KEGG ORTHOLOGY: K04344

ORTHOLOGY: K04344

Entry

K04344                      KO

Symbol

CACNA1A, CAV2.1

Name

voltage-dependent calcium channel P/Q type alpha-1A

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04721

Synaptic vesicle cycle

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04730

Long-term depression

map04742

Taste transduction

map04930

Type II diabetes mellitus

map05017

Spinocerebellar ataxia

map05032

Morphine addiction

map05033

Nicotine addiction

map05207

Chemical carcinogenesis - receptor activation

Disease

H00063

Spinocerebellar ataxia (SCA)

H00606

Early infantile epileptic encephalopathy

H00749

Episodic ataxias

H00775

Hemiplegic migraine

H01808

Hemiconvulsion-hemiplegia-epilepsy syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04020 Calcium signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04727 GABAergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04725 Cholinergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04728 Dopaminergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04726 Serotonergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04730 Long-term depression
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04723 Retrograde endocannabinoid signaling
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04721 Synaptic vesicle cycle
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09157 Sensory system
   04742 Taste transduction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09165 Substance dependence
   05032 Morphine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   05033 Nicotine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A

Other DBs

GO:

0005245

TC:	1.A.1.11.8 1.A.1.11.27

Genes

HSA:	773(CACNA1A)

PTR:	455766(CACNA1A)

PPS:	100971898(CACNA1A)

GGO:	101127257(CACNA1A)

PON:	100458387(CACNA1A)

NLE:	100602682(CACNA1A)

HMH:	116478572(CACNA1A)

MCC:	718291(CACNA1A)

MCF:	102130052(CACNA1A)

MTHB:

126942455

MNI:	105499905(CACNA1A)

CSAB:

103234371(CACNA1A)

CATY:

105601562(CACNA1A)

PANU:

101013922(CACNA1A)

TGE:	112612428(CACNA1A)

MLEU:

105550082(CACNA1A)

RRO:	104661142(CACNA1A)

RBB:	108544091(CACNA1A)

TFN:	117075607(CACNA1A)

PTEH:

111523866(CACNA1A)

CANG:

105519853(CACNA1A)

CJC:	100390599(CACNA1A)

SBQ:	101046396(CACNA1A)

CIMI:

108281958(CACNA1A)

CSYR:

103251529(CACNA1A)

MMUR:

105885431(CACNA1A)

LCAT:

123637429(CACNA1A)

PCOQ:

105807961(CACNA1A)

OGA:	100940437(CACNA1A)

MMU:	12286(Cacna1a)

MCAL:

110299941(Cacna1a)

MPAH:

110337404(Cacna1a)

RNO:	25398(Cacna1a)

MCOC:

116067850

ANU:	117722924(Cacna1a)

MUN:	110545836(Cacna1a)

CGE:	100758171(Cacna1a)

MAUA:

101838455(Cacna1a)

PROB:

127229890

PLEU:

114684157(Cacna1a)

MORG:

121455716(Cacna1a)

MFOT:

126487773

AAMP:

119801772(Cacna1a)

NGI:	103751913(Cacna1a)

HGL:	101725815(Cacna1a)

CPOC:

100726277(Cacna1a)

CCAN:

109681262(Cacna1a)

DORD:

105999228(Cacna1a)

DSP:	122100293(Cacna1a)

PLOP:

125348843(Cacna1a)

NCAR:

124969155

OCU:	100009265(CACNA1A)

OPI:	101520695(CACNA1A)

TUP:	102473903(CACNA1A)

GVR:	103595819(CACNA1A)

CFA:	100686650(CACNA1A)

CLUD:

112666862(CACNA1A)

VVP:	112908114(CACNA1A)

VLG:	121495291(CACNA1A)

NPO:	129522364(CACNA1A)

AML:	100473951(CACNA1A)

UMR:	103682191(CACNA1A)

UAH:	113247199(CACNA1A)

UAR:	123801736(CACNA1A)

ELK:

111162543

LLV:

125083811

MPUF:

101674676(CACNA1A)

MNP:	132011054(CACNA1A)

MLK:	131823608(CACNA1A)

NVS:	122909666(CACNA1A)

ORO:	101378448(CACNA1A)

EJU:	114197735(CACNA1A)

ZCA:	113918149(CACNA1A)

MLX:	118005966(CACNA1A)

NSU:	110593832(CACNA1A)

