Entry
Symbol
purB, ADSL
Name
adenylosuccinate lyase [EC:
4.3.2.2 ]
Pathway
map00250 Alanine, aspartate and glutamate metabolism
map01110 Biosynthesis of secondary metabolites
Module
M00048 De novo purine biosynthesis, PRPP + glutamine => IMP
M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
Reaction
R01083 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
R04559 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
Disease
H00197 Adenylosuccinate lyase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K01756 purB, ADSL; adenylosuccinate lyase
09105 Amino acid metabolism
00250 Alanine, aspartate and glutamate metabolism
K01756 purB, ADSL; adenylosuccinate lyase
Enzymes [BR:ko01000 ]
4. Lyases
4.3 Carbon-nitrogen lyases
4.3.2 Amidine-lyases
4.3.2.2 adenylosuccinate lyase
K01756 purB, ADSL; adenylosuccinate lyase
BRITE hierarchy
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Genes
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Taxonomy UniProt
Reference
Authors
Tsai M, Koo J, Yip P, Colman RF, Segall ML, Howell PL
Title
Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism.
Journal
Sequence
Reference
Authors
Kmoch S, Hartmannova H, Stiburkova B, Krijt J, Zikanova M, Sebesta I
Title
Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients.
Journal
Sequence