KEGG ORTHOLOGY: K04360

ORTHOLOGY: K04360

Entry

K04360                      KO

Symbol

NTRK2, TRKB

Name

neurotrophic tyrosine kinase receptor type 2 [EC:2.7.10.1]

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04722

Neurotrophin signaling pathway

map05034

Alcoholism

Disease

H00043

Neuroblastoma

H00606

Early infantile epileptic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04014 Ras signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04020 Calcium signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
   04151 PI3K-Akt signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
09160 Human Diseases
  09165 Substance dependence
   05034 Alcoholism
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  TRK family [OT]
   K04360  NTRK2, TRKB; neurotrophic tyrosine kinase receptor type 2

Genes

HSA:	4915(NTRK2)

PTR:	735394(NTRK2)

PPS:	100994887(NTRK2)

GGO:	101140182(NTRK2)

PON:	100441207(NTRK2)

NLE:	100605330(NTRK2)

HMH:	116475199(NTRK2)

MCC:	709757(NTRK2)

MCF:	102132446(NTRK2)

MTHB:

126937627

MNI:	105498757(NTRK2)

CSAB:

103219672(NTRK2)

CATY:

105584243(NTRK2)

PANU:

101009383(NTRK2)

TGE:	112607806(NTRK2)

MLEU:

105541629(NTRK2)

RRO:	104673903(NTRK2)

RBB:	108520515(NTRK2)

TFN:	117098409(NTRK2)

PTEH:

111554169(NTRK2)

CANG:

105514498(NTRK2)

CJC:	100388984(NTRK2)

SBQ:	101053284(NTRK2)

CIMI:

108289188(NTRK2)

CSYR:

103256424(NTRK2)

MMUR:

105879502 105883785

LCAT:

123645777(NTRK2)

PCOQ:

105806839(NTRK2)

OGA:	100956865(NTRK2)

MMU:	18212(Ntrk2)

MCAL:

110307883(Ntrk2)

MPAH:

110333600(Ntrk2)

RNO:	25054(Ntrk2)

MCOC:

116082168(Ntrk2)

ANU:	117713532(Ntrk2)

MUN:	110565075(Ntrk2)

CGE:	100754339(Ntrk2)

MAUA:

101839587(Ntrk2)

PROB:

127229167(Ntrk2)

PLEU:

114688557(Ntrk2)

MORG:

121443890 121453299

MFOT:

126502815

AAMP:

119816678(Ntrk2)

NGI:	103747093(Ntrk2)

HGL:	101720037(Ntrk2)

CPOC:

100723565 106028780

CCAN:

109677416(Ntrk2)

DORD:

105996846(Ntrk2)

DSP:	122122111(Ntrk2)

PLOP:

125340063(Ntrk2)

NCAR:

124964245

MMMA:

107159490(Ntrk2)

OCU:

100352548

OPI:	101517963(NTRK2)

TUP:

102497563

GVR:	103592883(NTRK2)

CFA:	484147(NTRK2)

CLUD:

112644636(NTRK2)

VVP:	112908664(NTRK2)

VLG:	121484579(NTRK2)

NPO:	129499796(NTRK2)

AML:	100477127(NTRK2)

UMR:	103667631(NTRK2)

UAH:	113269802(NTRK2)

UAR:

123781399

ELK:

111153613

LLV:

125083535

MPUF:

101674211(NTRK2)

MNP:	132024768(NTRK2)

MLK:	131812441(NTRK2)

NVS:	122917648(NTRK2)

ORO:	101364921(NTRK2)

EJU:	114223345(NTRK2)

ZCA:	113934282(NTRK2)

MLX:	118023317(NTRK2)

NSU:	110569991(NTRK2)

LWW:

102741802

FCA:	101101347(NTRK2)

PYU:	121014214(NTRK2)

PCOO:

112868641(NTRK2)

PBG:	122474678(NTRK2)

PVIV:

125150787(NTRK2)

LRUF:

124525122

PTG:	102950315(NTRK2)

PPAD:

109251704(NTRK2)

PUC:

125938004

AJU:

106978572

HHV:	120224500(NTRK2)

BTA:	505824(NTRK2)

BOM:	102269089(NTRK2)

BIU:	109563216(NTRK2)

BBUB:

102416668(NTRK2)

BBIS:

104988664(NTRK2)

CHX:	102180223(NTRK2)

OAS:	101116015(NTRK2)

BTAX:

128052378(NTRK2)

ODA:	120866819(NTRK2)

CCAD:

122431778(NTRK2)

MBEZ:

129556974(NTRK2)

SSC:	100519209(NTRK2)

CFR:	102507254(NTRK2)

CBAI:

105078857(NTRK2)

CDK:	105100473(NTRK2)

VPC:	102536840(NTRK2)

BACU:

103020777(NTRK2)

