KEGG   ORTHOLOGY: K04382Help
Entry
K04382                      KO                                     

Name
PPP2C
Definition
serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
Pathway
ko03015  mRNA surveillance pathway
ko04013  MAPK signaling pathway - fly
ko04071  Sphingolipid signaling pathway
ko04111  Cell cycle - yeast
ko04113  Meiosis - yeast
ko04114  Oocyte meiosis
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04350  TGF-beta signaling pathway
ko04390  Hippo signaling pathway
ko04391  Hippo signaling pathway - fly
ko04530  Tight junction
ko04728  Dopaminergic synapse
ko04730  Long-term depression
ko05142  Chagas disease (American trypanosomiasis)
ko05160  Hepatitis C
ko05165  Human papillomavirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04350 TGF-beta signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04390 Hippo signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04391 Hippo signaling pathway - fly
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04071 Sphingolipid signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04151 PI3K-Akt signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04152 AMPK signaling pathway
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04138 Autophagy - yeast
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04136 Autophagy - other
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  09143 Cell growth and death
   04111 Cell cycle - yeast
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04113 Meiosis - yeast
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04114 Oocyte meiosis
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  09156 Nervous system
   04728 Dopaminergic synapse
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   04730 Long-term depression
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
   05165 Human papillomavirus infection
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  09174 Infectious disease: parasitic
   05142 Chagas disease (American trypanosomiasis)
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-2 (PP2A)
    Catalytic subunits
     K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Other centromeric chromatin formation proteins
    PP2A (protein phosphatase 2A)
     K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04382  PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit
BRITE hierarchy
Other DBs
COG: COG0639
GO: 0004722
Genes
HSA: 5515(PPP2CA) 5516(PPP2CB)
PTR: 100614247(PPP2CA) 464100(PPP2CB) 471633
PPS: 100976101(PPP2CB) 100981626(PPP2CA) 100987323
GGO: 101125226(PPP2CB) 101152519(PPP2CA)
PON: 100437405(PPP2CB) 100461606(PPP2CA)
NLE: 100585393(PPP2CB) 100596525(PPP2CA)
MCC: 695118(PPP2CB) 710326(PPP2CA)
MCF: 101864925(PPP2CA) 102137928(PPP2CB)
CSAB: 103215586(PPP2CB) 103244545(PPP2CA)
