KEGG   ORTHOLOGY: K03868Help
Entry
K03868                      KO                                     

Name
RBX1, ROC1
Definition
RING-box protein 1 [EC:2.3.2.32]
Pathway
ko03420  Nucleotide excision repair
ko04066  HIF-1 signaling pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04114  Oocyte meiosis
ko04120  Ubiquitin mediated proteolysis
ko04141  Protein processing in endoplasmic reticulum
ko04310  Wnt signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04710  Circadian rhythm
ko05200  Pathways in cancer
ko05211  Renal cell carcinoma
Module
M00379  SCF-MET30 complex
M00380  SCF-BTRC complex
M00381  SCF-SKP2 complex
M00382  SCF-FBS complex
M00383  ECV complex
M00384  Cul3-SPOP complex
M00385  Cul4-DDB1-DDB2 complex
M00386  Cul4-DDB1-CSA complex
M00387  SCF-FBW7 complex
M00407  SCF-CDC4 complex
M00411  SCF-GRR1 complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03868  RBX1, ROC1; RING-box protein 1
   04120 Ubiquitin mediated proteolysis
    K03868  RBX1, ROC1; RING-box protein 1
  09124 Replication and repair
   03420 Nucleotide excision repair
    K03868  RBX1, ROC1; RING-box protein 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04341 Hedgehog signaling pathway - fly
    K03868  RBX1, ROC1; RING-box protein 1
   04350 TGF-beta signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04066 HIF-1 signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03868  RBX1, ROC1; RING-box protein 1
   04111 Cell cycle - yeast
    K03868  RBX1, ROC1; RING-box protein 1
   04114 Oocyte meiosis
    K03868  RBX1, ROC1; RING-box protein 1
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03868  RBX1, ROC1; RING-box protein 1
 09160 Human Diseases
  09161 Cancers
   05200 Pathways in cancer
    K03868  RBX1, ROC1; RING-box protein 1
   05211 Renal cell carcinoma
    K03868  RBX1, ROC1; RING-box protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03868  RBX1, ROC1; RING-box protein 1
   03400 DNA repair and recombination proteins
    K03868  RBX1, ROC1; RING-box protein 1
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00379  SCF-MET30 complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00380  SCF-BTRC complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00381  SCF-SKP2 complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00382  SCF-FBS complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00407  SCF-CDC4 complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00411  SCF-GRR1 complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00383  ECV complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00384  Cul3-SPOP complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00385  Cul4-DDB1-DDB2 complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00386  Cul4-DDB1-CSA complex
     K03868  RBX1, ROC1; RING-box protein 1
    M00387  SCF-FBW7 complex
     K03868  RBX1, ROC1; RING-box protein 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.32  cullin-RING-type E3 NEDD8 transferase
     K03868  RBX1, ROC1; RING-box protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  UBL E3 ligases
   K03868  RBX1, ROC1; RING-box protein 1
  Multi subunit Ring-finger type E3
   SCF complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   ECV complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul3 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul4 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul7 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul9 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K03868  RBX1, ROC1; RING-box protein 1
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      K03868  RBX1, ROC1; RING-box protein 1
BRITE hierarchy
Other DBs
COG: COG5194
GO: 0019788
Genes
HSA: 9978(RBX1)
PTR: 458860(RBX1)
PPS: 100981636(RBX1)
GGO: 101151577(RBX1)
PON: 100441665(RBX1)
NLE: 100596079(RBX1)
MCC: 710252(RBX1)
MCF: 102132483(RBX1)
CSAB: 103223367(RBX1)
RRO: 104673455(RBX1)
RBB: 108528465(RBX1)
CJC: 100391523(RBX1)
SBQ: 101031903(RBX1)
MMU: 56438(Rbx1)
RNO: 300084(Rbx1)
CGE: 100762556(Rbx1)
NGI: 103743488(Rbx1)
HGL: 101712475(Rbx1)
CCAN: 109686914(Rbx1)
OCU: 103352470(RBX1)
TUP: 102468598(RBX1)
CFA: 474494(RBX1)
AML: 100469702(RBX1)
UMR: 103674160(RBX1)
ORO: 101363104(RBX1)
FCA: 101087758(RBX1)
PTG: 102955881(RBX1)
BTA: 518880(RBX1) 780968
