KEGG   ORTHOLOGY: K01697
Entry
K01697                      KO                                     
Symbol
CBS
Name
cystathionine beta-synthase [EC:4.2.1.22]
Pathway
map00260  Glycine, serine and threonine metabolism
map00270  Cysteine and methionine metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
Module
M00035  Methionine degradation
M00338  Cysteine biosynthesis, homocysteine + serine => cysteine
Reaction
R00891  L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
R01290  L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
R04942  L-serine hydro-lyase (adding homocysteine)
Disease
H00183  Homocystinuria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K01697  CBS; cystathionine beta-synthase
   00270 Cysteine and methionine metabolism
    K01697  CBS; cystathionine beta-synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.22  cystathionine beta-synthase
     K01697  CBS; cystathionine beta-synthase
Other DBs
COG: COG0031 COG0517
GO: 0004122
Genes
HSA: 102724560(CBS) 875(CBS)
PTR: 736626(CBS)
PPS: 100974696(CBS)
GGO: 101149756(CBS)
PON: 100459501(CBS)
PPYG: 129022620(CBS)
NLE: 100597744(CBS)
HMH: 116482221(CBS)
SSYN: 129483030(CBS)
MCC: 100423684(CBS)
MCF: 102115084(CBS)
MTHB: 126950623
MNI: 105472571(CBS)
CSAB: 103221104(CBS)
CATY: 105575589(CBS)
PANU: 101007629(CBS)
TGE: 112620305(CBS)
MLEU: 105555593
RRO: 104677999(CBS)
RBB: 108529529(CBS)
TFN: 117095839(CBS)
PTEH: 111526481(CBS)
CANG: 105520393
CJC: 100414619(CBS)
SBQ: 101033999(CBS)
CIMI: 108311214(CBS)
ANAN: 105713305(CBS)
CSYR: 103265367
MMUR: 105879116(CBS)
LCAT: 123630779(CBS)
PCOQ: 105822916(CBS)
OGA: 100948655(CBS)
MMU: 12411(Cbs)
MCAL: 110312342(Cbs)
MPAH: 110338180(Cbs)
RNO: 24250(Cbs)
MCOC: 116075200(Cbs)
ANU: 117724422(Cbs)
MUN: 110553307(Cbs)
CGE: 100762141(Cbs)
MAUA: 101827489(Cbs)
PROB: 127224169(Cbs)
PLEU: 114704001(Cbs)
MORG: 121435457(Cbs)
MFOT: 126501106
AAMP: 119822586(Cbs)
NGI: 103729336(Cbs)
HGL: 101703797(Cbs)
CPOC: 100734876(Cbs)
CCAN: 109675930(Cbs)
DORD: 105993990(Cbs)
DSP: 122114243(Cbs)
PLOP: 125351424(Cbs)
NCAR: 124992998
MMMA: 107136514(Cbs)
OCU: 100008766(CBS)
OPI: 101516453(CBS)
TUP: 102470867(CBS)
GVR: 103581276
CFA: 611071(CBS)
CLUD: 112651104(CBS)
VVP: 112908011(CBS)
VLG: 121479499(CBS)
NPO: 129502140(CBS)
AML: 100471372(CBS)
UMR: 103680763(CBS)
UAH: 113254145(CBS)
UAR: 123777479(CBS)
ELK: 111155735
LLV: 125093684
MPUF: 101681189(CBS)
MNP: 132012436(CBS)
MLK: 131825423(CBS)
NVS: 122908265(CBS)
ORO: 101364319(CBS)
EJU: 114226394(CBS)
ZCA: 113918546(CBS)
MLX: 118026969(CBS)
NSU: 110571045(CBS)
LWW: 102749825
FCA: 101093038(CBS)
PYU: 121035894(CBS)
PCOO: 112849445(CBS)
PBG: 122491128(CBS)
PVIV: 125159103(CBS)
LRUF: 124526607
PTG: 102966178(CBS)
PPAD: 109256915(CBS)
PUC: 125920688
AJU: 106985645
HHV: 120240665(CBS)
BTA: 514525(CBS)
BOM: 102285677(CBS)
BIU: 109560704(CBS)
BBUB: 102391003(CBS)
BBIS: 104984942(CBS)
CHX: 102184667(CBS)
OAS: 101106301(CBS)
