KEGG   ORTHOLOGY: K02332Help
Entry
K02332                      KO                                     

Name
POLG
Definition
DNA polymerase gamma 1 [EC:2.7.7.7]
Pathway
ko04139  Mitophagy - yeast
Module
M00294  DNA polymerase gamma complex
Disease
H00469  Mitochondrial DNA depletion syndrome
H01118  Progressive external ophthalmoplegia
H01384  The ataxia neuropathy spectrum
H01389  Alpers syndrome
H01390  Mitochondrial neurogastrointestinal encephalomyopathy
H01395  POLG related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04139 Mitophagy - yeast
    K02332  POLG; DNA polymerase gamma 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K02332  POLG; DNA polymerase gamma 1
   03029 Mitochondrial biogenesis
    K02332  POLG; DNA polymerase gamma 1
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   DNA polymerase
    M00294  DNA polymerase gamma complex
     K02332  POLG; DNA polymerase gamma 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.7  DNA-directed DNA polymerase
     K02332  POLG; DNA polymerase gamma 1
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Elongation Factors
   DNA polymerase gamma complex (mitochondrial)
    K02332  POLG; DNA polymerase gamma 1
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA replication factors
   Mitochondrial DNA polymerase
    K02332  POLG; DNA polymerase gamma 1
BRITE hierarchy
Other DBs
COG: COG0749
GO: 0003887
Genes
HSA: 5428(POLG)
PTR: 467754(POLG)
PPS: 100972962(POLG)
GGO: 101143082(POLG)
PON: 100436469(POLG)
NLE: 100589628(POLG)
MCC: 699750(POLG)
MCF: 102137272(POLG)
CSAB: 103231149(POLG)
RRO: 104659373 104674354(POLG)
RBB: 108540902(POLG)
CJC: 100408039(POLG)
SBQ: 101042104(POLG)
MMU: 18975(Polg)
RNO: 85472(Polg)
CGE: 100755501(Polg)
NGI: 103749914(Polg)
HGL: 101700433(Polg)
CCAN: 109687556 109687557(Polg)
OCU: 100347697(POLG)
TUP: 102486190(POLG)
CFA: 100856383(POLG)
AML: 100476393(POLG)
UMR: 103660255(POLG)
ORO: 101379214(POLG)
FCA: 101083771(POLG)
PTG: 102964016(POLG)
AJU: 106965922(POLG)
BTA: 533090(POLG)
BOM: 102272159(POLG)
BIU: 109575478(POLG)
PHD: 102315334(POLG)
CHX: 102185224(POLG)
OAS: 101123414(POLG)
SSC: 100157469(POLG)
CFR: 102507047(POLG)
CDK: 105094752(POLG)
BACU: 103007350(POLG)
LVE: 103090207(POLG)
OOR: 101286727(POLG)
ECB: 100053827(POLG)
EPZ: 103563507(POLG)
EAI: 106831979(POLG)
MYB: 102246846(POLG)
MYD: 102774056(POLG)
HAI: 109381438(POLG)
RSS: 109444951(POLG)
PALE: 102881607(POLG)
LAV: 100675301(POLG)
TMU: 101348996
MDO: 100016380(POLG)
SHR: 100932218(POLG)
GGA: 404292(POLG)
MGP: 100545897(POLG)
CJO: 107318822(POLG)
APLA: 101791879(POLG)
ACYG: 106036491(POLG)
TGU: 100228317(POLG)
GFR: 102044345(POLG)
FAB: 101810621(POLG)
PHI: 102114280(POLG)
PMAJ: 107209482(POLG)
CCW: 104684090(POLG)
FPG: 101910722(POLG)
FCH: 102048998(POLG)
CLV: 102089058(POLG)
EGZ: 104123609(POLG)
AAM: 106497322(POLG)
ASN: 102383875(POLG)
AMJ: 102575367(POLG)
PSS: 102458352(POLG)
CMY: 102942303(POLG)
CPIC: 101941393(POLG)
ACS: 100553734(polg)
PVT: 110072961(POLG)
PBI: 103062476(POLG)
GJA: 107105495(POLG)
XLA: 397851(polg.L)
XTR: 100488393(polg)
