KEGG   ORTHOLOGY: K03164Help
Entry
K03164                      KO                                     

Name
TOP2
Definition
DNA topoisomerase II [EC:5.99.1.3]
Pathway
ko01524  Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09168 Drug resistance
   01524 Platinum drug resistance
    K03164  TOP2; DNA topoisomerase II
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K03164  TOP2; DNA topoisomerase II
   03036 Chromosome and associated proteins
    K03164  TOP2; DNA topoisomerase II
Enzymes [BR:ko01000]
 5. Isomerases
  5.99  Other isomerases
   5.99.1  Sole sub-subclass for isomerases that do not belong in the other subclasses
    5.99.1.3  DNA topoisomerase (ATP-hydrolysing)
     K03164  TOP2; DNA topoisomerase II
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Topoisomerases
   K03164  TOP2; DNA topoisomerase II
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    K03164  TOP2; DNA topoisomerase II
  Centrosome formation and ciliogenesis proteins
   Centriole proteins
    K03164  TOP2; DNA topoisomerase II
BRITE hierarchy
Other DBs
COG: COG0187 COG0188
GO: 0003918
Genes
HSA: 7153(TOP2A) 7155(TOP2B)
PTR: 454651(TOP2A) 460232(TOP2B)
PPS: 100975829(TOP2B) 100996214(TOP2A)
GGO: 101135259(TOP2B) 101151181(TOP2A)
PON: 100433973(TOP2A) 100439073(TOP2B)
NLE: 100584797(TOP2A) 100596241(TOP2B)
MCC: 677709(TOP2B) 700707(TOP2A)
MCF: 101866992(TOP2B) 102135121(TOP2A)
CSAB: 103241775(TOP2B) 103243514(TOP2A)
RRO: 104658074(TOP2B) 104682030(TOP2A)
RBB: 108534715(TOP2A) 108543073(TOP2B)
CJC: 100396004(TOP2B) 100411777(TOP2A)
SBQ: 101035877(TOP2A) 101041566(TOP2B)
MMU: 21973(Top2a) 21974(Top2b)
RNO: 360243(Top2a) 361100(Top2b)
CGE: 100689304(Top2a) 100770041(Top2b)
NGI: 103731125(Top2a) 103734261(Top2b)
CCAN: 109694415(Top2a) 109696876(Top2b)
OCU: 100351427(TOP2B) 100357676(TOP2A)
TUP: 102492167(TOP2B) 102499923(TOP2A)
CFA: 477044(TOP2B) 480525(TOP2A)
AML: 100463930(TOP2A) 100469273(TOP2B)
UMR: 103661780(TOP2A) 103682010(TOP2B)
ORO: 101376605(TOP2B) 101380745(TOP2A)
FCA: 101083813(TOP2A) 101088949(TOP2B)
PTG: 102960613(TOP2B) 102968667 102970050(TOP2A)
AJU: 106980548(TOP2A) 106988242(TOP2B)
BTA: 282097(TOP2B) 787696(TOP2A)
BOM: 102276087(TOP2A) 102276458(TOP2B)
PHD: 102333548(TOP2B) 102341133(TOP2A)
CHX: 102180187(TOP2B) 102188973(TOP2A)
OAS: 101103037(TOP2B) 101108762(TOP2A)
SSC: 100156319(TOP2B) 396917(TOP2A)
CFR: 102503932(TOP2A) 102523203(TOP2B)
CDK: 105095626(TOP2B) 105099019(TOP2A)
BACU: 103001897(TOP2B) 103010475(TOP2A)
LVE: 103074383 103080885(TOP2B) 103083356(TOP2A)
OOR: 101270209(TOP2B) 101270334(TOP2A)
ECB: 100054229(TOP2A) 100059572(TOP2B)
EPZ: 103549779(TOP2B) 103550180(TOP2A)
EAI: 106823875(TOP2B) 106826503(TOP2A)
MYB: 102247329(TOP2A) 102253721(TOP2B)
MYD: 102757012(TOP2A) 102759143(TOP2B)
HAI: 109374239(TOP2B) 109380662(TOP2A)
RSS: 109454534(TOP2B) 109455882(TOP2A)
PALE: 102879554(TOP2B) 102879885(TOP2A)
LAV: 100667411(TOP2A) 100668841(TOP2B)
MDO: 100016027(TOP2A) 100031654(TOP2B)