BTAX: 128045376(CBS)
ODA: 120883117(CBS)
CCAD: 122445387(CBS)
MBEZ: 129548156(CBS)
SSC: 110256498(CBS)
CFR: 102520717(CBS)
CBAI: 105078063(CBS)
CDK: 105105848(CBS)
VPC: 102532851(CBS)
BACU: 103018542(CBS)
BMUS: 118894704(CBS)
LVE: 103083927(CBS)
OOR: 101281381(CBS)
DLE: 111163819(CBS)
PCAD: 102987965(CBS)
PSIU: 116753445(CBS)
NASI: 112408692(CBS)
EPZ: 103559035
MYB: 102252595(CBS)
MYD: 102771679(CBS)
MMYO: 118676860(CBS)
MLF: 102433635(CBS)
PKL: 118723895(CBS)
EFUS: 103289791(CBS)
MNA: 107541251(CBS)
DRO: 112306128(CBS)
SHON: 118984864(CBS)
AJM: 119048800(CBS)
PDIC: 114490477(CBS)
PHAS: 123828046(CBS)
MMF: 118617380(CBS)
PPAM: 129074832(CBS)
HAI: 109395181(CBS)
RFQ: 117035995(CBS)
PALE: 102882734(CBS)
PGIG: 120598741(CBS)
PVP: 105305392(CBS)
RAY: 107510188(CBS)
MJV: 108392423(CBS)
TOD: 119257168(CBS)
SARA: 101543192(CBS)
SETR: 126025636(CBS)
LAV: 100658430(CBS)
TMU: 101347618
ETF: 101645570(CBS)
DNM: 101420461(CBS)
MDO: 100024374(CBS)
GAS: 123241643(CBS)
SHR: 100919929(CBS)
AFZ: 127553792
PCW: 110199155(CBS)
TVP: 118837872(CBS)
OAA: 100080879(CBS)
GGA: 418544 418545(CBS)
PCOC: 116229833 116229886(CBS)
TPAI: 128076492(CBS)
GFR: 102034131(CBS) 102037167
FAB: 101819123 101819452(CBS)
FPG: 101917543
CMAC: 104483202
LDI: 104351141(CBS) 104351143
AMJ: 102560906(CBS) 102563571
CABI: 116830590(CBS)
ACS: 100566358(cbs) 100566739
PMUA: 114596125 114596126(CBS)
XLA: 380308(cbs.L) 446655(cbs.S)
XTR: 493533(cbs)
RTEM: 120921674(CBS)
BBUF: 120994288(CBS)
BGAR: 122932865
MUO: 115470541(CBS)
GSH: 117359439(CBS)
DRE: 266987(cbsb) 550524(cbsa)
PTET: 122332290(cbsb) 122349069(cbsa)
OMC: 131539523(cbsa) 131547342(cbsb)
PPRM: 120487315(cbsb) 120488656(cbsa)
RKG: 130085850(cbsb) 130087817(cbsa)
MAMB: 125269972(cbsb) 125272285(cbsa)
TROS: 130556053(cbsb)
TDW: 130427251(cbsb)
MANU: 129451753(cbsb)
IPU: 100304674(cbsa) 108266313
IFU: 128601987(cbsa) 128608454
PHYP: 113537764(cbs) 113546747
SMEO: 124378308(cbsa) 124383202
AMEX: 103027202(cbsa) 103030674(cbsb)
CMAO: 118797906(cbsa) 118801748 118808299(cbsb)
TFS: 130522675(cbsb) 130522797(cbsa)
TBEN: 117481463(cbsb) 117499123(cbsa)
CGOB: 115018424
PGEO: 117459393(cbsa) 117466900(cbsb)
GACU: 117546673(cbsa) 117556851(cbsb)
EMAC: 134861130(cbsa) 134867496(cbsb)
ELY: 117255825
EFO: 125885227
PLEP: 121962760
SLUC: 116044613 116059043(cbsb)
ECRA: 117939669(cbsa) 117953208(cbsb)
GAT: 120824289
AFB: 129111678
CLUM: 117742512
PSWI: 130204572(cbsa)
MSAM: 119903488(cbsb) 119903997
SCHU: 122871764(cbsa) 122885471(cbsb)
CUD: 121506291 121522806(cbsb)
ALAT: 119015565
ONL: 100707752
OAU: 116316021(cbsb) 116318484
OML: 112155227 112160040(cbsa)
CSAI: 133425040 133445564(cbsb)
GAF: 122827278 122839401(cbsb)
PPRL: 129361270(cbsb) 129378644
CTUL: 119786333(cbsb) 119791185
GMU: 124861297 124870851(cbsb)
KMR: 108232423(cbsb) 108244998
NWH: 119419671(cbsb) 119428945
MCEP: 125001270 125017722(cbsB)
POV: 109639757
SSEN: 122765284
HHIP: 117775203(cbsa)
HSP: 118103168
