KEGG   ORTHOLOGY: K04346Help
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
ko04010  MAPK signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04270  Vascular smooth muscle contraction
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP - PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Organismal Systems
  Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
BRITE hierarchy
Genes
HSA: 2768(GNA12)
PTR: 463234(GNA12)
PPS: 100979605(GNA12)
GGO: 101147243(GNA12)
PON: 100173387(GNA12)
NLE: 100591916(GNA12)
MCC: 100429106(GNA12)
MCF: 101867258(GNA12)
CSAB: 103246857(GNA12)
RRO: 104664964(GNA12)
RBB: 108543875(GNA12)
CJC: 100387912(GNA12)
SBQ: 101042405(GNA12)
MMU: 14673(Gna12)
RNO: 81663(Gna12)
CGE: 100760944(Gna12)
NGI: 103748670(Gna12)
HGL: 101697421(Gna12)
CCAN: 109683409(Gna12)
OCU: 100347293(GNA12)
TUP: 102501406(GNA12)
CFA: 102154318(GNA12)
AML: 100465369(GNA12)
UMR: 103669942(GNA12)
ORO: 101371250(GNA12)
FCA: 101093316(GNA12)
PTG: 102961052(GNA12)
AJU: 106984497(GNA12)
BTA: 515159(GNA12)
BOM: 102265273(GNA12)
BIU: 109578204(GNA12)
PHD: 102322053(GNA12)
CHX: 102185175(GNA12)
OAS: 101111070(GNA12)
SSC: 100525156(GNA12)
CFR: 102524525(GNA12)
CDK: 105090390(GNA12)
BACU: 103009974(GNA12)
LVE: 103069136(GNA12)
OOR: 101281075(GNA12)
ECB: 100060005(GNA12)
EPZ: 103549418(GNA12)
EAI: 106834780(GNA12)
MYB: 102260289(GNA12)
MYD: 102763801(GNA12)
HAI: 109380223(GNA12)
RSS: 109461354(GNA12)
PALE: 102891706(GNA12)
LAV: 100676444(GNA12)
TMU: 101351796
MDO: 100010453(GNA12)
SHR: 100916443(GNA12)
OAA: 100082592(GNA12)
GGA: 769924(GNA12)
MGP: 100550659(GNA12)
CJO: 107320696(GNA12)
APLA: 101798445(GNA12)
ACYG: 106032065(GNA12)
TGU: 100225137(GNA12)
GFR: 102044790(GNA12)
FAB: 101818259(GNA12)
PHI: 102104762(GNA12)
PMAJ: 107211274(GNA12)
CCW: 104684810(GNA12)
FPG: 101917262(GNA12)
FCH: 102059010(GNA12)
CLV: 102088372(GNA12)
EGZ: 104132621(GNA12)
AAM: 106483939(GNA12)
ASN: 102377286(GNA12)
AMJ: 102559993(GNA12)
PSS: 102445616(GNA12)
CMY: 102931254(GNA12)
CPIC: 101947834(GNA12)
ACS: 100564021(gna12)
PVT: 110083721(GNA12)
PBI: 103050241(GNA12)
GJA: 107116703(GNA12) 107125403
DRE: 503589(gna12a)
IPU: 108257129(gna12)
AMEX: 103024018(gna12)
TRU: 101078184(gna12)
LCO: 104929956(gna12)
NCC: 104953206 104953227(gna12)
MZE: 101473086(gna12)
OLA: 101166935(gna12)
XMA: 102222306(gna12)
PRET: 103462653(gna12)
NFU: 107388805(gna12)
CSEM: 103383240(gna12)
LCF: 108888452(gna12)
HCQ: 109511425(gna12)
BPEC: 110153513(gna12)
ELS: 105006302(gna12)
SFM: 108927048(gna12)
LCM: 102367557(GNA12)
CMK: 103185131(gna12)
SPU: 414055
SKO: 100371005
DME: Dmel_CG17678(cta)
DSI: Dsimw501_GD17672(Dsim_GD17672)
DYA: Dyak_GE22695(Dyak_cta)
MDE: 101898580
AAG: 5570853
AME: 410906(GB12482) 727645
BIM: 100745931
BTER: 100649951
SOC: 105200292
AEC: 105147295
ACEP: 105624301
PBAR: 105431792
HST: 105181192
CFO: 105259283
LHU: 105675078
PGC: 109863777
NVI: 100115318(cta)
TCA: 661072
DPA: 109541992
BMOR: 100862775(Galpha12)
PMAC: 106720633
PRAP: 111001958
PXY: 105391521
API: 100165181
DNX: 107169778
ZNE: 110838798
FCD: 110848091
DPX: DAPPUDRAFT_190301(Gna12)
TUT: 107368817
CEL: CELE_F18G5.3(gpa-12)
CBR: CBG16182(Cbr-gpa-12)
BMY: Bm1_00355
TSP: Tsp_00479
CRG: 105341702
MYI: 110465109
LAK: 106174984
SHX: MS3_06267
EPA: 110251752
ADF: 107350389
HMG: 100192290(gna12)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8423800
  Authors
Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA
  Title
Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
  Journal
Mol Cell Biol 13:762-8 (1993)
  Sequence
[hsa:2768]
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507
  Sequence
[hsa:2768]

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