SHR: 100930373(TOP2B) 100934974(TOP2A)
OAA: 100075740(TOP2B) 100090593(TOP2A)
GGA: 395570(TOP2A) 395966(TOP2B)
MGP: 100541484(TOP2A) 100545483(TOP2B)
APLA: 101792282(TOP2A) 101793977(TOP2B)
ACYG: 106030293(TOP2B) 106049567(TOP2A)
TGU: 100231174(TOP2B) 100231343(TOP2A)
GFR: 102037381(TOP2B) 102040919(TOP2A)
FAB: 101814631(TOP2A) 101815052(TOP2B)
PHI: 102110562(TOP2B) 102111409(TOP2A)
PMAJ: 107200121(TOP2B) 107215111(TOP2A)
CCW: 104689051(TOP2B) 104697736(TOP2A)
FPG: 101911797(TOP2A) 101913022(TOP2B)
FCH: 102054858(TOP2A) 102059770(TOP2B)
CLV: 102091898(TOP2A) 102096719(TOP2B)
EGZ: 104122963(TOP2B) 104132239(TOP2A)
AAM: 106483492(TOP2B) 106486418(TOP2A)
ASN: 102379109(TOP2A) 102384021(TOP2B)
AMJ: 102563910(TOP2A) 102570158(TOP2B)
PSS: 102448610(TOP2B) 102450222(TOP2A)
CMY: 102930295(TOP2B) 102930501(TOP2A)
CPIC: 101948778(TOP2A) 101952681(TOP2B)
ACS: 100562686(top2a) 100563490(top2b)
PVT: 110071595 110085566(TOP2A) 110086615(TOP2B)
PBI: 103063882(TOP2B) 103065748(TOP2A)
GJA: 107107876(TOP2B) 107108908 107119950(TOP2A)
XLA: 100381038(top2b.L) 108719958 398512(top2a.L)
XTR: 100038293(top2a) 779457(top2b)
NPR: 108798407(TOP2B) 108804294(TOP2A)
DRE: 323733(top2a) 569877(top2b)
IPU: 108272783(top2b) 108274033(top2a)
AMEX: 103031333(top2a) 103034796(top2b)
TRU: 101075432(top2a) 101075827(top2b)
LCO: 104923244(top2a) 104931637(top2b)
NCC: 104946376(top2a) 104952711 104960822(top2b)
MZE: 101467018(top2b) 101474611(top2a)
OLA: 101157229(top2b) 101158729(top2a)
XMA: 102218577(top2a) 102228295(top2b)
PRET: 103471955(top2b) 103481989(top2a)
NFU: 107383244(top2b) 107388094
CSEM: 103381751 103394321(top2b)
LCF: 108875718(top2a) 108900254(top2b)
HCQ: 109507713(top2b) 109518650 109527427(top2a)
BPEC: 110153757(top2b) 110159759(top2a) 110175353
ELS: 105012550(top2b) 105024531(top2a)
SFM: 108928126(top2a) 108933428(top2b)
LCM: 102346568(TOP2B) 102360928(TOP2A)
CIN: 751087(ci-htf-1)
SPU: 578275(top2b)
APLC: 110983452
SKO: 100372229(TOP2B)
DME: Dmel_CG10223(Top2)
DSE: Dsec_GM17008(Dsec_Top2)
DSI: Dsimw501_GD21758(Dsim_Top2)
MDE: 101893954
AAG: 5580262
AME: 724215(Top2)
BIM: 100741177
BTER: 100650868
SOC: 105201702
AEC: 105144262
ACEP: 105619228
PBAR: 105433086
HST: 105180567
CFO: 105251341
LHU: 105677045
PGC: 109854065
NVI: 100117297
TCA: 656003(Top2)
DPA: 109538111
NVL: 108563602
BMOR: 692558(TOP2)
PMAC: 106710437
PRAP: 110992227
PXY: 105383739
DNX: 107168938
FCD: 110863370
CEL: CELE_K12D12.1(top-2) CELE_R05D3.12(R05D3.12) CELE_ZK1127.7(cin-4)
TSP: Tsp_00990
CRG: 105343567
MYI: 110461167
OBI: 106883641
LAK: 106174550
SHX: MS3_03959
HMG: 100214280(top2b)
ATH: AT3G23890(TOPII)
CRB: 17891275
THJ: 104820131
CPAP: 110809287
CIT: 102610705
TCC: 18586085
GRA: 105776898
GHI: 107934399
VRA: 106762134
VAR: 108334280
CCAJ: 109796924
LJA: Lj3g3v0826110.1(Lj3g3v0826110.1) Lj4g3v0877830.1(Lj4g3v0877830.1)
LANG: 109355599
PPER: 18786685
PMUM: 103330635
PAVI: 110765834
ZJU: 107417559
CSV: 101215950
CMO: 103500322
MCHA: 111020305
CMAX: 111481402
CMOS: 111442005