PPLT: 128430857
SMAU: 118311295(cbsa)
XGL: 120798193(cbsa) 120801464(cbsb)
HCQ: 109528297
SSCV: 125987927
SBIA: 133504849(cbsa)
PEE: 133412330(cbsa)
PTAO: 133477070(cbsa)
MALB: 109960512
BSPL: 114844589 114846773(cbsb)
SJO: 128354415 128367653(cbsb)
ELS: 105027337 105031003(cbs)
SFM: 108920076 108933121(cbs)
LOC: 102682531(cbs)
ARUT: 117406668(cbsa)
PSEX: 120523077(cbsa)
LCM: 102364567(CBS)
CMK: 103188727(cbsa)
RTP: 109915507 109925172(cbsa)
CPLA: 122540519 122555442(cbsa)
HOC: 132821218(cbsa) 132829515
LERI: 129703088(cbsa)
PMRN: 116948170
LRJ: 133342089
BFO: 118422621
BBEL: 109484035
CIN: 100180445
SCLV: 120326886
DME: Dmel_CG1753(Cbs)
DER: 6549875
DSE: 6615182
DSI: Dsimw501_GD17507(Dsim_GD17507)
DAN: 6504383
DSR: 110175927
DPO: 4814369
DPE: 6597892
DMN: 108164659
DWI: 6648424
DGR: 6569974
DAZ: 108619926
DNV: 108659321
DHE: 111604236
DVI: 6629574
CCAT: 101457653
BOD: 106615708
BDR: 105224361
AOQ: 129238563
MDE: 101897352
SCAC: 106094518
LCQ: 111684334
LSQ: 119612368
GFS: 119644679
ECOE: 129946785
CLON: 129613165
AGA: 1272101
ACOZ: 120955704
AARA: 120906379
AMER: 121590415
AFUN: 125763386
AMOU: 128307031
AALI: 118458712
AALB: 109427518
AME: 551341(Cbs)
ACER: 108003422
ALAB: 122712463
ADR: 102677189
AFLR: 100863794
BIM: 100741040
BBIF: 117205676
BVK: 117231499
BTER: 100644376
BAFF: 126923221
BPYO: 122574643
BPAS: 132913340
FVI: 122527834
CCAL: 108623570
OBB: 114877262
OLG: 117604461
MGEN: 117220045
NMEA: 116432903
CGIG: 122402088
SOC: 105200196
MPHA: 105830356
AEC: 105153347
ACEP: 105621555
PBAR: 105425284
VEM: 105564237
HST: 105181778
DQU: 106750800
CFO: 105255802
FEX: 115242967
LHU: 105672985
PGC: 109853767
OBO: 105278845
PCF: 106788233
PFUC: 122517607
VPS: 122627284
VCRB: 124432736
VVE: 124946714
NVI: 100115316
CSOL: 105367239
TPRE: 106652234
MDL: 103575041
CGLO: 123260207
FAS: 105268383
DAM: 107039198
AGIF: 122857541
CINS: 118074912
VCAN: 122410404
CCIN: 107274101
DSM: 124405834
NPT: 124211609
NFB: 124175217
NLO: 107222445
NVG: 124297508
AROA: 105693832
TCA: 656954
CSET: 123317934
AGB: 108905110
NVL: 108557274
APLN: 108742572
OTU: 111416641
BMOR: 101742616
BMAN: 114245842
BANY: 112044302
NIQ: 126776165
PMAC: 106721687
PPOT: 106101132
PXU: 106120207
LSIN: 126972540
AAGE: 121726578
ATRA: 106129669
GMW: 113519745
PXY: 105382358
CFEL: 113374099
CCRN: 123291537
DNX: 107167969
AGS: 114132584
RMD: 113555619
ACOO: 126844879
DVT: 126897262
BTAB: 109033511
DCI: 103512733
CLEC: 106664078
HHAL: 106679146
NLU: 111049463
HVI: 124371914
MQU: 128983033
ZNE: 110839840
CSEC: 111870467
BROR: 134535998
IEL: 124168149
DPZ: 124351948
PVM: 113828392
PJA: 122248961
PCHN: 125041334
PMOO: 119591914
HAME: 121870017
PCLA: 123774180
CQD: 128694452
PTRU: 123498546
ESN: 127001693
MNZ: 135200451
HAZT: 108681828
EAF: 111706267
LSM: 121118231
TCF: 131884137
DSV: 119456476
RMP: 119171605
VDE: 111249919
TUT: 107361305
DPTE: 113798792
DFR: 124500124
CSCU: 111620368
ABRU: 129965485
