KEGG   ORTHOLOGY: K04119Help
Entry
K04119                      KO                                     

Name
AKR1C3
Definition
aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Pathway
ko00140  Steroid hormone biosynthesis
ko00590  Arachidonic acid metabolism
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
ko04913  Ovarian steroidogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
   00590 Arachidonic acid metabolism
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.188  prostaglandin-F synthase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
BRITE hierarchy
Other DBs
RN: R01836 R01838 R02799 R08955 R08957 R08960 R11763
GO: 0030283 0047017 0047026
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3)
PPS: 100971300 100986388(AKR1C3) 100987632
GGO: 101144878 101147265
PON: 100174617(AKR1C3)
NLE: 100604844
MCC: 711440
MCF: 102116465(AKR1C2) 102142023(HSD17B5) 102143072
CSAB: 103237812 103237813
RRO: 104674747
MCAL: 110308148
MPAH: 110333848
MUN: 110560700
HGL: 101702106
CFA: 497070(AKR1C3)
VVP: 112933725
ELK: 111158636
FCA: 100510801(AKR1C3)
PTG: 102963188
PPAD: 109273789
AJU: 106988139
BTA: 100139386(20ALPHA-HSD) 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
SSC: 733634(AKR1C1)
LVE: 103069218
PCAD: 102978533
ECB: 100070616
MYB: 102255491
OAA: 100085065
CMY: 102946053
GJA: 107108026
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 779627(akr1c3)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7650035
  Authors
Khanna M, Qin KN, Wang RW, Cheng KC
  Title
Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 270:20162-8 (1995)
DOI:10.1074/jbc.270.34.20162
  Sequence
[hsa:8644]
Reference
  Authors
Qiu W, Zhou M, Labrie F, Lin SX
  Title
Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.
  Journal
Mol Endocrinol 18:1798-807 (2004)
DOI:10.1210/me.2004-0032
Reference
  Authors
Komoto J, Yamada T, Watanabe K, Takusagawa F
  Title
Crystal structure of human prostaglandin F synthase (AKR1C3).
  Journal
Biochemistry 43:2188-98 (2004)
DOI:10.1021/bi036046x
Reference
  Authors
Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N
  Title
Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).
  Journal
Mol Cell Endocrinol 171:137-49 (2001)
DOI:10.1016/S0303-7207(00)00426-3
Reference
  Authors
Penning TM
  Title
New frontiers in androgen biosynthesis and metabolism.
  Journal
Curr Opin Endocrinol Diabetes Obes 17:233-9 (2010)
DOI:10.1097/MED.0b013e3283381a31
Reference
  Authors
Rizner TL, Penning TM
  Title
Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.
  Journal
Steroids 79:49-63 (2014)
DOI:10.1016/j.steroids.2013.10.012

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