RRO: 104659809(PPP2CA) 104668221(PPP2CB)
RBB: 108518653(PPP2CB) 108529557(PPP2CA)
CJC: 100395261(PPP2CB) 100398536(PPP2CA)
SBQ: 101028752(PPP2CA) 101037428(PPP2CB)
MMU: 19052(Ppp2ca) 19053(Ppp2cb)
MCAL: 110299736(Ppp2cb) 110305092(Ppp2ca)
MPAH: 110331422(Ppp2ca) 110336304(Ppp2cb)
RNO: 103694903 24672(Ppp2ca) 24673(Ppp2cb)
MUN: 110548328(Ppp2cb) 110549625(Ppp2ca)
CGE: 100757400(Ppp2cb) 103164195
NGI: 103729809(Ppp2ca) 103743584(Ppp2cb)
HGL: 101707511(Ppp2ca) 101726191(Ppp2cb)
CCAN: 109689490(Ppp2ca) 109692163(Ppp2cb)
OCU: 100009252(PPP2CA) 100009300(PPP2CB)
TUP: 102479161(PPP2CA) 102487950 102500173(PPP2CB)
CFA: 403608(PPP2CA) 482873(PPP2CB)
VVP: 112916103(PPP2CB) 112917055(PPP2CA)
AML: 100464293(PPP2CA) 100473021(PPP2CB)
UMR: 103659105(PPP2CB)
UAH: 113261737(PPP2CA) 113262137(PPP2CB)
ORO: 101367482(PPP2CB) 101376533(PPP2CA)
FCA: 101094667(PPP2CB) 101099271(PPP2CA)
PTG: 102954008(PPP2CA) 102956715(PPP2CB)
PPAD: 109250803(PPP2CA) 109277271(PPP2CB)
AJU: 106966583(PPP2CB) 106984892(PPP2CA)
BTA: 282320(PPP2CA) 524361(PPP2CB)
BOM: 102266065(PPP2CA) 102279886 102282540(PPP2CB)
BIU: 109553505(PPP2CB) 109562017(PPP2CA)
BBUB: 102398465(PPP2CB) 102407460(PPP2CA)
CHX: 102175016(PPP2CA) 102182013(PPP2CB) 108637886
OAS: 101114930(PPP2CB) 443009(PPP2CA)
SSC: 397136(PPP2CB) 397656(PPP2CA)
CFR: 102509650(PPP2CB) 106728419(PPP2CA)
CDK: 105090279(PPP2CA) 105095814(PPP2CB)
BACU: 103000342(PPP2CB) 103018989(PPP2CA) 103019215
LVE: 103074714(PPP2CA) 103086967(PPP2CB)
OOR: 101282700 101286814(PPP2CB) 101289109(PPP2CA)
DLE: 111173481(PPP2CB) 111182447(PPP2CA)
PCAD: 102974912(PPP2CB) 102993796(PPP2CA)
ECB: 100062224(PPP2CB)
EPZ: 103543523(PPP2CA) 103565579(PPP2CB)
EAI: 106824437(PPP2CB) 106834655(PPP2CA)
MYB: 102246010(PPP2CA) 102255371(PPP2CB)
MYD: 102762679(PPP2CA) 102771922(PPP2CB)
MNA: 107525394(PPP2CA) 107534103(PPP2CB)
HAI: 109382627(PPP2CA) 109382969(PPP2CB)
DRO: 112306709(PPP2CB) 112318081(PPP2CA)
PALE: 102885289(PPP2CA) 102887013(PPP2CB)
RAY: 107505807(PPP2CB) 107506800(PPP2CA)
MJV: 108405988 108406080(PPP2CA)
LAV: 100664132(PPP2CA) 100676230(PPP2CB)
MDO: 100012652(PPP2CB) 100017519(PPP2CA)
SHR: 100921980(PPP2CB) 100927043(PPP2CA) 100932648
PCW: 110194908 110211727(PPP2CA) 110223036(PPP2CB)
OAA: 100082155(PPP2CA) 100082697(PPP2CB)
GGA: 396021(PPP2CB) 416318(PPP2CA)
MGP: 100546612(PPP2CA) 100549769(PPP2CB)
CJO: 107313198(PPP2CB) 107320210(PPP2CA)
NMEL: 110397684(PPP2CB) 110405289(PPP2CA)
APLA: 101799879(PPP2CB) 101803206(PPP2CA)
ACYG: 106032768(PPP2CA) 106035222(PPP2CB)
TGU: 100190531(PPP2CB) 100228749(PPP2CA)
LSR: 110471193(PPP2CB) 110481080(PPP2CA)
SCAN: 103817471(PPP2CA) 103823422(PPP2CB)
GFR: 102036925(PPP2CA) 102042538(PPP2CB)
FAB: 101814178(PPP2CA)
PHI: 102100299(PPP2CA) 102109205(PPP2CB)
PMAJ: 107203383(PPP2CB) 107210640(PPP2CA)
CCAE: 111928993(PPP2CB) 111935602(PPP2CA) 111942682