SDM: 118198327
LPOL: 106473377
PMEO: 129595495
CEL: CELE_F54A3.4(cbs-2) CELE_ZC373.1(cbs-1)
CBR: CBG_01937(Cbr-cbs-2)
BMY: BM_BM4331(Bm4331)
PVUL: 126829638
PCAN: 112568824
BGT: 106072866
CRG: 105336612
CANU: 128192466
CVN: 111123773
OED: 125681670
MYI: 110457846
PMAX: 117340170
MCAF: 127700556
MMER: 123561618
RPHI: 132713340
DPOL: 127855137
MAEA: 128234259
OBI: 106872868
OSN: 115212101
LJP: 135482354
LAK: 106161612
LLON: 135502476
EPA: 110242846
ATEN: 116305218
PDAM: 113672393
DGT: 114528080
XEN: 124446483
HSY: 130636287
RES: 135684191
SCE: YGR155W(CYS4)
SEUB: DI49_2118
ERC: Ecym_7341
KMX: KLMA_20288(CYS4)
CGR: 2887404(CYS4)
NCS: NCAS_0C05620(NCAS0C05620)
NDI: NDAI_0H00500(NDAI0H00500)
TPF: TPHA_0K01840(TPHA0K01840)
TBL: TBLA_0E01580(TBLA0E01580)
TDL: TDEL_0F02810(TDEL0F02810)
KAF: KAFR_0I01230(KAFR0I01230)
KNG: KNAG_0J02670(KNAG0J02670)
PIC: PICST_77227(CYS4)
SPAA: SPAPADRAFT_131723(CYS4)
LEL: PVL30_001564(CYS4)
CAL: CAALFM_C101870CA(CYS4)
CTEN: 18246987(CYS4)
SLB: AWJ20_5157(CYS4)
NCR: NCU08216
NTE: NEUTE1DRAFT64117(NEUTE1DRAFT_64117)
PBEL: QC761_703260(CYS4)
PPSD: QC762_703260(CYS4)
PPSP: QC763_703260(CYS4)
PPSA: QC764_703260(CYS4)
MGR: MGG_07384
PGRI: PgNI_02489
SSCK: SPSK_06205
TATV: 25775430(TrAtP1_005111)
MAW: 19253218(CYS4_1)
MAJ: MAA_09697
MBRN: 26238275(cysB)
CMT: CCM_08097
PLJ: 28882265(PLICBS_001696)
PTKZ: JDV02_009753(CYS4)
BFU: BCIN_16g03500(Bccys4)
MBE: MBM_09114
ALUC: AKAW2_60721A(CYS4)
ACHE: ACHE_50303A(CYS4)
APUU: APUU_10826A(CYS4)
ABE: ARB_07681
TVE: TRV_01035
PTE: PTT_02279
PTRR: 6349454(PtrM4_072650)
CNE: CNA06170
CNB: CNBA5980
CDEU: CNBG_1291
TASA: A1Q1_07527
CCAC: CcaHIS019_0107660(CYS4)
ABP: AGABI1DRAFT70201(AGABI1DRAFT_70201)
ABV: AGABI2DRAFT205908(AGABI2DRAFT_205908)
SCM: SCHCO_02619352(SCHCODRAFT_02619352)
DDI: DDB_G0267386(cysB)
DFA: DFA_09240(cysB)
SMIN: v1.2.004841.t1(symbB.v1.2.004841.t1)
PTI: PHATRDRAFT_42003(Cbs)
LMA: LMJF_17_0250(CYSB)
LIF: LINJ_17_0300(CYSB)
LPAN: LPMP_170210(CYSB)
ENC: ECL_02360
ECLX: LI66_09405
ECLY: LI62_10175
ECLO: ENC_13590
EEC: EcWSU1_01870(cbs)
ESA: ESA_02767
CSK: ES15_2857
CTU: CTU_11050
KPN: KPN_03409
KPU: KP1_4684
KPP: A79E_0713
KPJ: N559_0772
KPX: PMK1_00884(cbs)
KPNU: LI86_03740
KPNK: BN49_0695
KVA: Kvar_0682
KPE: KPK_0709
KOX: KOX_02795
KOE: A225_5008
EAE: EAE_18845
EAR: CCG30114
CKO: CKO_01706
HDE: HDEF_1873(cysK)
CLAP: NCTC11466_02217(cbs)
YEN: YE1470(uptG)
YEY: Y11_03511
YEW: CH47_888
YET: CH48_177
YEE: YE5303_13201(uptG)
YAL: AT01_1034
YFR: AW19_1752
YIN: CH53_217
YKR: CH54_4034
YRO: CH64_1104
YRU: BD65_3185
SMAR: SM39_1070
SPE: Spro_1627
SRL: SOD_c14980(cbs)
SPLY: Q5A_008100(cbs) Q5A_011975(cysM_1)
SMAF: D781_1541
SERF: L085_20420
SOF: NCTC11214_05286(cbs)
SGRI: SGBXF1_01602(cbs)
ECA: ECA4113
PATR: EV46_20470
PATO: GZ59_41670
PCT: PC1_3903
PLU: plu0524
PAY: PAU_00518(mtcB)
PMR: PMI0235
XBO: XBJ1_3501
XBV: XBW1_3932
XDO: XDD1_3040
XPO: XPG1_0659
PSI: S70_10355
PSX: DR96_1124
ETD: ETAF_1740(uptG)
