KEGG   ORTHOLOGY: K02145
Entry
K02145                      KO                                     
Symbol
ATPeV1A, ATP6A
Name
V-type H+-transporting ATPase subunit A [EC:7.1.2.2]
Pathway
map00190  Oxidative phosphorylation
map01100  Metabolic pathways
map04145  Phagosome
map04150  mTOR signaling pathway
map04721  Synaptic vesicle cycle
map04966  Collecting duct acid secretion
map05110  Vibrio cholerae infection
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05165  Human papillomavirus infection
map05323  Rheumatoid arthritis
Module
M00160  V-type ATPase, eukaryotes
Disease
H00557  Cutis laxa
H00606  Early infantile epileptic encephalopathy
H02150  Infantile or early childhood epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
 09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
 09150 Organismal Systems
  09155 Excretory system
   04966 Collecting duct acid secretion
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
  09156 Nervous system
   04721 Synaptic vesicle cycle
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
 09160 Human Diseases
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
  09163 Immune disease
   05323 Rheumatoid arthritis
    K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
Enzymes [BR:ko01000]
 7. Translocases
  7.1  Catalysing the translocation of hydrons
   7.1.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.1.2.2  H+-transporting two-sector ATPase
     K02145  ATPeV1A, ATP6A; V-type H+-transporting ATPase subunit A
Other DBs
COG: COG1155
GO: 0046961
TC: 3.A.2.2
Genes
HSA: 523(ATP6V1A)
PTR: 460590(ATP6V1A)
PPS: 100980582(ATP6V1A)
GGO: 101132508(ATP6V1A)
PON: 100172972(ATP6V1A)
NLE: 100591065(ATP6V1A)
MCC: 709958(ATP6V1A)
MCF: 102115629 102128783(ATP6V1A)
CSAB: 103228299(ATP6V1A)
CATY: 105596281(ATP6V1A)
PANU: 101007030(ATP6V1A)
TGE: 112618420(ATP6V1A)
RRO: 104660614(ATP6V1A)
RBB: 108519506(ATP6V1A)
TFN: 117083502(ATP6V1A)
PTEH: 111543504(ATP6V1A) 111549197
CJC: 100411357(ATP6V1A)
SBQ: 101041261(ATP6V1A)
CSYR: 103257766(ATP6V1A)
MMUR: 105883925(ATP6V1A)
OGA: 100958623(ATP6V1A)
MMU: 11964(Atp6v1a)
MCAL: 110311958(Atp6v1a)
MPAH: 110329651(Atp6v1a)
RNO: 685232(Atp6v1a)
MCOC: 116085932(Atp6v1a)
CGE: 100768315(Atp6v1a)
PLEU: 114694973(Atp6v1a)
NGI: 103741925(Atp6v1a)
HGL: 101717344(Atp6v1a)
CPOC: 100733879(Atp6v1a)
CCAN: 109698026(Atp6v1a)
DORD: 105994914(Atp6v1a)
DSP: 122105668(Atp6v1a)
NCAR: 124993037
OCU: 100347673(ATP6V1A)
OPI: 101517947(ATP6V1A)
TUP: 102480786(ATP6V1A)
CFA: 487981(ATP6V1A)
VVP: 112913438(ATP6V1A)
VLG: 121484682(ATP6V1A)
AML: 100472276(ATP6V1A)
UMR: 103678812(ATP6V1A)
UAH: 113251490(ATP6V1A)
UAR: 123784051(ATP6V1A)
