KEGG ORTHOLOGY: K02577

ORTHOLOGY: K02577

Entry

K02577                      KO

Symbol

NDST2

Name

heparan sulfate N-deacetylase/N-sulfotransferase NDST2 [EC:3.5.1.- 2.8.2.8]

Pathway

map00534

Glycosaminoglycan biosynthesis - heparan sulfate / heparin

map01100

Metabolic pathways

Module

M00059

Glycosaminoglycan biosynthesis, heparan sulfate backbone

Reaction

R13046

poly[(1->4)-beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl] amidohydrolase

R13047

3'-phosphoadenylyl-sulfate:heparosan-D-glucuronate N-sulfonotransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    K02577  NDST2; heparan sulfate N-deacetylase/N-sulfotransferase NDST2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K02577  NDST2; heparan sulfate N-deacetylase/N-sulfotransferase NDST2
Enzymes [BR:ko01000]
2. Transferases
  2.8  Transferring sulfur-containing groups
   2.8.2  Sulfotransferases
    2.8.2.8  [heparan sulfate]-glucosamine N-sulfotransferase
     K02577  NDST2; heparan sulfate N-deacetylase/N-sulfotransferase NDST2
Glycosyltransferases [BR:ko01003]
Unclassified
  Sulfotransferases
   K02577  NDST2; heparan sulfate N-deacetylase/N-sulfotransferase NDST2

Other DBs

GO:	0102140 0015016

Genes

HSA:	8509(NDST2)

PTR:	738171(NDST2)

PPS:	100982717(NDST2)

GGO:	101136173(NDST2)

PON:	100431291(NDST2)

PPYG:

129006924(NDST2)

NLE:	100596667(NDST2)

HMH:	116459663(NDST2)

SSYN:

129481009(NDST2)

MCC:	714578(NDST2)

MCF:	102139203(NDST2)

MTHB:

126962422

MNI:	105466012(NDST2)

CSAB:

103215989(NDST2)

CATY:

105597341(NDST2)

PANU:

101021405(NDST2)

TGE:	112631365(NDST2)

MLEU:

105547506(NDST2)

RRO:	104669973(NDST2)

RBB:	108516887(NDST2)

TFN:	117081988(NDST2)

PTEH:

111537842(NDST2)

CANG:

105502911(NDST2)

CJC:	100412886(NDST2)

SBQ:	101048060(NDST2)

CIMI:

108296954(NDST2)

ANAN:

105722604(NDST2)

CSYR:

103271492(NDST2)

MMUR:

105868863(NDST2)

LCAT:

123650287(NDST2)

PCOQ:

105825472(NDST2)

OGA:	100943609(NDST2)

MMU:	17423(Ndst2)

MCAL:

110309243(Ndst2)

MPAH:

110325394(Ndst2)

RNO:	114002(Ndst2)

MCOC:

116084776(Ndst2)

ANU:	117705473(Ndst2)

MUN:	110552002(Ndst2)

CGE:	100758914(Ndst2)

MAUA:

101833357(Ndst2)

PROB:

127214117(Ndst2)

PLEU:

114700206(Ndst2)

MORG:

121438675(Ndst2)

MFOT:

126491384

AAMP:

119799741(Ndst2)

NGI:	103736935(Ndst2)

HGL:	101717521(Ndst2)

CPOC:

100725589(Ndst2)

CCAN:

109693245(Ndst2)

DORD:

105992670(Ndst2)

DSP:	122116596(Ndst2)

PLOP:

125346472(Ndst2)

NCAR:

124984562

MMMA:

107158157(Ndst2)

OCU:

100357859

OPI:	101527961(NDST2)

TUP:	102472573(NDST2)

GVR:	103595126(NDST2)

CFA:	100856320(NDST2)

CLUD:

112651191(NDST2)

VVP:	112924484(NDST2)

VLG:	121486861(NDST2)

NPO:	129509475(NDST2)