ETE: ETEE_4004
ETR: ETAE_1928(uptG)
XFA: XF_0603
XFT: PD_1548(cysM)
XCC: XCC0597(cysB)
XCB: XC_3636
XCP: XCR_0750
XCV: XCV3726
XAX: XACM_3503
XAC: XAC3603(cysB)
XCI: XCAW_04305(cysK)
XOM: XOO0707(XOO0707)
XOO: XOO0777(cysB)
XOP: PXO_03155(cysB)
XOR: XOC_3871(cysB)
XAL: XALC_2713
XPH: XppCFBP6546_16305(XppCFBP6546P_16305)
XHD: LMG31886_36930(cbs)
XAG: HEP73_03686(cysB)
XAS: HEP74_03551(cysB)
SML: Smlt0616(cbsB)
SMT: Smal_0488
SMZ: SMD_0527(cbsB)
SACZ: AOT14_06060(cbsB)
SINC: DAIF1_05490(cbs)
PSUW: WQ53_11130
PSD: DSC_02405
LEZ: GLE_4250
LEM: LEN_0952
LHX: LYSHEL_08850(cysB)
LCAS: LYSCAS_08850(cysB)
LLZ: LYB30171_02318(cbs)
DKO: I596_69
RBD: ALSL_2383
PAE: PA0399
PAEV: N297_410
PAEI: N296_410
PAEP: PA1S_02025
PAEM: U769_02060
PAEL: T223_02020
PAEG: AI22_01875
PAEC: M802_409
PAEO: M801_410
SECH: B18_05870
PCQ: PcP3B5_05400(cbs)
PFS: PFLU_3406
PFB: VO64_0543
PMAN: OU5_5248
PKC: PKB_0418
PCHP: C4K32_1812
PSEM: TO66_08620
PANR: A7J50_3129
PSET: THL1_259
PSIL: PMA3_16725
PDW: BV82_3029
PSEP: C4K39_0192
ILO: IL0218(cysM)
PSEN: PNC201_10885(cbs)
RVI: RVIR1_06850(cysK)
FRC: KX01_933
HCH: HCH_03693
KKO: Kkor_1767
CVI: CV_3395(cysB2)
CHAE: CH06BL_11240(uptG)
PSE: NH8B_0056
BGP: BGL_2c03850(cysB)
AXX: ERS451415_01161(cbs)
POL: Bpro_2830
RGE: RGE_20080(cbs)
RDP: RD2015_67
JAG: GJA_2053
CFU: CFU_1537(cysM)
CARE: LT85_3220
DSU: Dsui_2043
ABRE: pbN1_27460
MLO: mll4505
MHUA: MCHK_5667
AMIH: CO731_00550(cysK_1)
AMIS: Amn_02410
ANJ: AMD1_0452
RGA: RGR602_PC00900(cysK-2)
BBT: BBta_0633
RPD: RPD_4194
RPT: Rpal_2600
VGO: GJW-30_1_02182(cbs)
MIND: mvi_57450
RVA: Rvan_1851
BVR: BVIR_363
RBM: TEF_00860
CAK: Caul_4907
PZU: PHZ_c0071
BVY: NCTC9239_02030(cbs)
TSV: DSM104635_02815(cbs)
RRU: Rru_A0787
RRF: F11_04035
RCE: RC1_1987(cbs)
TMO: TMO_c0648(cysB)
MXA: MXAN_2041
CCX: COCOR_06049(cbs1)
SCL: sce0438 sce8782(cysB)
HOH: Hoch_5286
BBA: Bd3796
BBAT: Bdt_3675
BBW: BDW_13965
BBAC: EP01_11485
BEX: A11Q_2499
BMX: BMS_3011
SAY: TPY_1780
MANA: MAMMFC1_00304(cbs)
MTU: Rv1077(cbs)
MTV: RVBD_1077
MTC: MT1108
MRA: MRA_1087(cbs)
MTUR: CFBS_1139(cbs)
MTO: MTCTRI2_1105(cbs)
MTD: UDA_1077(cbs)
MTN: ERDMAN_1202(cbs)
MTUE: J114_05815
MTUL: TBHG_01061
MTUT: HKBT1_1138(cbs)
MTUU: HKBT2_1143(cbs)
MTQ: HKBS1_1140(cbs)
MBO: BQ2027_MB1106(cbs)
MBB: BCG_1135(cbs)
MBT: JTY_1108(cbs)
MBM: BCGMEX_1107(cbs)
MBX: BCGT_0896
MAF: MAF_10900(cbs)
MCE: MCAN_10831(cbs)
MCQ: BN44_11193(cbs)
MCV: BN43_30130(cbs)
MCX: BN42_20925(cbs)
MCZ: BN45_30118(cbs)
MORY: MO_001157
MLE: ML2396(cysM2)
MLB: MLBr02396(cysM2)
MPA: MAP_1024(cysM2)
MAO: MAP4_2833
MAVI: RC58_14040
MAVU: RE97_14065
MAV: MAV_1201
MIT: OCO_11060
MIA: OCU_11050
MID: MIP_01784
MYO: OEM_11170
MIR: OCQ_11090
MLP: MLM_1148
MMAN: MMAN_54330(cbs)
MUL: MUL_0203(cbs)
MMI: MMAR_4390(cbs)
MMAE: MMARE11_42100(cbs)
MLI: MULP_04605(cbs)
MPSE: MPSD_45330(cbs)
MSHO: MSHO_01630(cbs)
MMC: Mmcs_4149
MKM: Mkms_4224
MJL: Mjls_4380
MMM: W7S_05415
MHAD: B586_06980
MSHG: MSG_03948(cbs)
