KEGG   ORTHOLOGY: K01408Help
Entry
K01408                      KO                                     

Name
IDE, ide
Definition
insulysin [EC:3.4.24.56]
Pathway
ko05010  Alzheimer's disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K01408  IDE, ide; insulysin
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.56  insulysin
     K01408  IDE, ide; insulysin
Peptidases [BR:ko01002]
 Metallo Peptidases
  Family M16: pitrilysin family
   K01408  IDE, ide; insulysin
BRITE hierarchy
Genes
HSA: 3416(IDE)
PTR: 450608(IDE)
PPS: 100987046(IDE)
GGO: 101141069(IDE)
PON: 100434053(IDE)
NLE: 100593040(IDE)
MCC: 698640(IDE)
MCF: 102128252(IDE)
CSAB: 103216264(IDE)
RRO: 104676500(IDE)
RBB: 108532590(IDE)
CJC: 100385143(IDE)
SBQ: 101050161(IDE)
MMU: 15925(Ide)
RNO: 25700(Ide)
CGE: 100763752(Ide)
NGI: 103747266(Ide)
HGL: 101706921(Ide)
CCAN: 109688019(Ide)
OCU: 100341888(IDE)
TUP: 102491829(IDE)
CFA: 477768(IDE)
AML: 100482236(IDE)
UMR: 103667958(IDE)
ORO: 101380916(IDE)
FCA: 101093646(IDE)
PTG: 102971779(IDE)
AJU: 106965844(IDE)
BTA: 523752(IDE)
BOM: 102265572(IDE)
BIU: 109552990(IDE)
PHD: 102323180(IDE)
CHX: 102173809(IDE)
OAS: 101104194(IDE)
SSC: 100155309(IDE)
CFR: 102505022(IDE)
CDK: 105084233(IDE)
BACU: 103000770(IDE)
LVE: 103074682(IDE)
OOR: 101275790(IDE)
ECB: 100071303(IDE)
EPZ: 103545264 103559075(IDE)
EAI: 106845083(IDE)
MYB: 102263187(IDE)
MYD: 102758781(IDE)
HAI: 109380938(IDE)
RSS: 109451288(IDE)
PALE: 102895302(IDE)
LAV: 100655439(IDE)
TMU: 101340940
MDO: 100024067(IDE)
SHR: 100919889(IDE)
OAA: 100074945(IDE)
GGA: 423814(IDE)
MGP: 100542747(IDE)
CJO: 107315974(IDE)
APLA: 101796419(IDE)
ACYG: 106039786(IDE)
TGU: 100232369(IDE)
GFR: 102044722(IDE)
FAB: 101813235(IDE)
PHI: 102107945(IDE)
PMAJ: 107206642(IDE)
CCW: 104696227(IDE)
FPG: 101918348(IDE)
FCH: 102053322(IDE)
CLV: 102093029(IDE)
EGZ: 104129064(IDE)
AAM: 106491518(IDE)
ASN: 102372742(IDE)
AMJ: 102565114(IDE)
PSS: 102457580(IDE)
CMY: 102939264(IDE)
CPIC: 101951441(IDE)
ACS: 100562442(ide) 103282118
PVT: 110073578(IDE)
PBI: 103061171 103064318(IDE)
GJA: 107106472(IDE) 107110237
XLA: 108696126(ide.L) 108697399(ide.S)
XTR: 100490154(ide)
NPR: 108788832(IDE)
DRE: 561390(ide)
SRX: 107719220(ide) 107747278
IPU: 108263145(ide)
AMEX: 103033253(ide)
TRU: 101066029(ide)
LCO: 104921911(ide)
XMA: 102221704
PRET: 103477096(ide)
NFU: 107375781(ide)
CSEM: 103387481(ide)
LCF: 108886288(ide)
HCQ: 109523193(ide)
BPEC: 110161080(ide)
ELS: 105005727(ide)
SFM: 108925811(ide)
LCM: 102363186(IDE)
CMK: 103180581(ide)
CIN: 100177319
SPU: 591315(IDE)
APLC: 110981248
DME: Dmel_CG5517(Ide)
DSI: Dsimw501_GD12197(Dsim_GD12197)
MDE: 101899568
AAG: 5575268
AME: 413539
BIM: 100740682
BTER: 100644699
ACEP: 105620850
NVI: 100114345
TCA: 660586
DPA: 109543947
NVL: 108562427
BMOR: 101745525
PMAC: 106716963
PRAP: 110998472
DNX: 107173966
ZNE: 110833158
CEL: CELE_C02G6.2(C02G6.2) CELE_C28F5.4(C28F5.4) CELE_F44E7.4(F44E7.4) CELE_Y70C5C.1(Y70C5C.1)
CBR: CBG09322
BMY: Bm1_26615
TSP: Tsp_00424
EPA: 110231484
ADF: 107350280
AQU: 100632301
CPAP: 110811224
VRA: 106757584
VAR: 108328969
CCAJ: 109797247
CAM: 101508744
ADU: 107492618
AIP: 107645485
LJA: Lj0g3v0331639.1(Lj0g3v0331639.1) Lj0g3v0331639.2(Lj0g3v0331639.2)
FVE: 101297565
PPER: 18771330
PAVI: 110773385
