KEGG   ORTHOLOGY: K02154Help
Entry
K02154                      KO                                     

Name
ATPeV0A, ATP6N
Definition
V-type H+-transporting ATPase subunit a
Pathway
ko00190  Oxidative phosphorylation
ko01100  Metabolic pathways
ko04142  Lysosome
ko04145  Phagosome
ko04721  Synaptic vesicle cycle
ko04966  Collecting duct acid secretion
ko05110  Vibrio cholerae infection
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05152  Tuberculosis
ko05165  Human papillomavirus infection
ko05323  Rheumatoid arthritis
Module
M00160  V-type ATPase, eukaryotes
Disease
H00428  Distal renal tubular acidosis (RTA type 1)
H00436  Osteopetrosis
H00557  Cutis laxa
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
   04142 Lysosome
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
 09150 Organismal Systems
  09155 Excretory system
   04966 Collecting duct acid secretion
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
  09156 Nervous system
   04721 Synaptic vesicle cycle
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
 09160 Human Diseases
  09162 Immune diseases
   05323 Rheumatoid arthritis
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
  09167 Infectious diseases
   05110 Vibrio cholerae infection
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
   05152 Tuberculosis
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
   05165 Human papillomavirus infection
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
KEGG modules [BR:ko00002]
 Structural complex
  Energy metabolism
   ATP synthesis
    M00160  V-type ATPase, eukaryotes
     K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K02154  ATPeV0A, ATP6N; V-type H+-transporting ATPase subunit a
BRITE hierarchy
Other DBs
COG: COG1269
TC: 3.A.2.2
Genes
HSA: 10312(TCIRG1) 23545(ATP6V0A2) 50617(ATP6V0A4) 535(ATP6V0A1)
PTR: 452354(ATP6V0A2) 454685(ATP6V0A1) 463765(ATP6V0A4) 466895(TCIRG1)
PPS: 100971999(ATP6V0A4) 100974286(ATP6V0A2) 100990028(ATP6V0A1) 100995029(TCIRG1)
GGO: 101139544(ATP6V0A1) 101140521(ATP6V0A4) 101141834(ATP6V0A2) 101148242(TCIRG1)
PON: 100173661(ATP6V0A1) 100451994(TCIRG1) 100460887(ATP6V0A4) 100939293(ATP6V0A2)
NLE: 100583652(TCIRG1) 100598544(ATP6V0A4) 100598741(ATP6V0A2) 100603157(ATP6V0A1)
MCC: 677865(ATP6V0A1) 710162(ATP6V0A2) 710650(TCIRG1) 715492(ATP6V0A4)
MCF: 101867133 102118234(TCIRG1) 102118312(ATP6V0A4) 102127448(ATP6V0A1) 102129208
CSAB: 103215553(TCIRG1) 103227405(ATP6V0A4) 103239340(ATP6V0A2) 103243409(ATP6V0A1)