AML:	100477145(NDST2)

UMR:	103667834(NDST2)

UAH:	113259190(NDST2)

UAR:	123782878(NDST2)

ELK:

111145133

LLV:

125084659

MPUF:

101688818(NDST2)

MNP:	132016513(NDST2)

MLK:	131828815(NDST2)

NVS:	122900804(NDST2)

ORO:	101367273(NDST2)

EJU:	114214077(NDST2)

ZCA:	113919531(NDST2)

MLX:	118021677(NDST2)

NSU:	110589140(NDST2)

LWW:	102746768(NDST2)

FCA:	101088957(NDST2)

PYU:	121036799(NDST2)

PCOO:

112854499(NDST2)

PBG:	122493464(NDST2)

PVIV:

125148334(NDST2)

LRUF:

124506915

PTG:	102959179(NDST2)

PPAD:

109264421(NDST2)

PUC:

125933296

AJU:

106970981

HHV:	120233743(NDST2)

BTA:	286838(NDST2)

BOM:	102277980(NDST2)

BIU:	109553696(NDST2)

BBUB:

102408622(NDST2)

BBIS:

104997516(NDST2)

CHX:	102187918(NDST2)

OAS:	101120545(NDST2)

BTAX:

128047378(NDST2)

ODA:	120865283(NDST2)

CCAD:

122446385(NDST2)

MREE:

136159877(NDST2)

MBEZ:

129555699(NDST2)

SSC:	100151795(NDST2)

CFR:	102515285(NDST2)

CBAI:

105075361(NDST2)

CDK:	105092454(NDST2)

VPC:	102539651(NDST2)

BACU:

103006232(NDST2)

BMUS:

118882502(NDST2)

LVE:	103069336(NDST2)

OOR:	101283750(NDST2)

DLE:	111183529(NDST2)

PCAD:

102973206(NDST2)

PSIU:

116741277(NDST2)

NASI:

112396784(NDST2)

ECB:	100064113(NDST2)

EPZ:	103549462(NDST2)

EAI:	106843542(NDST2)

MYB:	102249911(NDST2)

MYD:	102756949(NDST2)

MMYO:

118670157(NDST2)

MLF:	102437591(NDST2)

MDT:	132214815(NDST2)

PKL:	118718856(NDST2)

EFUS:

103289459(NDST2)

MNA:	107545836(NDST2)

DRO:	112305428(NDST2)

SHON:

118980021 118993494(NDST2)

AJM:	119038070(NDST2) 119048590

PDIC:

114495964(NDST2)

PHAS:

123821005(NDST2)

MMF:	118632415(NDST2)

PPAM:

129069868(NDST2)

HAI:	109372524(NDST2)

RFQ:	117035833(NDST2)

PALE:

102880350(NDST2)

PGIG:

120609537(NDST2)

PVP:	105288865(NDST2)

RAY:	107498250(NDST2)

MJV:	108398756(NDST2)

TOD:	119234185(NDST2)

SARA:

101555573(NDST2)

SETR:

126030856(NDST2)

LAV:	100653641(NDST2)

TMU:

101350831

ETF:	101645498(NDST2)

DNM:	101427841(NDST2)

MDO:	100010852(NDST2)

GAS:	123232947(NDST2)

SHR:	100918059(NDST2)

AFZ:

127551908

PCW:	110221434(NDST2)

TVP:	118829171(NDST2)

OAA:	100089473(NDST2)

GGA:	423738(NDST2)

PCOC:

116235086(NDST2)

MGP:	100541975(NDST2)

CJO:	107315836(NDST2)

TPAI:

128078210(NDST2)

LMUT:

125693505(NDST2)

NMEL:

110399307(NDST2)

APLA:

101803296(NDST2)

ACYG:

106033174(NDST2)

CATA:

118247361(NDST2)

AFUL:

116491517(NDST2)

TGU:	100220252(NDST2)

LSR:	110480711(NDST2)

