Entry
Symbol
ALG8
Name
Pathway
Module
M00055 N-glycan precursor biosynthesis
Reaction
R06263 dolichyl beta-D-glucosyl phosphate:D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase
Disease
H00118 Congenital disorders of glycosylation type I
H00545 Polycystic liver disease
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00510 N-Glycan biosynthesis
K03849 ALG8; alpha-1,3-glucosyltransferase
09180 Brite Hierarchies
09181 Protein families: metabolism
01003 Glycosyltransferases
K03849 ALG8; alpha-1,3-glucosyltransferase
Enzymes [BR:ko01000 ]
2. Transferases
2.4 Glycosyltransferases
2.4.1 Hexosyltransferases
2.4.1.265 dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase
K03849 ALG8; alpha-1,3-glucosyltransferase
Glycosyltransferases [BR:ko01003 ]
N-Glycan biosynthesis
Dol-linked oligosaccharide
K03849 ALG8; alpha-1,3-glucosyltransferase
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Stagljar I, te Heesen S, Aebi M
Title
New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus.
Journal
Sequence
Reference
Authors
Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P.
Title
Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate.
Journal