RRO: 104656614(ATP6V0A4) 104664717(TCIRG1) 104666329(ATP6V0A2) 104680265(ATP6V0A1)
RBB: 108518317(ATP6V0A1) 108518675(TCIRG1) 108534827(ATP6V0A4) 108540639(ATP6V0A2)
CJC: 100405532(TCIRG1) 100406490(ATP6V0A4) 100412131(ATP6V0A1) 100896337(ATP6V0A2)
SBQ: 101037096(ATP6V0A2) 101045262(ATP6V0A4) 101049040(ATP6V0A1) 101053813(TCIRG1)
MMU: 11975(Atp6v0a1) 140494(Atp6v0a4) 21871(Atp6v0a2) 27060(Tcirg1)
RNO: 116455(Atp6v0a2) 293650(Tcirg1) 296981(Atp6v0a4) 29757(Atp6v0a1)
CGE: 100755303(Tcirg1) 100756648(Atp6v0a1) 100766909(Atp6v0a2) 100769769(Atp6v0a4)
NGI: 103726084(Atp6v0a4) 103735898(Atp6v0a1) 103739020(Atp6v0a2) 103744516(Tcirg1)
HGL: 101700877(Atp6v0a2) 101718747(Atp6v0a1) 101719254(Atp6v0a4) 101720677(Tcirg1)
CCAN: 109676700 109676703 109684877(Atp6v0a2) 109687326(Atp6v0a1) 109692077(Tcirg1)
OCU: 100125982(ATP6V0A1) 100125983(ATP6V0A2) 100347541(ATP6V0A4)
TUP: 102475330(ATP6V0A4) 102493162(ATP6V0A1) 102499874(ATP6V0A2) 102500889(TCIRG1)
CFA: 482779(ATP6V0A4) 483691(TCIRG1) 486245(ATP6V0A2) 607705(ATP6V0A1)
AML: 100470696(ATP6V0A1) 100472613(TCIRG1) 100482982(ATP6V0A4) 105238191(ATP6V0A2)
UMR: 103661250(ATP6V0A2) 103669049(ATP6V0A4) 103672574(ATP6V0A1) 103679623(TCIRG1)
ORO: 101374534(ATP6V0A1) 101376099(TCIRG1) 101381351(ATP6V0A4) 101382977(ATP6V0A2)
FCA: 101083709(TCIRG1) 101084995(ATP6V0A2) 101089593(ATP6V0A4) 101096367(ATP6V0A1)
PTG: 102948629(ATP6V0A4) 102948736(ATP6V0A1) 102958914(ATP6V0A2) 107180732
AJU: 106970427(ATP6V0A4) 106971092 106971174 106972610(ATP6V0A1) 106978342(ATP6V0A2)
BTA: 286768(ATP6V0A1) 338038(ATP6V0A2) 513684(TCIRG1) 518974(ATP6V0A4)
BOM: 102267750(TCIRG1) 102271215(ATP6V0A4) 102281348(ATP6V0A1) 102285852(ATP6V0A2)
BIU: 109553028 109554146(TCIRG1) 109557679(ATP6V0A4) 109571337(ATP6V0A2) 109573940(ATP6V0A1)
PHD: 102326293(ATP6V0A4) 102331486(ATP6V0A2) 102331795(TCIRG1) 102341031(ATP6V0A1) 102342726
CHX: 102171404(ATP6V0A4) 102179797(ATP6V0A2) 102186280(TCIRG1) 102186995(ATP6V0A1)
OAS: 101104057(ATP6V0A4) 101113184(TCIRG1) 101121550(ATP6V0A2) 101123476(ATP6V0A1)
SSC: 100154525(ATP6V0A2) 100519402(ATP6V0A4) 100521769(TCIRG1) 100523018(ATP6V0A1)
CFR: 102519197(ATP6V0A1) 102520369(ATP6V0A4) 102520543(TCIRG1) 102523048(ATP6V0A2)
CDK: 105090506(ATP6V0A1) 105091627(ATP6V0A4) 105094334(ATP6V0A2) 105104407(TCIRG1)
BACU: 103002161(ATP6V0A2) 103010634(TCIRG1) 103016593 103019480 103019646(ATP6V0A4)
LVE: 103068412(TCIRG1) 103068959(ATP6V0A1) 103073171(ATP6V0A4) 103076601(ATP6V0A2)
