K02085                      KO                                     
adenomatosis polyposis coli protein
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04550  Signaling pathways regulating pluripotency of stem cells
map04810  Regulation of actin cytoskeleton
map04934  Cushing syndrome
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05165  Human papillomavirus infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05217  Basal cell carcinoma
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
H00017  Esophageal cancer
H00018  Gastric cancer
H00020  Colorectal cancer
H00044  Cancer of the anal canal
H00047  Gallbladder cancer
H00718  Sotos syndrome
H01025  Familial adenomatous polyposis
H01431  Cushing syndrome
H01667  Medulloblastoma
H01881  Complex cortical dysplasia with other brain malformations
H02049  Bilateral macronodular adrenal hyperplasia
H02302  Hepatoblastoma
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02085  APC; adenomatosis polyposis coli protein
   04390 Hippo signaling pathway
    K02085  APC; adenomatosis polyposis coli protein
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K02085  APC; adenomatosis polyposis coli protein
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K02085  APC; adenomatosis polyposis coli protein
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02085  APC; adenomatosis polyposis coli protein
   05206 MicroRNAs in cancer
    K02085  APC; adenomatosis polyposis coli protein
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02085  APC; adenomatosis polyposis coli protein
   05225 Hepatocellular carcinoma
    K02085  APC; adenomatosis polyposis coli protein
   05226 Gastric cancer
    K02085  APC; adenomatosis polyposis coli protein
   05217 Basal cell carcinoma
    K02085  APC; adenomatosis polyposis coli protein
   05213 Endometrial cancer
    K02085  APC; adenomatosis polyposis coli protein
   05224 Breast cancer
    K02085  APC; adenomatosis polyposis coli protein
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K02085  APC; adenomatosis polyposis coli protein
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02085  APC; adenomatosis polyposis coli protein
   05022 Pathways of neurodegeneration - multiple diseases
    K02085  APC; adenomatosis polyposis coli protein
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02085  APC; adenomatosis polyposis coli protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K02085  APC; adenomatosis polyposis coli protein
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K02085  APC; adenomatosis polyposis coli protein
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K02085  APC; adenomatosis polyposis coli protein
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02085  APC; adenomatosis polyposis coli protein
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centriole associated proteins
    K02085  APC; adenomatosis polyposis coli protein
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
   Tubulin-binding proteins
    EB / APC
     K02085  APC; adenomatosis polyposis coli protein
HSA: 10297(APC2) 324(APC)
PTR: 455551(APC2) 461999(APC)
PPS: 100992823(APC)
GGO: 101130129(APC2) 101137098(APC)
PON: 100431482(APC) 100435472(APC2)
NLE: 100585467(APC) 100602025(APC2)
MCC: 693443(APC) 707345(APC2)
MCF: 102123489(APC2) 102126553(APC)
CSAB: 103234321(APC2) 103244338(APC)
CATY: 105590693(APC) 105591719(APC2)
