Entry |
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Symbol |
hemD, UROS
|
Name |
uroporphyrinogen-III synthase [EC: 4.2.1.75]
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Pathway |
map01110 | Biosynthesis of secondary metabolites |
map01120 | Microbial metabolism in diverse environments |
|
Module |
M00121 | Heme biosynthesis, plants and bacteria, glutamate => heme |
M00846 | Siroheme biosynthesis, glutamyl-tRNA => siroheme |
M00868 | Heme biosynthesis, animals and fungi, glycine => heme |
M00926 | Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme |
|
Reaction |
R03165 | hydroxymethylbilane hydro-lyase(cyclizing) |
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Disease |
H00201 | Erythropoietic porphyria |
|
Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
K01719 hemD, UROS; uroporphyrinogen-III synthase
Enzymes [BR:ko01000]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
K01719 hemD, UROS; uroporphyrinogen-III synthase
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Other DBs |
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Genes |
» show all
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Reference |
|
Authors |
Tsai SF, Bishop DF, Desnick RJ |
Title |
Human uroporphyrinogen III synthase: molecular cloning, nucleotide sequence, and expression of a full-length cDNA. |
Journal |
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Sequence |
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Reference |
|
Authors |
Jordan PM, Mgbeje BI, Alwan AF, Thomas SD |
Title |
Nucleotide sequence of hemD, the second gene in the hem operon of Escherichia coli K-12. |
Journal |
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