OOR: 101271452(TCIRG1) 101282363(ATP6V0A1) 101282573(ATP6V0A4) 101289177(ATP6V0A2)
ECB: 100052802(ATP6V0A1) 100061140(ATP6V0A2) 100064797(ATP6V0A4) 100146660(TCIRG1)
EPZ: 103545630 103549891(ATP6V0A2) 103550363(ATP6V0A1) 103551282(TCIRG1) 103559330(ATP6V0A4)
EAI: 106826331(ATP6V0A1) 106842224(ATP6V0A2) 106842640(ATP6V0A4) 106844252(TCIRG1)
MYB: 102242178(ATP6V0A4) 102247063(ATP6V0A2) 102257182(TCIRG1) 102263953(ATP6V0A1)
MYD: 102752608(ATP6V0A1) 102757306(ATP6V0A4) 102761519(TCIRG1) 102762561(ATP6V0A2)
HAI: 109386107(ATP6V0A2) 109388515 109388528 109389291(TCIRG1) 109395731(ATP6V0A1)
RSS: 109437965(TCIRG1) 109440127 109441395 109455801(ATP6V0A1) 109456471(ATP6V0A2) 109457486(ATP6V0A4)
PALE: 102881960(ATP6V0A4) 102883439(ATP6V0A1) 102887580(TCIRG1) 102896777(ATP6V0A2)
LAV: 100661949(ATP6V0A2) 100664975(ATP6V0A4) 100667060(TCIRG1) 100670350(ATP6V0A1)
MDO: 100011213(ATP6V0A1) 100013156(TCIRG1) 100017370(ATP6V0A4) 103101820(ATP6V0A2)
SHR: 100917978(TCIRG1) 100919520(ATP6V0A1) 100934805(ATP6V0A4) 105749382 111719266(ATP6V0A2) 111720526
OAA: 100076253(ATP6V0A2) 100091892(ATP6V0A4) 100092966(ATP6V0A1)
GGA: 395472(TCIRG1) 395473(ATP6V0A2) 395474(ATP6V0A1) 418104(ATP6V0A4)
MGP: 100539317(ATP6V0A2) 100547817(ATP6V0A4) 100549264(TCIRG1) 100549598(ATP6V0A1)
CJO: 107314206(TCIRG1) 107316067(ATP6V0A4) 107321171(ATP6V0A2) 107325148(ATP6V0A1)
APLA: 101797534(ATP6V0A4) 101798773(TCIRG1) 101799483(ATP6V0A2) 101805176(ATP6V0A1)
ACYG: 106031020(ATP6V0A4) 106031422(ATP6V0A2) 106048007(ATP6V0A1) 106048262(TCIRG1)
TGU: 100218036(ATP6V0A2) 100221499(ATP6V0A4) 100229310(ATP6V0A1) 100231607(TCIRG1)
GFR: 102033999(ATP6V0A4) 102035817(ATP6V0A1) 102037158(ATP6V0A2) 102043537(TCIRG1)
FAB: 101806637(ATP6V0A2) 101808415(TCIRG1) 101810144(ATP6V0A1) 101819803(ATP6V0A4)
PHI: 102100193(ATP6V0A4) 102102158(ATP6V0A1) 102103818(TCIRG1) 102107361(ATP6V0A2)
PMAJ: 107204916(ATP6V0A4) 107206490(TCIRG1) 107211844(ATP6V0A2) 107215116(ATP6V0A1)
CCW: 104688729(ATP6V0A2) 104693012(TCIRG1) 104696215(ATP6V0A4) 104697763(ATP6V0A1)
FPG: 101913873(ATP6V0A2) 101917386(ATP6V0A1) 101919327(TCIRG1) 101921111(ATP6V0A4)
FCH: 102046363(TCIRG1) 102052471(ATP6V0A2) 102053061(ATP6V0A1) 102058535(ATP6V0A4)
CLV: 102089335(ATP6V0A1) 102089604(ATP6V0A2) 102090200(ATP6V0A4) 102096711(TCIRG1)
EGZ: 104130155(ATP6V0A2) 104134802(ATP6V0A1) 104135570(ATP6V0A4)
AAM: 106487926(TCIRG1) 106488372(ATP6V0A4) 106491100(ATP6V0A1) 106497686(ATP6V0A2)