RCU: 8259305
JCU: 105628725
JRE: 108988265
VVI: 100253371
SLY: 101250733
SPEN: 107006903
SOT: 102583378
CANN: 107839447
NSY: 104246720
NTO: 104120783
INI: 109147754
SIND: 105169247
LSV: 111908304
DCR: 108227933
OSA: 4330426
DOSA: Os02t0699700-01(Os02g0699700)
ATS: 109731952(LOC109731952) 109734932(LOC109734932) 109734933(LOC109734933) 109734934(LOC109734934) 109755815(LOC109755815) 109755816(LOC109755816) 109783779(LOC109783779)
SITA: 101760596
EGU: 105044001
AOF: 109838351
ATR: 18428924
CRE: CHLREDRAFT_38019(TOP2)
APRO: F751_1302
SCE: YNL088W(TOP2)
KMX: KLMA_80207(TOP2)
NCS: NCAS_0G02740(NCAS0G02740)
NDI: NDAI_0F02550(NDAI0F02550)
TPF: TPHA_0C02900(TPHA0C02900)
TBL: TBLA_0E03570(TBLA0E03570)
TDL: TDEL_0C04170(TDEL0C04170)
KAF: KAFR_0J01230(KAFR0J01230)
PIC: PICST_74317(TOP2)
CAL: CAALFM_C406600WA(TOP2)
CDU: CD36_46080(TOP2)
CAUR: QG37_06171
SLB: AWJ20_4495(TOP2) AWJ20_4496(TOP2)
NCR: NCU06338
NTE: NEUTE1DRAFT79101(NEUTE1DRAFT_79101)
SMP: SMAC_01010(putative top2)
MGR: MGG_06162
MAW: MAC_06425
MAJ: MAA_05049
CMT: CCM_04288
BFU: BCIN_07g03390(Bctop2)
MBE: MBM_04172
ANI: AN5406.2
ANG: ANI_1_1186074(An08g08550)
PCS: Pc22g00700(top2)
ABE: ARB_01513
TVE: TRV_04248
PTE: PTT_11728
SPO: SPBC1A4.03c(top2)
CNE: CNA03600
CNB: CNBA3470
MRR: Moror_378
ABP: AGABI1DRAFT117173(AGABI1DRAFT_117173)
ABV: AGABI2DRAFT197775(AGABI2DRAFT_197775)
MGL: MGL_0413
DDI: DDB_G0270418(top2) DDB_G0279737(top2mt)
DFA: DFA_00132(top2) DFA_03520(top2mt)
EHI: EHI_120640(138.t00004)
PYO: PY17X_1012900(PY03394)
PCB: PCHAS_101220(PC000063.00.0)
TAN: TA13325
TPV: TP02_0467
BBO: BBOV_III004820(17.m07431)
CPV: cgd4_780
SMIN: v1.2.006137.t1(symbB.v1.2.006137.t1) v1.2.006137.t2(symbB.v1.2.006137.t2) v1.2.006137.t3(symbB.v1.2.006137.t3) v1.2.006138.t1(symbB.v1.2.006138.t1) v1.2.006541.t1(symbB.v1.2.006541.t1) v1.2.011504.t1(symbB.v1.2.011504.t1) v1.2.011504.t2(symbB.v1.2.011504.t2) v1.2.012523.t1(symbB.v1.2.012523.t1) v1.2.012523.t2(symbB.v1.2.012523.t2) v1.2.014754.t1(symbB.v1.2.014754.t1) v1.2.015202.t1(symbB.v1.2.015202.t1) v1.2.015289.t1(symbB.v1.2.015289.t1) v1.2.015327.t1(symbB.v1.2.015327.t1) v1.2.016997.t1(symbB.v1.2.016997.t1) v1.2.033145.t1(symbB.v1.2.033145.t1) v1.2.033147.t1(symbB.v1.2.033147.t1) v1.2.035889.t1(symbB.v1.2.035889.t1) v1.2.035890.t1(symbB.v1.2.035890.t1)
FCY: FRACYDRAFT_145893(Top2a_1) FRACYDRAFT_185561(Top2b_1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2845399
  Authors
Tsai-Pflugfelder M, Liu LF, Liu AA, Tewey KM, Whang-Peng J, Knutsen T, Huebner K, Croce CM, Wang JC
  Title
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.
  Journal
Proc Natl Acad Sci U S A 85:7177-81 (1988)
DOI:10.1073/pnas.85.19.7177
  Sequence
[hsa:7153 7155]
Reference
  Authors
Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S
  Title
The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.
  Journal
Cell 113:905-17 (2003)
DOI:10.1016/S0092-8674(03)00436-7
  Sequence
[hsa:7155]

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