ELK: 111151188
LLV: 125097455
MPUF: 101693688(ATP6V1A)
ORO: 101365768(ATP6V1A)
EJU: 114214765(ATP6V1A)
ZCA: 113918902(ATP6V1A)
MLX: 118007092(ATP6V1A)
FCA: 101091723(ATP6V1A)
PYU: 121036251(ATP6V1A)
PBG: 122491453(ATP6V1A)
PTG: 102953506(ATP6V1A)
PPAD: 109266406(ATP6V1A)
AJU: 106977759(ATP6V1A)
HHV: 120248329(ATP6V1A)
BTA: 282147(ATP6V1A)
BOM: 102276594(ATP6V1A)
BIU: 109562499(ATP6V1A)
BBUB: 102410690(ATP6V1A)
CHX: 102186053(ATP6V1A)
OAS: 101102025(ATP6V1A)
ODA: 120851553(ATP6V1A)
CCAD: 122445555(ATP6V1A)
SSC: 445531(ATP6V1A)
CFR: 102523779(ATP6V1A)
CBAI: 105081572(ATP6V1A)
CDK: 105093200(ATP6V1A)
VPC: 102542005(ATP6V1A)
BACU: 103010870(ATP6V1A)
LVE: 103082380(ATP6V1A)
OOR: 101271026(ATP6V1A)
DLE: 111164226(ATP6V1A)
PCAD: 102996583(ATP6V1A)
PSIU: 116753026(ATP6V1A)
ECB: 100061223(ATP6V1A)
EPZ: 103552845(ATP6V1A)
EAI: 106829494(ATP6V1A)
MYB: 102251036(ATP6V1A)
MYD: 102758035(ATP6V1A)
MMYO: 118676142(ATP6V1A)
MLF: 102427446(ATP6V1A)
MNA: 107527450(ATP6V1A)
PKL: 118724554(ATP6V1A)
HAI: 109387972(ATP6V1A)
DRO: 112320533(ATP6V1A)
SHON: 118994737(ATP6V1A)
AJM: 119043041(ATP6V1A) 119058082
PDIC: 114489695(ATP6V1A)
PHAS: 123827197(ATP6V1A)
MMF: 118617111(ATP6V1A)
RFQ: 117036068(ATP6V1A)
PALE: 102898547(ATP6V1A)
PGIG: 120586637(ATP6V1A)
PVP: 105303967(ATP6V1A)
RAY: 107513702(ATP6V1A)
MJV: 108396238(ATP6V1A)
TOD: 119257512(ATP6V1A)
SARA: 101541862(ATP6V1A)
LAV: 100653567(ATP6V1A)
TMU: 101355338
DNM: 101423869(ATP6V1A)
MDO: 100011348(ATP6V1A)
GAS: 123239493(ATP6V1A)
SHR: 100934335(ATP6V1A)
PCW: 110222274(ATP6V1A)
OAA: 100088320(ATP6V1A)
GGA: 395821(ATP6V1A) 776719(ATP6V1AL)
PCOC: 116238450 116242412(ATP6V1A)
MGP: 100540888 100542050(ATP6V1A)
CJO: 107319452(ATP6V1A) 107324585
NMEL: 110387806 110399040(ATP6V1A)
APLA: 101794496(ATP6V1A)
ACYG: 106045723(ATP6V1A)
AFUL: 116488671(ATP6V1A) 116499711
TGU: 100229321(ATP6V1A) 115498404
LSR: 110479041 110480867(ATP6V1A)
SCAN: 103827128(ATP6V1A)
PMOA: 120506364(ATP6V1A) 120506538
OTC: 121338567 121339217(ATP6V1A)
PRUF: 121351537(ATP6V1A) 121360146
GFR: 102038391(ATP6V1A)
FAB: 101819791 101819794(ATP6V1A)
PHI: 102103005(ATP6V1A) 102106908
PMAJ: 107208653(ATP6V1A)
CCAE: 111938686(ATP6V1A)
CCW: 104687098(ATP6V1A)
ETL: 114062558(ATP6V1A) 114071451
ZAB: 102063891(ATP6V1A)
FPG: 101914658 101919463(ATP6V1A)
FCH: 102049220(ATP6V1A) 102060150
CLV: 102086044(ATP6V1A) 102095060
EGZ: 104126513(ATP6V1A)
NNI: 104008620(ATP6V1A) 104014444
ACUN: 113477758(ATP6V1A)
TALA: 104356646(ATP6V1A) 116962201
PADL: 103921291(ATP6V1A)
ACHC: 115344050(ATP6V1A) 115346515
AAM: 106493007 106497259(ATP6V1A)
AROW: 112965950(ATP6V1A) 112974578
NPD: 112955229 112960086(ATP6V1A)
DNE: 112985084(ATP6V1A) 112995682
