KEGG   ORTHOLOGY: K03347Help
Entry
K03347                      KO                                     

Name
CUL1, CDC53
Definition
cullin 1
Pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04114  Oocyte meiosis
ko04120  Ubiquitin mediated proteolysis
ko04141  Protein processing in endoplasmic reticulum
ko04310  Wnt signaling pathway
ko04340  Hedgehog signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04710  Circadian rhythm
ko05168  Herpes simplex infection
ko05200  Pathways in cancer
Module
M00379  SCF-MET30 complex
M00380  SCF-BTRC complex
M00381  SCF-SKP2 complex
M00382  SCF-FBS complex
M00387  SCF-FBW7 complex
M00407  SCF-CDC4 complex
M00411  SCF-GRR1 complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03347  CUL1, CDC53; cullin 1
   04120 Ubiquitin mediated proteolysis
    K03347  CUL1, CDC53; cullin 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03347  CUL1, CDC53; cullin 1
   04340 Hedgehog signaling pathway
    K03347  CUL1, CDC53; cullin 1
   04341 Hedgehog signaling pathway - fly
    K03347  CUL1, CDC53; cullin 1
   04350 TGF-beta signaling pathway
    K03347  CUL1, CDC53; cullin 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03347  CUL1, CDC53; cullin 1
   04111 Cell cycle - yeast
    K03347  CUL1, CDC53; cullin 1
   04114 Oocyte meiosis
    K03347  CUL1, CDC53; cullin 1
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03347  CUL1, CDC53; cullin 1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K03347  CUL1, CDC53; cullin 1
  09167 Infectious diseases
   05168 Herpes simplex infection
    K03347  CUL1, CDC53; cullin 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03347  CUL1, CDC53; cullin 1
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00379  SCF-MET30 complex
     K03347  CUL1, CDC53; cullin 1
    M00380  SCF-BTRC complex
     K03347  CUL1, CDC53; cullin 1
    M00381  SCF-SKP2 complex
     K03347  CUL1, CDC53; cullin 1
    M00382  SCF-FBS complex
     K03347  CUL1, CDC53; cullin 1
    M00407  SCF-CDC4 complex
     K03347  CUL1, CDC53; cullin 1
    M00411  SCF-GRR1 complex
     K03347  CUL1, CDC53; cullin 1
    M00387  SCF-FBW7 complex
     K03347  CUL1, CDC53; cullin 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Cullin
     K03347  CUL1, CDC53; cullin 1
BRITE hierarchy
Other DBs
COG: COG5647
Genes
HSA: 8454(CUL1)
PTR: 463821(CUL1)
PPS: 100972042(CUL1)
GGO: 101123881(CUL1) 109024916 109025459
NLE: 100580180(CUL1)
MCC: 710581(CUL1)
MCF: 101867010(CUL1)
CSAB: 103227180(CUL1)
RRO: 104667014(CUL1)
RBB: 108522304(CUL1)
CJC: 100395702(CUL1)
SBQ: 101051291(CUL1)
MMU: 26965(Cul1)
RNO: 362356(Cul1)
CGE: 100757763(Cul1)
NGI: 103731381(Cul1)
HGL: 101703786(Cul1)
CCAN: 109695511(Cul1)
OCU: 100345752(CUL1)
TUP: 102497446(CUL1)
CFA: 475512(CUL1)
AML: 100466596(CUL1)
UMR: 103668956(CUL1)
ORO: 101369645(CUL1)
FCA: 101087051(CUL1)
PTG: 102957061(CUL1)
AJU: 106981418(CUL1)
BTA: 407228(CUL1)
BIU: 109557757(CUL1)
PHD: 102319372 102337109(CUL1)
CHX: 102189276(CUL1)
OAS: 101106584(CUL1)
SSC: 100524037(CUL1)
CFR: 102517054(CUL1)
CDK: 105085195(CUL1)
BACU: 103011656(CUL1)
LVE: 103070988(CUL1)
OOR: 101280362(CUL1)
ECB: 100051217(CUL1)
EPZ: 103553705(CUL1)
EAI: 106842121(CUL1)
MYB: 102245795(CUL1)
MYD: 102771406(CUL1)
HAI: 109395450(CUL1)
RSS: 109440215 109451281(CUL1)
PALE: 102887109(CUL1)
LAV: 100664600(CUL1)
TMU: 101360163
MDO: 100013348(CUL1)
SHR: 100926417(CUL1)
OAA: 100073945(CUL1)
GGA: 420783(CUL1)
MGP: 100540218(CUL1)
CJO: 107309836(CUL1)
APLA: 101793264(CUL1)
ACYG: 106048734(CUL1)
TGU: 100223849(CUL1)
GFR: 102038503(CUL1)
FAB: 101810352(CUL1)
PHI: 102100590(CUL1)
PMAJ: 107200314(CUL1)
CCW: 104688924(CUL1)
FPG: 101911159(CUL1)
FCH: 102056187(CUL1)
CLV: 102093584(CUL1)
EGZ: 104124772(CUL1)
AAM: 106495275(CUL1)
