KEGG   ORTHOLOGY: K04344
Entry
K04344                      KO                                     

Name
CACNA1A, CAV2.1
Definition
voltage-dependent calcium channel P/Q type alpha-1A
Pathway
ko04010  MAPK signaling pathway
ko04020  Calcium signaling pathway
ko04721  Synaptic vesicle cycle
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko04742  Taste transduction
ko04930  Type II diabetes mellitus
ko05017  Spinocerebellar ataxia
ko05032  Morphine addiction
ko05033  Nicotine addiction
Disease
H00063  Spinocerebellar ataxia (SCA)
H00606  Early infantile epileptic encephalopathy
H00749  Episodic ataxias
H00775  Hemiplegic migraine
H01808  Hemiconvulsion-hemiplegia-epilepsy syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04020 Calcium signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04727 GABAergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04725 Cholinergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04728 Dopaminergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04726 Serotonergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04730 Long-term depression
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04723 Retrograde endocannabinoid signaling
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04721 Synaptic vesicle cycle
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09157 Sensory system
   04742 Taste transduction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09165 Substance dependence
   05032 Morphine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   05033 Nicotine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
Other DBs
GO: 0005245
TC: 1.A.1.11.8 1.A.1.11.27
Genes
HSA: 773(CACNA1A)
PTR: 455766(CACNA1A)
PPS: 100971898(CACNA1A)
GGO: 101127257(CACNA1A)
PON: 100458387(CACNA1A)
NLE: 100602682(CACNA1A)
MCC: 718291(CACNA1A)
MCF: 102130052(CACNA1A)
CSAB: 103234371(CACNA1A)
RRO: 104661142(CACNA1A)
RBB: 108544091(CACNA1A)
CJC: 100390599(CACNA1A)
SBQ: 101046396(CACNA1A)
MMU: 12286(Cacna1a)
MCAL: 110299941(Cacna1a)
MPAH: 110337404(Cacna1a)
RNO: 25398(Cacna1a)
MUN: 110545836(Cacna1a)
CGE: 100758171(Cacna1a)
NGI: 103751913(Cacna1a)
HGL: 101725815(Cacna1a)
CCAN: 109681262(Cacna1a)
OCU: 100009265(CACNA1A)
TUP: 102473903(CACNA1A)
CFA: 100686650(CACNA1A)
VVP: 112908114(CACNA1A)
AML: 100473951(CACNA1A)
UMR: 103682191
UAH: 113247199(CACNA1A)
ORO: 101378448(CACNA1A)
ELK: 111162543
FCA: 101094827(CACNA1A)
PTG: 102962991(CACNA1A)
PPAD: 109254011(CACNA1A)
AJU: 106986103(CACNA1A)
BTA: 282648(CACNA1A)
BOM: 102266763(CACNA1A)
BIU: 109560900(CACNA1A)
BBUB: 102404131(CACNA1A)
CHX: 102168441(CACNA1A)
OAS: 101120920(CACNA1A)
SSC: 100525387(CACNA1A)
CFR: 102516820(CACNA1A)
CDK: 105100784(CACNA1A)
BACU: 103007483(CACNA1A)
LVE: 103068318(CACNA1A)
OOR: 101275783(CACNA1A)
DLE: 111166727(CACNA1A)
PCAD: 102977865(CACNA1A)
ECB: 100063873(CACNA1A)
EPZ: 103566268(CACNA1A)
EAI: 106844288(CACNA1A)
MYB: 102257882(CACNA1A)
MYD: 102771143(CACNA1A)
MNA: 107541038(CACNA1A)
HAI: 109394251(CACNA1A)
DRO: 112301443(CACNA1A)
PALE: 102891789(CACNA1A)
RAY: 107519399(CACNA1A)
MJV: 108399643(CACNA1A)
LAV: 100655176(CACNA1A)
TMU: 101341628
MDO: 100021108(CACNA1A)
SHR: 100925240(CACNA1A)
PCW: 110214234(CACNA1A)
OAA: 100078981(CACNA1A)
GGA: 107049790
LSR: 110481525(CACNA1A)
PHI: 102099919(CACNA1A)
ETL: 114072531(CACNA1A)
FPG: 101919186(CACNA1A)
ASN: 102376033(CACNA1A)
AMJ: 102564806(CACNA1A)
CMY: 102933709(CACNA1A)
CPIC: 101943820(CACNA1A)
ACS: 100557580(cacna1a)
PVT: 110082653(CACNA1A)
PBI: 103050605(CACNA1A)
PMUR: 107286895(CACNA1A)
TSR: 106547348(CACNA1A)
PMUA: 114590816(CACNA1A)
GJA: 107116856(CACNA1A)
XLA: 108710372 373828(cacna1a.S)
XTR: 100492135(cacna1a)
NPR: 108794965(CACNA1A)
DRE: 562059(cacna1aa) 569528(cacna1ab)
CCAR: 109060317
PHYP: 113523781(cacna1a) 113525358
TRU: 101065285 101072720(cacna1a)
LCO: 104936743 109138994(cacna1a)
MZE: 101480217 101484868(cacna1a)
ONL: 100694261 100709811(cacna1a)
OLA: 101170273 105357443(cacna1a)
XMA: 102225112 102236322(cacna1a)
XCO: 114145343(cacna1a) 114159632
PRET: 103462507(cacna1a) 103468620
NFU: 107376625 107391184(cacna1a)
KMR: 108239282 108247309(cacna1a)
ALIM: 106527230(cacna1a) 106535455
CSEM: 103383187(cacna1a) 103392961
LCF: 108880719 108880807(cacna1a)
SDU: 111227043 111235833(cacna1a)
BPEC: 110156590(cacna1a)
MALB: 109970352(cacna1a)
ELS: 105012190(cacna1a) 105024166
SFM: 108927499(cacna1a) 108930696
PKI: 111843226 111845281(cacna1a)
LCM: 102354855(CACNA1A)
RTP: 109912552
SPU: 574743
SKO: 100373523
DER: 6551177
PGC: 109856977
CRG: 105322251
 » show all
Reference
  Authors
Rose SJ, Kriener LH, Heinzer AK, Fan X, Raike RS, van den Maagdenberg AM, Hess EJ
  Title
The first knockin mouse model of episodic ataxia type 2.
  Journal
Exp Neurol 261:553-62 (2014)
DOI:10.1016/j.expneurol.2014.08.001
  Sequence
[hsa:773]
Reference
  Authors
Hans M, Urrutia A, Deal C, Brust PF, Stauderman K, Ellis SB, Harpold MM, Johnson EC, Williams ME
  Title
Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage-activated calcium channels.
  Journal
Biophys J 76:1384-400 (1999)
DOI:10.1016/S0006-3495(99)77300-5

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