KEGG   ORTHOLOGY: K02091Help
Entry
K02091                      KO                                     

Name
CDK6
Definition
cyclin-dependent kinase 6 [EC:2.7.11.22]
Pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04934  Cushing syndrome
ko05160  Hepatitis C
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05214  Glioma
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Module
M00692  Cell cycle - G1/S transition
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K02091  CDK6; cyclin-dependent kinase 6
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02091  CDK6; cyclin-dependent kinase 6
   04115 p53 signaling pathway
    K02091  CDK6; cyclin-dependent kinase 6
   04218 Cellular senescence
    K02091  CDK6; cyclin-dependent kinase 6
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05206 MicroRNAs in cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05203 Viral carcinogenesis
    K02091  CDK6; cyclin-dependent kinase 6
  09162 Cancers: Specific types
   05212 Pancreatic cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05225 Hepatocellular carcinoma
    K02091  CDK6; cyclin-dependent kinase 6
   05214 Glioma
    K02091  CDK6; cyclin-dependent kinase 6
   05220 Chronic myeloid leukemia
    K02091  CDK6; cyclin-dependent kinase 6
   05218 Melanoma
    K02091  CDK6; cyclin-dependent kinase 6
   05224 Breast cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05222 Small cell lung cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05223 Non-small cell lung cancer
    K02091  CDK6; cyclin-dependent kinase 6
  09167 Endocrine and metabolic diseases
   04934 Cushing syndrome
    K02091  CDK6; cyclin-dependent kinase 6
  09172 Infectious diseases: Viral
   05162 Measles
    K02091  CDK6; cyclin-dependent kinase 6
   05160 Hepatitis C
    K02091  CDK6; cyclin-dependent kinase 6
   05163 Human cytomegalovirus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05169 Epstein-Barr virus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05165 Human papillomavirus infection
    K02091  CDK6; cyclin-dependent kinase 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02091  CDK6; cyclin-dependent kinase 6
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00692  Cell cycle - G1/S transition
     K02091  CDK6; cyclin-dependent kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02091  CDK6; cyclin-dependent kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02091  CDK6; cyclin-dependent kinase 6
BRITE hierarchy
Genes
HSA: 1021(CDK6)
PTR: 746968(CDK6)
PPS: 100981258(CDK6)
GGO: 109023121(CDK6)
PON: 100454924(CDK6)
NLE: 100602542(CDK6)
MCC: 701822(CDK6)
MCF: 102140874(CDK6)
CSAB: 103226555(CDK6)
RRO: 104682750(CDK6)
RBB: 108528490(CDK6)
CJC: 100385604(CDK6)
SBQ: 101040507(CDK6)
MMU: 12571(Cdk6)
RNO: 114483(Cdk6)
CGE: 100764515(Cdk6)
NGI: 103725210(Cdk6)
HGL: 101719908(Cdk6)
CCAN: 109684667 109684671
OCU: 100009040(CDK6)
TUP: 102488432(CDK6)
CFA: 609920(CDK6)
AML: 100476389(CDK6)
UMR: 103658796(CDK6)
ORO: 101378405(CDK6)
FCA: 100037415(CDK6)
PTG: 102967948(CDK6)
AJU: 106969949(CDK6)
BTA: 511754(CDK6)
BOM: 102264992(CDK6)
BIU: 109558203(CDK6)
PHD: 102321501(CDK6)
CHX: 102180182(CDK6)
OAS: 100144761(CDK6)
CFR: 102520456(CDK6)
CDK: 105088747(CDK6)
BACU: 103011327(CDK6)
LVE: 103081338(CDK6)
OOR: 101271733(CDK6)
ECB: 100061625(CDK6)
EPZ: 103549196(CDK6)