ASN: 102371987(CUL1)
AMJ: 102562508(CUL1)
PSS: 102452815(CUL1)
CMY: 102932876(CUL1)
CPIC: 101938030(CUL1)
ACS: 100562987 100563024(cul1)
PVT: 110088676(CUL1)
PBI: 103051969(CUL1)
GJA: 107119625(CUL1)
XLA: 734414(cul1.S) 734526
XTR: 734121(cul1)
NPR: 108794363(CUL1)
DRE: 323883(cul1a) 406816(cul1b)
IPU: 108256454(cul1) 108280768
AMEX: 103026940(cul1) 111194478
TRU: 101068951(cul1)
LCO: 104933878(cul1)
NCC: 104940785(cul1)
MZE: 101485891(cul1)
OLA: 101155471(cul1)
XMA: 102238349(cul1)
PRET: 103457010(cul1)
NFU: 107383137(cul1)
CSEM: 103377187(cul1)
LCF: 108885000(cul1)
HCQ: 109530293(cul1)
BPEC: 110158319(cul1)
ELS: 105022041(cul1) 105024245
SFM: 108919683(cul1) 108935504
LCM: 102360768(CUL1)
CMK: 103187003(cul1)
CIN: 100177902
SPU: 589630
APLC: 110975971
SKO: 100376800
DME: Dmel_CG11261(CG11261) Dmel_CG1877(Cul1)
DSI: Dsimw501_GD10516(Dsim_GD10516) Dsimw501_GD12683(Dsim_GD12683)
MDE: 101893739
AAG: 5578149
AME: 410565
BIM: 100744502
BTER: 100650301
SOC: 105194500
AEC: 105148148
ACEP: 105627427
PBAR: 105429209
HST: 105188454
CFO: 105249516
LHU: 105671349
PGC: 109855807
NVI: 100123219(CUL1)
TCA: 660670
DPA: 109542635
NVL: 108569883
PMAC: 106715294
PRAP: 110997214
API: 100160902
DNX: 107165762
ZNE: 110837048
FCD: 110848553
TUT: 107366218
CEL: CELE_D2045.6(cul-1) CELE_K08E7.7(cul-6)
CBR: CBG18382(Cbr-cul-1)
BMY: Bm1_21420
TSP: Tsp_02228
MYI: 110451924
SHX: MS3_02506
EPA: 110254577
ADF: 107336444
HMG: 100206949(cul1) 101238456
AQU: 100638896
CPAP: 110821436
LJA: Lj0g3v0209709.1(Lj0g3v0209709.1) Lj0g3v0209709.2(Lj0g3v0209709.2) Lj1g3v4916290.1(Lj1g3v4916290.1) Lj4g3v2365220.2(Lj4g3v2365220.2) Lj4g3v2365220.3(Lj4g3v2365220.3) Lj4g3v2367300.2(Lj4g3v2367300.2)
VVI: 100233054(CUL1) 100261361
DOSA: Os01t0369000-01(Os01g0369000) Os01t0369200-01(Os01g0369200)
ATS: 109738966(LOC109738966) 109765974(LOC109765974)
DCT: 110116436
ATR: 18422906
SMO: SELMODRAFT_158171(CUL1-2) SELMODRAFT_173394(CUL1-1)
CRE: CHLREDRAFT_116937(CUL3)
APRO: F751_6385
SCE: YDL132W(CDC53)
ERC: Ecym_8046
KMX: KLMA_60494(CDC53)
NCS: NCAS_0A13810(NCAS0A13810)
NDI: NDAI_0A02230(NDAI0A02230)
TPF: TPHA_0P00850(TPHA0P00850)
TBL: TBLA_0A05930(TBLA0A05930)
TDL: TDEL_0H01480(TDEL0H01480)
KAF: KAFR_0B01150(KAFR0B01150)
PIC: PICST_29770(CDC53)
CAL: CAALFM_C301700WA(CDC53)
SLB: AWJ20_2132(CDC53)
NCR: NCU05204(cul-1)
NTE: NEUTE1DRAFT80573(NEUTE1DRAFT_80573)
MGR: MGG_07145
MAW: MAC_08080
MAJ: MAA_05122
CMT: CCM_04213
MBE: MBM_02956
ANI: AN1019.2
ANG: ANI_1_830074(An08g05870)
PBN: PADG_11387(PADG_02155)
ABE: ARB_01462
TVE: TRV_05741
PTE: PTT_04953
SPO: SPAC17G6.12(cul1)
CNE: CNN01140
CNB: CNBN1130
ABP: AGABI1DRAFT113105(AGABI1DRAFT_113105) AGABI1DRAFT120802(AGABI1DRAFT_120802)
ABV: AGABI2DRAFT179345(AGABI2DRAFT_179345) AGABI2DRAFT195832(AGABI2DRAFT_195832)
MGL: MGL_2715
DDI: DDB_G0267384(culB) DDB_G0278991(culE) DDB_G0291972(culA)
DFA: DFA_07621(culE) DFA_09462(culA) DFA_11253(culB)
EHI: EHI_156450(100.t00027)
PYO: PY17X_1428600(PY01171)
PCB: PCHAS_142830(PC000389.02.0)
SMIN: v1.2.024830.t1(symbB.v1.2.024830.t1)
PTI: PHATRDRAFT_29317(CUL1_3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Petroski MD, Deshaies RJ.
  Title
Function and regulation of cullin-RING ubiquitin ligases.
  Journal
Nat Rev Mol Cell Biol 6:9-20 (2005)
DOI:10.1038/nrm1547
Reference
PMID:9499404
  Authors
Patton EE, Willems AR, Sa D, Kuras L, Thomas D, Craig KL, Tyers M
  Title
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.
  Journal
Genes Dev 12:692-705 (1998)
DOI:10.1101/gad.12.5.692
  Sequence
[sce:YDL132W]
Reference
PMID:9663463
  Authors
Michel JJ, Xiong Y
  Title
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
  Journal
Cell Growth Differ 9:435-49 (1998)
  Sequence
[hsa:8454]

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