FCA:	101094827(CACNA1A)

PYU:	121014070(CACNA1A)

PCOO:

112852304(CACNA1A)

PBG:	122486958(CACNA1A)

PVIV:

125160139(CACNA1A)

LRUF:

124523140

PTG:	102962991(CACNA1A)

PPAD:

109254011(CACNA1A)

PUC:

125928736

AJU:

106986103

HHV:	120245276(CACNA1A)

BTA:	282648(CACNA1A)

BOM:	102266763(CACNA1A)

BIU:	109560900(CACNA1A)

BBUB:

102404131(CACNA1A)

BBIS:

104999898(CACNA1A)

CHX:	102168441(CACNA1A)

OAS:	101120920(CACNA1A)

BTAX:

128050795(CACNA1A)

ODA:	120864066(CACNA1A)

CCAD:

122440510(CACNA1A)

MBEZ:

129559399(CACNA1A)

SSC:	100525387(CACNA1A)

CFR:	102516820(CACNA1A)

CBAI:

105068402(CACNA1A)

CDK:	105100784(CACNA1A)

VPC:	102529757(CACNA1A)

BACU:

103007483(CACNA1A)

BMUS:

118892680(CACNA1A)

LVE:	103068318(CACNA1A)

OOR:	101275783(CACNA1A)

DLE:	111166727(CACNA1A)

PCAD:

102977865(CACNA1A)

PSIU:

116751638(CACNA1A)

NASI:

112414738(CACNA1A)

ECB:	100063873(CACNA1A)

EPZ:	103566268(CACNA1A)

EAI:	106844288(CACNA1A)

MYB:	102257882(CACNA1A)

MYD:	102771143(CACNA1A)

MMYO:

118652720(CACNA1A)

MLF:	102423622(CACNA1A)

PKL:	118710344(CACNA1A)

EFUS:

103301061(CACNA1A)

MNA:	107541038(CACNA1A)

DRO:	112301443(CACNA1A)

SHON:

118984103(CACNA1A)

AJM:	119049676(CACNA1A)

PDIC:

114502598(CACNA1A)

PHAS:

123828203(CACNA1A)

MMF:	118615449(CACNA1A)

PPAM:

129062544(CACNA1A)

HAI:	109394251(CACNA1A)

RFQ:	117037598(CACNA1A)

PALE:

102891789(CACNA1A)

PGIG:

120618508(CACNA1A)

PVP:	105307194(CACNA1A)

RAY:	107519399(CACNA1A)

MJV:	108399643(CACNA1A)

TOD:	119241018(CACNA1A)

SARA:

101538128(CACNA1A)

SETR:

126030243(CACNA1A)

LAV:	100655176(CACNA1A)

TMU:

101341628

ETF:	101655311(CACNA1A)

DNM:

101424427

MDO:	100021108(CACNA1A)

GAS:	123256466(CACNA1A)

SHR:	100925240(CACNA1A)

AFZ:

127544819

PCW:	110214234(CACNA1A)

OAA:	100078981(CACNA1A)

GGA:

107049790

LSR:	110481525(CACNA1A)

PMOA:

120506097(CACNA1A)

PHI:	102099919(CACNA1A)

ETL:	114072531(CACNA1A)

SVG:	106863679(CACNA1A)

HRT:	120748314(CACNA1A)

FPG:	101919186(CACNA1A)

ACHC:

115337976(CACNA1A)

HLE:

104833250

AGEN:

126042843

SHAB:

115603568(CACNA1A)

RTD:	128901420(CACNA1A)

TGT:

104572093

ASN:	102376033(CACNA1A)

AMJ:	102564806(CACNA1A)

CMY:	102933709(CACNA1A)

CCAY:

125627419(CACNA1A)

DCC:	119845817(CACNA1A)

CPIC:

101943820(CACNA1A)

TST:	117888655(CACNA1A)

CABI:

116817734(CACNA1A)

MRV:	120390882(CACNA1A)

ACS:	100557580(cacna1a)

ASAO:

132768731(CACNA1A)

PVT:	110082653(CACNA1A)

SUND:

121920977(CACNA1A)

PBI:	103050605(CACNA1A)

PMUR:

107286895(CACNA1A)

CTIG:

120307742(CACNA1A)

TSR:	106547348(CACNA1A)

PGUT:

117658819(CACNA1A)

APRI:

131190955(CACNA1A)

PTEX:

113433536(CACNA1A)

NSS:

113418247

VKO:	123035671(CACNA1A)

PMUA:

114590816(CACNA1A)

PRAF:

128407692(CACNA1A)

ZVI:	118079990(CACNA1A)

HCG:	128342803(CACNA1A)

GJA:	107116856(CACNA1A)

STOW:

125429002(CACNA1A)

EMC:	129328091(CACNA1A)

XLA:	108710372 373828(cacna1a.S)

XTR:	100492135(cacna1a)

NPR:	108794965(CACNA1A)

RTEM:

120933383(CACNA1A)

BBUF:

120986472(CACNA1A)

BGAR:

122929365(CACNA1A)

MUO:	115465998(CACNA1A)

GSH:	117350148(CACNA1A)

DRE:	562059(cacna1aa) 569528(cacna1ab)

SRX:	107723201 107737248 107737767 107751115

SANH:

107689683 107690704 107691280 107695065

SGH:	107556305 107570979 107571502 107582970

CCAR:

109060317

CAUA:

113045209 113055310 113076290 113099701 113111049

CGIB:

127950577 127952121 127968201 128022206

PTET:

122330866(cacna1aa) 122354178(cacna1ab)

LROH:

127157773(cacna1aa) 127173546(cacna1ab)

OMC:	131538013(cacna1aa) 131549851(cacna1ab)

PPRM:

120480842(cacna1ab) 120490329(cacna1aa)

RKG:	130083588(cacna1ab) 130088409(cacna1aa)

MAMB:

125256929(cacna1ab) 125274988(cacna1aa)

CIDE:

127509613 127522219

MASI:

127425925 127427705 127450446 127451684

TROS:

130561735(cacna1aa) 130571108(cacna1ab)

TDW:	130410129(cacna1ab) 130426178(cacna1aa)

MANU:

129428059(cacna1ab) 129435450(cacna1aa)

IPU:	108259478(cacna1ab) 108273835(cacna1aa)

IFU:	128602643 128624940(cacna1aa)

PHYP:

113523781(cacna1a) 113525358

SMEO:

124379733(cacna1ab) 124396841(cacna1aa)

TFD:	113647092(cacna1ab) 113662432(cacna1aa)

TVC:	132839061(cacna1ab) 132860598(cacna1aa)

AMEX:

103024922 103034375

CMAO:

118802488(cacna1aa) 118803808(cacna1ab)

EEE:	113568055 113586749

CHAR:

105892182(cacna1aa) 105900243(cacna1ab)

TRU:	101065285 101072720(cacna1a)

TFS:	130514509(cacna1aa) 130527070(cacna1ab)

TNG:	GSTEN00021312G001 GSTEN00023728G001

LCO:	104936743 109138994(cacna1a)

TBEN:

117482107(cacna1ab) 117492927(cacna1aa)

CGOB:

115005468 115012056

PGEO:

117450818(cacna1aa)

GACU:

117557103 117558110(cacna1aa)

EMAC:

134865000(cacna1ab) 134878025(cacna1aa)

ELY:	117254987(cacna1ab) 117268021(cacna1aa)

EFO:	125880085(cacna1aa) 125885789(cacna1ab)

PLEP:

121942442(cacna1ab) 121956459(cacna1aa)

SLUC:

116042548(cacna1ab) 116051851(cacna1aa)

ECRA:

117958666(cacna1aa) 117961643(cacna1ab)

ESP:

116703362

PFLV:

114546705(cacna1a) 114569401

GAT:	120827313(cacna1aa)

PPUG:

119217852(cacna1ab) 119220171(cacna1aa)

AFB:	129096531(cacna1ab) 129098553(cacna1aa)

CLUM:

117729425(cacna1ab) 117734603

PSWI:

130188457(cacna1aa) 130190740(cacna1ab)

MSAM:

119887893(cacna1aa) 119898592(cacna1ab)

SCHU:

122868473(cacna1aa) 122873436(cacna1ab)

CUD:	121503961(cacna1aa) 121508767(cacna1ab)

ALAT:

119013820(cacna1aa) 119016818(cacna1ab)

MZE:	101480217 101484868(cacna1a)

ONL:	100694261 100709811(cacna1a)

OAU:	116326122(cacna1ab) 116329204

OLA:	101170273 105357443(cacna1a)