ZJU: 107431720
CMO: 103486819
MCHA: 111021555
CMAX: 111481567
CMOS: 111441824
CPEP: 111790335
POP: 7473617
SLY: 101244763 543773(ide)
SIND: 105159756
OEU: 111365873
HAN: 110884632
LSV: 111879375
DCR: 108227588
BVG: 104889352
SOE: 110779098
DOSA: Os01t0778800-01(Os01g0778800) Os01t0779100-00(Os01g0779100) Os07t0570100-01(Os07g0570100) Os07t0570300-01(Os07g0570300) Os07t0570500-01(Os07g0570500)
ATS: 109743057(LOC109743057) 109775769(LOC109775769)
PDA: 103717655
EGU: 105046510
MUS: 103975260
AOF: 109833714
APRO: F751_6272
SCE: YLR389C(STE23)
ERC: Ecym_3273
KMX: KLMA_70067(STE23)
NCS: NCAS_0J01470(NCAS0J01470)
NDI: NDAI_0J02240(NDAI0J02240)
TPF: TPHA_0B02260(TPHA0B02260)
TBL: TBLA_0A08050(TBLA0A08050) TBLA_0I02940(TBLA0I02940)
TDL: TDEL_0E01250(TDEL0E01250)
KAF: KAFR_0A05970(KAFR0A05970)
CAL: CAALFM_C602860WA(STE23)
CAUR: QG37_03694
SLB: AWJ20_816(STE23)
NCR: NCU00481
NTE: NEUTE1DRAFT82494(NEUTE1DRAFT_82494)
MGR: MGG_13149
MAW: MAC_03112
CMT: CCM_02661
MBE: MBM_00273
ANI: AN8044.2
ANG: ANI_1_262144(An16g01860)
PBN: PADG_07053 PADG_11423(PADG_02421)
ABE: ARB_00823
TVE: TRV_07483
PTE: PTT_06680
SPO: SPACUNK4.12c(mug138)
CNE: CNL05710
CNB: CNBI1120
ABP: AGABI1DRAFT68291(AGABI1DRAFT_68291)
ABV: AGABI2DRAFT199158(AGABI2DRAFT_199158)
MGL: MGL_1347
DFA: DFA_01586
SMIN: v1.2.006079.t1(symbB.v1.2.006079.t1) v1.2.006081.t1(symbB.v1.2.006081.t1) v1.2.016757.t1(symbB.v1.2.016757.t1) v1.2.019310.t1(symbB.v1.2.019310.t1) v1.2.033058.t1(symbB.v1.2.033058.t1) v1.2.037748.t1(symbB.v1.2.037748.t1) v1.2.038222.t1(symbB.v1.2.038222.t1)
NGD: NGA_0335320(IDE) NGA_0415400(IDE)
LMA: LMJF_31_3090(SCG5)
LIF: LINJ_31_3210(SCG5)
LBZ: LBRM_31_3470(SCG5) LBRM_31_3520(SCG5)
CTR: CT_806(ptr)
CTD: CTDEC_0806(ptr)
CTF: CTDLC_0806(ptr)
CTA: CTA_0878(ptr)
CTY: CTR_8111(ptr)
CRA: CTO_0878
CTRQ: A363_00869
CTB: CTL0175(ptr)
CTL: CTLon_0176(ptr)
CTO: CTL2C_538
CTJ: JALI_8121(ptr)
CTZ: CTB_8121(ptr)
CTRB: BOUR_00864
CTEC: EC599_8481(ptr)
CTFW: SWFP_8861(ptr)
CTCH: O173_04510
CTCT: CTW3_04525
CMU: TC_0190
CMUR: Y015_01005
CMX: DNC_00975
CMZ: TAC_01005
CPN: CPn0957(ide)
CPA: CP_0903
CPJ: ide(ide)
CPT: CpB0994
CPM: G5S_0078
CPEC: CPE3_0772
CPEO: CPE1_0771(ide)
CPER: CPE2_0772
CHB: G5O_0851
CHR: Cpsi_7971
CPSC: B711_0929
CPSN: B712_0871
CPSG: B598_0867
CPSM: B602_0872
CPSI: B599_0867
CPSV: B600_0926
CPSW: B603_0871
CPST: B601_0870
CPSD: BN356_8001
CCA: CCA_00812(ide)
CAB: CAB782
CABO: AB7_8631
CFE: CF0202(ide1) CF0203(ide2)
PNL: PNK_0535
PUV: PUV_02500(IDE)
WCH: wcw_0398(ide)
OBG: Verru16b_00710(ptrA_1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2126597
  Authors
Kuo WL, Gehm BD, Rosner MR
  Title
Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
  Journal
Mol Endocrinol 4:1580-91 (1990)
DOI:10.1210/mend-4-10-1580
  Sequence
Reference
PMID:2293021
  Authors
Affholter JA, Hsieh CL, Francke U, Roth RA
  Title
Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes.
  Journal
Mol Endocrinol 4:1125-35 (1990)
DOI:10.1210/mend-4-8-1125
  Sequence
[hsa:3416]
Reference
  Authors
Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ
  Title
Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
  Journal
J Biol Chem 282:25453-63 (2007)
DOI:10.1074/jbc.M701590200

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