PANU: 101015820(APC)
TGE: 112612730(APC2) 112625954(APC)
RRO: 104669245(APC) 104671452(APC2)
RBB: 108530233(APC2) 108540305(APC)
TFN: 117064818(APC) 117076657(APC2)
PTEH: 111534247 111542693(APC)
CJC: 100385653(APC) 100397972(APC2)
SBQ: 101034942(APC2) 101049516
CSYR: 103263000(APC)
MMUR: 105860762(APC2) 105870856(APC)
OGA: 100950293(APC) 100966348(APC2)
MMU: 11789(Apc) 23805(Apc2)
MCAL: 110284455(Apc) 110303367(Apc2)
MPAH: 110326173(Apc2) 110333195(Apc)
RNO: 24205(Apc) 299611(Apc2)
MCOC: 116075850(Apc2) 116086966(Apc)
MUN: 110551111(Apc) 110551354(Apc2)
CGE: 100750563(Apc) 100767273(Apc2)
PLEU: 114684081(Apc2) 114705120(Apc)
NGI: 103735168(Apc) 103737324(Apc2)
HGL: 101699189(Apc2) 101704055(Apc)
CPOC: 100723694(Apc) 100735498(Apc2)
CCAN: 109691007(Apc2) 109699342(Apc)
DORD: 105988701(Apc) 105990328(Apc2)
DSP: 122118219(Apc) 122122822(Apc2)
OCU: 100353976(APC) 103346018
OPI: 101516222(APC2) 101526321(APC)
TUP: 102470052(APC2) 102484859(APC)
CFA: 479139(APC) 485084(APC2)
VVP: 112915436(APC) 112935524(APC2)
VLG: 121489860(APC) 121495587(APC2)
AML: 100465768(APC2) 100472257(APC)
UMR: 103675797(APC)
UAH: 113242735(APC2) 113254991(APC)
UAR: 123779308(APC) 123794019(APC2)
MPUF: 101673283(APC2) 101687635(APC)
ORO: 101371790(APC) 101372249(APC2)
EJU: 114208628(APC) 114226123(APC2)
ZCA: 113916148(APC2) 113928748(APC)
MLX: 118005119(APC2) 118017527(APC)
FCA: 101096138(APC) 101097211(APC2)
PYU: 121011897(APC) 121021383(APC2)
PBG: 122488602(APC2) 122491978(APC)
PTG: 102948725(APC)
PPAD: 109257701(APC2) 109267599(APC)
AJU: 106973163(APC) 106983719(APC2)
HHV: 120236758(APC) 120242387(APC2)
BTA: 526572(APC2) 533233(APC)
BOM: 102272116(APC) 102282143(APC2)
BIU: 109561990(APC2) 109564604(APC)
BBUB: 102396874(APC) 102413003(APC2)
CHX: 102177435(APC2) 102184724(APC)
OAS: 101104664(APC) 101115458(APC2)
CCAD: 122439955(APC2) 122442941(APC)
SSC: 100517932(APC) 100579172(APC2)
CFR: 102521446(APC2) 102522612(APC)
CBAI: 105078357(APC2) 105082033(APC)
CDK: 105095381(APC) 105104128(APC2)
VPC: 102536812(APC)
BACU: 103001169(APC) 103014178(APC2)
LVE: 103083467(APC) 103084983(APC2)
OOR: 101275920(APC) 101276919(APC2)
DLE: 111170519(APC2) 111183639(APC)
PCAD: 102973647(APC) 102990003(APC2)
PSIU: 116750639(APC) 116750869(APC2)
ECB: 100064431(APC) 100147102(APC2)
EPZ: 103561228(APC)
EAI: 106832251(APC) 106834222(APC2)
MYB: 102243742(APC2) 102246124(APC)
MYD: 102751934(APC) 102768246(APC2)
MMYO: 118655759(APC) 118658707(APC2)
MLF: 102420488(APC2) 102438347(APC)
MNA: 107534581(APC2) 107546495(APC)
PKL: 118703090(APC) 118711738(APC2)
HAI: 109390647(APC2) 109391522(APC)
DRO: 112307214(APC) 112312489(APC2)
SHON: 118977277(APC) 118984418(APC2)
AJM: 119043997(APC2) 119065104(APC)
PDIC: 114493533(APC) 114502890(APC2)
MMF: 118616287(APC2) 118641379(APC)
RFQ: 117024772(APC) 117037610(APC2)
PALE: 102880260(APC) 102891886(APC2)
PGIG: 120583698(APC2) 120590819(APC)
PVP: 105295478(APC) 105302259(APC2)
RAY: 107500934(APC2) 107512008(APC)
MJV: 108404758(APC2) 108408639(APC)
TOD: 119240507(APC2) 119260791(APC)
SARA: 101536960(APC2) 101550252(APC)
LAV: 100659017(APC)
DNM: 101412070(APC2) 101415427(APC)
MDO: 100013592(APC) 100020785(APC2)
GAS: 123235937(APC) 123256777(APC2)
SHR: 100915224(APC) 100925931(APC2)
PCW: 110223441(APC2) 110223808(APC)
OAA: 100082114(APC) 100682203(APC2)
GGA: 415607(APC) 429363(APC2)
PCOC: 116235793(APC2) 116239722(APC)
MGP: 100544685(APC2) 104915165