BMUS:

118896868(NTRK2)

LVE:

103069787

OOR:	101281465(NTRK2)

DLE:	111166804(NTRK2)

PCAD:

102987032(NTRK2)

PSIU:

116755336(NTRK2)

NASI:

112405444(NTRK2)

ECB:	100061700(NTRK2)

EPZ:	103551809(NTRK2)

EAI:	106822031(NTRK2)

MYB:	102238774(NTRK2)

MYD:	102755544(NTRK2)

MMYO:

118667416(NTRK2)

MLF:	102426842(NTRK2)

PKL:	118716438(NTRK2)

EFUS:

103286498(NTRK2)

MNA:	107545009(NTRK2)

DRO:	112304477(NTRK2)

SHON:

118979587(NTRK2)

AJM:	119060018(NTRK2)

PDIC:

114492084(NTRK2)

PHAS:

123820257(NTRK2)

MMF:	118629607(NTRK2)

PPAM:

129078231(NTRK2)

HAI:	109372375 109374619

RFQ:	117032168(NTRK2)

PALE:

102882910(NTRK2)

PGIG:

120612943(NTRK2)

PVP:	105300054(NTRK2)

RAY:	107502751(NTRK2)

MJV:	108400418(NTRK2)

TOD:	119232387(NTRK2)

SARA:

101538939(NTRK2)

LAV:	100675363(NTRK2)

TMU:

101342178

ETF:	101654367(NTRK2)

DNM:

101424677

MDO:	100029389(NTRK2)

GAS:	123232189(NTRK2)

SHR:	100927322(NTRK2)

AFZ:

127541058

PCW:	110194558(NTRK2)

OAA:	100080080(NTRK2)

GGA:	396157(NTRK2)

PCOC:

116234674(NTRK2)

MGP:	100545915(NTRK2)

CJO:	107306253(NTRK2)

TPAI:

128089796(NTRK2)

LMUT:

125686640(NTRK2)

NMEL:

110389852(NTRK2)

APLA:

101797842(NTRK2)

ACYG:

106045383(NTRK2)

CATA:

118257362(NTRK2)

AFUL:

116500354(NTRK2)

TGU:	751985(NTRK2)

LSR:	110472599(NTRK2)

SCAN:

103822953(NTRK2)

PMOA:

120511955(NTRK2)

OTC:	121332035(NTRK2)

PRUF:

121360713(NTRK2)

GFR:	102044793(NTRK2)

FAB:	101810339(NTRK2)

OMA:	130265122(NTRK2)

PHI:	102100533(NTRK2)

PMAJ:

107216220(NTRK2)

CCAE:

111940854(NTRK2)

CCW:	104692002(NTRK2)

CBRC:

103619849(NTRK2)

ETL:	114055895(NTRK2)

ZAB:	102071660(NTRK2)

SVG:	106848895(NTRK2)

MMEA:

130575834(NTRK2)

HRT:	120765042(NTRK2)

FPG:	101919319(NTRK2)

FCH:	102055826(NTRK2)

CLV:	102092182(NTRK2)

EGZ:	104135554(NTRK2)

NNI:	104011761(NTRK2) 104013813

EHS:	104509980(NTRK2)

PCAO:

104047642(NTRK2)

ACUN:

113490005(NTRK2)

TALA:

104360530(NTRK2)

PADL:

103920397(NTRK2)

AFOR:

103893878(NTRK2)

ACHC:

115336699(NTRK2)

HLE:	104832455(NTRK2)

AGEN:

126035573 126036174

GCL:	127027121 127027278

CMAC:

104481337

BREG:

104642870

OHA:	104331165(NTRK2)

SHAB:

115619908

DPUB:

104306765(NTRK2)

CPEA:

104386799(NTRK2)

CVF:	104282810 104287176(NTRK2)

RTD:	128901988 128902295(NTRK2)

CUCA:

104059913(NTRK2)

BRHI:

104494965(NTRK2)

AAM:	106489062 106500348

AROW:

112976815(NTRK2)

NPD:	112942772(NTRK2)

TGT:	104571302(NTRK2)

DNE:	112978757(NTRK2)

SCAM:

104147228 104150004(NTRK2)

ASN:

102372380

AMJ:	102559730(NTRK2)

CPOO:

109323426(NTRK2)

GGN:	109297554(NTRK2)

PSS:	102446411(NTRK2)

CMY:	102937131(NTRK2)

CCAY:

125637459(NTRK2)

DCC:	119855704(NTRK2)

CPIC:

101947563(NTRK2)

TST:	117879171(NTRK2)

CABI:

116819442(NTRK2)

MRV:	120407553(NTRK2)

ACS:	100558067(ntrk2)

ASAO:

132767314(NTRK2)

PVT:	110089898(NTRK2)

SUND:

121922417(NTRK2)

PBI:	103063871(NTRK2)

PMUR:

107294568(NTRK2)

CTIG:

120299078(NTRK2)

TSR:	106556809(NTRK2)

PGUT:

117661392(NTRK2)

APRI:

131191380

PTEX:

113438479(NTRK2)

NSS:	113416674(NTRK2)

VKO:	123031550(NTRK2)

PMUA:

114606265(NTRK2)

PRAF:

128423560(NTRK2)

ZVI:	118076712(NTRK2)

HCG:	128347805(NTRK2)

GJA:	107117206(NTRK2)

STOW:

125436997(NTRK2)

EMC:	129335135(NTRK2)

XLA:	379266(ntrk2.L) 779173(ntrk2.S)

XTR:	780110(ntrk2)

NPR:	108798612(NTRK2)

RTEM:

120942448(NTRK2)

BBUF:

120989115(NTRK2)

BGAR:

122922907(NTRK2)

MUO:	115463288(NTRK2)

GSH:	117351949(NTRK2)

DRE:	570240(ntrk2b) 65090(ntrk2a)

SRX:	107728215 107730333 107752549 107757434

SANH:

107664539(ntrk2) 107678451 107684341 107691713

SGH:	107553150(ntrk2) 107562658 107596017 107600581

CCAR:

109049076 109049386 109100514

CAUA:

113039658 113049835 113084010 113107417

CGIB:

127958034 127963718 127993795 128018220

PTET:

122345312(ntrk2b) 122350518(ntrk2a)

LROH:

127165292(ntrk2b) 127169494(ntrk2a)

OMC:	131540693(ntrk2b) 131546137(ntrk2a)

PPRM:

120472250(ntrk2b) 120481295(ntrk2a)

RKG:	130082074(ntrk2a) 130099688(ntrk2b)

MAMB:

125267895(ntrk2b) 125280346(ntrk2a)

CIDE:

127513233 127517760

MASI:

127415116 127424667 127430760 127439849

TROS:

130568042(ntrk2a) 130569064

TDW:	130407138(ntrk2a) 130419056(ntrk2b)

MANU:

129414231(ntrk2a) 129441150(ntrk2b)

IPU:	108259739(ntrk2b) 108265887(ntrk2a)

IFU:	128603314(ntrk2b) 128607487(ntrk2a)

PHYP:

113531639 113533488(ntrk2)

SMEO:

124378880(ntrk2b) 124399876(ntrk2a)

TFD:	113641793(ntrk2b) 113656183(ntrk2a)

TVC:	132841093(ntrk2b) 132853765(ntrk2a)

AMEX:

103036414(ntrk2) 103044160

CMAO:

118813320(ntrk2a) 118814584(ntrk2b)

EEE:	113578767(ntrk2) 113586931

CHAR:

105894377(ntrk2a) 105902823(ntrk2b)

TRU:	101077811(ntrk2) 101078202

TFS:	130516728(ntrk2b) 130525542(ntrk2a)

TNG:	GSTEN00014464G001 GSTEN00029370G001

LCO:	104920263(ntrk2) 109141561

TBEN:

117472851(ntrk2a) 117478737(ntrk2b)

CGOB:

115013223(ntrk2) 115016885

PGEO:

117443819 117452155(ntrk2a)

GACU:

117558654(ntrk2a)

EMAC:

134868054(ntrk2b) 134874132(ntrk2a)

ELY:	117252134(ntrk2a) 117269771(ntrk2b)

EFO:	125889747(ntrk2a) 125906192(ntrk2b)

PLEP:

121944306(ntrk2a) 121960280(ntrk2b)

SLUC:

116056646(ntrk2a) 116062849(ntrk2b)

ECRA:

117944365(ntrk2a) 117959577(ntrk2b)

ESP:	116688894(ntrk2) 116704792

PFLV:

114556221(ntrk2) 114571365

GAT:	120830317(ntrk2a) 120831671(ntrk2b)

PPUG:

119224481(ntrk2a) 119226742(ntrk2b)

AFB:	129100957(ntrk2a) 129102532(ntrk2b)

CLUM:

117736319(ntrk2a) 117740508(ntrk2b)

PSWI:

130196581(ntrk2a) 130205362(ntrk2b)

MSAM:

119892041(ntrk2a) 119914353(ntrk2b)

SCHU:

122865556(ntrk2b) 122876204(ntrk2a)

CUD:	121509635(ntrk2a) 121525675(ntrk2b)

ALAT:

119019740(ntrk2a) 119030549(ntrk2b)

MZE:	101467169 101477733

ONL:	100692708(ntrk2) 100697438

OAU:	116331856(ntrk2b) 116336448(ntrk2a)

OLA:	101159930 101172248(ntrk2)

OML:	112148088(ntrk2a) 112163033(ntrk2b)