ASN: 102375315 102375327(ATP6V1A)
AMJ: 102571000(ATP6V1A) 102575551(ATP6V1A)
CPOO: 109319171(ATP6V1A)
GGN: 109304391(ATP6V1A)
PSS: 102447139 102448205(ATP6V1A)
CMY: 102933977(ATP6V1A) 102935107
CPIC: 101943757(ATP6V1A) 101945735
TST: 117869553 117886381(ATP6V1A)
CABI: 116820873(ATP6V1A) 116825333
MRV: 120390273 120400535(ATP6V1A)
ACS: 100554836(atp6v1a) 100562722
PVT: 110076930(ATP6V1A) 110088132
SUND: 121915662 121920986(ATP6V1A)
PBI: 103048956 103058633(ATP6V1A)
PMUR: 107284113(ATP6V1A) 107293815
PGUT: 117661875(ATP6V1A) 117670836
VKO: 123032950 123033254(ATP6V1A)
PMUA: 114586258 114588141(ATP6V1A)
ZVI: 118075888 118097619(ATP6V1A)
GJA: 107107967 107111856(ATP6V1A)
STOW: 125425231(ATP6V1A) 125442213
XLA: 108709283(atp6v1a.S) 379796(atp6v1al.L) 734627(atp6v1a.L)
XTR: 394868(atp6v1al) 493238(atp6v1a)
NPR: 108794245 108800123(ATP6V1A)
RTEM: 120920858 120928065(ATP6V1A)
BBUF: 120982091 120994374(ATP6V1A)
BGAR: 122930645(ATP6V1A)
DRE: 337583(atp6v1ab) 394110(atp6v1aa)
PPRM: 120470431(atp6v1aa) 120476058(atp6v1ab)
MAMB: 125257539(atp6v1ab) 125266619(atp6v1aa)
IPU: 108256618(atp6v1ab)
PHYP: 113531406 113541262(atp6v1a)
SMEO: 124375340(atp6v1ab)
TFD: 113661674(atp6v1ab)
AMEX: 103041856(atp6v1a) 103045016
EEE: 113570270 113576113(atp6v1a)
TRU: 101062023(atp6v1a) 101072050
LCO: 109141826(atp6v1a)
NCC: 104940997 104965997(atp6v1a)
CGOB: 115019245 115025374(atp6v1a)
ELY: 117247362 117265017(atp6v1ab)
PLEP: 121952431 121960857(atp6v1ab)
SLUC: 116037917(atp6v1ab) 116064917
ECRA: 117938134(atp6v1ab) 117956094
PFLV: 114549431(atp6v1a) 114566429
GAT: 120811495(atp6v1ab) 120822162
PPUG: 119198835(atp6v1ab) 119215685
MSAM: 119895749 119909978(atp6v1ab)
CUD: 121518645 121527207(atp6v1ab)
MZE: 101464477(atp6v1a) 101468244
ONL: 100710668 100710754(atp6v1a)
OAU: 116314434(atp6v1ab) 116336189
OLA: 101165416 101175115(atp6v1a)
OML: 112142898 112151199(atp6v1ab)
XMA: 102221550(atp6v1a) 102233759
XCO: 114136704(atp6v1a) 114153696
XHE: 116711746(atp6v1a) 116728956
PRET: 103456644(atp6v1a) 103475419
PFOR: 103139754(atp6v1a) 103141584
PLAI: 106944636(atp6v1a) 106952452
PMEI: 106909200(atp6v1a) 106921950
GAF: 122824629(atp6v1ab) 122844473
CVG: 107097936(atp6v1a) 107104603
CTUL: 119778325 119789033(atp6v1ab)
GMU: 124858379(atp6v1ab) 124875818
NFU: 107382853(atp6v1a) 107386421
KMR: 108230230(atp6v1ab) 108236878
ALIM: 106513412(atp6v1a) 106526133
AOCE: 111583144(atp6v1a) 111587180
CSEM: 103377240(atp6v1a) 103395476
POV: 109628772 109629865(atp6v1a)
SSEN: 122777717(atp6v1ab) 122780170
HHIP: 117753792(atp6v1ab) 117774902
LCF: 108881739(atp6v1a) 108893523
SDU: 111221014(atp6v1a) 111234447
SLAL: 111662977(atp6v1a) 111666254 111666874