NPR: 108799947(POLG)
DRE: 100150924(polg)
SRX: 107720751(polg)
SANH: 107673230(polg)
IPU: 108275148(polg)
AMEX: 103040749(polg)
TRU: 101072474(polg)
LCO: 104925275(polg)
NCC: 104944014(polg)
MZE: 101487408(polg)
OLA: 101156890(polg)
XMA: 102218875(polg)
PRET: 103466110(polg)
NFU: 107388971(polg)
CSEM: 103380522(polg)
LCF: 108875308(polg)
HCQ: 109530368(polg)
BPEC: 110165932(polg)
SASA: 106573318(polg)
ELS: 105018416(polg)
SFM: 108942048(polg)
LCM: 102350058(POLG)
CMK: 103188385(polg)
CIN: 100179190
SPU: 100891679
APLC: 110979608
SKO: 100370404
DME: Dmel_CG8987(tam)
DSI: Dsimw501_GD22040(Dsim_GD22040)
MDE: 101887948
AAG: 5579242
AME: 411763(tam)
BIM: 100744779
BTER: 100649081
SOC: 105195239
AEC: 105154753
ACEP: 105626886
PBAR: 105421958
HST: 105182619
CFO: 105248885
LHU: 105669577
PGC: 109851705
NVI: 100118160
TCA: 657330
DPA: 109540837
NVL: 108557569
BMOR: 101736791
PMAC: 106719735
PRAP: 110999849
PXY: 105392340
API: 103307715
DNX: 107169323
ZNE: 110837733
FCD: 110842443
TUT: 107368353
CEL: CELE_Y57A10A.15(polg-1)
CBR: CBG20918
BMY: Bm1_11960
TSP: Tsp_05486
CRG: 105332538
MYI: 110460053
OBI: 106877835
HMG: 100211228
AQU: 100640381
SCE: YOR330C(MIP1)
ERC: Ecym_5063
KMX: KLMA_50110(MIP1)
NCS: NCAS_0E02270(NCAS0E02270)
NDI: NDAI_0E03810(NDAI0E03810)
TPF: TPHA_0N00510(TPHA0N00510)
TBL: TBLA_0E02450(TBLA0E02450)
TDL: TDEL_0H03870(TDEL0H03870)
KAF: KAFR_0E02360(KAFR0E02360)
PIC: PICST_14247(MIP1)
CAL: CAALFM_C601550CA(CaO19.3431)
CAUR: QG37_03500
SLB: AWJ20_4977(MIP1)
NCR: NCU00276(mip-1)
NTE: NEUTE1DRAFT82069(NEUTE1DRAFT_82069)
MGR: MGG_08913
MAW: MAC_02542
MAJ: MAA_03468
CMT: CCM_07551
BFU: BCIN_08g06200(Bcmip1)
MBE: MBM_01892
ANI: AN0040.2
ANG: ANI_1_896124(An14g06560)
ABE: ARB_03390
TVE: TRV_08074
PNO: SNOG_10490(SNOG_10489)
PTE: PTT_03429
NPA: UCRNP2_55
SPO: SPCC24B10.22(pog1)
CNE: CNB00310
CNB: CNBB5370
ABP: AGABI1DRAFT123715(AGABI1DRAFT_123715)
ABV: AGABI2DRAFT114559(AGABI2DRAFT_114559)
MGL: MGL_4012
VG: 14013897(F417_gp119)
 » show all
TaxonomyVtaxonomyKoalaUniProt
Reference
  Authors
Eerola J, Luoma PT, Peuralinna T, Scholz S, Paisan-Ruiz C, Suomalainen A, Singleton AB, Tienari PJ
  Title
POLG1 polyglutamine tract variants associated with Parkinson's disease.
  Journal
Neurosci Lett 477:1-5 (2010)
DOI:10.1016/j.neulet.2010.04.021
Reference
PMID:8798543
  Authors
Lewis DL, Farr CL, Wang Y, Lagina AT 3rd, Kaguni LS
  Title
Catalytic subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, bacterial overexpression, and biochemical characterization.
  Journal
J Biol Chem 271:23389-94 (1996)
DOI:10.1074/jbc.271.38.23389
  Sequence
Reference
  Authors
Zhang Y, Qi H, Taylor R, Xu W, Liu LF, Jin S
  Title
The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains.
  Journal
Autophagy 3:337-46 (2007)
DOI:10.4161/auto.4127
Reference
  Authors
Stumpf JD, Bailey CM, Spell D, Stillwagon M, Anderson KS, Copeland WC
  Title
mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae.
  Journal
Hum Mol Genet 19:2123-33 (2010)
DOI:10.1093/hmg/ddq089
  Sequence
[sce:YOR330C]

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