CSAI:

133451272(ntrk2a) 133454953(ntrk2b)

XMA:	102228507(ntrk2) 102229659

XCO:	114149964 114154115(ntrk2)

XHE:	116724170 116729328(ntrk2)

PRET:

103470214(ntrk2) 103473467

PFOR:

103135387(ntrk2) 103155137

PLAI:

106953461(ntrk2) 106954505

PMEI:

106912368 106922120(ntrk2)

GAF:	122827783(ntrk2a) 122846831(ntrk2b)

PPRL:

129365724(ntrk2a) 129374151(ntrk2b)

CVG:	107084447(ntrk2) 107088955

CTUL:

119776552(ntrk2b) 119796910(ntrk2a)

GMU:	124872807(ntrk2b) 124878106(ntrk2a)

NFU:	107374736 107394032(ntrk2)

KMR:	108231044(ntrk2b) 108234558(ntrk2a)

ALIM:

106516247 106534176

NWH:	119413056(ntrk2a) 119424497(ntrk2b)

AOCE:

111564839 111567414(ntrk2)

MCEP:

124997035(ntrk2b) 125011773(ntrk2a)

CSEM:

103390423 103397098 103398177(ntrk2)

POV:	109626472 109639804

SSEN:

122757981(ntrk2b) 122770195(ntrk2a)

HHIP:

117767472(ntrk2a) 117771866(ntrk2b)

HSP:	118114803(ntrk2a) 118125518(ntrk2b)

SMAU:

118285316(ntrk2b) 118314359(ntrk2a)

LCF:	108873999(ntrk2b) 108878348(ntrk2a)

SDU:	111230804(ntrk2) 111239875

SLAL:

111656813 111660950(ntrk2)

XGL:	120804936(ntrk2a) 120806465(ntrk2b)

HCQ:	109514240(ntrk2) 109527923

SSCV:

125979592 125993771

SBIA:

133490454(ntrk2b) 133499310(ntrk2a)

PEE:	133399870(ntrk2a) 133413559(ntrk2b)

PTAO:

133475300(ntrk2a) 133489820(ntrk2b)

BPEC:

110153486(ntrk2) 110157504

MALB:

109961608(ntrk2) 109972366

BSPL:

114861658(ntrk2a) 114866706(ntrk2b)

SJO:	128364465(ntrk2a) 128380216(ntrk2b)

SASA:

106562076 106568346 106580092 106585685(ntrk2)

STRU:

115149342 115159210 115164837(ntrk2) 115199819

OTW:	112219765 112248257(ntrk2a) 112257428 112264138

OMY:	110523884(ntrk2b) 110525378(ntrk2a) 110535778 110537044

OGO:	124000909 124034546 124036057 124047784

ONE:	115104744 115111349(ntrk2) 115126741 115139779

OKI:	109868201 109876480(ntrk2) 109893637 109895673

OKE:	118358081 118388023 118391497 118392951(ntrk2a)

SALP:

111958102 111961321 111973875 111981917

SNH:	120025623 120044794 120050479(ntrk2a) 120063544

CCLU:

121550303 121574532 121582807 121584541(ntrk2a)

ELS:	105014455(ntrk2) 105027931

SFM:	108931316 108938645(ntrk2)

PKI:	111839208(ntrk2) 111851431

AANG:

118206745(ntrk2a) 118212214

LOC:	102691261(ntrk2)

PSPA:

121299406(ntrk2a) 121318701

ARUT:

117408862 117421120

PSEX:

120527322(ntrk2a)

LCM:	102363882(NTRK2)

CMK:	103187358(ntrk2a)

RTP:	109920280(ntrk2a)

CPLA:

122561340(ntrk2a)

HOC:	132828245(ntrk2a)

LERI:

129695733(ntrk2a)

PMRN:

103091785 116940892

LRJ:	133346751 133355128

SPU:

APLC:

SKO:

BANY:

MJU:

DCI:

FOC:

TPAL:

DMK:

PJA:

HAME:

PCLA:

PTRU:

ESN:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

ABRU:

UDV:	129224093 129226702

LPOL:

PVUL:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:	110443153 110461163

PMAX:

MCAF:

MMER:

RPHI:

OBI:

Reference

PMID:8287802

Authors

Dechant G, Biffo S, Okazawa H, Kolbeck R, Pottgiesser J, Barde YA

Title

Expression and binding characteristics of the BDNF receptor chick trkB.

Journal

Development 119:545-58 (1993)

Sequence

[gga:396157]

Reference

PMID:17918233

Authors

Chen Z, Simmons MS, Perry RT, Wiener HW, Harrell LE, Go RC

Title

Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease.

Journal

Am J Med Genet B Neuropsychiatr Genet 147:363-9 (2008)
DOI:10.1002/ajmg.b.30607

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