KEGG   ORTHOLOGY: K03156Help
Entry
K03156                      KO                                     

Name
TNF, TNFA
Definition
tumor necrosis factor superfamily, member 2
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04060  Cytokine-cytokine receptor interaction
ko04064  NF-kappa B signaling pathway
ko04071  Sphingolipid signaling pathway
ko04150  mTOR signaling pathway
ko04210  Apoptosis
ko04217  Necroptosis
ko04350  TGF-beta signaling pathway
ko04380  Osteoclast differentiation
ko04612  Antigen processing and presentation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04640  Hematopoietic cell lineage
ko04650  Natural killer cell mediated cytotoxicity
ko04657  IL-17 signaling pathway
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04920  Adipocytokine signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04940  Type I diabetes mellitus
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05133  Pertussis
ko05134  Legionellosis
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05143  African trypanosomiasis
ko05144  Malaria
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05168  Herpes simplex infection
ko05205  Proteoglycans in cancer
ko05310  Asthma
ko05321  Inflammatory bowel disease (IBD)
ko05322  Systemic lupus erythematosus
ko05323  Rheumatoid arthritis
ko05330  Allograft rejection
ko05332  Graft-versus-host disease
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05414  Dilated cardiomyopathy (DCM)
ko05418  Fluid shear stress and atherosclerosis
Disease
H00079  Asthma
H00080  Systemic lupus erythematosus
H00083  Allograft rejection
H00084  Graft-versus-host disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04350 TGF-beta signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04064 NF-kappa B signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04668 TNF signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04071 Sphingolipid signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04150 mTOR signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04217 Necroptosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04620 Toll-like receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04621 NOD-like receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04622 RIG-I-like receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04625 C-type lectin receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04650 Natural killer cell mediated cytotoxicity
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04612 Antigen processing and presentation
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04660 T cell receptor signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04657 IL-17 signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04664 Fc epsilon RI signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09158 Development
   04380 Osteoclast differentiation
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09160 Human Diseases
  09161 Cancers
   05205 Proteoglycans in cancer
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09162 Immune diseases
   05310 Asthma
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05322 Systemic lupus erythematosus
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05323 Rheumatoid arthritis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05321 Inflammatiory bowel disease (IBD)
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05330 Allograft rejection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05332 Graft-versus-host disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09163 Neurodegenerative diseases
   05010 Alzheimer disease
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05014 Amyotrophic lateral sclerosis (ALS)
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09165 Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05410 Hypertrophic cardiomyopathy (HCM)
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05414 Dilated cardiomyopathy (DCM)
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09166 Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04940 Type I diabetes mellitus
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04931 Insulin resistance
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   04933 AGE-RAGE signaling pathway in diabetic complications
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09167 Infectious diseases
   05133 Pertussis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05134 Legionellosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05152 Tuberculosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05166 HTLV-I infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05164 Influenza A
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05161 Hepatitis B
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05160 Hepatitis C
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05168 Herpes simplex infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05163 Human cytomegalovirus infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05165 Human papillomavirus infection
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05146 Amoebiasis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05144 Malaria
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05145 Toxoplasmosis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05140 Leishmaniasis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05142 Chagas disease (American trypanosomiasis)
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   05143 African trypanosomiasis
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
  09168 Drug resistance
   01523 Antifolate resistance
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
   00536 Glycosaminoglycan binding proteins
    K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Tumor necrosis fators
   K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Cytokines
   K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
BRITE hierarchy
Other DBs
GO: 0005164
Genes
HSA: 7124(TNF)
PTR: 494186(TNF)
PPS: 100977674(TNF)
GGO: 101151555(TNF)
PON: 100447558(TNF)
NLE: 100583968(TNF)
MCC: 715467(TNF)
MCF: 102139631(TNF)
RRO: 104661913(TNF)
RBB: 108520255(TNF)
CJC: 100397484(TNF)
SBQ: 101031357(TNF)
MMU: 21926(Tnf)
RNO: 103694380 24835(Tnf)
CGE: 100764780(Tnf)
NGI: 103724452(Tnf)
HGL: 101718432(Tnf)
CCAN: 109690391(Tnf)
OCU: 100009088(TNF)
TUP: 102497973(TNF)
CFA: 403922(TNF)
AML: 100471563(TNF)
UMR: 103682322(TNF)
ORO: 101368209(TNF)
FCA: 493755(TNF)
PTG: 102958919(TNF)
AJU: 106983958(TNF)
BTA: 280943(TNF)
BOM: 102277911(TNF)
BIU: 109577428(TNF)
PHD: 102321354(TNF)
CHX: 100861232(TNF)
OAS: 443540(TNF)
SSC: 397086(TNF)
CFR: 102510424(TNF)
CDK: 105087473(TNF)
BACU: 103005897(TNF)
LVE: 103083231(TNF)
OOR: 101269870(TNF)
ECB: 100033834(TNF)
EPZ: 103562469(TNF)
EAI: 106825034(TNF)
MYB: 102246703(TNF)
MYD: 102758774(TNF)
HAI: 109373073(TNF)
RSS: 109436728(TNF)
PALE: 102887632(TNF)
LAV: 100677125(TNF)
TMU: 101342656(TNF)
MDO: 100023069(TNF)
SHR: 100921875(TNF)
OAA: 100085643(TNF)
ASN: 102378738(TNF)
AMJ: 102569751(TNF)
PSS: 102449532(TNF)
CMY: 102936332
CPIC: 101949059(TNF)
PVT: 110069889(TNF)
PBI: 103052729
GJA: 107119827
XLA: 100137625(tnf.L) 108700235(tnf.S)
XTR: 100134991(tnf)
NPR: 108793742
DRE: 405785(tnfa)
SANH: 107694347
CCAR: 109063472
IPU: 100304592(tnf)
AMEX: 103032568
TRU: 654303(tnfa)
OLA: 101172593
XMA: 102231253
PRET: 103472136
CSEM: 103394480
BPEC: 110168066
SASA: 100136457(tnf-alpha-1) 100136458(tnf-alpha-2) 100136509
ELS: 105031348
SFM: 108935614
LCM: 102357196(TNF) 102363112
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9089109
  Authors
Iraqi F, Teale A
  Title
Cloning and sequencing of the tnfa genes of three inbred mouse strains.
  Journal
Immunogenetics 45:459-61 (1997)
DOI:10.1007/s002510050233
  Sequence
[mmu:21926]

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