KEGG   ORTHOLOGY: K04097
Entry
K04097                      KO                                     

Name
HPGDS
Definition
prostaglandin-H2 D-isomerase / glutathione transferase [EC:5.3.99.2 2.5.1.18]
Pathway
ko00480  Glutathione metabolism
ko00590  Arachidonic acid metabolism
ko00980  Metabolism of xenobiotics by cytochrome P450
ko00982  Drug metabolism - cytochrome P450
ko01100  Metabolic pathways
ko05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
   00982 Drug metabolism - cytochrome P450
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.99  Other intramolecular oxidoreductases
    5.3.99.2  prostaglandin-D synthase
     K04097  HPGDS; prostaglandin-H2 D-isomerase / glutathione transferase
Other DBs
RN: R02266 R03522 R07002 R07003 R07004 R07023 R07024 R07025 R07026 R07069 R07070 R07083 R07084 R07091 R07092 R07093 R07094 R07100 R07113 R07116 R08280 R09409
GO: 0004667 0004364
Genes
HSA: 27306(HPGDS)
PTR: 743219(HPGDS)
PPS: 100990241(HPGDS)
GGO: 101123835(HPGDS)
PON: 100442014(HPGDS)
NLE: 100598180(HPGDS)
MCC: 705227(HPGDS)
MCF: 102131661(HPGDS)
CSAB: 103235987(HPGDS)
RRO: 104679857(HPGDS)
RBB: 108531868(HPGDS)
CJC: 100399167(HPGDS)
SBQ: 101048967(HPGDS)
MMU: 54486(Hpgds)
MCAL: 110295631(Hpgds)
MPAH: 110317199(Hpgds)
RNO: 58962(Hpgds)
MUN: 110564343(Hpgds)
CGE: 100768035(Hpgds)
NGI: 103743362(Hpgds)
HGL: 101706734(Hpgds)
OCU: 100353701(HPGDS)
TUP: 102485301(HPGDS)
CFA: 478481(HPGDS)
VVP: 112932672(HPGDS)
AML: 100466392(HPGDS)
UMR: 103677906(HPGDS)
UAH: 113263135(HPGDS)
ORO: 101376365(HPGDS)
ELK: 111157708
FCA: 101083337(HPGDS)
PTG: 102970849(HPGDS)
PPAD: 109275800(HPGDS)
AJU: 106988526(HPGDS)
BTA: 100139892(HPGDS)
BOM: 102269024(HPGDS)
BIU: 109559997(HPGDS)
BBUB: 102404824(HPGDS)
CHX: 102191223(HPGDS)
OAS: 101116145(HPGDS)
SSC: 100623584(HPGDS)
CFR: 102513633(HPGDS)
CDK: 105089526(HPGDS)
BACU: 103019771(HPGDS)
LVE: 103079273(HPGDS)
OOR: 101285619(HPGDS)
DLE: 111179078(HPGDS)
PCAD: 102992900(HPGDS)
ECB: 100053460(HPGDS)
EPZ: 103552392(HPGDS)
EAI: 106829529(HPGDS)
MYB: 102240667(HPGDS)
MYD: 102767586(HPGDS)
MNA: 107532072(HPGDS)
HAI: 109385325(HPGDS)
DRO: 112317839(HPGDS)
PALE: 102895654(HPGDS)
RAY: 107510631(HPGDS)
MJV: 108393953(HPGDS)
LAV: 100666840(HPGDS)
TMU: 101346527
MDO: 100016454(HPGDS)
SHR: 100926080(HPGDS)
PCW: 110223073(HPGDS)
OAA: 100078645(HPGDS)
GGA: 395863(HPGDS)
MGP: 100541600 104910670(HPGDS)
CJO: 107313254(HPGDS)
NMEL: 110397718(HPGDS)
APLA: 101796320(HPGDS)
ACYG: 106041241(HPGDS)