ASN: 102368239(ATP6V0A2) 102382487(ATP6V0A1) 102383193(ATP6V0A4) 102386370(TCIRG1)
AMJ: 102559672(TCIRG1) 102569694(ATP6V0A2) 102572518(ATP6V0A1) 106736679(ATP6V0A4)
PSS: 102449675(ATP6V0A2) 102458115(TCIRG1) 102460878(ATP6V0A1) 102462728(ATP6V0A4)
CMY: 102933238(ATP6V0A1) 102935940(ATP6V0A4) 102936752(TCIRG1) 102946850(ATP6V0A2)
CPIC: 101932343(ATP6V0A4) 101936540(TCIRG1) 101944206(ATP6V0A2) 101951107(ATP6V0A1)
ACS: 100557621 100558287(atp6v0a2) 100559109(tcirg1) 100565909(atp6v0a1) 103278839(atp6v0a4)
PVT: 110074888(ATP6V0A1) 110076588(ATP6V0A2) 110082682(ATP6V0A4) 110085637(TCIRG1)
PBI: 103050744 103055362(TCIRG1) 103057407(ATP6V0A2) 103058859(ATP6V0A1) 103063299
GJA: 107111498(ATP6V0A1) 107115497(ATP6V0A4) 107117220(ATP6V0A2) 107121287(TCIRG1)
XLA: 108696325(tcirg1.L) 108702456(atp6v0a1.S) 108716527 379986(atp6v0a1.L) 398897(atp6v0a4.L)
XTR: 100036694(atp6v0a1) 100135019(atp6v0a4) 548977(atp6v0a2) 549603(tcirg1)
NPR: 108787776(ATP6V0A2) 108792988(ATP6V0A1) 108797770(ATP6V0A4) 108801105(TCIRG1)
DRE: 100003139(tcirg1a) 324307(atp6v0a1a) 406342(tcirg1b) 553691(atp6v0a1b) 561117(atp6v0a2b) 561469(atp6v0a2a)
IPU: 108255708(atp6v0a2) 108255723(atp6v0a1) 108256301 108256678(Atp6v0a1) 108268578(tcirg1) 108277010 108280432
TRU: 101064814 101070581(atp6v0a1) 101071950 101076056 101076155(atp6v0a2)
NCC: 104942922 104945931(tcirg1) 104946399(atp6v0a1) 104950174(atp6v0a2) 104965709 104966366
MZE: 101465343 101465924 101468634(atp6v0a2) 101479892(atp6v0a1) 101481389
NFU: 107373005 107374275 107375989(tcirg1) 107378446(atp6v0a1) 107394195(atp6v0a2)
SFM: 108919860(atp6v0a1) 108930107 108932589(atp6v0a2) 108935917 108941770
LCM: 102351124(ATP6V0A2) 102352206 102354813 102356894(ATP6V0A4) 102362237(TCIRG1) 102365079(ATP6V0A1)
CMK: 103181272 103187833 103188002(atp6v0a2) 103189172(atp6v0a1) 103189838(atp6v0a4)
DME: Dmel_CG12602(Vha100-5) Dmel_CG1709(Vha100-1) Dmel_CG18617(Vha100-2) Dmel_CG30329(Vha100-3) Dmel_CG7678(Vha100-4)
DSI: Dsimw501_GD20170(Dsim_GD20170) Dsimw501_GD20171(Dsim_GD20171) Dsimw501_GD21418(Dsim_GD21418) Dsimw501_GD23787(Dsim_GD23787) Dsimw501_GD25346(Dsim_GD25346)
CEL: CELE_C26H9A.1(vha-7) CELE_F35H10.4(vha-5) CELE_VW02B12L.1(vha-6) CELE_ZK637.8(unc-32)
CBR: CBG01592(Cbr-vha-5) CBG02894(Cbr-vha-6) CBG03483(Cbr-vha-7) CBG06881(Cbr-unc-32)
SHX: MS3_04995
ADF: 107332674
HMG: 100209321
AQU: 100638908
ATH: AT2G21410(VHA-A2) AT2G28520(VHA-A1) AT4G39080(VHA-A3)
