL: 108624475
AEC: 105146908
ACEP: 105627376
DQU: 106741339
CFO: 105252674
OBO: 105284231
PCF: 106790486
FCD: 110852181
DPTE: 113792611
PTEP: 107450796
LAK: 106167228
EGL: EGR_02195
NAU: 109220629
DFA: DFA_03112
TPV: TP02_0140
SLI: Slin_5291
ZPR: ZPR_4593
WIN: WPG_0559
 » show all
Reference
  Authors
Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
  Title
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
  Journal
Science 319:624-7 (2008)
DOI:10.1126/science.1150110
Reference
PMID:8703060
  Authors
Gelb BD, Shi GP, Chapman HA, Desnick RJ
  Title
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
  Journal
Science 273:1236-8 (1996)
DOI:10.1126/science.273.5279.1236
Reference
  Authors
Tepel C, Bromme D, Herzog V, Brix K
  Title
Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.
  Journal
J Cell Sci 113 Pt 24:4487-98 (2000)
  Sequence
[mmu:13038]

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