TGU: 100224496(HPGDS)
LSR: 110481595(HPGDS)
SCAN: 103826041(HPGDS)
GFR: 102044676(HPGDS)
FAB: 101817277(HPGDS)
PHI: 102102732(HPGDS)
PMAJ: 107203035(HPGDS)
CCAE: 111928487(HPGDS)
CCW: 104697200(HPGDS)
ETL: 114067155(HPGDS)
FPG: 101913476(HPGDS)
FCH: 102054810(HPGDS)
CLV: 102094022(HPGDS)
EGZ: 104122621(HPGDS)
NNI: 104021198(HPGDS)
ACUN: 113479530(HPGDS)
PADL: 103921746(HPGDS)
AAM: 106491909(HPGDS)
ASN: 102384182(HPGDS)
AMJ: 102574977(HPGDS)
PSS: 102450743(HPGDS)
CMY: 102944217(HPGDS)
CPIC: 101943956(HPGDS)
XLA: 379417(hpgds.S) 398969(hpgds.L)
XTR: 448666(hpgds)
IPU: 100528611(gst28)
SASA: 100196042(hpgds)
OTW: 112248322(hpgds)
SALP: 111973822(hpgds)
ELS: 105014622(hpgds)
LCM: 102352378(HPGDS)
CMK: 103184489(hpgds)
RTP: 109912194(hpgds)
DME: Dmel_CG8938(GstS1)
DER: 6548275
DSI: Dsimw501_GD25495(Dsim_GD25495)
DSR: 110182597
DPE: 6592395
DWI: 6646015
DAZ: 108616338
DNV: 108654342
DHE: 111595404
MDE: 101890455(GST)
LCQ: 111687996
AGA: AgaP_AGAP010404(GST_ANOGA)
AAG: 5575278
AALB: 109401280
AME: 411045(GstS4) 552283 552304(GstS1)
BMOR: 692543(GSTs2) 692631(GSTs1)
CSCU: 111638117
CEL: CELE_C02A12.1(gst-33) CELE_R11G1.3(gst-11) CELE_ZK546.11(gst-30)
CBR: CBG00918(Cbr-gst-13) CBG02264(Cbr-gst-6.1) CBG02265 CBG02278(Cbr-gst-30) CBG03411(Cbr-gst-3) CBG03451 CBG03453 CBG06381 CBG06384 CBG14247(Cbr-gst-11) CBG20632(Cbr-gst-5) CBG20649 CBG20668 CBG22411(Cbr-gst-33) CBG22850(Cbr-gst-38) CBG24808(Cbr-gst-6.2) CBG24809(Cbr-gst-7)
SHX: MS3_06482
EGL: EGR_04787
ANG: ANI_1_1838144(An16g06100)
SLA: SERLADRAFT_417671(glt1.1)
SMIN: v1.2.000995.t1(symbB.v1.2.000995.t1) v1.2.003070.t1(symbB.v1.2.003070.t1) v1.2.014814.t1(symbB.v1.2.014814.t1) v1.2.014815.t1(symbB.v1.2.014815.t1) v1.2.017551.t1(symbB.v1.2.017551.t1) v1.2.017577.t1(symbB.v1.2.017577.t1) v1.2.040628.t1(symbB.v1.2.040628.t1) v1.2.040628.t2(symbB.v1.2.040628.t2)
SAZ: Sama_0385
SAGA: M5M_17045
RFR: Rfer_3267
MCG: GL4_2957
 » show all
Reference
  Authors
Kanaoka Y, Fujimori K, Kikuno R, Sakaguchi Y, Urade Y, Hayaishi O
  Title
Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase.
  Journal
Eur J Biochem 267:3315-22 (2000)
DOI:10.1046/j.1432-1327.2000.01362.x
  Sequence
[hsa:27306] [mmu:54486]
Reference
  Authors
Pinzar E, Miyano M, Kanaoka Y, Urade Y, Hayaishi O
  Title
Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis.
  Journal
J Biol Chem 275:31239-44 (2000)
DOI:10.1074/jbc.M000750200

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