KEGG   ORTHOLOGY: K04388
Entry
K04388                      KO                                     
Symbol
TGFBR2
Name
TGF-beta receptor type-2 [EC:2.7.11.30]
Pathway
map04010  MAPK signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04068  FoxO signaling pathway
map04144  Endocytosis
map04218  Cellular senescence
map04350  TGF-beta signaling pathway
map04380  Osteoclast differentiation
map04390  Hippo signaling pathway
map04520  Adherens junction
map04659  Th17 cell differentiation
map04926  Relaxin signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map05142  Chagas disease
map05161  Hepatitis B
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05220  Chronic myeloid leukemia
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05415  Diabetic cardiomyopathy
Disease
H00017  Esophageal cancer
H00020  Colorectal cancer
H00048  Hepatocellular carcinoma
H00800  Loeys-Dietz syndrome
H00801  Familial thoracic aortic aneurysm and dissection
H02565  Hereditary nonpolyposis colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04350 TGF-beta signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04390 Hippo signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
   04068 FoxO signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04388  TGFBR2; TGF-beta receptor type-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04388  TGFBR2; TGF-beta receptor type-2
  09143 Cell growth and death
   04218 Cellular senescence
    K04388  TGFBR2; TGF-beta receptor type-2
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04388  TGFBR2; TGF-beta receptor type-2
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K04388  TGFBR2; TGF-beta receptor type-2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04388  TGFBR2; TGF-beta receptor type-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05202 Transcriptional misregulation in cancer
    K04388  TGFBR2; TGF-beta receptor type-2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05212 Pancreatic cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05225 Hepatocellular carcinoma
    K04388  TGFBR2; TGF-beta receptor type-2
   05226 Gastric cancer
    K04388  TGFBR2; TGF-beta receptor type-2
   05220 Chronic myeloid leukemia
    K04388  TGFBR2; TGF-beta receptor type-2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04388  TGFBR2; TGF-beta receptor type-2
   05161 Hepatitis B
    K04388  TGFBR2; TGF-beta receptor type-2
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04388  TGFBR2; TGF-beta receptor type-2
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K04388  TGFBR2; TGF-beta receptor type-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04388  TGFBR2; TGF-beta receptor type-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04388  TGFBR2; TGF-beta receptor type-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     K04388  TGFBR2; TGF-beta receptor type-2
Protein kinases [BR:ko01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   K04388  TGFBR2; TGF-beta receptor type-2
Other DBs
GO: 0005026
Genes
HSA: 7048(TGFBR2)
PTR: 460243(TGFBR2)
PPS: 100985497(TGFBR2)