CJO: 107306337(APC) 107325420(APC2)
NMEL: 110389073(APC2) 110390295(APC)
APLA: 101793979(APC2) 101795988(APC)
ACYG: 106042343(APC) 106048197(APC2)
AFUL: 116498976(APC2) 116500517(APC)
TGU: 100217575(APC2) 100231767(APC)
LSR: 110467601(APC) 110480191(APC2)
SCAN: 103822055(APC2) 103824192(APC)
PMOA: 120500892(APC) 120513460(APC2)
OTC: 121333117(APC) 121342399(APC2)
PRUF: 121355547(APC) 121360801(APC2)
GFR: 102038857(APC2) 102041365(APC)
FAB: 101819406(APC) 101820774(APC2)
PHI: 102099173(APC) 102111044(APC2)
PMAJ: 107215377(APC2) 107216177(APC)
CCAE: 111940694(APC)
CCW: 104684175(APC) 104697069(APC2)
ETL: 114054675(APC) 114066385(APC2)
ZAB: 102070087(APC)
FPG: 101912417(APC2) 101913625(APC)
FCH: 102051031(APC) 102052505(APC2)
CLV: 102093207(APC) 102094189(APC2)
EGZ: 104128291 104135069(APC)
NNI: 104016295(APC2) 104022195(APC)
ACUN: 113489551(APC)
TALA: 104358037(APC) 116963923(APC2)
PADL: 103914450(APC)
ACHC: 115336672(APC) 115348841(APC2) 121232399
AAM: 106486559(APC2)
AROW: 112963118(APC) 112965605(APC2)
NPD: 112946889(APC2) 112958884(APC)
DNE: 112993218(APC2) 112995240(APC)
ASN: 102376341(APC2) 102377654(APC)
AMJ: 102567239(APC) 102570878(APC2)
CPOO: 109308176(APC) 109312398(APC2)
GGN: 109294711(APC2) 109297482(APC)
PSS: 102462387(APC) 102463006(APC2)
CMY: 102943104(APC) 102947058(APC2)
CPIC: 101935001(APC2) 101952269(APC)
TST: 117868794(APC2) 117879169(APC)
CABI: 116817832(APC) 116831262(APC2)
MRV: 120391683(APC2) 120408706(APC)
ACS: 100559625(apc2) 100561377(apc)
PVT: 110072031(APC) 110072522(APC2)
SUND: 121921273(APC) 121937000(APC2)
PBI: 103062549(APC) 103068257(APC2)
PMUR: 107282849(APC2) 107293244(APC)
TSR: 106540739(APC) 106554481
PGUT: 117668615(APC2) 117674641(APC)
VKO: 123031206(APC) 123036595(APC2)
PMUA: 114588347(APC2) 114606736(APC)
ZVI: 118076844(APC) 118087960(APC2)
GJA: 107116347(APC2) 107116684(APC)
STOW: 125432348(APC2) 125436511(APC)
XLA: 108704666 108707215(apc.S) 108712468(apc2.L) 399455(apc.L)
XTR: 100487473(apc2) 779466(apc)
NPR: 108791892(APC) 108793493(APC2)
RTEM: 120913502(APC2) 120931734(APC)
BBUF: 120990916(APC2) 120992575(APC)
BGAR: 122924639(APC) 122927273(APC2)
DRE: 386762(apc) 565771(apc2)
PPRM: 120464195(apc2) 120479106(apc)
MAMB: 125256485(apc2) 125262456(apc)
IPU: 108270570(apc2) 108277162(apc)
PHYP: 113530619(apc2) 113544727(apc)
SMEO: 124391518(apc2) 124393273(apc)
TFD: 113638302(apc) 113657671(apc2)
AMEX: 103031611(apc) 103040193(apc2)
EEE: 113568528 113573290(apc)
TRU: 101062949 101079661(apc)
LCO: 104935740(apc2) 104937427
NCC: 104945360 104953209(apc)
CGOB: 115006676
ELY: 117254493(apc2) 117269591(apc)
PLEP: 121941080(apc2) 121960314(apc)
SLUC: 116065918(apc) 116066740(apc2)
ECRA: 117950740(apc2) 117959791(apc)
PFLV: 114551633 114562099(apc2)
GAT: 120823883(apc2) 120831685
PPUG: 119217164(apc2) 119226830(apc)
CUD: 121512380(apc2) 121524668(apc)
MZE: 101476338(apc) 101485384(apc2)
ONL: 100696028(apc2) 100709462
OAU: 116321852(apc) 116333058(apc2)
OLA: 101162682(apc) 101169683(apc2)
OML: 112138598(apc) 112150228(apc2)
XMA: 102216614(apc) 102228122(apc2)
XCO: 114136953(apc) 114150859(apc2)
XHE: 116724072(apc) 116725437(apc2)
PRET: 103460454(apc) 103463143(apc2)
PFOR: 103130351 103153769(apc2)
PLAI: 106939086(apc) 106942250(apc2)
PMEI: 106906682 106930185(apc2)
GAF: 122819412(apc) 122838538(apc2)
CVG: 107089202(apc2) 107098056(apc)
CTUL: 119774466(apc) 119784740(apc2)