XGL: 120789658(atp6v1ab) 120803034
HCQ: 109514041(atp6v1a) 109517920
BPEC: 110160930(atp6v1a)
MALB: 109959440 109960156(atp6v1a)
SASA: 106563593(VATA) 106579446(VATA) 106590474(VATA) 106603053(VATA)
ELS: 105021970(atp6v1a) 105027670
SFM: 108939659(atp6v1a)
PKI: 111860990(atp6v1a)
AANG: 118235026
LOC: 102694402(atp6v1a)
PSPA: 121302701(atp6v1ab) 121305444
LCM: 102350094(ATP6V1A) 102351436
CMK: 103177564(atp6v1ab)
RTP: 109914252(atp6v1a)
BFO: 118413398
BBEL: 109484061
CIN: 100184809
SCLV: 120327134
APLC: 110990397
SKO: 100370533
DME: Dmel_CG12403(Vha68-1) Dmel_CG3762(Vha68-2) Dmel_CG5075(Vha68-3)
DSI: Dsimw501_GD22093(Dsim_Vha68-1) Dsimw501_GD23860(Dsim_GD23860) Dsimw501_GD23861(Dsim_GD23861)
AGA: AgaP_AGAP003153(VATA_ANOGA)
ACOZ: 120953943
AARA: 120895218
AAG: 5571080
AALB: 109419385
CPII: 120414792
CNS: 116340625
AME: 551093
ACER: 108000577
ALAB: 122713496
BIM: 100741754
BBIF: 117207127
BVK: 117233993
BVAN: 117158755
BTER: 100643332
BPYO: 122571165
CCAL: 108623939
OBB: 114875345
MGEN: 117224713
NMEA: 116430840
CGIG: 122396943
SOC: 105198578
MPHA: 105835098
AEC: 105143572
ACEP: 105620523
PBAR: 105428407
VEM: 105562334
HST: 105188914
DQU: 106743069
CFO: 105248952
FEX: 115237789
LHU: 105676545
PGC: 109856838
OBO: 105286286
PCF: 106784270
PFUC: 122521450
VPS: 122638207
MDL: 103575260
AGIF: 122847487
TCA: 663322(NtpA)
SOY: 115876394
CSET: 123309375
AGB: 108917437
LDC: 111502435
NVL: 108562512
APLN: 108738043
PPYR: 116168190
OTU: 111416830
BMOR: 100037424
BMAN: 114250130
MSEX: 115446150
BANY: 112047593
PMAC: 106708426
PPOT: 106100861
PRAP: 110991936
ZCE: 119833081
HAW: 110369820
TNL: 113496116
SLIU: 111356441
OFU: 114349659
PXY: 105392322
API: 100161355
DNX: 107169017
AGS: 114119053
RMD: 113552175
BTAB: 109030986
DCI: 103507511
CLEC: 106673030
HHAL: 106678503
NLU: 111053189
ZNE: 110826824
CSEC: 111861955
FCD: 110845211
DMK: 116919536
PVM: 113801067
PJA: 122249954
PCHN: 125025958
HAME: 121874102
PCLA: 123771441
PTRU: 123511865
HAZT: 108672304
EAF: 111697030
LSM: 121132321
DSV: 119455928
RSAN: 119393986
RMP: 119172104
VDE: 111254335
VJA: 111263492
TUT: 107363049
DFR: 124490497
CSCU: 111642525
PTEP: 107456819
SDM: 118200698
CEL: CELE_Y49A3A.2(vha-13)
CBR: CBG_04632(Cbr-vha-13)
PCAN: 112567939
BGT: 106070709
GAE: 121386261
CRG: 105321678
MYI: 110462983
PMAX: 117341302
MMER: 123561296
OBI: 106869851
OSN: 115221352
EGL: EGR_04878
NVE: 5504836
EPA: 110251138
ATEN: 116298244
ADF: 107358398
AMIL: 114953903
PDAM: 113666489
SPIS: 111342449
DGT: 114524380
XEN: 124446515
HMG: 100198784
AQU: 100633644
ATH: AT1G78900(VHA-A)
ALY: 9325282
CRB: 17896555
CPAP: 110807980
CIT: 102578066
PVY: 116116295
TCC: 18595594