EAI: 106832259(CDK6)
MYB: 102258140(CDK6)
MYD: 102760528(CDK6)
HAI: 109373596(CDK6)
RSS: 109446377(CDK6)
PALE: 102896272(CDK6)
LAV: 100655429(CDK6)
TMU: 101350687 111819047
MDO: 100021675(CDK6)
SHR: 100924154(CDK6)
OAA: 100091822(CDK6)
GGA: 420558(CDK6)
MGP: 100539044(CDK6)
CJO: 107309074(CDK6)
APLA: 101793324(CDK6)
ACYG: 106039673(CDK6)
TGU: 100229620(CDK6)
SCAN: 103812819(CDK6)
GFR: 102034159(CDK6)
FAB: 101815768(CDK6)
PHI: 102114646(CDK6)
PMAJ: 107200146(CDK6)
CCAE: 111924218(CDK6)
CCW: 104689173(CDK6)
FPG: 101921135(CDK6)
FCH: 102047555(CDK6)
CLV: 102091430(CDK6)
EGZ: 104128955(CDK6)
NNI: 104014021(CDK6)
ACUN: 113476723(CDK6)
AAM: 106483627(CDK6)
ASN: 102387975(CDK6)
AMJ: 102561028(CDK6)
PSS: 102454031(CDK6)
CMY: 102944070(CDK6)
CPIC: 101938073(CDK6)
ACS: 100558412(cdk6)
PVT: 110074720(CDK6)
PBI: 103059655(CDK6)
PMUR: 107283642(CDK6)
GJA: 107108272(CDK6)
XLA: 108718479 108719900
XTR: 100489734(cdk6)
NPR: 108787899(CDK6)
DRE: 100034507(cdk6) 569515(cdk21)
SRX: 107712927 107720098 107722162 107738149
SANH: 107654471 107667775 107669887 107674697
SGH: 107558583 107567973 107581773 107591488
CCAR: 109051258 109052112 109069875 109111198 109111768
IPU: 108257114(cdk6) 108274791
PHYP: 113528439 113536004(cdk6)
AMEX: 103047757(cdk6)
TRU: 101070296(cdk6) 101078305
TNG: GSTEN00027855G001 GSTEN00032981G001
LCO: 104926452 104927455(cdk6)
NCC: 104944671
MZE: 101464773(cdk6) 101478399
OLA: 101165981 101168879(cdk6)
XMA: 102235700(cdk6) 102237928
PRET: 103469340 103472249(cdk6)
NFU: 107378559 107383310(cdk6)
KMR: 108237737 108241821(cdk6)
CSEM: 103392753 103394142(cdk6)
LCF: 108872758 108877644(cdk6)
SDU: 111217648 111223044(cdk6)
HCQ: 109527671(cdk6) 109532677
BPEC: 110159294
MALB: 109963185 109968183(cdk6)
SASA: 100286677(cdk6) 106588946 106600958
OTW: 112229496 112229497 112258622 112259968
SALP: 111954777 111955311 111955811 111981062
ELS: 105007255 105022797(cdk6)
SFM: 108921985(cdk6)
LCM: 102353660(CDK6) 102366718
CMK: 103183765 103185269(cdk6)
BFO: BRAFLDRAFT_241390
CIN: 100175205
SPU: 373289(cdk4)
APLC: 110984198
SKO: 100371039
FCD: 110852991
ISC: IscW_ISCW016926
TUT: 107365344
CEL: CELE_F18H3.5(cdk-4)
HRO: HELRODRAFT_186752 HELRODRAFT_97484
LGI: LOTGIDRAFT_220339
CRG: 105327718 105346043
MYI: 110452126
OBI: 106881146
LAK: 106162008
SHX: MS3_06893
OVI: T265_00535
EGL: EGR_00718
NVE: NEMVE_v1g244885
EPA: 110244942
PDAM: 113669926
SPIS: 111332639
HMG: 100206502
TAD: TRIADDRAFT_52937
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lucas JJ, Domenico J, Gelfand EW
  Title
Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.
  Journal
Mol Cancer Res 2:105-14 (2004)
  Sequence
[hsa:1021]
Reference
PMID:1639063
  Authors
Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH
  Title
A family of human cdc2-related protein kinases.
  Journal
EMBO J 11:2909-17 (1992)
  Sequence
[hsa:1021]

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (45)   
   KEGG PATHWAY (44)   
   KEGG MODULE (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (8)   
   KEGG DRUG (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1259)   
   KEGG GENES (186)   
   KEGG MGENES (39)   
   RefGene (1028)   
   OC (6)   
Protein sequence (70)   
   UniProt (67)   
   SWISS-PROT (3)   
Literature (2)   
   PubMed (2)   
All databases (1390)   

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