CCW: 104683725(PPP2CA) 104696831(PPP2CB)
ETL: 114063911(PPP2CA) 114069590(PPP2CB)
FPG: 101919502(PPP2CA) 101920842(PPP2CB)
FCH: 102052989(PPP2CB) 102058381(PPP2CA)
CLV: 102085353 102093920(PPP2CA)
EGZ: 104133477(PPP2CA) 104135437(PPP2CB)
NNI: 104012002(PPP2CA) 104016606(PPP2CB)
ACUN: 113479507(PPP2CB) 113485243(PPP2CA)
PADL: 103913386(PPP2CB) 103915849(PPP2CA)
AAM: 106487221(PPP2CA) 106494814
ASN: 102386870(PPP2CB) 102387234(PPP2CA)
AMJ: 102576713(PPP2CB) 102576911(PPP2CA)
PSS: 102446185(PPP2CA) 102457538(PPP2CB)
CMY: 102942368 102945505(PPP2CB)
CPIC: 101939877(PPP2CA) 101952365(PPP2CB)
ACS: 100558622(ppp2cb) 100568233(ppp2ca)
PVT: 110079404(PPP2CA) 110087364(PPP2CB)
PBI: 103051395(PPP2CA) 103064597(PPP2CB)
PMUR: 107285618(PPP2CB) 107294933(PPP2CA)
TSR: 106539522 106539819(PPP2CB)
PMUA: 114587315(PPP2CB) 114591271(PPP2CA)
GJA: 107110575 107125982(PPP2CA)
XLA: 108706827 108712618 380045(ppp2ca.L) 399343(ppp2cb.L)
XTR: 394888(ppp2ca) 448031(ppp2cb)
NPR: 108792131 108798842(PPP2CB)
DRE: 393885(zgc:56064) 406582(ppp2cb) 550585(ppp2ca)
IPU: 100528132(ppp2cb) 108274658(ppp2ca)
PHYP: 113543531(ppp2cb) 113547123
AMEX: 103033752(ppp2cb) 103045214(ppp2ca)
EEE: 113569990(ppp2cb) 113578036(ppp2ca) 113586037
TRU: 101065017(ppp2cb) 101068850(ppp2ca)
LCO: 104924365(ppp2ca) 104935225(ppp2cb) 104938463
MZE: 101470047(ppp2ca) 101479611(ppp2cb) 101487597
OLA: 101157601(ppp2cb) 101173325(ppp2ca)
XMA: 102221749(ppp2ca) 102223777 102237558(ppp2cb)
XCO: 114138792 114144578(ppp2cb) 114152467(ppp2ca)
PRET: 103459981(ppp2ca) 103470779(ppp2cb) 103471193
NFU: 107373442 107386136(ppp2cb) 107386839(ppp2ca)
KMR: 108238074(ppp2ca) 108240607 108245884(ppp2cb)
CSEM: 103391208 103394862(ppp2ca) 103398006(ppp2cb) 103399619
POV: 109628717(ppp2ca) 109643848
SDU: 111226526 111234362(ppp2ca) 111236941(ppp2cb)
MALB: 109957364(ppp2cb) 109966816(ppp2ca) 109971173
PKI: 111835938(ppp2cb) 111839546 111847940(ppp2ca)
LCM: 102349792(PPP2CA) 102350821
CMK: 103183681(ppp2ca) 103186729
CIN: 100186064
SPU: 580852
APLC: 110977570
SKO: 100374420
DME: Dmel_CG7109(mts)
DER: 6541132
DSI: Dsimw501_GD23492(Dsim_GD23492)
DSR: 110176970
DPE: 6589526
DMN: 108162378
DWI: 6641730
DAZ: 108610140
DNV: 108657888
DHE: 111602517
MDE: 101900976
LCQ: 111680733
AAG: 5580325
AME: 550710
BIM: 100741688
BTER: 100646859
CCAL: 108623154
OBB: 114881738
SOC: 105201502
MPHA: 105831626
AEC: 105143155
ACEP: 105627845
PBAR: 105425620
VEM: 105565436
HST: 105189916
DQU: 106744327
CFO: 105257262
LHU: 105668142
PGC: 109863721
OBO: 105275036
PCF: 106785183
NVI: 100118571
CSOL: 105368684
MDL: 103575423
TCA: 662352
DPA: 109536915
ATD: 109604044
NVL: 108568419
BMOR: 101737820
BMAN: 114252409
PMAC: 106710258
PRAP: 110995428
HAW: 110380514
TNL: 113499516
API: 100144917
DNX: 107167247
AGS: 114123131
RMD: 113551529
BTAB: 109044302
CLEC: 106665085