GGO: 101146131(TGFBR2)
PON: 100459236(TGFBR2)
NLE: 100606849(TGFBR2)
MCC: 114675335 703088(TGFBR2)
MCF: 102134273(TGFBR2)
CSAB: 103241808(TGFBR2)
CATY: 105578253(TGFBR2)
PANU: 101023107(TGFBR2)
TGE: 112618545(TGFBR2)
RRO: 104655082(TGFBR2)
RBB: 108516558(TGFBR2)
TFN: 117084287(TGFBR2)
PTEH: 111526524(TGFBR2)
CJC: 100404359(TGFBR2)
SBQ: 101034142(TGFBR2)
CSYR: 103261716(TGFBR2)
MMUR: 105883482(TGFBR2)
OGA: 100960821(TGFBR2)
MMU: 21813(Tgfbr2)
MCAL: 110301725(Tgfbr2)
MPAH: 110327573(Tgfbr2)
RNO: 81810(Tgfbr2)
MCOC: 116073579(Tgfbr2)
MUN: 110547249(Tgfbr2)
CGE: 100773953(Tgfbr2)
PLEU: 114704977(Tgfbr2)
NGI: 103744639(Tgfbr2)
HGL: 101704397(Tgfbr2)
CPOC: 100718284(Tgfbr2)
CCAN: 109681522(Tgfbr2)
DORD: 105994860(Tgfbr2)
DSP: 122096026(Tgfbr2)
OCU: 100344335(TGFBR2)
OPI: 101534968(TGFBR2)
TUP: 102486518(TGFBR2)
CFA: 477039(TGFBR2)
VVP: 112921591(TGFBR2)
VLG: 121478523(TGFBR2)
AML: 100482939(TGFBR2)
UMR: 103682015(TGFBR2)
UAH: 113253847(TGFBR2)
UAR: 123777686(TGFBR2)
ELK: 111158999
MPUF: 101679858(TGFBR2)
ORO: 101364575(TGFBR2)
EJU: 114212271(TGFBR2)
ZCA: 113916407(TGFBR2)
MLX: 118002661(TGFBR2)
FCA: 101091725(TGFBR2)
PYU: 121033562(TGFBR2)
PBG: 122492079(TGFBR2)
PTG: 102958413(TGFBR2)
PPAD: 109251365(TGFBR2)
AJU: 106984570(TGFBR2)
HHV: 120224680(TGFBR2)
BTA: 535376(TGFBR2)
BOM: 102267018(TGFBR2)
BIU: 109576148(TGFBR2)
BBUB: 102415303(TGFBR2)
CHX: 100861300(TGFBR2)
OAS: 494191(TGFBR2)
ODA: 120867879(TGFBR2)
CCAD: 122424266(TGFBR2)
SSC: 100038019(TGFBR2)
CFR: 102509744(TGFBR2)
CBAI: 105072636(TGFBR2)
CDK: 105087202(TGFBR2)
BACU: 103005777(TGFBR2)
LVE: 103077265(TGFBR2)
OOR: 101289351(TGFBR2)
DLE: 111164342(TGFBR2)
PCAD: 102995949(TGFBR2)
PSIU: 116761798(TGFBR2)
ECB: 100033860(TGFBR2)
EPZ: 103567708(TGFBR2)
EAI: 106830994(TGFBR2)
MYB: 102248472(TGFBR2)
MYD: 102767756(TGFBR2)
MMYO: 118668257(TGFBR2)
MLF: 102434274(TGFBR2)
MNA: 107526381(TGFBR2)
PKL: 118715431(TGFBR2)
HAI: 109394441(TGFBR2)
DRO: 112309970(TGFBR2)
SHON: 119004086(TGFBR2)
AJM: 119039725(TGFBR2)
PDIC: 114501577(TGFBR2)
PHAS: 123830471(TGFBR2)
MMF: 118633307(TGFBR2)
RFQ: 117036921(TGFBR2)
PALE: 102889618(TGFBR2)
PGIG: 120586804(TGFBR2)
PVP: 105292451(TGFBR2)
RAY: 107508791(TGFBR2)
MJV: 108391859(TGFBR2)
TOD: 119257560(TGFBR2)
SARA: 101553495(TGFBR2)
LAV: 100671392(TGFBR2)
TMU: 101354258
DNM: 101430016(TGFBR2)
MDO: 100031897(TGFBR2)
GAS: 123249688(TGFBR2)
SHR: 100913352(TGFBR2)
PCW: 110212998(TGFBR2)
OAA: 100076965(TGFBR2)
GGA: 396399(TGFBR2) 424261(AMHR2)
PCOC: 116227122(TGFBR2) 116227394
MGP: 100546861(TGFBR2) 100549829
CJO: 107309296(TGFBR2) 107316805
NMEL: 110393465(TGFBR2) 110399236
APLA: 101794795(TGFBR2) 101801641
ACYG: 106029911 106043323(TGFBR2)
AFUL: 116486426(TGFBR2) 116490458
TGU: 100220619(TGFBR2) 100224677
LSR: 110468201(TGFBR2) 110468281
SCAN: 103813156(TGFBR2) 103814641
PMOA: 120498661 120501746(TGFBR2)
OTC: 121337638(TGFBR2) 121338419
PRUF: 121353051(TGFBR2) 121356695
GFR: 102040558(TGFBR2) 102044945
FAB: 101808986 101811048(TGFBR2)
PHI: 102099204 102112281(TGFBR2)
PMAJ: 107200593(TGFBR2) 107207553
CCAE: 111923501(TGFBR2) 111932269
CCW: 104689295(TGFBR2) 104694032
ETL: 114064578(TGFBR2) 114067323