SCAN:

103813997(NDST2)

PMOA:

120510910(NDST2)

OTC:	121336214(NDST2)

PRUF:

121358204(NDST2)

GFR:	102036683(NDST2)

FAB:	101814289(NDST2)

OMA:	130254905(NDST2)

PHI:	102104815(NDST2)

PMAJ:

107206751(NDST2)

CCAE:

111931071(NDST2)

CCW:	104697450(NDST2)

CBRC:

103624447(NDST2)

ETL:	114058123(NDST2)

ZAB:	102071212(NDST2)

ZLE:	135449618(NDST2)

ACHL:

103806874(NDST2)

SVG:	106855326(NDST2)

MMEA:

130579911(NDST2)

HRT:	120756087(NDST2)

SATI:

136364261(NDST2)

FPG:	101915190(NDST2)

FCH:	102057487(NDST2)

CCRI:

104167277(NDST2)

NNT:	104405402(NDST2)

SHAB:

115609131(NDST2)

ACUN:

113481516(NDST2)

TALA:

104366765(NDST2)

ACHC:

115348578(NDST2)

HALD:

104311118(NDST2)

HLE:	104831904(NDST2)

AGEN:

126043253

GCL:

127017790

CSTI:

104561806

LDI:	104343430(NDST2)

MNB:	103777462(NDST2)

DPUB:

104297671(NDST2)

AVIT:

104276687(NDST2)

BRHI:

104490464(NDST2)

EGZ:	104129106(NDST2)

NNI:	104017042(NDST2)

PCRI:

104033353

PCAO:

104047327(NDST2)

PADL:

103915584(NDST2)

AFOR:

103897594(NDST2)

FGA:

104082218

GSTE:

104251444(NDST2)

CLV:	102086332(NDST2)

MUI:	104543619(NDST2)

PGUU:

104465249(NDST2)

PLET:

104628770(NDST2)

EHS:	104510451(NDST2)

CMAC:

104481438(NDST2)

CUCA:

104067923(NDST2)

TEO:	104382789(NDST2)

BREG:

104635334

OHA:	104335780(NDST2)

ACAR:

104529532(NDST2)

CPEA:

104391461(NDST2)

CVF:	104289764(NDST2)

RTD:	128911402(NDST2)

AAM:	106498939(NDST2)

AROW:

112961009(NDST2)

NPD:	112951775(NDST2)

TGT:	104571146(NDST2)

DNE:	112980226(NDST2)

SCAM:

104141765(NDST2)

ASN:	102376164(NDST2)

AMJ:	102569219(NDST2)

CPOO:

109324087(NDST2)

GGN:	109287382(NDST2)

PSS:	102452785(NDST2)

CMY:	102934951(NDST2)

CCAY:

125639534(NDST2)

DCC:	119858646(NDST2)

CPIC:

101934645(NDST2)

TST:	117880075(NDST2)

CABI:

116823617(NDST2)

MRV:	120409080(NDST2)

ACS:	100552204(ndst2)

ASAO:

132771309(NDST2)

PVT:	110077771(NDST2)

SUND:

121926603(NDST2)

PBI:	103064441(NDST2)

PMUR:

107294326(NDST2) 107302453

CTIG:

120315520(NDST2)

TSR:	106544288(NDST2)

PGUT:

117676102(NDST2)

APRI:

131201046(NDST2)

PTEX:

113443079(NDST2)

NSS:	113416400(NDST2)

VKO:	123018275(NDST2)

PMUA:

114597033(NDST2)

PRAF:

128413699(NDST2)

ZVI:	118096404(NDST2)

HCG:	128349084(NDST2)

GJA:	107109044(NDST2)

STOW:

125436230(NDST2)

EMC:	129331802(NDST2)

XLA:	108696256(ndst2.L) 108697506(ndst2.S) 108697947

XTR:	100217321(ndst2)

NPR:	108798216(NDST2)