LJA: Lj0g3v0009329.1(Lj0g3v0009329.1) Lj0g3v0112099.1(Lj0g3v0112099.1) Lj0g3v0228679.1(Lj0g3v0228679.1) Lj0g3v0240579.1(Lj0g3v0240579.1) Lj3g3v0129330.1(Lj3g3v0129330.1) Lj3g3v0129340.1(Lj3g3v0129340.1) Lj3g3v0129350.1(Lj3g3v0129350.1) Lj3g3v3087270.1(Lj3g3v3087270.1) Lj3g3v3087270.2(Lj3g3v3087270.2) Lj3g3v3375980.1(Lj3g3v3375980.1) Lj3g3v3375990.1(Lj3g3v3375990.1)
DOSA: Os01t0834200-01(Os01g0834200) Os03t0251500-01(Os03g0251500) Os10t0184300-01(Os10g0184300)
ATS: 109740366(LOC109740366) 109754404(LOC109754404) 109765369(LOC109765369) 109768245(LOC109768245) 109770769(LOC109770769)
MNG: MNEG_4418
APRO: F751_3451
SCE: YMR054W(STV1) YOR270C(VPH1)
KMX: KLMA_40417(VPH1) KLMA_60192(STV1)
NCS: NCAS_0A08230(NCAS0A08230) NCAS_0B00440(NCAS0B00440)
NDI: NDAI_0E00940(NDAI0E00940) NDAI_0G04680(NDAI0G04680)
TPF: TPHA_0G00710(TPHA0G00710) TPHA_0N01550(TPHA0N01550)
TBL: TBLA_0B03580(TBLA0B03580) TBLA_0C01430(TBLA0C01430)
TDL: TDEL_0A06620(TDEL0A06620) TDEL_0B07100(TDEL0B07100)
KAF: KAFR_0A04090(KAFR0A04090) KAFR_0B05200(KAFR0B05200)
PIC: PICST_52299(VPH1) PICST_67737(VPH3)
SLB: AWJ20_3320(VPH1) AWJ20_417(VPH1)
NCR: NCU03463(vph-1)
NTE: NEUTE1DRAFT65999(NEUTE1DRAFT_65999)
MGR: MGG_03947
MAW: MAC_02909
CMT: CCM_04783
MBE: MBM_01498
ANG: ANI_1_886184(An04g05310)
ABE: ARB_02317
TVE: TRV_05055
PNO: SNOG_06418(SNOG_06417)
PTE: PTT_18920
SPO: SPAC16E8.07c(vph1)
CNE: CND02320
CNB: CNBD4040
ABP: AGABI1DRAFT111634(AGABI1DRAFT_111634)
ABV: AGABI2DRAFT217333(AGABI2DRAFT_217333)
MGL: MGL_0542
DDI: DDB_G0291858(vatM)
DFA: DFA_09893(vatM)
EHI: EHI_074020(79.t00005) EHI_107280(105.t00023)
PYO: PY17X_1227000(PY05420)
PCB: PCHAS_122440(PC301455.00.0)
TAN: TA10280
TPV: TP04_0731
BBO: BBOV_III008300(17.m07725)
CPV: cgd4_1470
SMIN: v1.2.002108.t1(symbB.v1.2.002108.t1) v1.2.019191.t1(symbB.v1.2.019191.t1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Cipriano DJ, Wang Y, Bond S, Hinton A, Jefferies KC, Qi J, Forgac M
  Title
Structure and regulation of the vacuolar ATPases.
  Journal
Biochim Biophys Acta 1777:599-604 (2008)
DOI:10.1016/j.bbabio.2008.03.013
Reference
  Authors
Jefferies KC, Cipriano DJ, Forgac M
  Title
Function, structure and regulation of the vacuolar (H+)-ATPases.
  Journal
Arch Biochem Biophys 476:33-42 (2008)
DOI:10.1016/j.abb.2008.03.025
Reference
PMID:8579597
  Authors
Li YP, Chen W, Stashenko P
  Title
Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit.
  Journal
Biochem Biophys Res Commun 218:813-21 (1996)
DOI:10.1006/bbrc.1996.0145
  Sequence
[hsa:10312]

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