ZAB: 102071453(TGFBR2) 102074010
FPG: 101911268(TGFBR2) 101924328
FCH: 102048632 102053489(TGFBR2)
CLV: 102083591(TGFBR2) 102091992
EGZ: 104122957(TGFBR2) 104128099
NNI: 104013882(TGFBR2) 104020241
ACUN: 113477102(TGFBR2) 113482298
TALA: 104361811(TGFBR2) 104365779
PADL: 103917105(TGFBR2) 103919595
ACHC: 115339536(TGFBR2) 115342465
AAM: 106491249(TGFBR2) 106498480
AROW: 112965329(TGFBR2) 112976316
NPD: 112952606(TGFBR2) 112954963
DNE: 112982398(TGFBR2) 112988508
ASN: 102371879 102380434(TGFBR2)
AMJ: 102567839(TGFBR2) 102573702
CPOO: 109310907(TGFBR2) 109322762
GGN: 109291697(TGFBR2) 109301398
PSS: 102444710(TGFBR2) 102457599
CMY: 102946534 102947040(TGFBR2)
CPIC: 101930851 101936050(TGFBR2)
TST: 117872410(TGFBR2) 117885102
CABI: 116827024(TGFBR2) 116832884
MRV: 120375044 120398476(TGFBR2)
ACS: 100552899(tgfbr2) 100556560
PVT: 110086832(TGFBR2) 110090113
SUND: 121934614(TGFBR2)
PBI: 103057562(TGFBR2) 103063579
PMUR: 107284378(TGFBR2) 107290268
TSR: 106543204 106547952(TGFBR2)
PGUT: 117656107(TGFBR2) 117674410
VKO: 123016834(TGFBR2) 123027347
PMUA: 114604090 114607243(TGFBR2)
ZVI: 118091951 118092373(TGFBR2)
XLA: 108702885(tgfbr2l.S) 108718935(tgfbr2.L) 108719963(tgfbr2.S) 373815(tgfbr2l.L)
XTR: 100487430(tgfbr2.2) 100488582(tgfbr2)
RTEM: 120940316(TGFBR2)
BBUF: 121002016(TGFBR2)
BGAR: 122938407(TGFBR2)
DRE: 30739(tgfbr2b) 560446(si:dkey-101k6.5)
IPU: 108266333(tgfbr2l) 108270231(tgfbr2b) 108274807(tgfbr2a)
SMEO: 124383254(tgfbr2l) 124384386(tgfbr2b) 124392955
LCO: 104922506(tgfbr2) 104923102
SLUC: 116046615(tgfbr2l) 116047287 116066638(tgfbr2b)
GAT: 120810689(tgfbr2b) 120826425 120833504(tgfbr2l)
PPUG: 119197680(tgfbr2b) 119219642 119229310
MSAM: 119898112(tgfbr2b) 119903766(tgfbr2l) 119907257
CUD: 121513411(tgfbr2b) 121522309(tgfbr2l) 121523898
OAU: 116312139(tgfbr2b) 116312450(tgfbr2l) 116319415
OLA: 101170689(tgfbr2) 101174785
OML: 112155588(tgfbr2l) 112162680(tgfbr2b)
PRET: 103465886(tgfbr2) 103472661
PFOR: 103136959 103144447(tgfbr2)
PMEI: 106915864(tgfbr2) 106917549
GAF: 122831193(tgfbr2b) 122843422
CVG: 107086189(tgfbr2) 107098322
KMR: 108237979 108247742(tgfbr2b) 108247801(tgfbr2l)
SSEN: 122764845(tgfbr2l) 122775221 122786700
HHIP: 117754491(tgfbr2l) 117770903 117777178
HCQ: 109516370(tgfbr2) 109530278
OMY: 101268944(tgfr2) 110496033 110501778 110518401(tgfbr2b) 110520304(tgfbr2l)
SFM: 108918826 108935840(tgfbr2)
PKI: 111857200 111857846(tgfbr2)
AANG: 118207140(tgfbr2b) 118214501(tgfbr2l) 118233779
LOC: 102682723(tgfbr2) 102692092
PSPA: 121312913(tgfbr2b) 121314717 121322376(tgfbr2l) 121322837
LCM: 102346621(TGFBR2) 102356233
CMK: 103176334(tgfbr2b) 103188937(tgfbr2l)
BFO: 118403077
BBEL: 109475792
CIN: 778778(tgfbr-iib)
SCLV: 120343230
SPU: 580712
APLC: 110984215
SKO: 100329004(TGFbRII)
EPA: 110254510
ATEN: 116295466
 » show all
Reference
PMID:1310899
  Authors
Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodish HF
  Title
Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.
  Journal
Cell 68:775-85 (1992)
DOI:10.1016/0092-8674(92)90152-3
  Sequence
[hsa:7048]

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