MFJ: MFLOJ_47190(cbs)
MSTO: MSTO_51140(cbs)
MSIM: MSIM_37120(cbs)
MSAK: MSAS_22490(cbs)
MXE: MYXE_13710(cbs)
MNV: MNVI_06440(cbs)
MCOO: MCOO_20670(cbs)
MBAI: MB901379_03847(cbs)
MSEO: MSEO_27260(cbs)
MHEK: JMUB5695_01315(cbs)
MLJ: MLAC_06380(cbs)
MBRD: MBRA_27050
MSHJ: MSHI_02780(cbs)
MLM: MLPF_0471(cbs)
MKY: IWGMT90018_50580(cbs)
MSG: MSMEI_5131(cbs)
MVA: Mvan_4674
MGI: Mflv_2043
MPHL: MPHLCCUG_04264(cbs)
MVQ: MYVA_4502
MTHN: 4412656_03584(cbs)
MHAS: MHAS_03247(cbs)
MAUU: NCTC10437_04400(cbs)
MMAG: MMAD_43050
MMOR: MMOR_17970
MFX: MFAL_37620(cysM2)
MAIC: MAIC_44190
MALV: MALV_48130
MARZ: MARA_53990
MGAD: MGAD_29930
MHEV: MHEL_10430
MSAR: MSAR_26610
MANY: MANY_27300
MAUB: MAUB_43100
MPOF: MPOR_47390
MPHU: MPHO_26360
MBOK: MBOE_26840
MFLV: NCTC10271_01070(cbs)
MCEE: MCEL_43730
MAB: MAB_1195
MABB: MASS_1193
MCHE: BB28_05940
MSTE: MSTE_01163
MSAL: DSM43276_01063(cbs)
MJD: JDM601_1023(cbs)
MTER: 4434518_01009(cbs)
MMIN: MMIN_26660
MHIB: MHIB_05840
ASD: AS9A_3444
CJK: jk1981(cysY)
CPL: Cp3995_0630(cbs)
CPP: CpP54B96_0630(cbs)
CPZ: CpPAT10_0620(cbs)
COR: Cp267_0647(cbs)
COD: Cp106_0603(cbs)
COS: Cp4202_0613(cbs)
CPSE: CPTA_01170
CPSU: CPTB_00362
CPSF: CPTC_01160
CRD: CRES_0026
CUL: CULC22_00669(tsb)
CUN: Cul210932_0697(cbs)
CUQ: Cul210931_0666(cbs)
CUZ: Cul05146_0715(cbs)
CUJ: CUL131002_0675c(cbs)
CUS: CulFRC11_0666(cbs)
CCYC: SCMU_30860
CHAD: CHAD_11420(cbs)
NFR: ERS450000_05046(cysM_2) ERS450000_05083(cbs)
NAD: NCTC11293_06193(cbs) NCTC11293_06242(cysM_3)
RER: RER_42660(cbs)
REY: O5Y_19970
ROP: ROP_59040(cbs)
RHB: NY08_1978
RFA: A3L23_00312(cbs)
RHS: A3Q41_03095(cbs)
RHU: A3Q40_02404(cbs)
RRT: 4535765_01156(cbs)
RCR: NCTC10994_01582(cbs)
REQ: REQ_12820(cysB)
GBR: Gbro_1617
GPO: GPOL_c14990(cysB)
GOR: KTR9_1593
GRU: GCWB2_08065(cbs)
GOM: D7316_01615(cbs) D7316_02853(cysK)
TPR: Tpau_3152
SCO: SCO3077(SCE25.18c)
SALB: XNR_1985
SGR: SGR_4452
SGB: WQO_13265
SFI: SFUL_2683
SHY: SHJG_4550
SMAL: SMALA_3191
SFA: Sfla_3825
SBH: SBI_04548
SVE: SVEN_2831
SDV: BN159_5202(cbs)
SALS: SLNWT_2621
STRP: F750_2908
SLV: SLIV_22310(cbs)
SGU: SGLAU_14015(cbs)
STRM: M444_14480
SAMB: SAM23877_3129(cbs)
SPRI: SPRI_4467
SRW: TUE45_04581(cbs) TUE45_06288(cysK)
SLE: sle_41970(sle_41970)
SRN: A4G23_02101(cbs)
SNR: SNOUR_24980(cbs)
STRD: NI25_23390
SLAU: SLA_2809
SLX: SLAV_05465(cysM1) SLAV_22665(cbs)
SFK: KY5_3275c
SGE: DWG14_04990(cbs) DWG14_08225(mccA)
SRJ: SRO_4395
SNF: JYK04_03650(cbs)
SHUN: DWB77_04595(cbs)
SCYG: S1361_16575(cbs)
SAUH: SU9_013255
SXT: KPP03845_103181(cbs)
SCT: SCAT_2096(CBS)
KSK: KSE_47260(cbs)
LXX: Lxx17700(cysM2)
CMI: CMM_0872(cysB)
CMS: CMS0127
CMC: CMN_00832(cysB)
MTS: MTES_2412
MOO: BWL13_00473(cbs)
MLV: CVS47_02739(cbs)
MOY: CVS54_02913(cbs)
AMAU: DSM26151_05240(cbs)
AUT: AINA4_10170(cysK)
ARR: ARUE_c31870(cbs1) ARUE_c37930(cbs2)
ARM: ART_2207
ARX: ARZXY2_640 ARZXY2_96(cysK)
AAGI: NCTC2676_1_02401(cbs)
GCR: GcLGCM259_2139(cbs)
GMY: XH9_13620
BCV: Bcav_1054
LMOI: VV02_09000