RTEM:

120908929(NDST2)

BBUF:

121006112(NDST2)

BGAR:

122940077(NDST2)

MUO:	115470334(NDST2)

GSH:	117359544(NDST2)

DRE:	793524(ndst2a) 798226(ndst2b)

SRX:	107726987 107743572 107749844 107755463

SANH:

107666426 107684097 107690932 107696866

SGH:	107561853 107565926(ndst2) 107568546 107601424

CCAR:

109072881 109079785

CAUA:

113056010 113056016 113057302 113111627 113112730

CGIB:

127968923 127970087 128025446 128026271

PTET:

122355686 122355837 122356525(ndst2a)

LROH:

127173998(ndst2b) 127174933(ndst2a)

OMC:	131551125(ndst2b) 131552442(ndst2a)

PPRM:

120474698(ndst2b) 120480056(ndst2a)

RKG:	130069671(ndst2b) 130089138(ndst2a)

MAMB:

125255301(ndst2b) 125276813(ndst2a)

CIDE:

127524190 127524892

CERY:

137007339(ndst2b) 137020494(ndst2a)

MASI:

127412491 127414193 127422839 127426931

TROS:

130559042(ndst2a) 130569275(ndst2b)

TDW:	130432076(ndst2a) 130438957(ndst2b)

MANU:

129415402(ndst2a) 129420908(ndst2b)

IPU:	108263104(ndst2a) 108273828(ndst2b)

IFU:	128605903(ndst2a) 128616560(ndst2b)

PHYP:

113527724 113541848(ndst2)

SMEO:

124388817(ndst2b) 124400584(ndst2a)

TFD:	113639017(ndst2b) 113661009(ndst2a)

TVC:	132837478(ndst2b) 132847496(ndst2a)

TRN:	134314802(ndst2a) 134321867(ndst2b)

AMEX:

103031986(ndst2b) 103043063(ndst2a)

CMAO:

118809349(ndst2b) 118810604(ndst2a)

EEE:	113577650 113578289

CHAR:

105892791(ndst2b) 105900277(ndst2a)

TRU:	101068100(ndst2)

TFS:

130533512

TNG:	GSTEN00008654G001 GSTEN00008656G001 GSTEN00010669G001

LCO:	104924870(ndst2)

NCC:

104960020

TBEN:

117492027(ndst2a)

CGOB:

115020223

PGEO:

117444654(ndst2a)

GACU:

117561975(ndst2a)

EMAC:

134858538(ndst2a)

ELY:	117248268(ndst2a)

EFO:	125903951(ndst2a)

PLEP:

121954281

SLUC:

116050366(ndst2a)

ECRA:

117960341(ndst2a)

ESP:	116705627(ndst2)

PFLV:

114572079(ndst2)

GAT:	120820664(ndst2a)

PPUG:

119214171(ndst2a)

AFB:	129092157(ndst2a)

CLUM:

117743860(ndst2a)

PSWI:

130206858(ndst2a)

CANA:

137780255(ndst2a)

MSAM:

119916834(ndst2a)

SCHU:

122883916(ndst2a)

CUD:

121511069

ALAT:

119033835(ndst2a)

ASTR:

137603620(ndst2a)

MZE:

101477074

ONL:

100692215

OAU:

116325449

OLA:	101167762(ndst2)

OML:

112138739

CSAI:

133463474(ndst2a)

XMA:	102231013(ndst2)

XCO:	114137968(ndst2)

XHE:

116713229

PRET:

103476673(ndst2)

PFOR:

103154287(ndst2)

PLAI:

106936388

PMEI:

106908049

GAF:	122842856(ndst2a)

PPRL:

129354611 129356554

CVG:

107088918

CTUL:

119792658

GMU:	124859010(ndst2a)

KMR:

108244821

ALIM:

106537134(ndst2)

NWH:	119407624(ndst2a)

AOCE:

111563643(ndst2)

MCEP:

