KEGG   ORTHOLOGY: K02159Help
Entry
K02159                      KO                                     

Name
BAX
Definition
apoptosis regulator BAX
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04071  Sphingolipid signaling pathway
ko04115  p53 signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04722  Neurotrophin signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05016  Huntington's disease
ko05020  Prion diseases
ko05152  Tuberculosis
ko05161  Hepatitis B
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00020  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02159  BAX; apoptosis regulator BAX
 Environmental Information Processing
  Signal transduction
   04071 Sphingolipid signaling pathway
    K02159  BAX; apoptosis regulator BAX
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K02159  BAX; apoptosis regulator BAX
   04215 Apoptosis - multiple species
    K02159  BAX; apoptosis regulator BAX
   04217 Necroptosis
    K02159  BAX; apoptosis regulator BAX
   04115 p53 signaling pathway
    K02159  BAX; apoptosis regulator BAX
 Organismal Systems
  Nervous system
   04722 Neurotrophin signaling pathway
    K02159  BAX; apoptosis regulator BAX
  Aging
   04211 Longevity regulating pathway - mammal
    K02159  BAX; apoptosis regulator BAX
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K02159  BAX; apoptosis regulator BAX
   05202 Transcriptional misregulation in cancers
    K02159  BAX; apoptosis regulator BAX
   05203 Viral carcinogenesis
    K02159  BAX; apoptosis regulator BAX
   05210 Colorectal cancer
    K02159  BAX; apoptosis regulator BAX
   05212 Pancreatic cancer
    K02159  BAX; apoptosis regulator BAX
   05225 Hepatocellular carcinoma
    K02159  BAX; apoptosis regulator BAX
   05226 Gastric cancer
    K02159  BAX; apoptosis regulator BAX
   05214 Glioma
    K02159  BAX; apoptosis regulator BAX
   05216 Thyroid cancer
    K02159  BAX; apoptosis regulator BAX
   05220 Chronic myeloid leukemia
    K02159  BAX; apoptosis regulator BAX
   05217 Basal cell carcinoma
    K02159  BAX; apoptosis regulator BAX
   05218 Melanoma
    K02159  BAX; apoptosis regulator BAX
   05213 Endometrial cancer
    K02159  BAX; apoptosis regulator BAX
   05224 Breast cancer
    K02159  BAX; apoptosis regulator BAX
   05222 Small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
   05223 Non-small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    K02159  BAX; apoptosis regulator BAX
   05016 Huntington's disease
    K02159  BAX; apoptosis regulator BAX
   05020 Prion diseases
    K02159  BAX; apoptosis regulator BAX
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02159  BAX; apoptosis regulator BAX
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02159  BAX; apoptosis regulator BAX
  Infectious diseases
   05152 Tuberculosis
    K02159  BAX; apoptosis regulator BAX
   05166 HTLV-I infection
    K02159  BAX; apoptosis regulator BAX
   05161 Hepatitis B
    K02159  BAX; apoptosis regulator BAX
   05163 Human cytomegalovirus infection
    K02159  BAX; apoptosis regulator BAX
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K02159  BAX; apoptosis regulator BAX
   05165 Human papillomavirus infection
    K02159  BAX; apoptosis regulator BAX
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K02159  BAX; apoptosis regulator BAX
   01524 Platinum drug resistance
    K02159  BAX; apoptosis regulator BAX
   01522 Endocrine resistance
    K02159  BAX; apoptosis regulator BAX
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K02159  BAX; apoptosis regulator BAX
Transporters [BR:ko02000]
 Other Transporters
  Pores ion channels
   K02159  BAX; apoptosis regulator BAX
BRITE hierarchy
Other DBs
TC: 1.A.21.1.2
Genes
HSA: 581(BAX)
PTR: 747093(BAX)
PPS: 100991820(BAX)
GGO: 101152769(BAX)
PON: 100450682(BAX)
NLE: 100593013(BAX)
MCC: 718948(BAX)
MCF: 102132255(BAX)
CSAB: 103235004(BAX)
RRO: 104666540(BAX)
RBB: 108523624(BAX)
CJC: 100391322(BAX)
SBQ: 101050177(BAX)
MMU: 12028(Bax)
RNO: 24887(Bax)
CGE: 100689032(Bax)
NGI: 103743639(Bax)
HGL: 101713575(Bax)
CCAN: 109682703(Bax)
OCU: 100355675(BAX)
TUP: 102471776(BAX)
CFA: 403523(BAX)
AML: 100471095(BAX)
UMR: 103657107(BAX)
ORO: 101371652(BAX)
FCA: 493837(BAX)
PTG: 102949153(BAX)
AJU: 106988699(BAX)
BTA: 280730(BAX)
BOM: 102279740(BAX)
BIU: 109571778(BAX) 109571977
PHD: 102323618(BAX)
CHX: 100846984(BAX)
OAS: 443059(BAX)
SSC: 396633(BAX)
CFR: 102512073(BAX)
CDK: 105102890(BAX)
BACU: 103019528(BAX)
LVE: 103084066(BAX)
OOR: 101285349(BAX)
ECB: 100054674(BAX)
EPZ: 103553312(BAX)
EAI: 106838268(BAX)
MYB: 106723573(BAX)
MYD: 102761803(BAX)
HAI: 109391068(BAX)
RSS: 109452567(BAX)
PALE: 102885135(BAX)
LAV: 100673560(BAX)
TMU: 101356564
MDO: 100030412(BAX)
TGU: 100227148(BAX)
PHI: 102106020(BAX)
PMAJ: 107199046(BAX)
FPG: 101920283(BAX)
ASN: 102384471(BAX)
AMJ: 102568113(BAX) 106737548
PSS: 102446385
CMY: 102942796(BAX)
CPIC: 101948093(BAX) 101948354
ACS: 100561911 100562834(bax)
XLA: 108696744 373637(bax.L)
XTR: 394793(bax)
NPR: 108796054(BAX)
DRE: 100004321 58081(baxa) 767645(zgc:153993)
SFM: 108923902 108941669(bax)
LCM: 102352490(BAX) 102359041
CIN: 100179864
SPU: 586236
APLC: 110974870
SKO: 102808194
CRG: 105326257
MYI: 110461955
OBI: 106869728
LAK: 106168833
EPA: 110245059
ADF: 107346175
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8358790
  Authors
Oltvai ZN, Milliman CL, Korsmeyer SJ
  Title
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
  Journal
Cell 74:609-19 (1993)
DOI:10.1016/0092-8674(93)90509-O
  Sequence
[hsa:581]
Reference
  Authors
Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ
  Title
Proapoptotic BAX and BAK control multiple initiator caspases.
  Journal
EMBO Rep 6:379-85 (2005)
DOI:10.1038/sj.embor.7400375
Reference
  Authors
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD
  Title
BAX activation is initiated at a novel interaction site.
  Journal
Nature 455:1076-81 (2008)
DOI:10.1038/nature07396
  Sequence
[hsa:581]

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