BOM: 102272719(RBX1)
BIU: 109559850(RBX1)
CHX: 102187112(RBX1) 102188771
OAS: 101109871(RBX1)
SSC: 110260638(RBX1)
CFR: 102515877(RBX1)
CDK: 105091911(RBX1)
BACU: 102998295(RBX1)
LVE: 103090829(RBX1)
OOR: 101287254(RBX1) 101289349
ECB: 100055581(RBX1)
EPZ: 103556120(RBX1)
EAI: 106842455(RBX1)
MYD: 102760790(RBX1)
HAI: 109392275(RBX1)
RSS: 109448834(RBX1)
PALE: 102893437(RBX1)
LAV: 100657479(RBX1)
TMU: 101349359
MDO: 100013521(RBX1)
SHR: 100918404(RBX1)
OAA: 100076928(RBX1)
GGA: 418001(RBX1)
MGP: 100543550(RBX1)
CJO: 107312930(RBX1)
APLA: 101796040(RBX1)
ACYG: 106035919(RBX1)
TGU: 100190092(RBX1)
GFR: 102037823(RBX1)
FAB: 101806409(RBX1)
PHI: 102102832(RBX1)
PMAJ: 107204430(RBX1)
CCW: 104696532(RBX1)
FPG: 101916874(RBX1)
FCH: 102049129(RBX1)
CLV: 102095842(RBX1)
AAM: 106488968(RBX1)
ASN: 102372162(RBX1)
AMJ: 102571619(RBX1)
PSS: 102451113(RBX1)
CMY: 102943754(RBX1)
CPIC: 101936281(RBX1)
ACS: 100566553(rbx1)
PVT: 110076073(RBX1)
PBI: 103065423(RBX1)
GJA: 107117140(RBX1)
XLA: 108714482(rbx1.L) 108715730(rbx1.S)
XTR: 100379935(rbx1)
NPR: 108788200(RBX1)
DRE: 449846(rbx1)
SANH: 107672143(rbx1) 107695112
SGH: 107580054 107602336(rbx1)
CCAR: 109076699(rbx1)
AMEX: 107197156(rbx1)
TRU: 101079814(rbx1)
LCO: 104932083(rbx1)
NCC: 104945083(rbx1)
MZE: 101480103(rbx1)
OLA: 101170590(rbx1)
XMA: 102233269(rbx1)
PRET: 103468459(rbx1)
NFU: 107376330(rbx1)
CSEM: 103393328(rbx1)
LCF: 108877581(rbx1)
HCQ: 109514860(rbx1)
BPEC: 110162377(rbx1)
SASA: 100136424(rbx1) 106601243(rbx1)
ELS: 105025789(rbx1)
LCM: 102352187(RBX1)
CMK: 103189242(rbx1)
CIN: 100182516
SPU: 591601
APLC: 110984414
DME: Dmel_CG16982(Roc1a) Dmel_CG16988(Roc1b)
DSI: Dsimw501_GD11014(Dsim_GD11014) Dsimw501_GD16520(Dsim_GD16520)
AAG: 5565270
AME: 408691(Roc1a)
BIM: 100750218
BTER: 100643234
SOC: 105195164
AEC: 105148347
ACEP: 105626311
PBAR: 105432274
HST: 105188519
CFO: 105252239
LHU: 105674184
PGC: 109852514
NVI: 100115578
TCA: 655935
DPA: 109536288
NVL: 108557707
BMOR: 692971
PMAC: 106708735
PRAP: 110992851
PXY: 105397966
DNX: 107162314
ZNE: 110832453
FCD: 110848901
TUT: 107362230
CEL: CELE_ZK287.5(rbx-1)
CBR: CBG19342(Cbr-rbx-1)
BMY: Bm1_05985
CRG: 105317988
MYI: 110455961
OBI: 106882699
LAK: 106150763
SHX: MS3_02947
EPA: 110249442
ADF: 107349974
HMG: 100204043
AQU: 100636037
ATH: AT3G42830 AT5G20570(RBX1)
ALY: ARALYDRAFT_488960(RBX1)
CPAP: 110817690
TCC: 18588272
LJA: Lj0g3v0042719.1(Lj0g3v0042719.1) Lj0g3v0262469.1(Lj0g3v0262469.1) Lj3g3v1339080.1(Lj3g3v1339080.1)
ZJU: 107423885
NNU: 104600540
DOSA: Os01t0106800-01(Os01g0106800) Os02t0708300-01(Os02g0708300)
ATS: 109737146(LOC109737146) 109777151(LOC109777151)
CRE: CHLREDRAFT_79815(RBX1)
MNG: MNEG_4176
OLU: OSTLU_119493(rbx1)
MIS: MICPUN_113936(RBX1)
APRO: F751_6626
SCE: YOL133W(HRT1)
ERC: Ecym_2029
KMX: KLMA_70161(HRT1)
NCS: NCAS_0C04480(NCAS0C04480)
NDI: NDAI_0G03860(NDAI0G03860)
TPF: TPHA_0P01470(TPHA0P01470)
TBL: TBLA_0B08710(TBLA0B08710)
TDL: TDEL_0A00470(TDEL0A00470)
KAF: KAFR_0C01780(KAFR0C01780)
PIC: PICST_37145(HRT1)
CAL: CAALFM_C302450WA(HRT1)
CAUR: QG37_05948
NTE: NEUTE1DRAFT116888(NEUTE1DRAFT_116888)
MGR: MGG_08844
MAW: MAC_01896
MAJ: MAA_00593
CMT: CCM_05836
BFU: BCIN_03g07500(Bchrt1)
MBE: MBM_08230
ANI: AN8844.2
ANG: ANI_1_294154(An17g02100)
ABE: ARB_07022
TVE: TRV_07648
PTE: PTT_16968
SPO: SPAC23H4.18c(rbx1)
CNE: CNB03140
CNB: CNBB2560
ABP: AGABI1DRAFT130185(AGABI1DRAFT_130185)
ABV: AGABI2DRAFT139777(AGABI2DRAFT_139777)
MGL: MGL_0788
DDI: DDB_G0287629(rbx1)
EHI: EHI_151630(2.t00108)
PYO: PY17X_0809400(PY00969)
PCB: PCHAS_080650(PC000269.01.0)
TAN: TA10565
TPV: TP04_0669
BBO: BBOV_III007590(17.m07664)
CPV: cgd8_930
SMIN: v1.2.005788.t1(symbB.v1.2.005788.t1) v1.2.035375.t1(symbB.v1.2.035375.t1)
PTI: PHATRDRAFT_39090(Rbx1)
NGD: NGA_0441600(RBX1)
SPAR: SPRG_11654
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG Jr, Elledge SJ, Conaway RC, Harper JW, Conaway JW
  Title
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
  Journal
Science 284:657-61 (1999)
DOI:10.1126/science.284.5414.657
  Sequence
[sce:YOL133W]
Reference
  Authors
Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW
  Title
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.
  Journal
Genes Dev 13:2928-33 (1999)
DOI:10.1101/gad.13.22.2928
  Sequence
[hsa:9978] [sce:YOL133W]

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