125019121(ndst2a)

CSEM:

103387783

POV:	109639871(ndst2)

SSEN:

122762498(ndst2a)

HHIP:

117775890(ndst2a)

HSP:	118118993(ndst2a)

PPLT:

128453240(ndst2a)

SMAU:

118283315(ndst2a)

LCF:	108894856 108894859

SDU:	111239216(ndst2)

SLAL:

111669509(ndst2)

XGL:	120796273(ndst2a)

BPEC:

110156999

MALB:

109964327(ndst2)

BSPL:

114870749(ndst2a)

SJO:	128373067(ndst2a)

SASA:

106576965 106606834

STRU:

115153188 115193804

OTW:	112252983(ndst2a) 112254357

OMY:	110502443 110528470

OGO:	124038241 124041280

ONE:	115113237 115135140

OKI:	109889918(ndst2) 109899708

OKE:	118369680 118400321

SALP:

111951660 111977593

SNH:	120017632 120046552

CCLU:

121553513 121570369

ELS:	105023247(ndst2)

SFM:	108918091(ndst2) 108934866

PKI:	111848469 111853426 111855601

AANG:

118218223(ndst2a) 118220817(ndst2b)

LOC:	102696116(ndst2)

PSPA:

121321779 121325535

ARUT:

117415824 117417710

LCM:	102367227(NDST2)

CMK:	103181540(ndst2a)

RTP:	109916080(ndst2a)

CPLA:

122541896(ndst2a)

HOC:	132835071(ndst2a)

LERI:

129712890(ndst2a)

PMRN:

116937933 116940373 116951028

LRJ:	133350503 133354527

BFO:

BBEL:

CIN:

SPU:

ARUN:

AJC:

SKO:

DME:	Dmel_CG8339(sfl)

DER:

6545438

DSE:

6611030

DSI:	Dsimw501_GD13961(Dsim_GD13961)

DYA:	Dyak_GE21567

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12102

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:	119604754 119607552 119613721

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ008241

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105676489(sfl)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:	108564782 108564783

DCOR:

135796687(sfl)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_215886

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:	100159124 100169222

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

MQU:

PHU:	Phum_PHUM458660

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_61590

DMK:	116922101 123471507

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:	136838809(sfl)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136968200 136971373

PTEP:

107436619

ABRU:

129988090

UDV:	129226519 129226857

SDM:

118200329

LPOL:

106457993 106460391 106471405

PMEO:

129583907

LOA:	LOAG_17115

TSP:

Tsp_06799

LGI:	LOTGIDRAFT_232790

PVUL:

126810824

PCAN:

112557821

BGT:	106064227 106070909

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_134250

SHX:	MS3_00002993(NDST2)

EGL:

EGR_10430

LLON:

135486659

EPA:	110233816 110233818

ADF:	107350755 107350771

AMIL:

114946985 114946986

PDAM:

113679606 113679607

SPIS:

111344176 111344184

DGT:	114538588 114538594

XEN:	124449311 124456391

AQU:

100632000

» show all

Reference

PMID:9915799

Authors

Aikawa J, Esko JD

Title

Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.

Journal

J Biol Chem 274:2690-5 (1999)
DOI:10.1074/jbc.274.5.2690

Sequence

[mmu:17423]

Reference

PMID:10758005

Authors

Pikas DS, Eriksson I, Kjellen L

Title

Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.

Journal

Biochemistry 39:4552-8 (2000)
DOI:10.1021/bi992524l

Reference

PMID:16343444

Authors

Duncan MB, Liu M, Fox C, Liu J

Title

Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2.

Journal

Biochem Biophys Res Commun 339:1232-7 (2006)
DOI:10.1016/j.bbrc.2005.11.142

All links

Ontology (5)   
   KEGG BRITE (3)   
   GO (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (4)   
Gene (1974)   
   KEGG GENES (735)   
   KEGG MGENES (413)   
   RefGene (825)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (1994)   

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