ZNE: 110831023
FCD: 110842354
TUT: 107362015
DPTE: 113795159
PTEP: 107441025
CEL: CELE_F38H4.9(let-92)
CBR: CBG06179(Cbr-let-92)
TSP: Tsp_04401
CRG: 105341231
MYI: 110457665
LAK: 106170761
SHX: MS3_05437
EGL: EGR_09643
ADF: 107352888
AMIL: 114962991
PDAM: 113681459
SPIS: 111321943
DGT: 114520874
HMG: 100201603
AQU: 100641577
ATH: AT1G10430(PP2A-2) AT1G59830(PP2A-1) AT1G69960(PP2A) AT2G42500(PP2A-3) AT3G58500(PP2A-4)
LJA: Lj0g3v0138929.1(Lj0g3v0138929.1) Lj1g3v4763900.1(Lj1g3v4763900.1) Lj2g3v1364780.1(Lj2g3v1364780.1) Lj4g3v2603900.1(Lj4g3v2603900.1)
SLY: 101245881 101252803 101257003 544183(PP2Ac1) 544262(PP2Ac2)
DOSA: Os02t0217600-01(Os02g0217600) Os03t0167700-01(Os03g0167700) Os03t0805300-01(Os03g0805300) Os06t0574500-01(Os06g0574500)
ATS: 109733394(LOC109733394) 109770537(LOC109770537) 109771013(LOC109771013) 109771400(LOC109771400) 109775911(LOC109775911)
APRO: F751_0347
SCE: YDL134C(PPH21) YDL188C(PPH22)
ERC: Ecym_8052
KMX: KLMA_60499(PPH21)
NCS: NCAS_0A13850(NCAS0A13850) NCAS_0E03680(NCAS0E03680)
NDI: NDAI_0A02190(NDAI0A02190) NDAI_0A02950(NDAI0A02950)
TPF: TPHA_0A03180(TPHA0A03180) TPHA_0P00880(TPHA0P00880)
TBL: TBLA_0A05910(TBLA0A05910) TBLA_0F02060(TBLA0F02060)
TDL: TDEL_0C02450(TDEL0C02450)
KAF: KAFR_0B01120(KAFR0B01120)
CAL: CAALFM_C301600WA(PPH21)
SLB: AWJ20_1003(PPH21) AWJ20_4729(PPH21)
NCR: NCU06630(pph-1)
NTE: NEUTE1DRAFT59886(NEUTE1DRAFT_59886)
MGR: MGG_06099
SSCK: SPSK_07591
MAW: MAC_06412
MAJ: MAA_05062
CMT: CCM_04272
MBE: MBM_01984
ANI: AN6391.2
ANG: ANI_1_1608104(An12g02970) ANI_1_58094(An11g00420)
ABE: ARB_02777
TVE: TRV_03388
PTE: PTT_16076
ZTR: MYCGRDRAFT_101229(MgPP2Ac)
SPO: SPAC823.15(ppa1) SPBC16H5.07c(ppa2)
CNE: CNE03610
CNB: CNBE3610
PPL: POSPLDRAFT_122071(PP2A-2) POSPLDRAFT_90738(PP2A-3)
ABP: AGABI1DRAFT114427(AGABI1DRAFT_114427)
ABV: AGABI2DRAFT191462(AGABI2DRAFT_191462)
MGL: MGL_0499
MRT: MRET_2324
DDI: DDB_G0290263(pho2A)
EHI: EHI_011950(16.t00005)
PYO: PY17X_0829500(PY00926)
PCB: PCHAS_082650(PC000855.01.0)
TAN: TA15515
TPV: TP02_0853
BBO: BBOV_I000740(16.m00696)
SMIN: v1.2.018382.t1(symbB.v1.2.018382.t1) v1.2.019959.t1(symbB.v1.2.019959.t1) v1.2.019959.t2(symbB.v1.2.019959.t2) v1.2.033440.t1(symbB.v1.2.033440.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2849764
  Authors
Stone SR, Mayer R, Wernet W, Maurer F, Hofsteenge J, Hemmings BA
  Title
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A alpha catalytic subunit.
  Journal
Nucleic Acids Res 16:11365 (1988)
DOI:10.1093/nar/16.23.11365
  Sequence
[hsa:5515]
Reference
PMID:2849765
  Authors
Hemmings BA, Wernet W, Mayer R, Maurer F, Hofsteenge J, Stone SR
  Title
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit.
  Journal
Nucleic Acids Res 16:11366 (1988)
DOI:10.1093/nar/16.23.11366
  Sequence
[hsa:5516]

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