XCE: Xcel_2671
CFL: Cfla_0925
MPH: MLP_44570(cbs)
NCA: Noca_0939
NDK: I601_1991(cbs)
NAQU: ENKNEFLB_03779(cbs)
PSIM: KR76_08975
KFL: Kfla_5676
TFU: Tfu_0438
NDA: Ndas_0083
NAL: B005_2873
STRR: EKD16_20140(cbs)
TCU: Tcur_1048
NCX: Nocox_37355(cbs)
TBI: Tbis_3118
FAL: FRAAL0784(cysM) FRAAL3001
NML: Namu_4422
GOB: Gobs_4209
BSD: BLASA_4025(cbs)
MMAR: MODMU_4605(cbs)
KRA: Krad_1082
SEN: SACE_0899(cysM2)
SACC: EYD13_17670(cbs)
AMD: AMED_8107
AMN: RAM_41650
AMM: AMES_7985
AMZ: B737_7986
AMQ: AMETH_5891(cysM2)
AMYY: YIM_05015(cbs)
AORI: SD37_06025
PSEA: WY02_04595
PSEH: XF36_20675
PAUT: Pdca_10470
AMI: Amir_0700
SESP: BN6_07740
KAL: KALB_840
ACTI: UA75_03950
ACAD: UA74_03850
AHG: AHOG_03680(cbs)
ALO: CRK61565
ACTU: Actkin_00706(cbs)
MIL: ML5_1162
ASE: ACPL_4764(cysM) ACPL_952
AMS: AMIS_7790
ACTN: L083_1111(cysM)
AFS: AFR_05430
CAI: Caci_0644
SNA: Snas_0943
BLO: BL1156(cbsSV)
BLJ: BLD_0914(cysK)
BLF: BLIF_0472
BLL: BLJ_0532
BLB: BBMN68_918(cysK)
BLM: BLLJ_0455
BLG: BIL_13890
BAD: BAD_0490(cbsSV)
BADL: BADO_0502
BLA: BLA_1096(cbsSV)
BBB: BIF_00615
BBC: BLC1_0538
BLV: BalV_0541
BLW: W7Y_0566
BLS: W91_0587
BANI: BL12_02835
BANL: BLAC_02845
BANM: EN10_02870
BDE: BDP_0670(cysK)
BDN: BBDE_0641
BBP: BBPR_1344(cysK)
BBI: BBIF_1302(cysK)
BBF: BBB_1324(cysB)
BBRU: Bbr_0538(cysK)
BBRE: B12L_0456
BBRV: B689b_0516
BBRJ: B7017_0491
BBRC: B7019_0498
BBRN: B2258_0490
BBRS: BS27_0529(cysK)
BBRD: BBBR_0462
BTP: D805_1238
BKS: BBKW_0515
BCAT: BBCT_0473
BPSP: AH67_03185
BANG: BBAG_0433
BPSC: BBPC_0529
BSCA: BBSC_0711
BALA: DSM104299_05619(cbs)
CWO: Cwoe_0908
SBAE: DSM104329_00277(cbs)
GLJ: GKIL_3014
AVA: Ava_4156
HAU: Haur_3718
PBF: CFX0092_A0187(cbs)
STI: Sthe_2024
VAB: WPS_19600
PUV: PUV_18680(cbs)
WCH: wcw_1144(cysK)
MTAR: DF168_00139(cbs)
GES: VT84_23005(cysK_2) VT84_30235(cbs)
ULI: ETAA1_33390(cysK) ETAA1_47060(cbs)
SACI: Sinac_7195
PBOR: BSF38_05618(cbs)
AGV: OJF2_11660(cbs) OJF2_31700(cysK_1)
ABAC: LuPra_04149(cbs)
GAU: GAU_3907(cbs)
GBA: J421_0897
BLQ: L21SP5_03369(cbs)
CPI: Cpin_3667
FLN: FLA_4253
SGN: SGRA_2550
PHE: Phep_1434
SMIZ: 4412673_01065(cbs) 4412673_01966(cysK)
SDJ: NCTC13534_02748(cysM_1) NCTC13534_03679(cbs)
MUC: MuYL_1946
MGOT: MgSA37_03351(cbs)
SLI: Slin_5829
FAE: FAES_3839
HSW: Hsw_0648
FLM: MY04_3160
PPSV: PEPS_39700(cysB)
FJG: BB050_00103(cbs_1) BB050_00678(cbs_2)
FSN: GS03_00090(cbs_1) GS03_02195(cbs_2)
COC: Coch_1829
CBAL: M667_14005
CBAT: M666_13875
DDO: I597_1696(cbs_1) I597_1749(cbs_2)
ZGA: ZOBELLIA_2590(cysK2) ZOBELLIA_4054(cysK1)
POM: MED152_00895(cysK) MED152_03850(cbs)
PHG: KCTC32516_01819(cbs_1) KCTC32516_02337(cbs_2)
MYR: MYRA21_2090(cbs)
MPW: MPR_0888
TMAR: MARIT_1683 MARIT_1686(cysK)
AALG: AREALGSMS7_04518(cbs)
KAN: IMCC3317_12620(cbs_1) IMCC3317_18030(cbs_2)
MARF: CJ739_3344
FBU: UJ101_00487(CBS)
RAI: RA0C_0694
RAR: RIA_1801
RAG: B739_1544
RAE: G148_1149
RAT: M949_1970
ELB: VO54_00107(cbs_1) VO54_01609(cbs_2)
CHZ: CHSO_2070(srpG2) CHSO_2714(srpG2) CHSO_3814(srpG)