VRA: 106773955
VAR: 108320634
VUN: 114167641
CCAJ: 109807965
CAM: 101513091
LJA: Lj3g3v2038850.1(Lj3g3v2038850.1)
ADU: 107482513
AIP: 107638381
FVE: 101313037
RCN: 112188147
PPER: 18781851
PMUM: 103327431
PAVI: 110750002
PDUL: 117620709
ZJU: 107428241
MNT: 21387324
CSV: 101216234(VHA-A)
CMO: 103500619
BHJ: 120086726
MCHA: 111016598
RCU: 8259960
JCU: 105646144
JRE: 109004247
CCAV: 112508797
DCR: 108209232
BVG: 104906090(BV-70/5)
SOE: 110792750
DOSA: Os02t0175400-01(Os02g0175400) Os06t0662000-01(Os06g0662000)
ATS: 109765103
DCT: 110095096
PEQ: 110025190
ATR: 18440712
VCN: VOLCADRAFT_74447(atpva1)
APRO: F751_4958
SCE: YDL185W(VMA1)
SEUB: DI49_0895
ERC: Ecym_8050
KMX: KLMA_60497(VMA1)
NCS: NCAS_0A13840(NCAS0A13840)
NDI: NDAI_0A02200(NDAI0A02200)
TPF: TPHA_0A03200(TPHA0A03200)
TBL: TBLA_0D04500(TBLA0D04500)
TDL: TDEL_0H01420(TDEL0H01420)
KAF: KAFR_0B01130(KAFR0B01130)
KNG: KNAG_0C04050(KNAG0C04050)
PIC: PICST_75615(TFP1)
SPAA: SPAPADRAFT_61841(TFP1)
CAL: CAALFM_C301630WA(TFP1)
SLB: AWJ20_1002(VMA1)
BNN: FOA43_001134(TFP1)
BBRX: BRETT_003548(TFP1)
NCR: NCU01207(vma-1)
NTE: NEUTE1DRAFT115912(NEUTE1DRAFT_115912)
MGR: MGG_08087
SSCK: SPSK_04862
MAW: MAC_02085
MAJ: MAA_01535
CMT: CCM_03228
BFU: BCIN_04g03660(Bcvma1)
MBE: MBM_08417
ANI: AN8021.2
ANG: ANI_1_1468024(An02g10440)
ALUC: AKAW2_10888S(VMA1)
ACHE: ACHE_51016S(VMA1)
APUU: APUU_41553A(VMA1)
ABE: ARB_06796
PTE: PTT_06684
SPO: SPAC343.05(vma1)
CNE: CNE02210
CNB: CNBE2200
TASA: A1Q1_03876
MORE: E1B28_002672(VMA1)
ABP: AGABI1DRAFT53440(AGABI1DRAFT_53440)
ABV: AGABI2DRAFT216840(AGABI2DRAFT_216840)
WSE: WALSEDRAFT_23147(VmaA)
MGL: MGL_0569
MRT: MRET_4319
DDI: DDB_G0287127(vatA)
DFA: DFA_05337(vatA) DFA_05595
EHI: EHI_043010(111.t00022)
PCB: PCHAS_141230(PC001409.02.0)
TAN: TA10370
TPV: TP04_0714
BBO: BBOV_III008150(17.m07713)
CPV: cgd7_5000
SMIN: v1.2.035366.t1(symbB.v1.2.035366.t1)
TPS: THAPSDRAFT_37123(VAT2)
SPAR: SPRG_12251
EHX: EMIHUDRAFT_439538(ATPVA)
 » show all
Reference
  Authors
Cipriano DJ, Wang Y, Bond S, Hinton A, Jefferies KC, Qi J, Forgac M
  Title
Structure and regulation of the vacuolar ATPases.
  Journal
Biochim Biophys Acta 1777:599-604 (2008)
DOI:10.1016/j.bbabio.2008.03.013
Reference
  Authors
Jefferies KC, Cipriano DJ, Forgac M
  Title
Function, structure and regulation of the vacuolar (H+)-ATPases.
  Journal
Arch Biochem Biophys 476:33-42 (2008)
DOI:10.1016/j.abb.2008.03.025
Reference
PMID:8463241
  Authors
van Hille B, Richener H, Evans DB, Green JR, Bilbe G
  Title
Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma.
  Journal
J Biol Chem 268:7075-80 (1993)
  Sequence
[hsa:523]

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