GMU: 124872706(apc) 124873874(apc2)
NFU: 107374978(apc) 107392633(apc2)
KMR: 108228399(apc) 108246653(apc2)
ALIM: 106520257(apc2) 106537373
NWH: 119424671(apc) 119430481(apc2)
AOCE: 111568825(apc) 111575977(apc2)
CSEM: 103390350(apc) 103398463(apc2)
SSEN: 122758515(apc) 122781114(apc2)
HHIP: 117760864(apc2) 117771291(apc)
SDU: 111231812(apc2) 111238745(apc)
SLAL: 111670241(apc) 111671636
XGL: 120790340(apc2) 120806227(apc)
HCQ: 109506820(apc2) 109527897
BPEC: 110166035(apc) 110166729(apc2)
MALB: 109965259(apc2) 109973127(apc)
ELS: 105011386(apc2) 105029631(apc)
SFM: 108925092(apc) 108930605(apc2) 108938110
PKI: 111835593(apc) 111844637(apc2) 111856563
LOC: 102693649(apc2) 102695054(apc)
LCM: 102356342(APC) 102364375(APC2)
CMK: 103181147(apc) 103182088(apc2)
RTP: 109914901 109929957(apc)
BFO: 118411611
BBEL: 109468773
CIN: 778909
SCLV: 120336871
SPU: 578083
APLC: 110987304
SKO: 100371477(apc)
DME: Dmel_CG1451(Apc) Dmel_CG6193(Apc2)
DSI: Dsimw501_GD18013(Dsim_GD18013) Dsimw501_GD21072(Dsim_GD21072)
DGR: 6567368
CCAT: 101452201
BOD: 106616045
MDE: 101895218
SCAC: 106080627
LCQ: 111678274
ACOZ: 120951118
AARA: 120905868
AAG: 110674862
CPII: 120424024
CNS: 116343560
ACER: 107995316
ALAB: 122718592
BIM: 100744104
BBIF: 117206217
BVK: 117240889
BVAN: 117162117
BTER: 100644421
BPYO: 122570354
CCAL: 108632269
OBB: 114875758
MGEN: 117224212
NMEA: 116429512
CGIG: 122396064
SOC: 105197114
MPHA: 105837282
AEC: 105148599
ACEP: 105620768
PBAR: 105433821
VEM: 105563321
HST: 105181272
DQU: 106741609
CFO: 105251334
FEX: 115236533
LHU: 105675015
PGC: 109851743
OBO: 105283639
PCF: 106791038
PFUC: 122518035
VPS: 122634351
NVI: 100118980
CSOL: 105364598
TPRE: 106654206
CGLO: 123270267
FAS: 105264034
DAM: 107041242
CCIN: 107273236
TCA: 661294
SOY: 115874953
AGB: 108913937
LDC: 111505255
NVL: 108559352
APLN: 108738806
OTU: 111428436
BMOR: 101745327
BMAN: 114240012
BANY: 112047899
PMAC: 106711851
PXU: 106117050
PRAP: 110992028
ZCE: 119839446
HAW: 110376150
TNL: 113493222
SLIU: 111362128
OFU: 114352794
API: 100166146
DNX: 107163228
AGS: 114122080
RMD: 113556003
BTAB: 109042562
CLEC: 106664239
HHAL: 106685549
NLU: 111044809
FOC: 113216618
ZNE: 110840108
CSEC: 111871273
FCD: 110849042
PVM: 113804138
PJA: 122263163
PCHN: 125045836
HAME: 121867580
PCLA: 123762695
PTRU: 123506875
HAZT: 108682645
EAF: 111704252
LSM: 121114662
DSV: 119456221
RSAN: 119393317
RMP: 119171561
VDE: 111244083
VJA: 111269635
TUT: 107365525
DPTE: 113789679
DFR: 124498445
PCAN: 112558128
GAE: 121373432
HRF: 124117596
HRJ: 124290110
CRG: 105323165
MYI: 110447351
PMAX: 117315711
OBI: 106883440
OSN: 115210882
LAK: 106157029
EGL: EGR_05086
NVE: 116609777
EPA: 110239175
ATEN: 116298456
AMIL: 114964480
PDAM: 113670901
SPIS: 111324332
DGT: 114525251
XEN: 124452252
HMG: 100203938
 » show all
Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Nathke IS
A role for the Adenomatous Polyposis Coli protein in chromosome segregation.
Nat Cell Biol 3:429-32 (2001)
van Es JH, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, Destree O, Peifer M, Clevers H
Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor.
Curr Biol 9:105-8 (1999)
Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W, Groden J, Stevens J, Spirio L, Robertson M, et al.
Identification of deletion mutations and three new genes at the familial polyposis locus.
Cell 66:601-13 (1991)

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