OML:	112141681(cacna1ab) 112146767(cacna1aa)

CSAI:

133421663(cacna1aa) 133442970(cacna1ab)

XMA:	102225112 102236322(cacna1a)

XCO:	114145343(cacna1a) 114159632

XHE:	116720012(cacna1a) 116735966

PRET:

103462507(cacna1a) 103468620

PFOR:

103145506 103153249(cacna1a)

PLAI:

106946811(cacna1a) 106950739

PMEI:

106922842(cacna1a) 106923783

GAF:	122822399(cacna1aa) 122829890(cacna1ab)

PPRL:

129363260(cacna1aa) 129367079(cacna1ab)

CVG:	107084276 107096037

CTUL:

119772641(cacna1aa) 119786986(cacna1ab)

GMU:	124862209 124864229 124868854(cacna1ab)

NFU:	107376625 107391184(cacna1a)

KMR:	108239282(cacna1aa) 108247309(cacna1ab)

ALIM:

106527230(cacna1a) 106535455

NWH:	119421129(cacna1aa)

AOCE:

111587522 111588675

MCEP:

124998058(cacna1aa) 125002981(cacna1ab)

CSEM:

103383187(cacna1a) 103392961

POV:	109639428 109640172

SSEN:

122770849 122785004(cacna1aa)

HHIP:

117752728(cacna1ab) 117766571(cacna1aa)

HSP:	118098171(cacna1ab) 118123248(cacna1aa)

SMAU:

118288823(cacna1aa) 118312622(cacna1ab)

LCF:	108880719 108880807(cacna1ab)

SDU:	111227043 111235833(cacna1a)

SLAL:

111646711 111665625

XGL:	120785766(cacna1aa) 120800346(cacna1ab)

HCQ:	109511051 109526983

SSCV:

125968978 125983110

SBIA:

133505768(cacna1ab) 133514690(cacna1aa)

PEE:	133404583(cacna1ab) 133414507(cacna1aa)

PTAO:

133466040(cacna1aa) 133476798(cacna1ab)

BPEC:

110156590(cacna1a)

MALB:

109970352(cacna1a)

BSPL:

114853499(cacna1ab) 114860026(cacna1aa)

SJO:	128379454(cacna1aa) 128379827(cacna1ab)

SASA:

106606768 106606804

STRU:

115170706 115191199 115196908

OTW:	112225764 112238108 112240854(cacna1ab)

OMY:	110485216 110487190 110494931 110539011(cacna1aa)

OGO:	123998970 124015263 124017330

OKI:	109880125 109884352 109887500 116352993

OKE:	118374962 118375936

SNH:	120023380 120023395 120034271

CCLU:

121551350(cacna1aa) 121553876(cacna1ab) 121570749

ELS:	105012190(cacna1a) 105024166

SFM:	108927499(cacna1a) 108930696

PKI:	111843226 111845281(cacna1a)

AANG:

118216561 118221076(cacna1ab)

LOC:	102693691(cacna1a)

PSPA:

121304484(cacna1ab)

ARUT:

117402054 117971987

PSEX:

120540050

LCM:	102354855(CACNA1A)

CPLA:

HOC:

LERI:

LRJ:

SPU:

DER:

PGC:

OTA:	OT_ostta04g02830

MIS:	MICPUN_62568

» show all

Reference

PMID:25109669

Authors

Rose SJ, Kriener LH, Heinzer AK, Fan X, Raike RS, van den Maagdenberg AM, Hess EJ

Title

The first knockin mouse model of episodic ataxia type 2.

Journal

Exp Neurol 261:553-62 (2014)
DOI:10.1016/j.expneurol.2014.08.001

Sequence

[hsa:773]

Reference

PMID:10049321

Authors

Hans M, Urrutia A, Deal C, Brust PF, Stauderman K, Ellis SB, Harpold MM, Johnson EC, Williams ME

Title

Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage-activated calcium channels.

Journal

Biophys J 76:1384-400 (1999)
DOI:10.1016/S0006-3495(99)77300-5

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Ontology (5)   
   KEGG BRITE (2)   
   GO (1)   
   TC (2)   
Pathway (32)   
   KEGG PATHWAY (32)   
Disease (5)   
   KEGG DISEASE (5)   
Gene (2123)   
   KEGG GENES (448)   
   KEGG MGENES (761)   
   RefGene (905)   
   OC (9)   
Literature (2)   
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