CGLE: NCTC11432_00875(cbs_1) NCTC11432_02025(cbs_2)
CTAI: NCTC12078_00524(cbs_1) NCTC12078_03361(cbs_2)
CTAK: 4412677_00497(cbs_1) 4412677_00900(cbs_2)
CSAL: NBC122_01781(cbs_1) NBC122_02404(cbs_2)
CJG: NCTC13459_00687(cbs_1) NCTC13459_01129(cbs_2)
CANT: NCTC13489_00717(cbs_1) NCTC13489_01144(cbs_2)
BPOR: BPO_0065
PTAN: CRYO30217_01736(cbs)
CTE: CT1921
CPC: Cpar_0287
CCH: Cag_1634
CLI: Clim_2126
PVI: Cvib_0346
PLT: Plut_0281
PPH: Ppha_2553
PAA: Paes_1945
PROC: Ptc2401_02021(cbs)
SRM: SRM_01301(cysK) SRM_03001(cysB)
IAL: IALB_2142 IALB_2149(cysM)
MRO: MROS_2424
CPRV: CYPRO_2128
MARN: LN42_06055
CABY: Cabys_2929
PYN: PNA2_1580
TLT: OCC_05691
THS: TES1_1395
PPAC: PAP_08745
MBN: Mboo_1990
MPL: Mpal_1157
ACJ: ACAM_0775
 » show all
Reference
PMID:8366024
  Authors
Cherest H, Thomas D, Surdin-Kerjan Y
  Title
Cysteine biosynthesis in Saccharomyces cerevisiae occurs through the transsulfuration pathway which has been built up by enzyme recruitment.
  Journal
J Bacteriol 175:5366-74 (1993)
DOI:10.1128/jb.175.17.5366-5374.1993
  Sequence
[sce:YGR155W]

KEGG   ORTHOLOGY: K10150
Entry
K10150                      KO                                     
Symbol
cysO
Name
cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase [EC:2.5.1.47 2.5.1.65 4.2.1.22]
Pathway
map00260  Glycine, serine and threonine metabolism
map00270  Cysteine and methionine metabolism
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01230  Biosynthesis of amino acids
Module
M00035  Methionine degradation
M00338  Cysteine biosynthesis, homocysteine + serine => cysteine
Reaction
R00891  L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
R00897  O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
R01290  L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
R03601  O3-acetyl-L-serine acetate-lyase (adding hydrogen sulfide)
R04859  O3-acetyl-L-serine:thiosulfate 2-amino-2-carboxyethyltransferase (reducing, L-cysteine-forming)
R04942  L-serine hydro-lyase (adding homocysteine)
R07274  O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
   00270 Cysteine and methionine metabolism
    K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.47  cysteine synthase
     K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
    2.5.1.65  O-phosphoserine sulfhydrylase
     K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.22  cystathionine beta-synthase
     K10150  cysO; cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Other DBs
GO: 0004124 0033847 0004122
Genes
APE: APE_1586(cysK)
ACJ: ACAM_0997(cysK)
DFD: Desfe_0630
DMU: Desmu_0644
TAG: Tagg_1314
IAG: Igag_1783
THG: TCELL_0171
HBU: Hbut_1585
PFM: Pyrfu_1108
PDL: Pyrde_0768
PABI: PABY_05110
PIS: Pisl_1761
TPE: Tpen_1605
ASC: ASAC_0793
ACIA: SE86_05800
CCAI: NAS2_0810
 » show all
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
  Sequence
[ape:APE_1586]

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